Skin adnexal tumors with sebaceous differentiation are uncommon, difficult to classify, and may be controversial. (medscape.com)
Therefore, the term sebaceous neoplasm is necessary to include these complex skin adnexal tumors with varying degrees of sebaceous differentiation. (medscape.com)
The term sebaceous neoplasm includes benign and malignant tumors with different degrees of sebaceous differentiation. (medscape.com)
The following terms are recognized within this category: sebaceous adenoma, sebaceous epithelioma (sebaceoma), sebaceous carcinoma, basal cell carcinoma with sebaceous differentiation, sebocrine adenoma, and sebomatricoma. (medscape.com)
When patients with numerous sebaceous adenomas and/or other neoplasms with sebaceous differentiation have an associated internal malignancy, the clinical condition is known as Muir-Torre syndrome , a subtype of familial nonpolyposis gut carcinoma syndrome, or Lynch syndrome. (medscape.com)
Because of the intimate association of sebaceous glands with hair and apocrine ducts, many sebaceous neoplasms show complex histopathologic features with various elements of pilar and sweat gland differentiation. (medscape.com)
Pilar and sebaceous neoplasms share a common expression for both high and low molecular weight cytokeratin that is not seen in most eccrine or apocrine tumors, pointing to similar cellular differentiation patterns of hair and sebaceous structures. (medscape.com)
The clinical differential diagnosis included squamous cell carcinoma, basal cell carcinoma with sebaceous differentiation, and salivary gland neoplasms. (biomedcentral.com)
Neoplastic cells showed a range of sebaceous differentiation with finely vacuolated rather than clear cytoplasm. (biomedcentral.com)
Histology revealed a cystic lesion (8x4 cm) containing yellowish fluid, lined by a stratified squamous epithelium with focal sebaceous differentiation, and surrounded by lymphoid tissue. (unina.it)
Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)
Tangential shave biopsy of the lesion was performed and the histopathologic report revealed an adnexal neoplasm with trichilemmal differentiation, desmoplastic component, and atypia with margins involved (Figures 2A, 2B, 3A, and 3B). (jcadonline.com)
Tumors7
Furthermore, the architectural features of sebaceous tumors resemble those of pilar neoplasms, and not those of sweat gland tumors. (medscape.com)
Many antigens associated with sweat gland neoplasms, including S-100 protein, CA72.4, gross cystic disease fluid protein 15 (GCDFP-15), and carcinoembryonic antigen (CEA), are absent in sebaceous tumors. (medscape.com)
Sebaceous carcinoma should be distinguished from other tumors full of vacuolated clear cells. (biomedcentral.com)
BACKGROUND: Melanocytic tumors driven by MAP2K1 in-frame deletions are among the most recently described class of melanocytic neoplasms. (bvsalud.org)
We reviewed the clinical and histomorphological features of these tumors and compared them to similar neoplasms reported to date. (bvsalud.org)
Understanding of the cytologic features of skin adnexal tumors is valuable as distinguishing benign cutaneous neoplasms from malignant primaries or metastatic disease on cytology is often difficult. (emedinexus.com)
Tumors affecting the orbit include benign and malignant neoplasms arising from the various structures in the orbit including the blood vessels, nerves, bones, orbital fat and other soft tissues. (cybersight.org)
Adenomas2
Salivary gland tumours, also known as mucous gland adenomas or neoplasms, are tumours that form in the tissues of salivary glands. (wikipedia.org)
While several reports document sebaceous adenomas arising from sebaceous glands of the oral cavity, oral sebaceous carcinomas are extremely rare. (biomedcentral.com)
Benign neoplasm2
It is also referred to as dermoid cyst, although this name only is used for benign neoplasm . (cancerwall.com)
Benign prostatic hyperplasia (BPH) is the most common benign neoplasm of American men. (basicmedicalkey.com)
Adnexal neoplasm1
Poroma is a benign adnexal neoplasm of the intraepidermal portion of the sweat gland duct, called the acrosyringium . (clinicaladvisor.com)
Malignant neoplasms1
Primary malignant neoplasms of the sweat glands are rare, constituting less than 1% of all primary malignant skin lesions 1 . (bvsalud.org)
Nevus2
Skin lesions containing benign sebaceous gland proliferation (eg, sebaceous hyperplasia), congenital hamartomas (eg, nevus sebaceus), and lesions with ectopic sebaceous structures (eg, Fordyce spot, Montgomery tubercles) are generally not considered to be true sebaceous neoplasms. (medscape.com)
They generally arise de-novo but might also derivate from an underlying proliferating trichilemmal cyst with a loss of p53, a seborrheic keratosis, a nevus sebaceous, or a scar. (jcadonline.com)
Glands7
Sebaceous glands are holocrine, oil-producing glands present in the dermis of mammalian skin. (medscape.com)
Sebaceous glands are usually attached to hair follicles and are part of a complex skin-adnexal unit known as the folliculoapocrine (sweat) apparatus. (medscape.com)
Because of the intimate association of sebaceous glands with other adnexal structures in the folliculosebaceous-apocrine unit, many sebaceous neoplasms show complex histopathologic features with mixed sebaceous, pilar (hair), and apocrine (sweat) gland differentiations. (medscape.com)
Sebaceous glands are most abundant in the skin of the head and neck regions, particularly in the central face, but they are also present throughout the hair-bearing areas of the body and the mucocutaneous junction, including the labium minus. (medscape.com)
The eyelids have modified sebaceous glands (ie, Zeis glands of cilia associated with eyelashes, meibomian glands within the tarsal plates of the upper and lower eyelids). (medscape.com)
Using transmission electron microscopy, a small number of melanocytes can be identified that synthesize melanin-containing organelles (melanin granules) in the ducts and acini of human sebaceous glands. (medscape.com)
It seems that these intraoral sebaceous glands can rarely give rise to a variety of sebaceous neoplasms, such as sebaceous carcinoma [ 7 ]. (biomedcentral.com)
Carcinomas2
The challenging preoperative differential diagnosis of pancreatic LECs is among pseudocysts, cystic neoplasms and intraductal carcinomas. (unina.it)
Trichilemmal carcinomas (TCs) are rare, malignant, adnexal neoplasms that differentiate from the outer root sheath (ORS) of the hair follicle. (jcadonline.com)
Apocrine1
Although the histological features of apocrine and eccrine poromas are nearly identical, the presence of homogenous eosinophilic intraluminal secretion, lining cells with intensely eosinophilic cytoplasm, and small clusters of sebaceous cells surrounded by poroid cells is suggestive of apocrine lineage. (clinicaladvisor.com)
Cystic3
After renal function normalization, with the suspicion of a mucinous cystic neoplasm (MCN), the patient underwent surgery. (unina.it)
Cytology from EUS-FNA can help to distinguish LECs from cystic neoplasms. (unina.it)
The cystic part can be filled with mucinous or fatty-sebaceous fluid. (cancerwall.com)
Basal1
CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma. (asocolderma.org.co)
Lymphadenoma1
Calco GN‡, Davis JL , Chung J. Non-sebaceous lymphadenoma arising as a painless subcutaneous nodule on the eyebrow. (iu.edu)
Malignancies2
Regardless of the localization, sebaceous malignancies must be considered aggressive neoplasms with potential for regional and distant metastases. (biomedcentral.com)
6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
Eccrine1
2 With time, it became evident that poromas of an eccrine lineage also exist, but the historic view of poromas as neoplasms of eccrine lineage has persisted such that many poromas are assumed to be eccrine poromas. (clinicaladvisor.com)
Epithelium1
Sebaceous carcinoma is a very rare, aggressive, malignant tumor arising in the adnexal epithelium of the sebaceous gland. (biomedcentral.com)
Lesions1
Distinguishing benign from malignant periocular lesions can be challenging. (touchophthalmology.com)
Diagnosis3
Based on these findings, a diagnosis of sebaceous carcinoma of the lower lip was rendered. (biomedcentral.com)
This is a unique case due to the low frequency 2 , the atypical clinical history, but mainly the difficult histopathological differential diagnosis and immunohistochemical evaluation among these neoplasms. (bvsalud.org)
Schwannoma is rarely seen in vulvar area may mimic other subcutaneous nodules like sebaceous cyst or lipoma. (ijstd.org)
Pathogenesis1
The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
Primary2
Perhaps the most widely used currently is that system proposed by the World Health Organization in 2005, which classifies salivary neoplasms as primary or secondary, benign or malignant, and also by tissue of origin. (wikipedia.org)
While the cytomorphology of a variety of primary cutaneous neoplasms has been described knowledge of the cytological features of hidradenomas is limited because only rare case reports have been described in the literature. (emedinexus.com)
Foci1
Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). (samatashkhis.com)
Cancer1
This conference bids an unparalleled opportunity to network with colleagues and learn from the distinguished leaders in oncology and cancer research. (peersalleyconferences.com)
Structures2
these structures are not considered sebaceous neoplasias. (medscape.com)
As one of the skin's adnexal structures, the sebaceous gland is intimately associated with hair (pilar) and arrector pili muscle. (medscape.com)
Inflammatory1
In fact, clear cell acanthoma possesses a similar staining pattern to inflammatory dermatoses such as psoriasis vulgaris, lichen planus, and discoid lupus erythematosus and might be a localized form of inflammatory eruption rather than a neoplasm. (medscape.com)
Rare3
[ 1 ] True sebaceous neoplasms are relatively rare, while sebaceous hyperplasia is a frequent finding in individuals with chronically sun-exposed skin. (medscape.com)
Sebaceous carcinoma in the oral cavity is extremely rare, with only 14 cases reported in literature. (biomedcentral.com)
Therefore, antigenic similarities exist between the isthmus of the outer hair sheath and the germinative basaloid cells of the sebaceous gland. (medscape.com)
These antibodies are used as fluorescent markers to distinguish subsets of mouse thymic epithelial cells in genetic studies of the thymus . (wikipedia.org)
Includes1
The reported range of diagnoses and associated genomic aberrations in these neoplasms is wide and includes melanomas, deep penetrating melanocytomas, and pigmented epithelioid melanocytoma. (bvsalud.org)
Features1
A spectrum of morphologic features can be encountered within the same neoplasm. (medscape.com)
Hair1
Although the sebaceous gland is a glandular adnexal structure, it is topographically and ontogenetically related to the hair sheath. (medscape.com)
Clear1
The sharp demarcation of the borders of a clear cell acanthoma distinguishes clear cell acanthoma from psoriasis. (medscape.com)