4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. (wikipedia.org)
SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98). (wikipedia.org)
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes: 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene) CD98 light subunit protein encoded by the SLC7A5 gene SLC3A2 has been shown to interact with SLC7A7. (wikipedia.org)
Glycoprotein2
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). (exbio.cz)
Some animal proteins, for example, those in the LAT family (TC# 2.A.3.8) including ASUR4 (gbY12716) and SPRM1 (gbL25068) associate with a type 1 transmembrane glycoprotein that is essential for insertion or activity of the permease and forms a disulfide bridge with it. (tcdb.org)
Epithelial1
CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. (exbio.cz)
Heterodimer2
The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. (wikipedia.org)
The antibody MEM-108 reacts with an extracellular epitope of CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain). (exbio.cz)
Protein2
Cho JY, Skubitz KM, Katz DR, Chain BM: CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen-activated protein kinases. (exbio.cz)
These glycoproteins include the CD98 heavy chain protein of Mus musculus (gbU25708) and the orthologous 4F2 cell surface antigen heavy chain of Homo sapiens (spP08195). (tcdb.org)
Amino3
Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. (exbio.cz)
Dalton P, Christian HC, Redman CW, Sargent IL, Boyd CA: Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line. (exbio.cz)
Liu X, Charrier L, Gewirtz A, Sitaraman S, Merlin D: CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia. (exbio.cz)
Cell-surface antigen heavy chain1
4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. (wikipedia.org)
4F2hc1
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes: 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene) CD98 light subunit protein encoded by the SLC7A5 gene SLC3A2 has been shown to interact with SLC7A7. (wikipedia.org)
Subunit1
SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98). (wikipedia.org)
Proteins1
A bispecific antibody (BsAb) that recognized the HER2 and CD98 proteins was constructed from a humanized anti-HER2 (SER4) IgG and an anti-CD98 (HBJ127) single chain variable fragment, and this BsAb significantly inhibited the cell growth of SKBR3 cells. (bvsalud.org)
Molecular1
We herein showed that a newly discovered molecular complex between CD98 and HER2 affected HER function and cancer cell growth. (bvsalud.org)