• Topolovčan, N., Degač, M., Čikoš, A. & Gredičak, M. (2022) Chemoselective and Regioselective Synthesis of Spiroisoindolinone Indenes via an Intercepted Meyer-Schuster Rearrangement/Intramolecular Friedel-Crafts Alkylation Relay . (irb.hr)
  • Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Biochemistry;Reagents for Oligosaccharide Synthesis;Highly Purified Reagents;Other Categories;Zone Refined Products;Buffer;ACS Grade Buffers;ACS Grade;Biological Buffers;Buffers A to Z;Building Blocks;C3 to C8;Chemical Synthesis;Essential Chemicals;Heterocyclic Building Blocks;Imidazoles;Inorganic Salts;Research Essentials;Solutions and Reagents;Intermediate for Propafenone hydrochloride. (lookchem.com)
  • The synthesis and structures of two new octadentate, Schiff-base calixpyrrole macrocycles are presented in which modifications at the meso-substituents (L1) or the aryl spacer between the two pyrrole-imine donor compartments (L2) are introduced. (sharif.edu)
  • Beriša, A. & Gredičak, M. (2023) Chiral phosphoric acid-catalyzed Friedel-Crafts reaction of 2,5-disubstituted and 2-monosubstituted pyrroles with isoindolinone-derived ketimines . (irb.hr)
  • For example, 1-acetyl imidazole is a stable acylating agent, after reaction with pyrrole, it becomes 1-acetyl pyrrole. (lookchem.com)
  • Herein, we report an efficient one-pot four-component reaction of commercially available 1,3-dicarbonyl compounds, aromatic aldehydes, amines, and nitromethane in the presence of ZnO nanoparticles, which leads to highly substituted pyrroles in moderate to good yields. (sharif.edu)
  • In the first chapter, high substituted pyrrole derivaitives were synthesized through a one pot four compounent reaction using carbonyl and amin compounds at the presence of magnetic nanoparticles of superparamagnetic ferrospinel NiFe2O4nanoparticles as catalyst.In the second chapter, NiFe2O4magnetic nanoparticles were employed in the Sonogashira reactions using phenyl acetylene as coupling partner with different types of aryle and alkyl halides in water as a green solvent. (sharif.edu)
  • Pyrroles also readily underwent Michael addition at Α-positions under the same reaction conditions. (sharif.edu)
  • An operationally simple and entirely green protocol for heteropoly acid catalyst conjugate addition of indoles and pyrrole to unsaturated carbonyl compounds and nitro-alkene in water was investigated. (sharif.edu)
  • 1. Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer. (nih.gov)
  • 2. Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI. (nih.gov)
  • 4. Specific alkylation of human telomere repeat sequences by a tandem-hairpin motif of pyrrole-imidazole polyamides with indole-seco-CBI. (nih.gov)
  • 6. Photocontrollable sequence-specific DNA alkylation by a pyrrole-imidazole polyamide seco-CBI conjugate. (nih.gov)
  • 8. Sequence-specific DNA alkylation and transcriptional inhibition by long-chain hairpin pyrrole-imidazole polyamide-chlorambucil conjugates targeting CAG/CTG trinucleotide repeats. (nih.gov)
  • 10. Sequence-specific DNA alkylation targeting for Kras codon 13 mutation by pyrrole-imidazole polyamide seco-CBI conjugates. (nih.gov)
  • 12. Targeting specific gene by alkylating pyrrole-imidazole polyamides. (nih.gov)
  • 14. An investigation of targeted inhibition of transcription factor activity with pyrrole imidazole polyamide (PA) in chronic myeloid leukemia (CML) blast crisis cells. (nih.gov)
  • 15. Synthesis and biological properties of pyrrole-imidazole polyamide conjugates. (nih.gov)
  • 16. Synthesis of pyrrole-imidazole polyamide seco-1-chloromethyl-5-hydroxy-1,2-dihydro-3h-benz[e]indole conjugates with a vinyl linker recognizing a 7 bp DNA sequence. (nih.gov)
  • 17. Application of DNA-Alkylating Pyrrole-Imidazole Polyamides for Cancer Treatment. (nih.gov)
  • 18. Evaluation of the DNA Alkylation Properties of a Chlorambucil-Conjugated Cyclic Pyrrole-Imidazole Polyamide. (nih.gov)
  • 20. Targeted suppression of metastasis regulatory transcription factor SOX2 in various cancer cell lines using a sequence-specific designer pyrrole-imidazole polyamide. (nih.gov)
  • Conjugate 1, which covalently binds to the RUNX-binding sequences, was reported to inhibit the binding of RUNX proteins to their target sites and suppress cancer growth. (bvsalud.org)
  • The selective recognition of double-stranded DNA sequences by transcription factors is used by cells to respond to environmental changes, regulating which genes are switched on or off, and is used to control differentiation from one cell type into another. (webflow.io)
  • The group is developing a new generation of synthetic transcription factors that selectively recognise DNA sequences and modulate the expression of target genes. (webflow.io)
  • 13. Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes. (nih.gov)
  • 19. Evaluation of PI polyamide conjugates with eight-base pair recognition and improvement of the aqueous solubility by PEGylation. (nih.gov)
  • 3. Molecular Characteristics of DNA-Alkylating PI Polyamides Targeting RUNX Transcription Factors. (nih.gov)
  • We found that they possessed different DNA-alkylating properties in vitro. (bvsalud.org)
  • DNA origami nanotechnology for the visualization, analysis, and control of molecular events with nanoscale precision. (kansai-u.ac.jp)
  • And conjugates 1-3 were shown to have anticancer effects by inducing apoptosis in PANC-1 cells. (bvsalud.org)
  • Photocontrolled DNA nanotubes as stiffness tunable matrices for controlling cellular behavior. (kansai-u.ac.jp)
  • Biomimetic DNA Nanotechnology to Understand and Control Cellular Responses. (kansai-u.ac.jp)
  • Non-Invasive Regulation of Cellular Morphology Using a Photo-Responsive Mechanical DNA Polymer. (kansai-u.ac.jp)
  • Furthermore, conjugates 2 and 3 suppressed cancer growth in PANC-1 xenograft mice, with activity equivalent to a 50-fold dose of gemcitabine. (bvsalud.org)
  • Especially, 3 showed the highest alkylation efficiency, specificity, and better anticancer effects against pancreatic cancer than 1 in vivo without significant body weight loss. (bvsalud.org)
  • Zeptoliter DNA Origami Reactor to Reveal Cosolute Effects on Nanoconfined G-Quadruplexes. (kansai-u.ac.jp)
  • Dissection of nanoconfinement and proximity effects on the binding events in DNA origami nanocavity. (kansai-u.ac.jp)