• Divergent synthesis and chemical reactivity of bicyclic lactone fragments of complex rearranged spongian diterpenes. (mysciencework.com)
  • The synthesis and direct comparison of the chemical reactivity of the two highly oxidized bicyclic lactone fragments found in rearranged spongian diterpenes (8-substituted 6-acetoxy-2,7-dioxabicyclo[3.2.1]octan-3-one and 6-substituted 7-acetoxy-2,8-dioxabicyclo[3.3.0]octan-3-one) are reported. (mysciencework.com)
  • Aspects of the chemical reactivity and Golgi-modifying properties of these bicyclic lactone analogs of rearranged spongian diterpenes are also reported. (mysciencework.com)
  • Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma. (greenmedinfo.com)
  • Besides glycerides, phospholipids, sterols, tocopherols and waxes, the oil of green coffee Coffea arabica L. contains the naturally occurring diterpenes cafestol and kahweol. (anton-paar.com)
  • The diterpenes cafestol and kahweol in boiled coffee have been found to be responsible for the increase. (ahajournals.org)
  • 4-6 The diterpenes cafestol and kahweol, which are removed on filtering, were found to be responsible for the cholesterol-raising effect of boiled coffee. (ahajournals.org)
  • The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. (abcam.com)
  • Most of the research work on bioactive labdanes has been carried out on naturally occurring diterpenes and semisynthetic derivatives, but much less is known on the effects of diterpene dimers. (mdpi.com)
  • The marine soft coral Lobophytum pauciflorum collected from Mindoro Island, Philippines, yielded four new lobane diterpene derivatives: the acetate congeners of epoxylobatrienol and lobatrienediol (2 and 7, respectively), a methoxyl congener of lobatetraene (10), and an oxepin congener of lobatrienetriol (11), and six known derivatives (1, 3-6, and 8). (strath.ac.uk)
  • In this context, our research group recently demonstrated the in vitro antiplasmodial activity of oxidised/epoxidised ent -kaurane diterpene derivatives obtained from the naturally occurring ent-kaurenes of Wedelia paludosa DC (Batista et al. (fiocruz.br)
  • Kahweol is an antioxidant diterpene present in coffee beans and unfiltered coffee beverages. (oreilly.com)
  • The coffee diterpene kahweol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation. (abcam.com)
  • Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. (abcam.com)
  • Nuclear factor-kappaB/signal transducers and activators of transcription-1-mediated inflammatory responses in lipopolysaccharide-activated macrophages are a major inhibitory target of kahweol, a coffee diterpene. (abcam.com)
  • The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK. (abcam.com)
  • A complex gene cluster for indole-diterpene biosynthesis in the grass endophyte Neotyphodium lolii. (nih.gov)
  • Labdane diterpenoid biosynthesis most commonly requires the pairwise activity of class II and class I diterpene synthases (diTPSs) that convert the central precursor geranylgeranyl diphosphate into distinct diterpenoid scaffolds. (frontiersin.org)
  • Based on previous general knowledge of diterpene biosynthesis in angiosperms, and based on mining of our recently published transcriptome database obtained by deep 454-sequencing of cDNA from clary sage calices, we cloned and functionally characterized two new diterpene synthase (diTPS) enzymes for the complete biosynthesis of sclareol in clary sage. (biomedcentral.com)
  • Here, we describe the discovery of a biosynthetic route in Euphorbia lathyris L. (caper spurge) in which regio-specific oxidation of casbene is followed by an unconventional cyclization to yield jolkinol C, a probable key intermediate in the biosynthesis of macrocyclic diterpenes, including ingenol mebutate. (pnas.org)
  • Up to now, the polypharmacology of diterpene alkaloids isolated from Aconitum and Delphinium sp. (eurekaselect.com)
  • From 1998 to 2014, more than 400 new diterpene alkaloids were isolated from Nature. (eurekaselect.com)
  • In the present review, the antiarrhythmic, analgesic and anti-inflammatory activities of diterpene alkaloids as well as the pharmacological mechanisms were summarized. (eurekaselect.com)
  • Diterpene alkaloids, Aconitum, Delphinium sp. (eurekaselect.com)
  • Representatives of new classes of compounds (phenylbutanoids, glutarimide alkaloids, sarcopetalane diterpenes) have been isolated from Croton species. (scielo.br)
  • Cytotoxic effects also have been observed in assays with alkaloids (taspine) and with secokaurene, labdane and cembranoid diterpenes. (scielo.br)
  • A new acyclic diterpene ( 1 ) and a known acyclic diterpene, 12( S )-hydroxygeranylgeraniol ( 2 ) were isolated from the aerial parts of Carpesium divaricatum . (springer.com)
  • DTGs consist of a cyclic or acyclic diterpene (C 20 ) skeleton and attached sugar moieties that may bear additional functional groups. (plantcell.org)
  • Two New Clerodane Diterpenes from Tinospora sagittata - Descarga este documento en PDF. (duhnnae.com)
  • The clerodane diterpenes 1 and 2 were most active (LD 50 values 1.08 and 4.12 μg/ml respectively) followed by andrographolide and 3 . (biomedcentral.com)
  • The clerodane diterpenes ( 1, 2 ) which were more potent and selective than labdanes (andrographolide and 3 ) are promising for further studies and/or development. (biomedcentral.com)
  • Fig. 1 ) were more toxic to the axenically-cultured amastigotes of L. aethiopica parasites than the insect vector-stage, promastigotes, and the clerodane diterpenes ( 1, 2 ) appears to be much more selective to axenic amastigotes than the permissive host cell line, THP-1 cells. (biomedcentral.com)
  • The aim of the present work was to synthesize dimeric diterpenes from the labdane imbricatolic acid using esters, ethers and the triazole ring as linkers. (mdpi.com)
  • In order to quantify the amount of present diterpenes in Coffea arabica L., first the green coffee oil has to be extracted from the fruits, and furthermore alkaline treatment in methanol is necessary, since the diterpenes naturally occur as esters which have to be saponified prior to the analysis. (anton-paar.com)
  • We identified 11 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs) that occur in concentrations equivalent to starch (mg/g fresh mass) in aboveground tissues of coyote tobacco ( Nicotiana attenuata ) and differ in their sugar moieties and malonyl sugar esters (0-2). (plantcell.org)
  • The latex of Euphorbia poissonii contains esters of the diterpene tigliane type alcohols 12-deoxyphorbol and 12-deoxy-16-hydroxyphorbol, the diterpene daphnane type intoxicant resiniferol, and several esters of the macrocyclic diterpene intoxicant 19-hydroxyingol, e.g. the pentacyclic euphorianin. (codeforaotearoa.org)
  • We show that five root-expressed TPSs of an expanded subfamily-a type clade in the Arabidopsis TPS family function as class I diterpene synthases that predominantly convert geranylgeranyl diphosphate (GGPP) to different semi-volatile diterpene products, which are in part detectable at low levels in the ecotypes Columbia (Col) and Cape Verde Island (Cvi). (frontiersin.org)
  • The yeast cell preferably comprises an inducible nucleic acid sequence encoding geranylgeranyl pyrophosphate synthase, an inducible nucleic acid sequence encoding a soluble form of HMG-CoA reductase, a nucleic acid sequence of an allele that confers an increase in sterol metabolic flux and, in the diterpene-producing cell, a diterpene synthase. (rice.edu)
  • Bioactive Pimarane Diterpenes from the Arctic Fungus Eutypella sp. (deepdyve.com)
  • 5 During our research on S. divinorum , salvinorin A was first isolated from a single pharmacologically active TLC band using a solvent system of 100/10/1 CHCl 3 /MeOH/H 2 O. Differences in potency between the purified diterpene and the original TLC fraction led us to surmise that the latter contained other strongly bioactive compounds that co-chromatographed with salvinorin A during the chromatographic separation. (sagewisdom.org)
  • Bioactive abietanic diterpenes are synthesized in roots of Salvia sclarea (e.g. aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol), but at a very low level (about 1 % of root dry weight). (unisa.it)
  • Three new ent -kaurane diterpenes, 3 α -angeloyloxy-17-hydroxy- ent -kaur-15-en-19-oic acid ( 1 ), 3 α -tigloyloxy-17-hydroxy- ent -kaur-15-en-19-oic acid ( 2 ) and 3 α -cinnamoyloxykaur-9(11),16-dien-19-oic acid ( 3 ), along with five known compounds ( 4 - 8 ), were isolated from the herbs of Wedelia prostrata (Asteraceae). (springer.com)
  • Qiang Y, Du DL, Chen YJ, Gao K (2011) ent -Kaurane diterpenes and further constituents from Wedelia trilobata . (springer.com)
  • These data suggest PfATP6 as a potential target for the antimalarial ent -kaurane diterpenes. (fiocruz.br)
  • 2014) we investigated the interaction between the ent kaurane diterpenes and PfATP6 (Gardner et al. (fiocruz.br)
  • Lolitrems are a structurally diverse group of indole-diterpene mycotoxins synthesized by Epichloë/Neotyphodium endophytes in association with Pooid grasses. (nih.gov)
  • They are structurally characterized as polyhydroxylated cyclic diterpenes. (wikipedia.org)
  • The increasing number of structurally interesting and biologically active diterpene quinones that have been discovered and still to be isolated from many members of the genus salvia calls for an update review. (who.int)
  • Rosemary diterpenes have also been shown in recent years to inhibit neuronal cell death induced by a variety of agents both in vitro and in vivo . (hindawi.com)
  • Enhanced diterpene lactone (andrographolide) production from elicited adventitious root cultures. (deepdyve.com)
  • Analysis errors can occur in the desorbing process of ginkgo diterpene lactone meglumine injection (GDMI) by a conventional analysis method, due to several factors, such as easily crystallized samples, solvent volatility, time-consuming sample pre-processing, fixed method, and offline analysis. (bvsalud.org)
  • The enzyme TPS20 produces a macrocyclic dolabellane diterpene alcohol and a dolabellane-related diterpene olefin named dolathaliatriene with a so far unknown C6-C11 bicyclic scaffold besides several minor olefin products. (frontiersin.org)
  • Ingenol mebutate is a diterpene ester with a highly complex macrocyclic structure that has been approved for the treatment of actinic keratosis, a precondition of skin cancer. (pnas.org)
  • 3-Hydrogenkwadaphnin (3-HK) (Fig. 1) is a daphnane-type diterpene ester isolated from the leaves of Dendrostellera lessertii (Thymelaeaceae) with differentiation and apoptotic potency among several leukemic cells without any measurable adverse effects on normal cells [Moosavi, M.A., Yazdanparast, R., Sanati, M.H., Nejad, A.S., 2005a. (thefreelibrary.com)
  • Seven new diterpenes, named ovoideal A ( 1 ), B ( 2 ), C ( 3 ), D ( 4 ), E ( 5 ), F ( 6 ) and G ( 7 ), have been isolated along with eleven known diterpenes 8 - 18 from the petroleum ether soluble fraction of an ethanol extract of the aerial parts of Tirpitzia ovoidea . (mdpi.com)
  • This work provides a genetic foundation for elucidating the metabolic grid responsible for the diversity of indole-diterpenes synthesized by N. lolii. (nih.gov)
  • Wang, Bin 2018-01-01 00:00:00 Two new pimarane diterpenes, libertellenone M (1) and libertellenone N (2), together with five known compounds were isolated from the culture extract of Eutypella sp. (deepdyve.com)
  • In a screening program on natural resources with the ability to abrogate TRAIL resistance, the bioassay-guided fractionation of Boesenbergia pandurata rhizomes resulted in the isolation of 17 pimarane diterpenes and a monoterpene. (elsevier.com)
  • Among the most important group of compounds isolated from the plant are the abietane-type phenolic diterpenes that account for most of the antioxidant and many pharmacological activities of the plant. (hindawi.com)
  • It contains 13-15% antioxidative phenolic diterpenes and can be used to stabilize fatty oils and organic cosmetic formulations. (fromnaturewithlove.com)
  • A group of cembranoid diterpenes were isolated from the soft coral S. trocheliophorum by Chang-Yih Duh in National Sun Yat-sen University in Taiwan and was reported in 1996 in the Journal of Natural Products. (wordpress.com)
  • Salvinorin A (1) is a hallucinogenic neoclerodane diterpene isolated from the widely available psychoactive plant Salvia divinorum and is the first example of a non-nitrogenous opioid receptor ligand. (rti.org)
  • of the psychotropic Mexican labiate Salvia divinorum (Epling & Jativ -M.), we report the isolation and structure of a new trans -neoclerodane diterpene, salvinorin C ( 1 ). (sagewisdom.org)
  • Direct Analysis of Stevia Leaves for Diterpene Glycosides by Desorptio" by Ayanna U. Jackson, Alessandra Tata et al. (nova.edu)
  • Characteristic constituents of the Stevia plant are observed in both the positive and negative ion modes including a series of diterpene 'sweet' glycosides. (nova.edu)
  • Bioassays were also performed for the diterpene glycoside stevioside. (nutramedix.ec)
  • Waterman, Peter G. / A diterpene, a sesquiterpene and a flavonol glycoside from Piptostigma fasciculata (Annonaceae) . (strath.ac.uk)
  • Schmeda-Hirschmann, G. Dimeric Labdane Diterpenes: Synthesis and Antiproliferative Effects. (mdpi.com)
  • Pertino MW, Theoduloz C, Bastías M, Schmeda-Hirschmann G. Dimeric Labdane Diterpenes: Synthesis and Antiproliferative Effects. (mdpi.com)
  • Overall these results show that it is possible to boost the metabolic flow towards the synthesis of abietanic diterpenes in S. sclarea hairy roots by overexpressing genes involved in the first steps of the MEP-pathway and provide new insights for the large-scale production of this class of compounds, with potential application in cancer treatment. (unisa.it)
  • Synthetic studies of neoclerodane diterpenes from Salvia divinorum: Semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A . Journal of Natural Products , 69 (1), 107-112. (rti.org)
  • Manool also is a minor diterpene of this species and the main diterpene of related Salvia species. (biomedcentral.com)
  • N. N. Sabri ,A. M. El Lakany , Diterpenoidsin the genus salvia 1-diterpene quinones, Alex. (who.int)
  • Diterpene ginkgolides meglumine injection (DGMI) is a therapeutic extract of Ginkgo biloba L, which has been used for the treatment of cerebral ischemic stroke in China. (chinaphar.com)
  • A class II diTPS ( Ss LPPS) produced labda-13-en-8-ol diphosphate as major product from geranylgeranyl diphosphate (GGPP) with some minor quantities of its non-hydroxylated analogue, (9 S, 10 S) -copalyl diphosphate. (biomedcentral.com)
  • Tobacco-based transient expression assays of green fluorescent protein-fusion constructs revealed that both enzymes possess an N-terminal signal sequence that actively targets Ss LPPS and Ss SS to the chloroplast, a major site of GGPP and diterpene production in plants. (biomedcentral.com)
  • As shown in Figure 1 , monoterpenes and diterpenes were abundant in the gin headspace. (sigmaaldrich.com)
  • In this review, the chemistry and pharmacology of rosemary diterpenes are scrutinised by giving special emphasis to their therapeutic potential for Alzheimer's disease (AD). (hindawi.com)
  • Conclusion: Daphne Mucronata extract and its purified diterpene through increasing monocytes TNF-α releasing, potentially inhibit Leukemia cell line. (scirp.org)
  • Neorogioltriol and related diterpenes from the red alga Laurencia inhibit inflammatory bowel disease. (greenmedinfo.com)
  • Diterpene Alka loids: Antiarrhythmic, Analgesic and Anti-Inflammatory Effects", Mini-Reviews in Organic Chemistry (2017) 14: 304. (eurekaselect.com)
  • Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB. (chinaphar.com)
  • Semisynthetic compounds derived from diterpenes from the medicinal plant Wedelia paludosa were tested in silico against the Plasmodium falciparum Ca2+-ATPase, PfATP6. (fiocruz.br)
  • Thus, the aim of this study was to construct the PfATP6 enzyme model and perform a rigid and flexible molecular docking analysis of synthetic and semisynthetic diterpenes derived from W. paludosa DC. (fiocruz.br)
  • Inhibition of PfATP6 by diterpene compounds could promote a change in calcium homeostasis, leading to parasite death. (fiocruz.br)
  • Bifunctional diterpene cyclase that catalyzes the successive two-step type-B (protonation-initiated cyclization) and type-A (ionization-initiated cyclization) reactions of geranylgeranyl diphosphate (GGDP) producing successively (+)-copalyl diphosphate and miltiradiene. (uniprot.org)
  • EDWARDS, T.J. y DREWES, S.E. . Antiplasmodial activities of some abietane diterpenes from the leaves of five Plectranthus species . (scielo.org.za)
  • Together, our results demonstrate that divergence and pseudogenization in the Arabidopsis TPS gene family allow for structural plasticity in diterpene profiles of above- and belowground tissues. (frontiersin.org)
  • Muhammad Torequl Islam*, "Beneficial Effects and Therapeutic Promises of Diterpenes on Respiratory System", Current Respiratory Medicine Reviews (2017) 13: 99. (eurekaselect.com)
  • Two norcembranoidal diterpenes, 5-episinuleptolide acetate ( 1 ) and scabrolide D ( 2 ), were isolated from a Formosan octocoral identified as Sinularia sp. (mdpi.com)
  • Yeast-based production of sclareol by co-expresssion of Ss LPPS and Ss SS was efficient enough to warrant the development and use of such technology for the biotechnological production of scareol and other oxygenated diterpenes. (biomedcentral.com)
  • Changes in volatile terpene and diterpene resin acid composition of resistant and susceptible white spruce leaders exposed to simulated white pine weevil damage. (semanticscholar.org)
  • Induced (traumatic) resin in white spruce (Picea glauca (Moench) Voss) leaders resistant or susceptible to the white pine weevil (Pissodes strobi Peck) was analyzed for volatile terpenes and diterpene resin acids after simulated white pine weevil damage. (semanticscholar.org)
  • 10 Salvinorin A is the first diterpene to be identified as a hallucinogen in humans and is one of the most potent naturally occurring compounds thus far isolated. (sagewisdom.org)
  • Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators. (wizdom.ai)