Anesthetics, DissociativeXylazineKineticsAnalgesicsDissociative DisordersExcitatory Amino Acid AntagonistsAnesthetics, CombinedGuanine Nucleotide Dissociation InhibitorsProtein BindingAnestheticsMidazolamThiopentalReceptors, N-Methyl-D-AspartateDepressive Disorder, Treatment-ResistantDose-Response Relationship, DrugBinding SitesStereoisomerismAcepromazinerho-Specific Guanine Nucleotide Dissociation InhibitorsAnesthesia, IntravenousAnesthetics, IntravenousConscious SedationPropofolAnesthesiaMedetomidineAdjuvants, AnesthesiaPentobarbitalAnesthesia, CaudalSpectrometry, Mass, Electrospray IonizationPsychoses, Substance-InducedHydrogen-Ion ConcentrationBinding, CompetitiveMolecular Sequence DataAnesthesia, GeneralPreanesthetic MedicationMacromolecular SubstancesTime FactorsSpectrometry, FluorescenceAmino Acid SequenceProtein ConformationPain, PostoperativeAnalgesiaTiletamineRats, Sprague-DawleyDouble-Blind MethodRabbitsModels, MolecularThermodynamicsInjections, IntramuscularBrainMass SpectrometryElectronsAnalgesics, OpioidCalciumrho Guanine Nucleotide Dissociation Inhibitor alphaDrug InteractionsMorphineModels, ChemicalMathematicsTemperatureTandem Mass SpectrometryAntidepressive AgentsAdenosine TriphosphateLigandsRecombinant ProteinsCattlePain MeasurementPain, IntractableMagnesiumPhencyclidineIonsFentanylDimerizationEscherichia coliPeptidesZolazepamProtein Structure, TertiaryOxygenModels, BiologicalDizocilpine MaleateGuanosine DiphosphateN-MethylaspartateSurface Plasmon ResonanceChromatography, GelMemantineDiazepamCell LineInjections, SpinalRespirationGuanosine TriphosphateEtomidateHallucinogensCell MembraneMolecular WeightRats, WistarInfusions, IntravenousAdenosine DiphosphateAnesthesia, DentalDexmedetomidineElectrophoresis, Polyacrylamide Gel