Distinct e2f1 to induce. Medical search. Frequent questions

Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. (wikipedia.org)
The first project focuses on E2F1, a regulator of genes important for cell cycle progression and apoptosis. (mdanderson.org)
Interestingly, inhibition of either LDH or complex I alone does not induce apoptosis, whereas inhibiting both together causes depletion in cellular ATP pool resulting in metabolic catastrophe induced apoptosis. (dcaguide.org)
Extensive efforts have been dedicated to enhancing the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in cancer cells for the development of effective cancer treatments. (bvsalud.org)
Over-expressed NSP 5a3a in HN30 cells induced a significant degree of apoptosis, an average of a 10.85 fold increase compared to controls 3 days post-transfection. (oncotarget.com)
Though, the apoptosis induced in the WI38 control cell line showed an average of a 13.2 fold increase between treated and controls comparable to the HN30 cell line 3 days post-transfection. (oncotarget.com)
Molecular analysis indentified a novel p73 dependent mechanism independent of p53 and caspase 3 activity through which NSP 5a3a is inducing apoptosis. (oncotarget.com)
Apoptosis can be described as a series of tightly regulated series of molecular events that occur over three distinct stages though involve multiple and in tandem molecular pathways of activation [ 7 ]. (oncotarget.com)
Western blot also revealed 4HR-induced apoptosis of HUVECs by gradual increases in c-caspase 3 and PARP-1 expression at eight, 16, and 24 h, and by important raise in AIF at eight h along with a slight boost at 16 and 24 h. c-PARP-1 expression, indicating the inactivation of PARP-1, was decreased at 8 h but recovered progressively to handle level at 24 h. (caspaseinhibitor.com)
E2F1 (UniprotKB: Q01094), belongs to the E2F family of transcription factor (TF), has a central role in regulating cell cycle progression and apoptosis [ 11 , 12 ] and, therefore, E2F1 activity is tightly governed by multiple feedback mechanisms and by the tumour suppressor Rb. (biomedcentral.com)

ERR agonism also led to downregulation of cell cycle and development pathways, which was partially mediated by E2F1 in cardiomyocytes. (bvsalud.org)
To discover additional pathways, we conducted RNA-sequencing study of visceral adipose tissue from pairs of people with obesity matched for age, sex and BMI (all above 30 kg/m2), but who were disparate in the expression level of E2F1. (easo.org)
Global protein signaling pathways contributing for the 4HR-induced wound healing effect in HUVECs. (caspaseinhibitor.com)
Distinct protein signaling pathways positively or negatively influenced the wound healing impact. (caspaseinhibitor.com)
However, recent research unveiled that a number of the TGF B induced pathways are SMAD4 independent. (microrna1.com)

Each microRNA can regulate the expression of hundreds of genes by blocking mRNA translation and/or inducing mRNA decay. (thegomap.org)
Targeted cleavage of mRNA by human RNase P provides a unique approach to inactivate any RNA of known sequence expressed efficiency of the EGS-induced RNase P cleavage as well as its efficacy is required in order to develop EGSs for practical use both as a research tool and as a therapeutic agent for gene-targeting applications. (azd1152.com)
We investigated the activity of the EGS in inducing RNase P to cleave the target mRNA and its efficacy in inhibiting HCMV gene expression and growth in cultured cells. (azd1152.com)
E2F1 mRNA expression was also evaluated by RT-qPCR in the melanoma cell line, SK MEL 267, before and after exposure to heat stress. (biomedcentral.com)
Our results also suggest that environmental insults, such as heat stress, could contribute to an aberrant E2F1 activity by inducing E2F1 mRNA expression. (biomedcentral.com)

We have discovered that E2F1 localizes to sites of both DNA double-strand breaks and UV-induced DNA damage and that this involves the phosphorylation of E2F1 by the ATM or ATR kinases. (mdanderson.org)
The physiological relevance of E2F1 in the DNA damage response is now being explored using a novel knock-in mouse model we developed that blocks E2F1 phosphorylation by ATM/ATR. (mdanderson.org)
Phosphorylation of RB1 disturbs its interaction with E2F1. (proteopedia.org)
The cyclinD/CDK4/6 complexes induce the phosphorylation of retinoblastoma (Rb) protein and the release of E2F, which trigger G1 cell cycle progression. (biomedcentral.com)

Raw areca nut (RAN) consumption induces oral, esophageal and gastric cancers, which are significantly associated with the overexpression of pituitary tumor transforming gene 1/securin and chromosomal instability (CIN). (biomedcentral.com)
Therefore, present results have led to the hypothesis that RAN-induced changes in the epigenetic landscape, securin overexpression and subsequent elevation of chromosomal instability is probably byproducts of inactivation of the pRb pathway. (biomedcentral.com)
During the progression of NSCLC, E2F1 overexpression could produce more aggressive tumors with a high proliferation rate and chemoresistance. (aacrjournals.org)

CONCLUSIONS: ERR agonists maintain oxidative metabolism, which confers cardiac protection against pressure overload-induced HF in vivo. (bvsalud.org)

Moreover, our studies demonstrate that E2F1 recruits chromatin-modifying enzymes to sites of damage to facilitate access to the DNA repair machinery. (mdanderson.org)
These findings indicate that E2F1 stimulates DNA repair through a non-transcriptional mechanism that functions in the context of chromatin. (mdanderson.org)
RAN-mediated pRb-inactivation induced securin upregulation, a putative E2F1 target, by inducing misregulation in chromatin remodeling in its promoter region, which led to transcriptional activation and subsequent development of chromosomal instability. (biomedcentral.com)

This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. (wikipedia.org)
More recently, small interfering RNAs are effective in inducing endogenous RNase of the RNA-induced silencing complex in the RNA interference pathway to inhibit gene expression and growth of several human viruses (5,10,11). (azd1152.com)

Recent research has demonstrated that Siva is a direct transcriptional target for the tumor-suppressors p53 and E2F1. (wikipedia.org)
The present study revealed that E2F1 gene expression correlates with TS and Survivin gene expressions and tumor proliferation. (aacrjournals.org)
Emerging evidence suggests that the component secreted by exosomescan promote tumor survival,angiogenesis and metastasis, and also mediate tumor microenvironment induced drug resistance and immune escape. (bbrc.in)

We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase ( TS ) and Survivin , in case of non-small-cell lung cancer (NSCLC). (aacrjournals.org)
MicroRNA genes reside in regions of the genome as distinct transcriptional units as well as in clusters of polycistronic units. (thegomap.org)
Having identified the common set of microRNAs regulated by MTp53, we will next investigate (1) whether candidate microRNAs are also regulated by other aggressive mutants of p53 (such as R175H) (2) changes in transcription and regulation of candidate microRNA genes by MTp53 and MTp53-interacting transcription factors such as E2F1, ETS1 and p63/p73. (thegomap.org)
Here, we show that p16 Ink4a deficiency enhances fasting-induced hepatic glucose production in vivo by increasing the expression of key gluconeogenic genes. (diabetesjournals.org)
In contrast, nonpathogenic SIVagm infection induced DNA methylation in genes coding for regulatory proteins such as LAG-3, arginase-2, interleukin-21 and interleukin-31. (biomedcentral.com)

Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. (proteopedia.org)
Doxorubicin (DOX) is known as an anticancer drug that acts in the G2/M phase of the cell cycle to arrest cell proliferation and induce cellular senescence (see the upper left figure). (dojindo.com)

Using both in vitro and in vivo genetic dependency experiments, we show that ERRÎ³ is the main mediator of ERR agonism-induced transcriptional regulation and cardioprotection and definitively demonstrated target specificity. (bvsalud.org)

We investigated the effect of ERR agonist on cardiac function in a pressure overload-induced HF model in vivo. (bvsalud.org)
Cell, 2009) or adult alpha-cells induces their continued regeneration and conversion into beta-like cells, such cells being able to reverse several rounds of chemically-induced diabetes in vivo. (unice.fr)
Indeed, when provided to animals rendered diabetics, GABA could literally induce the regeneration of a functional beta-cell mass and thereby reverse the consequences of diabetes (multiple times) in vivo. (unice.fr)

Given the pivotal role that E2F1 has in cell proliferation, its involvement in melanoma growth and progression is not surprising. (biomedcentral.com)

Overall, our study suggests that LDH and complex I play distinct roles in regulating glycolysis and cell proliferation. (dcaguide.org)
Finally, we manually assembled a proposed regulation network model of subcutaneous preadipocyte differentiation base on the expression data, and suggested that E2F1 may serve as an important link between the processes of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)
In colorectal cell lines, TGF B induces proliferation by RAS independent manner. (microrna1.com)

One of the treatments applied in cancer is radiotherapy (RT), a therapeutic modality that uses ionizing radiation to induce damage in unwanted cells. (frontiersin.org)
In cancer cells, the MTp53 protein influences the transcriptome by interacting with several transcription factors including E2F1, ETS1 and the p53 family members, p63 and p73. (thegomap.org)
Consistent with the known oncogenic function of mutant p53, the presence of mutant p53 in H1299 cells induced an increased growth rate and random migration. (thegomap.org)
Cancers are composed of heterogeneous combinations of cells that exhibit distinct phenotypic characteristics and proliferative potentials. (nature.com)
Fluorescence-activated cell sorting and cDNA-microarray analyses revealed that each subclone was composed of distinct populations of cells. (nature.com)
We could then propose, using human cells and tissues, the following: Increased E2F1 in adipocytes up-regulates TRAIL. (easo.org)
Therefore, the 4HR-induced effects on HUVECs and RAW 264.7 cells are nonetheless protected and well balanced by cellular homeostasis. (caspaseinhibitor.com)

0.0001), although no correlation was observed between E2F1 gene expression and the apoptotic index. (aacrjournals.org)
Typically, this complex process which regulates cellular homeostasis is characterized by distinct morphological and biochemical signatures including nuclear condensation, cell shrinkage, formation of apoptotic bodies, cellular blebbing and the externalization of phosphatidylserine [ 5 - 6 ]. (oncotarget.com)

Quantitative reverse transcription-PCR was done to evaluate the gene expression of E2F1, TS , and Survivin . (aacrjournals.org)
Michel D, Chatelain G, North S, Brun G. Stress-induced transcription of the clusterin/apoJ gene. (u-bordeaux.fr)
North S, Espanel X, Tavitian B, Brun G, Gillet G. Two distinct regulatory elements control quail cdc2 transcription: possible involvement in the control of retinoblast differentiation. (u-bordeaux.fr)
LIG_RB_pABgroove_1 (LxDLFD), LIG_RB_LxCxE_1 (LxCxE) and LIG_RBL1_LxSxE_2 (LxSxE).The LxDLFD motif binds to a deep groove formed between the A and B subdomains and is present in E2F family transcription factors (E2F1-5). (eu.org)

The overall survival rate was significantly lower in patients with high- E2F1 tumors than in those with low- E2F1 tumors ( P = 0.0027), especially among patients with stage II to III NSCLCs ( P = 0.0188). (aacrjournals.org)
RESULTS: Both SLU-PP-332 and SLU-PP-915 significantly improved ejection fraction, ameliorated fibrosis, and increased survival associated with pressure overload-induced HF without affecting cardiac hypertrophy. (bvsalud.org)
Furthermore, we found that heat exposure alone can significantly induce E2F1 expression. (biomedcentral.com)

Immunohistochemistry was done to investigate the protein expression of E2F1, TS, and Survivin. (aacrjournals.org)
These results suggest that HUVECs have stronger wound healing properties soon after a 4HR therapy by way of the activation of RAS signaling, growthPLOS One particular https://doi.org/10.1371/journal.pone.0243975 December 15,25 /PLOS ONE4HR-induced protein expression changes in HUVECsFig 14. (caspaseinhibitor.com)
At the very same time, it suppresses proliferationPLOS One https://doi.org/10.1371/journal.pone.0243975 December 15,26 /PLOS ONE4HR-induced protein expression alterations in HUVECsby upregulating distinctive mitosis and cyclin-related proteins. (caspaseinhibitor.com)

Immunohistochemistry data revealed hyperphosphorylation of Rb and upregulation of E2F1 in the RAN-treated samples. (biomedcentral.com)

Two alternatively spliced transcript variants encoding distinct proteins have been described. (wikipedia.org)

Exogenous oleic acid alone successfully induced duck subcutaneous preadipocyte differentiation. (biomedcentral.com)

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres. (cnio.es)
Therefore, E2F1 has been considered as a potential therapeutic target for this form of skin cancer. (biomedcentral.com)

Alternative splicing results in multiple transcript variants encoding distinct isoforms. (cancerindex.org)

UV irradiation represents a major challenge to genomic integrity throughout the evolution of terrestrial organisms, resulting in the development of specific mechanisms that govern the cellular response to UV-induced DNA damage. (rupress.org)

therefore, it provides a unique opportunity to investigate the extent to which different sequence features acquire methylation as a result of common or distinct mechanisms. (biomedcentral.com)

E2F1 is a well-known cell-cycle regulator implicated in cancer, which we have previously established as a mediator of adipose tissue dysfunction in obesity. (easo.org)

Rather, p53 accumulation by either knockdown of Mdm2 or addition of an Mdm2 inhibitor, Nutlin-3, before irradiation strongly attenuated the UV-induced DDR and increased cell survival. (rupress.org)

have been found to be at higher large quantity in the colonic mucosa of individuals with UC relative to control individuals 64 65 and human being isolates of have been shown to induce colonic mucosal erosion in mice by rectal enema.66 The invasive ability Synephrine (Oxedrine) of human being isolates has a positive correlation with the. (conferencedequebec.org)

β-Cell-Specific E2f1 Deficiency Impairs Glucose Homeostasis, β-Cell Identity, and Insulin Secretion. (unice.fr)

TRAIL secreted from adipocytes induces enhanced expression and secretion of TL1A, specifically from adipose tissue T-lymphocytes. (easo.org)

The molecular mechanisms underlying HIV-induced inflammation, which persists even during effective long-term treatment, remain incompletely defined. (biomedcentral.com)

This is the first study that shows a relation between germline E2F1 CNV and melanoma, suggesting that altered copies of this gene might be a predisposing factor to skin cancer. (biomedcentral.com)

Structure-based design was performed using 35 cocrystal structures of CDK2 liganded with distinct analogues of the parent compound. (proteopedia.org)

NSP 5a3a along with three other distinct though similar splice variants were initially identified corresponding to locus HCMOGT-1 on chromosome 17p11.2 [1]. (oncotarget.com)

The specific changes on the DNA upon UV exposure are different from those induced by γ irradiation, mostly resulting in chemical modifications of single DNA strands such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts ( Balajee and Bohr, 2000 ). (rupress.org)

The pancreas can be subdivided into two distinct structures: the exocrine and the endocrine tissues. (unice.fr)

On main focus is to establish ways to induce pancreatic beta-cell regeneration in the context of diabetes research. (unice.fr)

RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas. (cnio.es)
Recent studies have demonstrated the existence of multiple copies of E2F1 gene in melanoma specimens which could explain the deregulated E2F1 activity in this type of cancer. (biomedcentral.com)

However, long-term depression (LTD) induced either by group I metabotropic glutamate receptors (mGluRs) agonist or by paired-pulse low-frequency stimulation (PP-LFS) was impaired in CDK4 inhibitor pretreated slices both from neonatal and adolescent animals. (biomedcentral.com)

This strongly supports the amplification of E2F1 gene in predisposing to cancer. (biomedcentral.com)

Considering that heat stress has been hypothesised as a contributing factor to skin cancer, we also investigated the effect of heat stress on E2F1 expression. (biomedcentral.com)

Gfi1 Loss Protects against Two Models of Induced Diabetes. (unice.fr)

Since the molecular mechanism underlying securin upregulation remains unclear, this study intended to investigate the association of securin upregulation with the Rb-E2F1 circuit and epigenetic histone (H3) modification patterns both globally and in the promoter region of the securin gene. (biomedcentral.com)

Although these regulatory modules are physicochemically distinct, they share an evolutionary plasticity that has facilitated a rapid growth of their use and resulted in their ubiquity in complex organisms. (biomedcentral.com)

In contrast, p53 was not required for UV-induced DDR. (rupress.org)

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization. (cnio.es)

The novelty of this study stems from the prior recognition of the role of E2F1 in adipose tissue biology. (easo.org)

Provided the complexity of dietary effects including such information is only going to be feasible in a big cohort study most likely.18 Age There can be an age-related variation in the distribution of IBD phenotypes with three distinct levels of onset. (conferencedequebec.org)

Since germline copy number variations (CNVs) have been associated with increased susceptibility to different types of cancer, the aim of our study was to assess germline E2F1 CNV in melanoma patients. (biomedcentral.com)

The mutagenicity and genotoxicity of RAN-alkaloids has been demonstrated in several short-term assays, and it has been suggested that RAN should be considered a human carcinogen since it induces preneoplastic and neoplastic lesions in experimental animals [ 9 ]. (biomedcentral.com)

Organisms1

Diseases7

Chemicals and Drugs4

Phenomena and Processes1

Apoptosis10

Pathways5

MRNA5

Phosphorylation4

Overexpression3

Conclusions1

Chromatin3

Pathway2

Tumor3

Genes5

Senescence2

Transcriptional1

Vivo3

Progression1

Proliferation3

Cells7

Apoptotic2

Transcription4

Significantly3

Protein expression3

Immunohistochemistry1

Proteins1

Differentiation1

Therapeutic2

Transcript variants encoding1

Cellular1

Methylation1

Regulator1

Survival1

Mice1

Homeostasis1

TRAIL1

Mechanisms1

Relation1

CDK21

Variants1

Exposure1

Tissues1

Regeneration1

Existence2

Agonist1

Strongly1

Expression1

Diabetes1

Investigate1

Regulatory1

Contrast1

Roles1

Role1

Effects1

Study1

Human1