• Proteolytic removal of the propeptide enables mature BMP-2 to form active disulfide linked homodimers and heterodimers with BMP-7 (2). (novusbio.com)
  • Here we present evidence that heterodimers of Ig alpha and Ig beta efficiently induced apoptosis while homodimers of either chain did not. (nih.gov)
  • CD8-positive αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas som e γδ T cells and NK cells express CD8αα homodimers. (bdbiosciences.com)
  • CD8 exists on the cell surface, where the CD8α chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8α. (peprotech.com)
  • Platelet-derived growth factor-D (PDGF-D) is a cytokine that associates into disulfide-linked homodimers that bind to PDGF R beta and trigger signaling through PDGF R beta homodimers and PDGF R alpha/beta heterodimers. (rndsystems.com)
  • It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. (biovision.com)
  • Although both IL-17A and IL- 17F were originally found to be produced as disulfide-linked homodimers, recent studies have confirmed the production of IL-17A/IL-17F heterodimers in in vitro-differentiated and polarized Th17 cells. (biovendor.com)
  • PDGFB can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Alpha. (medindex.am)
  • This cytokine can be secreted as disulfide-linked homodimer or heterodimer. (wikipedia.org)
  • CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. (biolegend.com)
  • Cell surface CD8α is expressed either as a disulfide-linked homodimer (CD8αα) or as a heterodimer (CD8αβ) when disulfide-bonded to a CD8 beta chain (CD8β). (bdbiosciences.com)
  • Description: The RPA-T8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). (thermofisher.com)
  • It is secreted as a latent homodimer which is activated by proteolysis to release a bioactive disulfide-linked dimer. (rndsystems.com)
  • Activated human CD4+ T cells in culture were found to secrete IL-17F homodimer at 10-fold higher levels than IL-17A homodimer, suggesting that the majority of the IL-17A protein expressed exists in the form of the IL-17AF heterodimer. (biovendor.com)
  • The β C subunit is able to form activin heterodimers with β A or β B subunits but is unable to dimerize with inhibin α. (wikidoc.org)
  • Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (nih.gov)
  • These undissociable hormones are not more active than their natural heterodimeric counterparts indicating that the ß-subunit seatbelt embracing the α-subunit ensures the αß heterodimer stability in physiological conditions. (bvsalud.org)
  • [11] [12] The subunits are linked by a single covalent disulfide bond. (wikidoc.org)
  • GPIIb is a two-chain protein containing disulfide-linked alpha and beta subunits. (rupress.org)
  • The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. (assaygenie.com)
  • PMet, a high affinity tyrosine kinase receptor for HGF, is a disulfide-linked heterodimer made of 45 kDa α-subunits and 145 kDa β-subunits. (cellcarta.com)
  • The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. (tumorportal.org)
  • IL-12 is a heterodimeric cytokine of disulfide-linked p35 and p40 subunits. (watson-bio.com)
  • Apparent molecular mass of 60 kDa in SDS-PAGE under non-reducing conditions, 41 kDa and 29 kDa under reducing conditions, a disulfide-linked heterodimer consisting of the 306 amino acid rHuIL-12 p40 and the 197 amino acid rHuIL-12 p35 subunits. (watson-bio.com)
  • The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond . (wikidoc.org)
  • Both the M protein and GP5 of LDV and PRRSV seem to be triple membrane-spanning proteins whose short ectodomains of approximately 11 and 30 amino acids, respectively, are disulfide linked ( 11 , 13 , 14 ). (cdc.gov)
  • The ectodomain heterodimer seems critical for the infection of macrophages, the primary host cell of all arteriviruses, perhaps playing a role in receptor interaction ( 14 ), but neither the GP5 ectodomain nor the M protein ectodomain appears to determine host cell tropism ( 15 , 16 ). (cdc.gov)
  • The gCI complex is comprised of dimeric molecules of glycoprotein B. The gCII complex is definitely a heterodimer consisted of gM and gN protein. (accessibletech4all.org)
  • Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains. (reliatech.de)
  • The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. (utsouthwestern.edu)
  • The structure revealed that tapasin interacts with both ERp57 catalytic domains, accounting for the stability of the heterodimer, and provided an example of a protein disulfide isomerase family member interacting with substrate. (cornell.edu)
  • N- and O-linked glycosylation happens in the majority of proteins that pass through the secretory pathway, and serves tasks in both protein folding, and function. (thinkbeforeyouclickca.org)
  • It is a 160,000-d protein composed of a disulfide-linked dimer with identical polypeptide chains. (medscape.com)
  • CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). (exbio.cz)
  • A disulphide-linked heterodimer, consisting of mb-1 (or CD79a), B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. (enquirebio.com)
  • This antibody recognises intracellular C-terminus of human and murine CD79b which is part of the B-cell antigen receptor which constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. (absoluteantibody.com)
  • The response of a B cell to antigen is dependent on the surface expression of a clonotypic B-cell receptor complex (BCR) consisting of membrane-bound Ig and disulfide-linked heterodimers of Ig alpha/beta. (nih.gov)
  • Platelet membrane glycoprotein IIb-IIIa forms a calcium-dependent heterodimer and constitutes the fibrinogen receptor on stimulated platelets. (rupress.org)
  • RON is a receptor tyrosine kinase that is translated as a single polypeptide and then proteolytically cleaved to yield a mature heterodimer consisting of an extracellular 35 kDa α chain disulfide-linked to a membrane-spanning 150 kDa beta chain. (affbiotech.com)
  • Met and Ron are receptor tyr kinases (RTKs) composed of an alpha-beta heterodimer. (umbc.edu)
  • The antibody MEM-108 reacts with an extracellular epitope of CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain). (exbio.cz)
  • The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic domain. (umbc.edu)
  • Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. (exbio.cz)
  • Antigen recognition is mediated by a disulfide-linked heterodimer whose two chains each contain variable and constant region domains. (nih.gov)
  • Dalton P, Christian HC, Redman CW, Sargent IL, Boyd CA: Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line. (exbio.cz)
  • The heterodimer is known as interleukin IL-23. (gentaur.fr)
  • Undissociable gonadotropins can be obtained either by chemical cross-linking of the natural heterodimeric hormones or by expressing recombinant single-chain molecules through the fusion of their α and ß polypeptide sequences. (bvsalud.org)
  • Secreted CV-2 is reported to be proteolytically cleaved to generate two fragments that are disulfide-linked (1, 2). (bio-techne.com)
  • CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. (ptglab.com)
  • PDGF-A and -B form as a disulfide-linked homo- or hetero-dimer: PDGF-AA, PDGF-BB or PDGF-AB. (biomedcentral.com)
  • The biologically active peptide is a heterodimer of an A chain and a B chain linked by two disulphide bonds. (guidetopharmacology.org)
  • Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer. (cornell.edu)
  • It functions within the multimeric peptide-loading complex (PLC) as a disulfide-linked, stable heterodimer with the thiol oxidoreductase ERp57, and this covalent interaction is required to support optimal PLC activity. (cornell.edu)
  • Mutational analysis identified a conserved surface on tapasin that interacted with MHC class I molecules and was critical for peptide loading and editing functions of the tapasin-ERp57 heterodimer. (cornell.edu)
  • The Ig molecule is a polypeptide heterodimer that is composed of 2 identical light chains and 2 identical heavy chains connected by disulfide bonds (see the image below). (medscape.com)
  • Nagata K, Nakamura T, Kitamura F, Kuramochi S, Taki S, Campbell KS, Karasuyama H: The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation. (exbio.cz)
  • Koyama M, Ishihara K, Karasuyama H, Cordell JL, Iwamoto A, Nakamura T: CD79 alpha/CD79 beta heterodimers are expressed on pro-B cell surfaces without associated mu heavy chain. (exbio.cz)
  • The mature chain (aa 43-461) is converted to two disulfide-linked chains (light: aa 43-199 and heavy: 200‑461) and both forms are inactive. (rndsystems.com)
  • The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. (biolegend.com)
  • The structure of approved drug insulin regular (which the link to DrugBank outlines) is identical to native human insulin. (guidetopharmacology.org)
  • The black line between the monomers represents a disulfide bond. (wikidoc.org)
  • CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. (exbio.cz)
  • Human enterokinase appears to be a disulfide-linked heterodimer, composed of a 784 amino acid heavy chain and a 235 amino acid light chain, derived by processing of the single-chain precursor. (medscape.com)
  • The exons encode the α chain, with four kringle structures (highly conserved triple disulfide loop structures), a short spacer region between the α and β chains, and the β chain ( Fig. 1A ) ( 4 - 6 ). (spandidos-publications.com)
  • Hispersistence finally led to the discovery of the link between thecongenital abnormalities and rubella infection early in themothers pregnancy. (vdocuments.net)
  • This enables API URLs which do not expire after a few minutes so while the setting is active, anyone in possession of the link provided can access the information. (lu.se)
  • Studies of Th17 polarized mouse splenocytes also indicate the majority of IL-17 made is the IL-17A/F heterodimer. (biovendor.com)
  • For example, GnTI-deficient HEK293S cells produce proteins with all high mannose glycans that can be deglycosylated with Endoglycosidase H (EndoH), leaving only the N-linked core N-Acetylglucosamine (N-GlcNAc) (Depetris et al. (thinkbeforeyouclickca.org)
  • [ 4 ] Beta-site APP-cleaving enzyme1 (BACE1), a protease that has been closely linked to the pathogenesis of Alzheimer disease but highly expressed in pancreatic acinar cells, could possibly protect the pancreas from premature trypsinogen activation. (medscape.com)
  • In order to enable an iCal export link, your account needs to have an API key created. (lu.se)
  • Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. (thermofisher.com)