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  • polyamide
  • Earlier, we have shown that an anti-TAR polyamide nucleotide analog (PNA TAR ) conjugated to a membrane transducing (MTD) peptide, transportan, is efficiently taken up by the cells and displays potent antiviral and virucidal activity [B. Chaubey, S. Tripathi, S. Ganguly, D. Harris, R. A. Casale and V. N. Pandey (2005) Virology , 331, 418- (pubmedcentralcanada.ca)
  • Protein
  • Two main directions for the development of bio-inspired nanomaterials are based either on the use of protein and peptide building blocks or, alternatively, on the use of DNA. (esrf.eu)
  • In their studies, Schepartz and colleagues synthesized a β-peptide they called Zwit1-F. They allowed the chain of β-amino acids to assemble into its own structure and then analyzed it with x-ray crystallography, a technique in which x-rays are directed through a crystal of a protein so that its structure can be deduced from the resulting diffraction pattern. (sciencecodex.com)
  • The receptors can include at least one protein receptor and at least one nucleic acid receptor. (google.com)
  • They contain eukaryotic protein motifs or organelle localization signals and have distinct subcellular localization, target to specific host cell molecules to promote infection. (springer.com)
  • fragment
  • Our approach made use of the sequence-dependant auto- and cross-catalytic functional characteristics of template-directed peptide fragment condensation reactions. (scripps.edu)
  • To facilitate the perception of the spectra and the recognition of the structural features of the analytes, an ion nomenclature closely leaned on the accepted nomenclature for fragment ions of peptides or nucleic acids is introduced. (uzh.ch)
  • aqueous
  • Our lab showed that carbonyl sulfide (COS), a simple gas that is present in the emissions from present-day volcanoes, is a condensing agent that brings about the formation of peptides from amino acids under mild conditions in aqueous solution. (scripps.edu)
  • assemblies
  • Furthermore, peptide assemblies have been shown to exhibit remarkable physical properties including high mechanical rigidity, luminescence, piezoelectricity, and semiconductivity . (esrf.eu)
  • She added that their findings about the structure of the molecule that she and her colleagues synthesized will help scientists construct more elaborate β-peptide assemblies and ones that possess true biologic function. (sciencecodex.com)
  • pathways
  • Starting with an array of 81 sequence similar 32-residue coiled-coil peptides, we estimated the relative stability difference between all plausible A2B-type coiled-coil ensembles and used this information to predict the auto- and cross-catalysis pathways and the resulting plausible network motif and connectivities. (scripps.edu)
  • Catabolism and anabolism have separate metabolic pathways controlled by a distinct set of hormones. (lumenlearning.com)
  • uptake
  • The uptake mechanisms by which cell-penetrating peptides enter cells depend on the conditions, such as the cell line the concentration and the temperature. (diva-portal.org)
  • Molecular
  • Polypeptide structures have the advantage of structural integrity and robustness while nucleic acids have the advantage of specific molecular recognition between complementary bases. (esrf.eu)
  • Our group has been extensively involved in the study of molecular self-assembly by extremely short peptide fragments. (esrf.eu)
  • reaction
  • Finally, the development and implementation of click nucleic acids (CNAs) based on the thiol-ene click reaction will be presented. (uh.edu)
  • suspension
  • Our protocol includes details on procedures to isolate mitotic chromosomes from adherent cell cultures, FISH using peptide nucleic acid (PNA) probes on chromosomes in suspension and flow cytometry setup and data acquisition. (scienceexchange.com)
  • If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised. (abcam.com)
  • Chemistry
  • Almost all discussions of prebiotic chemistry assume that amino acids and nucleotides condensed non-enzymatically to form oligomeric products. (scripps.edu)
  • different
  • In this study, RAFT polymerization of three monomers with markedly different properties, N , N -dimethylaminoethyl methacrylate (DMAEMA, cationic), n -butyl methacrylate (BMA, hydrophobic) and oligo(ethylene glycol) methyl ether methacrylate (OEGMA, hydrophilic) was conducted using an RGD peptide based RAFT agent as a chain transfer agent (RGD-CTA). (rsc.org)
  • 2. The method of claim 1 , wherein the at least two different target template nucleic acids are attached to different beads. (google.com)
  • The chemical properties of different formulation materials determine their special features for nucleic acid delivery, so understanding the property-function correlation of the formulation materials will inspire the development of next-generation gene delivery carriers. (mdpi.com)
  • Therefore, in this review, we focus on the chemical properties of different types of formulation materials and discuss how these formulation materials function as protectors and cellular pathfinders for nucleic acids, bringing them to their destination by overcoming different cellular barriers. (mdpi.com)
  • Of particular relevance is the fact that the signal patterns that are observed with analytes possessing different polyamine backbones are not only distinct with regard to mass distributions but also with regard to relative signal intensities, resulting in fingerprint-like signal patterns. (uzh.ch)
  • With this, the new approach is fundamentally different from the sequencing of peptides or nucleic acids, which are largely based on mass distributions. (uzh.ch)
  • Parallel
  • Parallel to the work on peptides, the field of DNA nanotechnology, pioneered by N.C. Seeman in the 1980s , is rapidly advancing and complex architectures at the nanoscale can be obtained. (esrf.eu)
  • The bundle contains eight copies of the beta-peptide Zwit-1F with parallel and antiparallel helices in like and unlike colors, respectively. (sciencecodex.com)
  • polymer
  • Here, we will focus on three distinct vignettes related to our implementation of photoclickable polymer systems. (uh.edu)
  • structure
  • Structure of the Zwit-1F beta-peptide bundle as determined by x-ray crystallography. (sciencecodex.com)
  • In previous studies, researchers had shown that β-peptides could fold from their chain-like primary structure into more complex secondary structures. (sciencecodex.com)
  • Target
  • This 36mer peptide directed against the HIV-1 glycoprotein gp41 ( 3 ) is administered by subcutaneous injection and is currently the only AIDS drug which exerts its action outside the target cell prior to infection. (pubmedcentralcanada.ca)
  • c) determining the addition of the nucleic acid segment to an oligonucleotide hybridized to one of the target template nucleic acids. (google.com)
  • properties
  • A new family of nanostructures sharing properties of both peptide and DNA was discovered. (esrf.eu)
  • The very unique architecture that results from both the peptide-like and DNA base pairing results also in unpredicted physical properties. (esrf.eu)
  • group
  • 13. The method of claim 12 , further comprising removing the label and the blocking group following determination of addition of the nucleic acid segment. (google.com)
  • natural
  • Recently, deoxyribonucleic acid (DNA) is studied for electronics due to its intrinsic benefits such as its natural plenitude, biodegradability, biofunctionality, and low-cost. (skku.edu)
  • shown
  • But we have now shown that experimental results mesh beautifully with the 'peptide-RNA' theory, and so these experiments provide quite compelling answers to what happened at the beginning of life on Earth. (eurekalert.org)