• HOXA9 knockout mice have been shown to develop a reduction in the number of circulating common myeloid progenitor cells, which differentiate into erythroid progenitor cells. (wikipedia.org)
  • Furthermore, transgenic mice with overexpressed HOXA9 developed a 15-fold increase in the amount of committed progenitor cells in the bone marrow, indicating that overexpressed HOXA9 induces expansion of the HSC population without disrupting differentiation. (wikipedia.org)
  • To facilitate the study of these neurons, transgenic mice were generated that express enhanced green fluorescent protein (EGFP) in subpopulations of GABAergic neurons. (jneurosci.org)
  • In hippocampal area CA1, two previously uncharacterized subtypes of interneurons were identified using the GIN mice: stratum pyramidale interneurons with lacunosum-moleculare axon arborization (P-LM cells) and stratum radiatum interneurons with lacunosum-moleculare axon arborization (R-LM cells). (jneurosci.org)
  • The restricted pattern of Kv2.2 expression persists in Kv2.1-KO mice, suggesting distinct cell- and layer-specific functions for these two highly related Kv2 subunits. (jneurosci.org)
  • We assessed the effect of Chop deletion in multiple mouse models of type 2 diabetes and found that Chop -/- mice had improved glycemic control and expanded β cell mass in all conditions analyzed. (jci.org)
  • We have previously demonstrated the utility and developmental neutrality of enhanced green fluorescent protein (EGFP) in embryonic stem (ES) cells and mice [ 2 ]. (biomedcentral.com)
  • To this end, we have established lines of ES cells together with viable and fertile mice having widespread expression of either the ECFP or EYFP GFP-variant reporters. (biomedcentral.com)
  • The ECFP and EYFP-expressing transgenic ES cells and mice that we have generated provide sources of cells and tissues for combinatorial, double-tagged recombination experiments, chimeras or transplantations. (biomedcentral.com)
  • Genetically manipulated mice, often incorporating gene-based reporters, are frequently being used to model and understand mammalian development and disease processes. (biomedcentral.com)
  • Consistently, decreased levels of OTUD3 are detected in transgenic PD mice expressing A53T mutant of human α-synuclein. (nature.com)
  • We find that in patDp/+ mice delay eyeblink conditioning-a form of cerebellum-dependent motor learning-is impaired, and observe deregulation of a putative cellular mechanism for motor learning, long-term depression (LTD) at parallel fibre-Purkinje cell synapses. (nature.com)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • Throughout the development of a mammal, there are three distinct stages of erythrocyte formation - embryonic, fetal and adult. (wikipedia.org)
  • Mammalian chimeras are valuable for studying early embryonic development. (asu.edu)
  • In this study we have used embryonic stem (ES) cell-mediated transgenesis to test the enhanced cyan fluorescent protein (ECFP) and enhanced yellow fluorescent protein (EYFP), two mutant and spectrally distinct color variants of wild type (wt) GFP. (biomedcentral.com)
  • But even this Bill of Rights may be inadequate to cope with rapid developments further down the line, such as human cloning, cell and tissue replacement and embryonic stem cell techniques. (i-sis.org.uk)
  • Efficient generation of embryonic stem cells from single blastomeres of cryopreserved mouse embryos in the presence of signalling modulators. (axonmedchem.com)
  • SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. (axonmedchem.com)
  • The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. (axonmedchem.com)
  • Several investigations [ 5 - 7 ] have been carried out with isolated embryonic, fetal, and adult SCs in a well-defined culture microenvironment to define the sequential steps and intracellular pathways that are involved in their differentiation into the specific cell lineages. (biomedcentral.com)
  • Recently, research has increased in the area of transplanting embryonic cells across species and growing kidneys and endocrine pancreas cells in situ. (medscape.com)
  • The chief inhibitory neurons of the mammalian brain, GABAergic neurons, are comprised of a myriad of diverse neuronal subtypes. (jneurosci.org)
  • The microanatomical features of these cells suggest that they function primarily as "input-biasing" neurons, in that synaptic volleys in stratum radiatum would lead to their activation, which in turn would result in selective suppression of excitatory input from the entorhinal cortex onto CA1 pyramidal cells. (jneurosci.org)
  • GABAergic neurons, the chief inhibitory neurons of the mammalian brain, are comprised of diverse neuronal subtypes distinguishable on the bases of location in given brain regions, microanatomical features, including dendritic arborizations and axonal projections, expression of specific macromolecules, and neurophysiological properties. (jneurosci.org)
  • Graves AR, Moore SJ, Bloss EB, Mensh BD, Kath WL, Spruston N. Hippocampal pyramidal neurons comprise two distinct cell types that are countermodulated by metabotropic receptors . (janelia.org)
  • The Kv2 family of voltage-gated potassium channel α subunits, comprising Kv2.1 and Kv2.2, mediate the bulk of the neuronal delayed rectifier K + current in many mammalian central neurons. (jneurosci.org)
  • Analyses of endogenous Kv2.2 in cortical neurons in situ and recombinant Kv2.2 expressed in heterologous cells reveal that Kv2.2 is largely refractory to stimuli that trigger robust, phosphorylation-dependent changes in Kv2.1 clustering and function. (jneurosci.org)
  • Immunocytochemistry and voltage-clamp recordings from outside-out macropatches reveal distinct cellular expression patterns for Kv2.1 and Kv2.2 in intratelencephalic and pyramidal tract neurons of L5, indicating circuit-specific requirements for these Kv2 paralogs. (jneurosci.org)
  • SIGNIFICANCE STATEMENT Neurons within the neocortex are arranged in a laminar architecture and contribute to the input, processing, and/or output of sensory and motor signals in a cell- and layer-specific manner. (jneurosci.org)
  • Neurons of different cortical layers express diverse populations of ion channels and possess distinct intrinsic membrane properties. (jneurosci.org)
  • We find that Kv2.1 and Kv2.2 exhibit distinct responses to acute phosphorylation-dependent regulation in brain neurons in situ and in heterologous cells in vitro . (jneurosci.org)
  • In the zebrafish, rprma mRNA is expressed in the olfactory placodes (OP) and olfactory epithelium (OE), rprmb is observed in the tectum opticum (TeO) and trigeminal ganglion (Tg), whereas rprml is found primarily in the telencephalon (Tel). At protein level, RPRM is present in a subset of cells in the OP, and neurons in the OE, TeO, hindbrain and sensory peripheral structures. (frontiersin.org)
  • We use the fly transgenic technique to express green fluorescent protein (GFP) in the dendritic arborization (da) neurons, a group of sensory neurons with a stereotyped dendritic branching pattern. (ucsf.edu)
  • Drosophila da neurons fall into four distinct morphological classes (I-IV). (ucsf.edu)
  • In contrast to Cut, Spineless (Ss), the homolog of the mammalian dioxin receptor, is expressed at similar levels in all da neurons. (ucsf.edu)
  • Alternatively, due to the high rate and relaxed replication of mtDNA, mosaicism can arise through clonal expansion and subsequent genetic drift between adjacent cells and tissues over time [ 6 ]. (biorxiv.org)
  • Indeed, there is continuous replication of mtDNA in all tissues, allowing variations in heteroplasmy to even develop between post-mitotic cells. (biorxiv.org)
  • Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
  • Research originated with the earliest steps in neural development (neurogenesis and neuronal cell fate specification) and gradually worked toward later steps (neuronal morphogenesis and the assembly of a functional neuronal circuit). (ucsf.edu)
  • 4] Porcine skin has been grafted onto burn patients,[5] and pig neuronal cells have been transplanted into patients with Parkinson (Parkinson's) disease and Huntington (Huntington's) disease. (medscape.com)
  • Adult erythrocytes are the most common blood cell type in mammals, and their characteristic biconcave shape, 7-8 µm diameter and enucleation are amongst the greatest commonalities between mammalian species. (wikipedia.org)
  • On the other hand, fewer studies exist on the non-mammalian kisspeptin, and somewhat contradictory results among different species appear to confuse general conclusions about the functions of kisspeptin, especially in teleosts. (frontiersin.org)
  • Recent literature on the kisspeptin of non-mammalian species suggests that the kiss1 and kiss2 systems may have undergone such evolutionary processes. (frontiersin.org)
  • Evidence in several species, however, suggests that differences in heteroplasmy between certain cell types is not random and may instead be deterministic. (biorxiv.org)
  • Mizuseki K, Diba K, Pastalkova E, Buzsaki G. Hippocampal CA1 pyramidal cells form functionally distinct sublayers . (janelia.org)
  • Here, through combined use of cortical layer markers and transgenic mouse lines, we show that Kv2.1 and Kv2.2 are localized to functionally distinct cortical cell types. (jneurosci.org)
  • Experimental and human studies with intravitreal bone marrow-derived stem cells have begun. (biomedcentral.com)
  • The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
  • Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
  • Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
  • Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
  • Cataracts are the leading cause of blindness worldwide and are characterized by progressive aggregation and precipitation of lens proteins, and the development of age‑related cataracts is associated with dysregulated cellular activities of lens epithelial cells. (spandidos-publications.com)
  • A luciferase assay demonstrated that transfection of lens epithelial cells with wild type TP53 3'‑UTR significantly reduced the luciferase activity of the miR‑125b overexpressing cells compared with scramble controls. (spandidos-publications.com)
  • Furthermore, it was demonstrated that the expression level of miR‑125 was comparable in epithelial cells from patients with age‑associated cataracts and controls, whereas the expression level of TP53 was significantly higher in the cataract group compared with controls. (spandidos-publications.com)
  • Additionally, transfection with 50 nM miR‑125b mimics markedly reduced the mRNA and protein expression levels of TP53 in the cultured lens epithelial cells, and miR‑125b significantly induced apoptosis in the epithelial cells compared with negative control cells. (spandidos-publications.com)
  • The directed expression of SV40 T antigen has led to the development of several important transgenic models with spontaneous epithelial tumor formation. (molvis.org)
  • We compiled data from ferrets inoculated with an extensive panel of over 50 human and zoonotic IAV (inclusive of swine-origin and high- and low-pathogenicity avian influenza viruses associated with human infection) under a consistent protocol, with all viruses concurrently tested in a human bronchial epithelial cell line (Calu-3). (cdc.gov)
  • We show that certain viral titer measurements following infection of a human bronchial epithelial cell line are positively correlated with viral titers in specimens collected from virus-inoculated ferrets and employ mathematical modeling to identify commonalities between viral infection progression between both models. (cdc.gov)
  • In one of the resulting transgenic lines, called GIN ( G FP-expressing I nhibitory N eurons), EGFP was found to be expressed in a subpopulation of somatostatin-containing GABAergic interneurons in the hippocampus and neocortex. (jneurosci.org)
  • In stratum oriens of the hippocampus, EGFP-expressing interneurons were comprised almost exclusively of oriens/alveus interneurons with lacunosum-moleculare axon arborization (O-LM cells). (jneurosci.org)
  • Indeed in the hematopoietic lineage, it has been found that HOXA9 is preferentially expressed in hematopoietic stem cells (HSCs), and is down-regulated as the cell differentiates and matures further. (wikipedia.org)
  • Given the tremendous promise of regenerative medicine to enhance human health and treat disease, Congress included a provision in the 21st Century Cures Act to support a Regenerative Medicine Innovation Project ($30 million distributed over FY17 through FY20) for the funding of clinical research to further the field of regenerative medicine (RM) using adult stem cells, including autologous, non-autologous use as well as eligible induced pluripotent stem cells (iPSC). (nih.gov)
  • Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. (axonmedchem.com)
  • Revealing cell populations catching the early stages of the human embryo development in naïve pluripotent stem cells. (axonmedchem.com)
  • All stem cells are undifferentiated cells that exhibit unlimited self-renewal and can generate multiple cell lineages or more restricted progenitor populations that can contribute to tissue homeostasis by replenishing the cells or to tissue regeneration after injury. (biomedcentral.com)
  • The remarkable progress of regenerative medicine in the last few years indicates promise for the use of stem cells in the treatment of ophthalmic disorders. (biomedcentral.com)
  • This paper reviews recent advances and potential sources of stem cells for cell therapy in retinal diseases. (biomedcentral.com)
  • Hematopoietic stem cells (HSCs) were first identified in 1961, and their ability to migrate and differentiate into multiple cell types was documented [ 2 ]. (biomedcentral.com)
  • 2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
  • Stem Cells Transl. (sciendo.com)
  • Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
  • Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
  • Adipose stem cells in reparative goat mastitis mammary gland. (sciendo.com)
  • Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)
  • In the fruit fly Drosophila, it has been suggested that nearly equal numbers of two subtypes of EEs (Allatostatin A: AstA and Diuretic hormone 31 : Dh31) are alternately produced from the intestinal stem cells in the posterior midgut. (bioone.org)
  • transgenic tdTomato (red, distal CA1) in a triple transgenic mouse. (janelia.org)
  • PYY is released from the L cells of the distal gut in response to ingested nutrients with two other gut hormones, GLP-1 and OXM. (hindawi.com)
  • Patients affected by SCAN-1 develop an adult onset devastating pathology characterized by peripheral axonal motor, sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait. (ataxia.org)
  • To educate its citizens about research into chimeras made from human and non-human animal cells, the United Kingdom's Human Fertilisation Embryology Authority published the consultation piece Hybrids and Chimeras: A Consultation on the Ethical and Social Implications of Creating Human/Animal Embryos in Research, in 2007. (asu.edu)
  • When two embryos are correctly joined before the 32-cell stage, the embryo will develop normally and exhibit a mosaic pattern of cells as an adult. (asu.edu)
  • diploid) chimeras comprising combinations of the ECFP and EYFP ES cells and/or embryos, demonstrate that populations of cells expressing each individual reporter can be distinguished within a single animal. (biomedcentral.com)
  • B-F) Tailbud tadpole stage embryos injected bilaterally at the two-cell stage with 50 ng control (CT) or pqbp1 (PQ) MOs as indicated (embryos in F received 100 ng MOs in total). (xenbase.org)
  • right panel, embryos injected dorsally with pqbp1 mRNA (2 ng) at the four-cell stage. (xenbase.org)
  • These procedures are likely to lead to an increase in international trafficking of human cells, eggs and embryos. (i-sis.org.uk)
  • In both genetic and diet-induced models of insulin resistance, CHOP deficiency improved β cell ultrastructure and promoted cell survival. (jci.org)
  • The ease of manipulating its genome has helped establish the mouse as the premier model organism for mammalian genetic studies. (biomedcentral.com)
  • Here, we leverage a set of genome-edited human PLIN2 reporter cell lines in a series of CRISPR-Cas9 loss-of-function screens, identifying genetic modifiers that influence PLIN2 expression and post-translational stability under different metabolic conditions and in different cell types. (stanford.edu)
  • This endocardial Notch signaling can in turn non-cell autonomously initiate myocardial Erbb2 and BMP signaling to promote cardiomyocyte reprogramming and heart regeneration, whereas its inhibition through either using tissue-specific genetic-based strategies or altering blood flow impairs this reparative event. (elifesciences.org)
  • This expression profile links to the importance of HOXA9 in the HSC, as it mirrors the fact that HSCs are absent in the developing embryo, undergoing initial production in the fetal stage, and are vital in the adult. (wikipedia.org)
  • The signaling requirements for ventral dermal cell development have not been established in either the chick or the mammalian embryo. (biologists.com)
  • As HOXA9 is part of the homeobox family, involved in setting the body plans of animals, it is likely that HOXA9 would display increased expression in cells with higher differentiation potentials. (wikipedia.org)
  • Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19. (axonmedchem.com)
  • In recent years green fluorescent protein (GFP) from the bioluminescent jellyfish Aequoria Victoria has gained popularity in mouse transgenic and gene targeting regimes [ 1 ]. (biomedcentral.com)
  • Lower vertebrate and neonatal mammalian hearts exhibit the remarkable capacity to regenerate through the reprogramming of pre-existing cardiomyocytes. (elifesciences.org)
  • Viral titers in ferret nasal wash specimens and nasal turbinate tissue correlated positively with peak titer in Calu-3 cells, whereas additional phenotypic and molecular determinants of influenza virus virulence and transmissibility in ferrets varied in their association with in vitro viral titer measurements. (cdc.gov)
  • Here, we found that givinostat inhibited proliferation and induced apoptosis of BCP-ALL CRLF2-rearranged cell lines, positive for exon 16 JAK2 mutations. (bvsalud.org)
  • These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in β cells under conditions of increased insulin demand. (jci.org)
  • In addition, flow cytometry analysis and the MTT assay were conducted to detect the effects of miR‑125b on apoptosis and cell viability. (spandidos-publications.com)
  • However, primitive and fetal erythrocytes, which circulate during early stages of development, are markedly different from their adult counterparts, most obviously through their larger size, shorter lifespan, nucleation, containment of different hemoglobin chains, and higher oxygen affinity. (wikipedia.org)
  • It increases slightly in the fetal stage, and then it is expressed highly in the adult erythrocyte precursors. (wikipedia.org)
  • Furthermore, in the fetal and adult precursors, not all precursor stages display HOXA9 expression. (wikipedia.org)
  • This is accomplished by intricately interconnected interneuronal networks, composed of various GABAergic subtypes, which strictly regulate pyramidal cell activity. (jneurosci.org)
  • Here, we show that the Kv2 family members Kv2.1 and Kv2.2 are expressed in distinct cortical layers and pyramidal cell types associated with specific corticostriatal pathways. (jneurosci.org)
  • Xenografts have been proposed as appropriate for infants who are physically too small to accommodate organs retrieved from adult or pediatric donors. (medscape.com)
  • One common denominator of these conditions is progressive loss of the neural cells of the eye - photoreceptors, interneurons, and retinal ganglion cells, or RGCs - and essential supporting cells such as the retinal pigment epithelium (RPE). (biomedcentral.com)
  • Symptoms seen with choroid plexus tumors generally result from blocking of the CSF pathways and debatably by secretion of CSF by tumor cells, both leading to increased fluid and, eventually, to hydrocephalus . (medscape.com)
  • Its most characterized member, RPRM , which duplicated to give rise rprma and rprmb in the fish lineage, is known to act as a tumor-suppressor gene in mammalian models. (frontiersin.org)
  • Choroidal melanoma is the most common primary malignant ocular tumor in human adults. (molvis.org)
  • The progression from insulin resistance to type 2 diabetes is caused by the failure of pancreatic β cells to produce sufficient levels of insulin to meet the metabolic demand. (jci.org)
  • Organic osmolytes accumulation is mediated by metabolic biosynthesis or transport into the cell via specialized organic osmolyte transporter proteins [5] . (prolekarniky.cz)
  • A chimera instead contains discrete cell populations with two unique sets of parental genes. (asu.edu)
  • This mechanism enables differentiated cells in a multicellular organism to express only the genes which are necessary for their own activity. (ac.ir)
  • 3] Porcine islet cells of Langerhans have been injected into patients with type 1 diabetes mellitus. (medscape.com)
  • Using a variety of mouse lines expressing Cre-recombinase (see gallery below), genetically defined cells are induced to express fluorescent reporter proteins using a variety of approaches. (janelia.org)
  • The most important difference between SCs and progenitor cells is that SCs can replicate indefinitely, whereas progenitor cells can divide only a limited number of times. (biomedcentral.com)
  • To address these problems, Mark Cembrowski (with help from many others at Janelia) is performing a hippocampus-wide screen of gene expression in genetically and anatomically defined cell types using next-generation RNA sequencing. (janelia.org)
  • Chimeras are organisms that contain two or more genetically distinct cell lines. (asu.edu)
  • When cells-but not DNA-from two or more genetically distinct individuals combine to form a new individual, the result is called a chimera. (asu.edu)
  • Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
  • In response to alterations in tonicity, virtually all cells activate mechanisms to regulate cell water and solute content [1] . (prolekarniky.cz)
  • These results indicate that the two intestinal secretory peptides antagonistically regulate adult lifespan and intestinal senescence through multiple pathways, irrespective of insulin, which implicates a complementary gradient distribution of each of the hormone-producing EEs, consistent with local requirements for cell activity along the posterior midgut. (bioone.org)
  • However, in earlier studies, clonal analysis was restricted by the lack of a cell marker, present at all times, that makes a distinction between the two parental cell types in situ. (asu.edu)
  • Likewise, givinostat killed primary cells, but not their normal hematopoietic counterparts, from patients carrying CRLF2 rearrangements. (bvsalud.org)
  • The results of this screen will be used for a variety of purposes, including identification of marker genes for cell types, comparison of gene expression across cell types, and analysis of gene ontology to infer function. (janelia.org)
  • Here, we describe in detail the spatiotemporal expression of three rprm genes ( rprma, rprmb , and rprm l) within distinct anatomical structures in the developing peripheral and central nervous system. (frontiersin.org)
  • By purifying and analysing mitochondria from different cell types, we show that PINK-1 and PDR-1 are required to set heteroplasmy differences between major somatic tissue groups in C. elegans and that removal of these genes equalises ΔmtDNA heteroplasmy across the organism. (biorxiv.org)
  • This is because Drosophila genes controlling fundamental cellular functions, such as cell growth and death, are quite identical to those found in human cells. (ataxia.org)
  • Employing in vivo imaging and biophysical assays, we precisely monitored the dynamic intracardiac blood flow changes in the injured zebrafish heart, and furthermore, measured their biophysical impact on the cardiac chamber walls using hemodynamic-responsive transgenic reporters. (elifesciences.org)
  • Epigenetic regulation is necessary for the production of differentiated cells throughout plant development, as well as maintaining the stability and integrity of the gene expression profiles. (ac.ir)
  • However, gut senescence does not appear to be the direct cause for longevity regulation, as knockdown of both hormone receptors did not affect adult lifespan. (bioone.org)
  • Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
  • Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. (bvsalud.org)
  • The molecular mechanisms of animal cell osmoregulation are poorly understood. (prolekarniky.cz)
  • In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)
  • Whereas a traditional view of GABAergic interneuronal function has been that of performing feedback inhibition, it has become increasingly evident that these cells perform much more complex functions that are crucial to controlling overall brain activity. (jneurosci.org)
  • 2009). A drawback of this approach, however, is the difficulty in assigning gene expression to a particular cell type or to return reliably to the same cells for comparative analysis of gene expression and function. (janelia.org)
  • As will be argued below, the non-mammalian kisspeptin systems show a wealth of diversity of gene expression ( kiss1 and/or kiss2 ) pattern in the brain and dynamic changes in expression according to the sex steroid milieu. (frontiersin.org)
  • This means that other fast dividing cells such as those responsible for hair growth and for replacement of the intestinal epithelium (lining) are also affected. (justia.com)
  • Enteroendocrine cells (EEs) are evolutionarily conserved gastrointestinal secretory cells that show scattered distribution in the intestinal epithelium. (bioone.org)
  • Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions. (axonmedchem.com)
  • numb functions as a cell fate determinant during asymmetric cell division. (ucsf.edu)
  • Together, these results support distinct roles for these two Kv2 channel family members in mammalian cortex. (jneurosci.org)
  • Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)
  • To counteract decreases in cell volume caused by hypertonic conditions, cells restore volume through the rapid accumulation of ions and water via the activation of various plasma membrane ion conductance pathways [2] . (prolekarniky.cz)
  • We show that midgut-preferential RNA knockdown of the peptide hormones AstA or Dh31 respectively results in decreased or increased adult lifespan. (bioone.org)
  • High-resolution profiling of histone methylations in the human genome, Cell, 129(4):823-37. (ac.ir)
  • Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
  • Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
  • Unfortunately, scientists have yet to be able to locate specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib). (justia.com)
  • Whole-cell patch-clamp recordings revealed that these cells were fast-spiking and showed virtually no spike frequency accommodation. (jneurosci.org)
  • The method may further comprise administering to the subject a cell growth inhibitor. (justia.com)
  • The composition of the mitochondrial DNA (mtDNA) in each cell is in constant flux through processes of mutation, replication, and degradation. (biorxiv.org)