• POU (pronounced 'pow') is a family of eukaryotic transcription factors that have well-conserved homeodomains. (wikipedia.org)
  • The acronym POU is derived from the names of three transcription factors: the Pituitary-specific Pit-1 the Octamer transcription factor proteins Oct-1 and Oct-2 (octamer sequence is ATGCAAAT) the neural Unc-86 transcription factor from Caenorhabditis elegans. (wikipedia.org)
  • Transcription factors (TFs), which bind to specific nucleotide sequences, have been shown to play important roles in the regulatory networks of numerous developmental processes in plants. (ashs.org)
  • There is a surprisingly high degree of amino acid sequence conservation (37%-42%) of POU homeodomains to the transcriptional regulator comS, the competence protein from the gram positive prokaryote Bacillus subtilis. (wikipedia.org)
  • The Engrailed homeodomain protein is an 'active' or dominant transcriptional repressor in cultured cells. (biologists.com)
  • Here, we develop HT-recruit, a pooled assay where protein libraries are recruited to a reporter, and their transcriptional effects are measured by sequencing. (stanford.edu)
  • A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
  • POU domain genes have been described in organisms as divergent as Caenorhabditis elegans, Drosophila, Xenopus, zebrafish and human but have not been yet identified in plants and fungi. (wikipedia.org)
  • In contrast, the Fushi Tarazu homeodomain protein is an activator, both in cultured cells and in Drosophila embryos, where it activates several known target genes, including its own gene. (biologists.com)
  • The mammalian Crx genes are highly divergent representatives of the Otx5 gene family, a gnathostome orthology class of orthodenticle-related homeogenes involved in the differentiation of retinal photoreceptors and circadian entrainment. (ox.ac.uk)
  • The mammalian Crx genes are highly divergent orthodenticle (otd)-related homeogenes that play important roles in the differentiation of retinal photoreceptors and the circadian entrainment. (ox.ac.uk)
  • Phylogenetic analyses of the coding sequences show that the mammalian Crx genes are orthologous to the Otx5-related genes isolated in other gnathostomes. (ox.ac.uk)
  • Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)
  • The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
  • Based on previous phylogenetic analyses in arabidopsis ( Arabidopsis thaliana ), our results showed that some tomato SL-ZH ( S. lycopersicum zinc-finger homeodomain) genes cluster into the same neighbor-joining (NJ) branch as arabidopsis, indicating that these genes may share similar structures and functions in these plants. (ashs.org)
  • Despite the lack of sequence homology, 3D structure of POUs is similar to 3D structure of bacteriophage lambda repressor and other members of HTH_3 family. (wikipedia.org)
  • We find a relationship between repressor function and evolutionary age for the KRAB domains, discover that Homeodomain repressor strength is collinear with Hox genetic organization, and identify activities for several domains of unknown function. (stanford.edu)
  • Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). (nature.com)
  • Homeodomain-interacting protein kinases (HIPKs) are an evolutionarily conserved kinase family comprising the members HIPK1, HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. (nature.com)
  • They act to fasten the protein to an AT RICH SEQUENCE in the DNA. (lookformedical.com)
  • Antennapedia homeodomain protein. (lookformedical.com)
  • Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. (lookformedical.com)
  • Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
  • One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)
  • Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin J Recombination Signal Sequence-Binding Protein" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Profiles. (harvard.edu)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • Commonly observed BASE SEQUENCE or nucleotide structural components which can be represented by a CONSENSUS SEQUENCE or a SEQUENCE LOGO. (lookformedical.com)
  • It is also called nucleotide sequence. (lookformedical.com)
  • The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. (lookformedical.com)
  • The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. (lookformedical.com)
  • The term epigenetic describes a number of chromatin modifications that stably alter gene expression without changing the sequence of the DNA. (musculoskeletalkey.com)
  • We used this information to develop the BrassicaEDB, including eFP, Treatment, Coexpression, and SRA Project modules based on gene expression profiles and Gene Feature, qPCR Primer, and BLAST modules based on gene sequences. (preprints.org)
  • Divergent Roles of Epithelium-Derived Alarmins in Notch Signaling-Deficient Skin. (harvard.edu)
  • Finally, we report new activator domains, including a divergent KRAB. (stanford.edu)
  • These regions are known as CpG islands (CGIs) and consist of short (~ 1000 bp) interspersed CpG-rich and predominantly unmethylated DNA sequences [ 1 ], which are associated with transcriptionally permissive chromatin state [ 2 ]. (biomedcentral.com)
  • Akin to the way that POU homeodomain regulators lead to tissue differentiation in metazoans, this transcription factor is critical for differentiation of a subpopulation of B. subtilis into a state of genetic competence. (wikipedia.org)
  • Cancer genome sequencing reveals diverse acquired mutations in CTCF , which we have shown, functions as a tumour suppressor gene. (preprints.org)
  • These stripes are regulated by a 300-bp enhancer (NEE) that contains high-affinity Dl-binding sites, Twist-binding sites, and "generic" E-box sequences that appear to bind ubiquitously distributed bHLH activators (Daughterless and Scute), which are present in the unfertilized egg. (sdbonline.org)
  • Within the HIPK family, HIPK1 and HIPK2 are the most closely related members, sharing about 93% sequence identity in their kinase domains, while HIPK3 is slightly less conserved with 87% identity. (nature.com)
  • The most divergent member of the family is HIPK4, which shares only 50% sequence identity with the catalytic domains of the three other HIPKs. (nature.com)
  • Members of the zinc-finger homeodomain (ZF-HD) family play a key role in the control of plant growth and development, which are involved in plant responses to stress. (ashs.org)
  • Both subdomains contain the structural motif 'helix-turn-helix', which directly associates with the two components of bipartite DNA binding sites, and both are required for high affinity sequence-specific DNA-binding. (wikipedia.org)
  • In accordance with the close relationship between HIPKs and other DYRK subfamily members, DYRK1A, a class I DYRK member, shares a sequence identity with HIPK3 of 38% within the catalytic domain. (nature.com)
  • These properties arise during a sequence of developmental events that require numerous gene regulatory and signaling processes. (biologists.com)
  • Here, we used ChIP followed by high-throughput sequencing (ChIP-seq) to analyse genomic occupancy of CFP1 in two human haematopoietic cell types. (biomedcentral.com)
  • POU (pronounced 'pow') is a family of eukaryotic transcription factors that have well-conserved homeodomains. (wikipedia.org)
  • Akin to the way that POU homeodomain regulators lead to tissue differentiation in metazoans, this transcription factor is critical for differentiation of a subpopulation of B. subtilis into a state of genetic competence. (wikipedia.org)
  • A family of transcription factors that contain a single cut domain and a divergent homeodomain. (nih.gov)
  • The PRH monomer has three functional domains: a 136 amino acid N-terminal glycine-, alanine- and proline-rich domain, a central 60 amino acid proline-rich homeodomain, and a 73 amino acid acidic C-terminal domain (Fig. 1 ). (biomedcentral.com)
  • Here we extend these studies using the publicly-available complete genome sequences of 243 insect species from 13 orders. (bvsalud.org)
  • The genome sequence is 810.3 megabases in span. (bvsalud.org)
  • The recent sequencing of the genome of two cnidarian species (Nematostella vectensis - sea anemone - and Hydra magnipapillata) indeed confirmed this high level of gene conservation from cnidarians to vertebrates. (unige.ch)
  • A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes. (lookformedical.com)
  • The wide- and thin-replum forms of this cis -element ( Shattering element-like ( Shl )) are named C- Shl and T- Shl after the Arabidopsis and Brassica sequences, respectively. (biomedcentral.com)
  • Characterization of threemembers of the Arabidopsis carotenoid cleavagedioxygenase family demonstrates the divergent rolesof this multifunctional enzyme family. (chinaagrisci.com)
  • Both subdomains contain the structural motif 'helix-turn-helix', which directly associates with the two components of bipartite DNA binding sites, and both are required for high affinity sequence-specific DNA-binding. (wikipedia.org)
  • The Hox gene cluster is an iconic example of evolutionary conservation between divergent animal lineages, providing evidence for ancient similarities in the genetic control of embryonic development. (bvsalud.org)
  • Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. (nih.gov)
  • The HAT3.1 homeodomain is highly divergent in sequence even at positions that are almost invariable among homeodomains. (or.jp)
  • All of those analyses utilized chromosomal tar get sequences that had been retrieved both by plasmid res cue from a heterogenous population of targeted cells or by PCR based methods making use of a restricted level of genomic DNA isolated from personal targeted clones grown on 96 properly plates. (plasignaling.com)