ChlorthalidoneHydrochlorothiazideHypertensionContaining a benzothiadiazineBeta BlockersBlockersChlorothiazideMedicationsInhibitorConcomitantBenzothiadiazineRenalHypovolemiaSodiumDoseCalciumMetolazoneExcretionPotassiumLoopRecommendsSignificantlyDiuresisUrineDecreasePatientsDrugsOutcomesEfficacyEffectExcessSevereSide effectsResultsBlood pressureReduceLevelsRiskSalt
Chlorthalidone3
- Chlorthalidone is unique amongst the thiazides in that it has a very long half-life which enables once daily dosing. (blogspot.com)
- Some evidence suggests that chlorthalidone is more effective than thiazides in reducing blood pressure, takes effect more quickly than thiazides after a dose, and reduces the risk of mortality more than thiazides. (medicalnewstoday.com)
- If a thiazide diuretic is used, chlorthalidone is the ideal one to use because it can be given once a day. (msdmanuals.com)
Hydrochlorothiazide2
- Two thiazides are common in high blood pressure treatment: metolazone and hydrochlorothiazide . (medicalnewstoday.com)
- Quinapril hydrochloride and hydrochlorothiazide is a fixed-combination tablet that combines an angiotensin-converting enzyme (ACE) inhibitor, quinapril hydrochloride, and a thiazide diuretic, hydrochlorothiazide. (nih.gov)
Hypertension15
- There is a good review article in this month's NEJM entitled "Use of Diuretics in Patients with Hypertension" by Ernst and Moser which focuses predominantly on the thiazide class of diuretics. (blogspot.com)
- The hypertension lowering properties of thiazides occur via two mechanisms: an early anti-hypertensive effect is observed as a result of volume depletion, while long-term benefits on blood pressure appear to be due to decreasing vascular resistance, via a mechanism which is not entirely clear. (blogspot.com)
- Can a person treat hypertension with diuretics? (medicalnewstoday.com)
- Are diuretics a suitable treatment option for hypertension? (medicalnewstoday.com)
- Can diuretics help with hypertension? (medicalnewstoday.com)
- Diuretics can help reduce blood pressure in people with hypertension . (medicalnewstoday.com)
- Several types of diuretics are available to manage hypertension. (medicalnewstoday.com)
- A physician can recommend the most appropriate diuretic depending on a person's overall physical health and other medications in their hypertension management plan. (medicalnewstoday.com)
- Loop diuretics are not a first-line treatment for hypertension. (medicalnewstoday.com)
- However, loop diuretics can be helpful for managing hypertension in patients who have specific types of heart failure called heart failure preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) . (medicalnewstoday.com)
- However, PSDs are not as potent as other diuretics, and doctors do not recommend them as a first-line treatment for hypertension. (medicalnewstoday.com)
- Classic or 'new' thiazide diuretics for hypertension? (diagnosticdetectives.com)
- Future for diuretics in hypertension and heart failure. (diagnosticdetectives.com)
- Thiazide diuretics may be used alone to treat hypertension. (webmd.com)
- Low-dose thiazide therapy can be prescribed as the first-line treatment of hypertension with confidence that the risk of death, coronary artery disease and stroke will be reduced. (cmaj.ca)
Containing a benzothiadiazine2
- The NEJM article breaks down thiazide diuretics into "thiazide-type" diuretics (which are structurally similar, containing a benzothiadiazine group--these include HCTZ and chlorothiazide, for instance) and the "thiazide-like" diuretics (which do not have the benzothiadiazine group--these include chlorthalidone, metolazone, and indapamide). (blogspot.com)
- This group of agents includes thiazides, containing a benzothiadiazine molecular structure, and also thiazide-like drugs with similar actions but without the benzothiadiazine structure, including chlortha-lidone (Thalitone), quinethazone (Hydromox), metolazone (Zaroxolyn), and indapamide (Lozol). (brainkart.com)
Beta Blockers4
- Low-dose diuretics, though, can also be used with other medications such as beta-blockers. (webmd.com)
- In 5 drug-drug trials comparing thiazides with beta-blockers, the former were associated with a significantly lower rate of withdrawal due to adverse effects (relative risk [RR] 0.69, 95% confidence interval [CI] 0.63-0.76). (cmaj.ca)
- The same cannot be said for high-dose thiazide therapy, beta-blockers, calcium-channel blockers or ACE inhibitors. (cmaj.ca)
- Commonly prescribed medications for heart failure include beta-blockers , diuretics (water pills), ACE (angiotensin converting enzyme) inhibitors, and ARBs (angiotensin receptor blockers). (hdkino.org)
Blockers2
- Gentamicin is the correct answer because it is known to interact with diuretics and neuromuscular blockers. (proprofs.com)
- Four drug classes were evaluated in the trials: thiazides (21 trials), beta-adrenergic blockers (5), calcium-channel blockers (4) and angiotensin-converting-enzyme (ACE) inhibitors (1). (cmaj.ca)
Chlorothiazide1
- A thiazide diuretic, chlorothiazide inhibits sodium-chloride symport, blocking sodium reabsorption in the distal convoluted tubule. (medscape.com)
Medications6
- The thiazides are considered a FUNCTIONAL rather than a STRUCTURAL class of medications--that is, not all compounds considered thiazides have the same chemical backbone, but rather they are classified as such based on their common ability to inhibit the sodium-chloride electroneutral transporter in the distal convoluted tubule. (blogspot.com)
- Diuretics, or water pills, are medications that help reduce the amount of water in the body. (medicalnewstoday.com)
- A doctor may prescribe only thiazides or recommend them along with other medications. (medicalnewstoday.com)
- The American Heart Association (AHA) recommends thiazide-like diuretics alongside other blood pressure medications and lifestyle adjustments. (medicalnewstoday.com)
- Diuretics are added to other blood pressure medications. (webmd.com)
- Diuretics are medications that increase urine production and can affect the levels of certain drugs in the body, including gentamicin. (proprofs.com)
Inhibitor3
- Other combinations may include an ACE inhibitor with a thiazide diuretic. (webmd.com)
- If the first drug is an ACE inhibitor or ARB, thiazide diuretics have proved to work well as second drugs, but a CCB could be added instead. (msdmanuals.com)
- If the first drug is a CCB, then an ACE inhibitor or an ARB usually works as a second drug, but if there is a risk of pregnancy, they need to be avoided, and a thiazide diuretic or other drug can be tried instead. (msdmanuals.com)
Concomitant2
- Conclusions: Tolvaptan exhibited significant diuretic effects in patients with CHF, including those with severe renal dysfunction, which were diminished with concomitant thiazide diuretic use. (elsevierpure.com)
- Concomitant potassium or K + -sparing diuretics. (empr.com)
Benzothiadiazine1
- A thiazide-like diuretic is a sulfonamide diuretic that has similar physiological properties to a thiazide diuretic, but does not have the chemical properties of a thiazide, lacking the benzothiadiazine molecular structure. (wikipedia.org)
Renal3
- Th iazide and thiazide-like diuretics are often used to decrease calcium excretion in patients with hyper-calciuria who form renal stones. (brainkart.com)
- Background: The diuretic effect of tolvaptan, a vasopressin V2 receptor antagonist, in patients with severe renal dysfunction remains poorly characterized. (elsevierpure.com)
- Thiazide and thiazide-like diuretics associated with improved cardiovascular and renal outcomes. (annals.edu.sg)
Hypovolemia3
- Side effects of thiazide diuretics include hypokalemia, hypovolemia (e.g., orthostatic hypotension), gout flares, a small but measurable increased susceptibility to the development of diabetes mellitus , and rarely causing an allergic reaction to individuals with a severe sulfa allergy. (blogspot.com)
- The most common side effect of diuretics is low body fluid levels, or hypovolemia. (medicalnewstoday.com)
- Severe hypovolemia can develop if a person takes too high a dose of diuretics, which can lead to low blood pressure, dizziness, and fainting. (medicalnewstoday.com)
Sodium6
- Diuretics work by triggering the release of more urine and electrolytes, such as sodium and potassium, from the body. (medicalnewstoday.com)
- Diuretics help remove sodium from the body and support the treatment of high blood pressure. (medicalnewstoday.com)
- Thiazides, loop diuretics, and potassium sparing diuretics (PSDs) all remove water and sodium from the body. (medicalnewstoday.com)
- These diuretics act at the distal tubule, including the connecting segment, and inhibition of sodium reabsorption at this site impairs diluting but not concentrating ability. (brainkart.com)
- In contrast to their effects on sodium excre-tion, thiazide and thiazide-like diuretics augment Ca 2 + reabsorption in the distal tubule. (brainkart.com)
- Although thiazide and thiazide-like diuretics deliver less sodium to the collecting tubules than loop diuretics, the increase in sodium excretion is enough to enhance K + secretion and frequently results in hypokalemia. (brainkart.com)
Dose5
- On page 79, the article asserts: 'The use of thiazide diuretics is the equivalent of lowering [italics mine] the lithium dose. (psychiatrist.com)
- In the trials that had an untreated control group, low-dose thiazide therapy was associated with a significant reduction in the risk of death (RR 0.89, 95% CI 0.81-0.99), stroke (RR 0.66, 95% CI 0.56-0.79), coronary artery disease (RR 0.71, 95% CI 0.60-0.84) and cardiovascular events (RR 0.68, 95% CI 0.62-0.75). (cmaj.ca)
- High-dose thiazide therapy, beta-blocker therapy and calcium-channel blocker therapy did not significantly reduce the risk of death or coronary artery disease. (cmaj.ca)
- That's been calculated in many different ways, but we looked at change in weight over the study period, divided by the cumulative loop diuretic dose that was required to get this change in weight, which has been shown in many different cohorts to be prognostically significant. (medscape.com)
- Monitor glycemic control especially when initiating, discontinuing, or increasing thiazide diuretic dose. (medscape.com)
Calcium1
- Thiazide diuretics are extremely helpful in decreasing calcium excretion in several conditions associated with nephrocalcinosis. (medscape.com)
Metolazone1
- Most thiazide diuretics tend to markedly decrease in efficacy at low GFR's (e.g., less than 40 ml/min), though the article states that metolazone is more resistant to this effect than other thiazides, explaining its occasional utility in the diuresis of individuals with the cardiorenal syndrome. (blogspot.com)
Excretion2
- When given alone, thiazide and thiazide-like diuretics increase Na + excretion to only 3-5% of the filtered load because of enhanced compensatory Na + reab-sorption in the collecting tubules. (brainkart.com)
- Indapamide has some vasodilating properties and is the only thiazide or thiazide-like diuretic with significant hepatic excretion. (brainkart.com)
Potassium3
- Other diuretics are highly effective, but a side effect can be low levels of potassium, a vital electrolyte, in the blood. (medicalnewstoday.com)
- For example, thiazides and loop diuretics can lead to low potassium, but PSDs can lead to high potassium. (medicalnewstoday.com)
- People using diuretics who have low potassium can take a potassium supplement to make sure they have enough. (medicalnewstoday.com)
Loop1
- The IV loop diuretic was protocolized as was when the addition of thiazide could happen. (medscape.com)
Recommends1
- The ADA recommends that people with kidney disease in this blood pressure category take an ACEi or ARB, plus either a diuretic or CCB. (drugs.com)
Significantly1
- In both the drug-drug and the drug-no treatment comparison trials, thiazides were significantly better at reducing systolic blood pressure than the other drug classes. (cmaj.ca)
Diuresis2
- That's a great question because although we don't know all the mechanisms that probably lead to the chronic benefits, for acute efficacy, we looked at the benefits across diuresis, natriuresis, and diuretic response, looking for any additive benefit acutely for a diuretic decongestive outcome and then safety across all the other outcomes. (medscape.com)
- Your goal was not a diuretic, rather your goal was the diuresis however you got there. (medscape.com)
Urine1
- Both groups had structural usual care, meaning that their intravenous (IV) diuretic regimen was protocolized and titrated to 3-5 L of urine output a day. (medscape.com)
Decrease1
- Thiazide diuretics can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. (medscape.com)
Patients3
- Thiazide diuretics reduce urinary volume (UV) in patients with nephrogenic diabetes insipidus, which lacks V2 receptor function. (elsevierpure.com)
- Objective: This retrospective study investigated the acute urinary effects of tolvaptan in patients with stage G5 chronic kidney disease and congestive heart failure (CHF), and the impact of thiazide diuretics on the urinary effects of tolvaptan. (elsevierpure.com)
- Methods: UVs 24 h before and after tolvaptan administration and 30-day dialysis initiation rate were compared between patients with and without thiazide diuretic administration. (elsevierpure.com)
Drugs2
- Some drugs mimic thiazides more effectively but at a lower cost. (medicalnewstoday.com)
- Lead poisoning and certain drugs, like diuretics and immunosuppressant drugs , can cause kidney damage that may lead to uric acid retention. (healthline.com)
Outcomes1
- Th iazide and thiazide-like diuretics are often selected as first-line agents in the treatment of hyperten-sion , and they have been shown to improve long-term outcomes in this disorder. (brainkart.com)
Efficacy1
- The primary efficacy outcome that we looked at was diuretic efficiency. (medscape.com)
Effect1
- They do not have as potent an effect as thiazides or thiazide-like diuretics on blood pressure. (medicalnewstoday.com)
Excess1
- Diuretics remove salt and excess water (fluid) from the body. (webmd.com)
Severe1
- However, diuretics can reduce blood pressure and the risk of severe health problems. (medicalnewstoday.com)
Side effects1
- When used in a drug combination, the diuretic has fewer side effects. (webmd.com)
Results2
- These are known as thiazide-like diuretics , and one has shown particularly effective results in research. (medicalnewstoday.com)
- Our results suggested that the use of thiazide diuretics may be associated with an increased risk of skin cancers. (jocmr.org)
Blood pressure3
- Read on to learn more about diuretics as a treatment for high blood pressure. (medicalnewstoday.com)
- Thiazides are a common first-line treatment for high blood pressure. (medicalnewstoday.com)
- For instance, if the person with high blood pressure also retains fluid, a diuretic may be added. (webmd.com)
Reduce1
- Diuretics may also help reduce the plasma volume of blood inside vessels. (medicalnewstoday.com)
Levels1
- Diuretics can also affect levels of electrolytes. (medicalnewstoday.com)
Risk1
Salt1
- Thiazide diuretics have been used as initial treatment, but salt intake in adolescents is usually so high that they are rarely effective. (msdmanuals.com)