• Together, these results show that Pax6 is required in developing cortical progenitors to control the cell-cycle duration, the rate of progression from symmetrical to asymmetrical division and the onset of expression of neural-specific markers. (biologists.org)
  • As cortical neurogenesis progresses, asymmetrical division, which occurs in a plane roughly parallel to the ventricular surface (also known as horizontal cleavage), starts to predominate. (biologists.org)
  • These divisions are important not only in an anatomical sense, but because they each contain the specific cells that will eventually differentiate into the different organs and body parts. (unam.mx)
  • As corticogenesis progresses, proportionately fewer progenitors are produced and, instead, cell divisions yield higher numbers of postmitotic neurones or glial cells. (biologists.org)
  • As the switch from the generation of progenitors to that of differentiated cells occurs, the orientation of cell division alters from predominantly symmetrical to predominantly asymmetrical. (biologists.org)
  • It has been hypothesised that symmetrical divisions expand the progenitor pool, whereas asymmetrical divisions generate postmitotic cells, although this remains to be proved. (biologists.org)
  • Although these hypotheses are attractive, there is no direct proof that the symmetry of division predicts the fates of the daughter cells in this way. (biologists.org)