• No expression could be detected in the ovary, the adipose tissue, and the bone marrow [(Uhlen et al. (springer.com)
  • A review in Advanced Science explores the interaction between the immune system and the sympathetic nervous system in regulating vital metabolic organs like the pancreas, liver, and adipose tissues. (news-medical.net)
  • The regular consumption of medium chain triglycerides increases metabolism, decreases fat deposition in adipose tissue, and reduces food intake, thereby lowering obesity levels. (grandviewresearch.com)
  • Within adipose tissue, the expression of lipolytic and lipogenic enzymes was higher, while those related to lipid oxidation were lower in the NDh group compared to the NDo group. (frontiersin.org)
  • Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. (wikipedia.org)
  • The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. (wikipedia.org)
  • Here, we present the backbone and side chain nuclear magnetic resonance assignments for the human DBNDD1 protein. (springer.com)
  • Our chemical-shift based secondary structure analysis reveals the human DBNDD1 as an intrinsically disordered protein. (springer.com)
  • 2021 ), https://pfam.xfam.org/ ] predicts human DBNDD1 mainly as an intrinsically disordered protein (IDP) and also the recently released AlphaFold database (Jumper et al. (springer.com)
  • Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. (bmj.com)
  • Plasma cells normally produce a slight excess of light chains that are either excreted or catabolized by the kidney, and only a minute amount of light-chain protein normally appears in the urine. (medscape.com)
  • Light-chain proteins appear in urine in high concentration either when the production of light-chain proteins is markedly increased or when the ability of the proximal tubules to reabsorb all the filtered protein is diminished. (medscape.com)
  • The term Bence Jones protein has been used to designate a urinary protein that leaves solution at approximately 56°C under certain conditions of pH and ionic strength and returns to the solution upon further heating to 100°C. The Bence Jones protein represents a homogeneous population of immunoglobulin light chains of either kappa type or lambda type and is the product of a presumed single clone of plasma cells. (medscape.com)
  • This process is exceedingly efficient, and only a minute amount of light-chain protein normally appears in the urine. (medscape.com)
  • [1] Hemoglobin A is a tetrameric protein that is composed of two α-globin chains and two β-globin chains. (medscape.com)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • Inheritance of Single-Gene Disorders Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body or code for functional RNA molecules. (msdmanuals.com)
  • Scientists at the National Institutes of Health have gained a major insight into how the rogue protein responsible for mad cow disease and related neurological illnesses destroys healthy brain tissue. (nih.gov)
  • The researchers discovered that the protein responsible for these disorders, known as prion protein (PrP), can sometimes wind up in the wrong part of a cell. (nih.gov)
  • However, the protein chains sometimes misfold. (nih.gov)
  • But exactly how this protein-based tissue assembles itself to achieve this flexibility remained an unsolved question - until now. (mit.edu)
  • Elastin tissues are made up of molecules of a protein called tropoelastin, which are strung together in a chain-like structure, and which Weiss and his team have been studying in the lab for many years. (mit.edu)
  • The globin part of haemoglobin is a protein that consists of the alpha (α) and beta (β) parts or chains, which are produced by the α-globin genes and β-globin genes. (thalassaemia.org.cy)
  • Amyloidosis is a term used to describe fibril deposition of proteins.AL amyloidosis is due to deposition of protein from immunoglobulin light chain fragments. (contemporaryobgyn.net)
  • Treatment of fatty acid oxidation disorders varies depending on the type of fatty substances that accumulate in the blood and tissues. (msdmanuals.com)
  • PBTs, in particular are a dangerous class of chemicals that linger in the environment and accumulate in living tissues. (ghanabusinessnews.com)
  • Aniline does not accumulate in the food chain. (cdc.gov)
  • A method for the detection of coxsackievirus B3 RNA was developed using the polymerase chain reaction based on the amplification of a cDNA copy of the positive-strand viral RNA. (nih.gov)
  • The results show that the polymerase chain reaction is a useful means for detecting coxsackie viral RNA and its application should help in the evaluation of hypotheses concerning the infectious etiology of human myocarditis and idiopathic dilated cardiomyopathy. (nih.gov)
  • Diagnosis is by skin biopsy with fluorescent antibody or polymerase chain reaction testing. (msdmanuals.com)
  • 260 "The polymerase chain reaction: an improved method for the analysis of nucleic acids":Hum.Genet. (globalchange.com)
  • RNA was isolated, followed by reverse transcription (RT) and polymerase chain reaction (PCR). (cdc.gov)
  • To increase the proportion of pregnant women with Zika virus infection who receive a definitive diagnosis, CDC recommends expanding real-time reverse transcription-polymerase chain reaction (rRT-PCR) testing. (cdc.gov)
  • The presence of light-chain proteins in the urine is associated with a number of systemic diseases (see Etiology ). (medscape.com)
  • The kidney is the major site of metabolism of light-chain proteins. (medscape.com)
  • The filtered light-chain proteins, reabsorbed by the proximal tubular cells via the tandem megalin/cubilin receptors, are catabolized by lysosomal enzymes. (medscape.com)
  • Metabolism (catabolism) of these filtered light-chain proteins depends on normal proximal tubular cell function, and damage to these cells can result in increased excretion of light-chain proteins in the urine. (medscape.com)
  • We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
  • We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
  • Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)
  • In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
  • We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
  • Amyloidosis results from a buildup of insoluble amyloid fibrils (abnormal proteins) in the body's tissues. (emedicinehealth.com)
  • Amyloidosis is a rare condition that occurs when there is a buildup of insoluble amyloid fibrils (abnormal proteins) in the body's tissues. (emedicinehealth.com)
  • Proteins are made up of long chains of molecules known as amino acids. (nih.gov)
  • Mutations can cause reduced production of the proteins, either the α-globin chains or the β- chains. (thalassaemia.org.cy)
  • The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice. (ironmagazine.com)
  • RD can be classified as a peroxisome biogenesis disorder. (medscape.com)
  • Refsum disease can be classified as a peroxisome biogenesis disorder. (medscape.com)
  • [ 1 ] Infantile Refsum disease is a peroxisome biogenesis disorder. (medscape.com)
  • To try to identify the substance responsible for this disorder, Virchow placed tissues from these organs in contact with Lugol's solution, which contains iodine. (mcgill.ca)
  • Amyloidosis can affect any part of the body and symptoms depend on the type of amyloidosis and the tissues and organs affected. (emedicinehealth.com)
  • Tissue may be taken from affected organs such as the kidneys, liver, heart, nerves, and other organs to confirm amyloid deposits. (emedicinehealth.com)
  • Rheumatic fever causes inflammation of tissues and organs and can result in serious damage to the heart valves, joints, central nervous system and skin. (encyclopedia.com)
  • These fatty acids are found in foods and the body's fat tissues. (medlineplus.gov)
  • Light chain (AL) amyloidosis is the most common type in the U.S. and is caused by a bone marrow disorder. (emedicinehealth.com)
  • The primary way amyloidosis is diagnosed is with a tissue biopsy. (emedicinehealth.com)
  • Light chain amyloidosis. (webmd.com)
  • Lambda light chains usually exist as dimers (44,000 d) and, therefore, are less likely to be filtered and appear in urine. (medscape.com)
  • Maple syrup urine disease (MSUD) is a rare recessively inherited metabolic disorder causing accumulation of branched chain amino acids leading to neonatal death, if untreated. (nature.com)
  • Maple syrup urine disease (MSUD, MIM: 248600) is one of the earliest described metabolic disorders. (nature.com)
  • This gene provides instructions for making an enzyme called medium-chain acyl-CoA dehydrogenase, which is required to break down (metabolize) a group of fats called medium-chain fatty acids. (medlineplus.gov)
  • During periods of fasting, fatty acids are also an important energy source for the liver and other tissues. (medlineplus.gov)
  • Without sufficient amounts of this enzyme, medium-chain fatty acids are not metabolized properly. (medlineplus.gov)
  • Medium-chain fatty acids or partially metabolized fatty acids may also build up in tissues and damage the liver and brain. (medlineplus.gov)
  • Fatty acid oxidation disorders are lipid metabolism disorders that are caused by a lack or deficiency of the enzymes needed to break down fats, resulting in delayed mental and physical development. (msdmanuals.com)
  • In fatty acid oxidation disorders, both parents of the affected child carry a copy of the abnormal gene. (msdmanuals.com)
  • Children who have a fatty acid oxidation disorder are missing or have a deficiency of the enzymes needed to break down (metabolize) fats. (msdmanuals.com)
  • It prevents people from properly metabolizing long-chain fatty acids, which can build up in the brain and other tissues (especially the adrenal gland) and cause a variety of symptoms. (sunjournal.com)
  • It makes sense that it might help, but since the body makes its own long-chain fatty acids, it is unlikely to prevent progression completely. (sunjournal.com)
  • Monocarboxylate transporter 1 (MCT1) plays a crucial role in the transport of lactate, pyruvate, ketone bodies, and short-chain fatty acids (SCFA), as well as MCT1-targeted drugs in various tissues. (news-medical.net)
  • Detecting fatty acid oxidation disorders and several organic acidurias. (kkh.com.sg)
  • Evaluating and monitoring patients with fatty acid oxidation and organic acid disorders. (kkh.com.sg)
  • Triheptanoin is being developed for the treatment of long-chain fatty acid oxidation disorders (LC-FAOD). (nihr.ac.uk)
  • LC-FAOD is a group of six rare and ultra-rare life-threatening genetic disorders in which the body is unable to convert dietary fatty acids into energy. (nihr.ac.uk)
  • Phytanic acid replaces other fatty acids, including such essential ones as linoleic and arachidonic acids, in lipid moieties of various tissues. (medscape.com)
  • An infantile form of Refsum disease also exists and is an autosomal recessive disorder of peroxisomal biogenesis, leading to many biochemical abnormalities, including elevated plasma concentration of phytanic acid, pristanic acid, very long chain fatty acids, and C27 bile acids. (medscape.com)
  • The cells of this cancer have features of plasma cells as well as lymphoid tissue. (webmd.com)
  • A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
  • Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
  • They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder. (lookformedical.com)
  • Symptomatic patients might have any of the characteristic manifestations of systemic iron overload: liver disease with the eventual development of cirrhosis and hepatocellular carcinoma, arthropathy, increased skin pigmentation, cardiomyopathy, diabetes mellitus, gonadal insufficiency and other endocrine disorders. (medscape.com)
  • Here, based on significant liver contribution to the catabolism of the branched chain amino acid leucine, we develop a liver-directed adeno-associated virus (AAV8) gene therapy for MSUD. (nature.com)
  • BCAA affects PPAR-alpha and UCP expression in muscle and liver tissue. (ironmagazine.com)
  • Mucopolysaccharidosis type II (MPS II) is a rare disease in which the body is missing or does not have enough of an enzyme needed to break down long chains of sugar molecules. (mountsinai.org)
  • These chains of molecules are called glycosaminoglycans (formerly called mucopolysaccharides). (mountsinai.org)
  • Without this enzyme, chains of sugar molecules build up in various body tissues, causing damage. (mountsinai.org)
  • Antioxidant compounds are molecules that can inhibit or delay the oxidation of lipids or other biomolecules by inhibiting the initiation and propagation of oxidative chain reactions [ 29 ]. (ijpsonline.com)
  • Sickle cell disease (SCD) is an autosomal, recessive hemoglobinopathy characterized by hemolytic anemia, intermittent occlusion of small vessels leading to acute and chronic tissue ischemia, and organ dysfunction. (medscape.com)
  • It is not implausible to imagine that more fully characterizing how O. unilateralis uses particular secondary metabolites to chemically induce host movement might pave the way for new drugs that mitigate the symptoms of individuals with neuromuscular disorders. (databasefootball.com)
  • magnetic resonance spectroscopy (MRS), diagnostic imaging technique based on the detection of metabolites in tissues. (britannica.com)
  • Since it is feasible to measure NfL concentration in the blood, it may be a promising biomarker for monitoring the disease course in CNS disorders and, ideally, for evaluating patients' response to treatments. (bmj.com)
  • This article describes the endocrine and metabolic disorders reported in patients with SCD, discusses their management, and identifies gaps in current knowledge and opportunities for future research. (medscape.com)
  • In patients with myocarditis, one of five specimens contained detectable viral RNA, whereas none of 11 specimens from patients with idiopathic dilated cardiomyopathy or 21 myocardial specimens from patients with a wide variety of other cardiac disorders contained detectable coxsackie B3 viral RNA. (nih.gov)
  • Because antibodies reactive with BDV have been found in the sera of patients with neuro- psychiatric disorders, this review examines the possible link between BDV and such disorders. (cdc.gov)
  • Seroepidemiologic and cerebrospinal fluid investigations of psychiatric patients suggest a causal role of BDV infection in human psychiatric disorders. (cdc.gov)
  • In diagnostically unselected psychiatric patients, the distribution of psychiatric disorders was found to be similar in BDV seropositive and seronegative patients. (cdc.gov)
  • Standard laboratory tests are not yet available to diagnose psychiatric disorders, as most can be attributable to poor understanding of their biological mechanisms or difficulty in routinely accessing brain tissue in live diseased patients. (psychiatrist.com)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
  • 1 Type II hypersensitivity reactions are common in some types of autoimmune diseases, such as autoimmune neutropenia of rheumatoid disorders . (bdbiosciences.com)
  • Hematopoietic stem cell (HSC) replacement transplantation can ameliorate diseased hematologic system, thus inhibiting immune disorders including autoimmune diseases and immunodeficient disorders. (stanford.edu)
  • Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
  • Fibrinogen alpha chain has been shown to interact with tissue plasminogen activator. (wikipedia.org)
  • He attributed this change to a starch-like substance in the tissues, which he named "amyloid", from the Greek amylo (starch) and - oid (similar to). (mcgill.ca)
  • AA amyloid deposits develop in all tissues, but the most commonly damaged organ is the kidneys. (emedicinehealth.com)
  • This type of amyloid is usually associated with systemic disease due to an underlying clonal plasma cell proliferative disorder or a B-cell lymphoma. (contemporaryobgyn.net)
  • Sickle cell disease (SCD) is a hereditary hemoglobino pathy characterized by abnormal hemoglobin production, hemolytic anemia, and intermittent occlusion of small vessels, leading to acute and chronic tissue ischemia, chronic organ damage, and organ dysfunction. (medscape.com)
  • Because usually two copies of the abnormal gene are necessary for the disorder to occur, usually neither parent has the disorder. (msdmanuals.com)
  • In other human disorders, genetic errors cause other abnormal forms of PrP to be produced. (nih.gov)
  • A tactical difference could be appreciated between the abnormal and normal tissue. (contemporaryobgyn.net)
  • This disorder is sometimes mistaken for Reye syndrome, a severe disorder that may develop in children while they appear to be recovering from viral infections such as chicken pox or flu. (medlineplus.gov)
  • Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases. (bmj.com)
  • This applies to central nervous system (CNS) disorders of all causes, including inflammatory, neurodegenerative, traumatic and vascular diseases. (bmj.com)
  • In CNS and peripheral nervous system diseases associated with axonal injury or degeneration, the concentration of neurofilament light chain (NfL) has been found to increase in cerebrospinal fluid (CSF) and blood. (bmj.com)
  • The World Health Organisation has identified mental disorders, including depression, cardiovascular diseases and diabetes among the six major non-communicable diseases [ 1 ]. (plos.org)
  • Symptoms of some debilitating diseases, such as multiple sclerosis and cerebral palsy, involve damaged brain-neuron-muscle communication chains. (databasefootball.com)
  • Medium chain triglycerides are widely used in formulating various health and dietary supplements owing to their ability to reduce and prevent the occurrence of several diseases including cardiovascular, Alzheimer's, Chyle Leaks, and gastrointestinal disorders. (grandviewresearch.com)
  • In addition, AEG-1 as a key modulator regulates aberrant cellular processes within the central nervous system (CNS), where it is involved in neurological diseases such as Huntington's chorea, migraine and HIV-induced neurological disorders ( 7-9 ). (spandidos-publications.com)
  • Inherited diseases of connective tissue. (mountsinai.org)
  • In an effort to advance the treatment strategies for the ocular surface diseases, I am focused on a regenerative medicine and single cell RNA sequencing based approaches to better comprehend the cellular biomarkers and molecular mechanisms involved in corneal tissue development and diseases. (stanford.edu)
  • Internal flesh browning-related disorders can result in severe economic losses to the apple industry through reduced consumer trust and market acceptability of susceptible cultivars. (mdpi.com)
  • Sickle cell disease is a group of inherited red blood cell disorders arising from a single genetic mutation that can cause severe pain and potentially lead to premature death. (scinfo.org)
  • Approximately 5-7% of the world population is a carrier of a severe haemoglobin disorder, including thalassaemia, and between 300-500 thousand children are born each year with a severe haemoglobin disorder. (thalassaemia.org.cy)
  • Although the function of AEG‑1 has been demonstrated in neurological disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis, the underlying mechanism of neuronal AEG‑1 function remains unclear. (spandidos-publications.com)
  • Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is a condition that prevents the body from converting certain fats to energy, particularly during periods without food (fasting). (medlineplus.gov)
  • The natural history of medium-chain acyl CoA dehydrogenase deficiency in the Netherlands: clinical presentation and outcome. (medlineplus.gov)
  • Dezateux C. Newborn screening for medium chain acyl-CoA dehydrogenase deficiency: evaluating the effects on outcome. (medlineplus.gov)
  • Spectrum of medium-chain acyl-CoA dehydrogenase deficiency detected by newborn screening. (medlineplus.gov)
  • Diagnosis can also be made by PCR of cerebrospinal fluid (CSF), saliva, or tissue. (msdmanuals.com)
  • Light chains (molecular weight 22,000 d) are polypeptides that are synthesized by plasma cells and form part of immunoglobulins. (medscape.com)
  • Light chains (molecular weight 22,000 d) are polypeptides synthesized by plasma cells and assembled with heavy chains to form the various classes of immunoglobulins, for example, immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA). (medscape.com)
  • Light chains are divided into 2 major classes based on the amino acid sequence in the constant portion of the polypeptide chain and are designated as kappa and lambda. (medscape.com)
  • Individual immunoglobulins have either kappa or lambda light chains, but not both. (medscape.com)
  • Kappa light chains usually exist as monomers (22,000 d) and are therefore small enough to be filtered through the glomerulus, but they may exist as dimers. (medscape.com)
  • At times, light chains of either kappa or lambda type may form tetramers (88,000 d), which are not filtered, and a patient may have light-chain proteinemia without light-chain proteinuria. (medscape.com)
  • However, except for cases with plasma cell differentiation, these techniques often fail to identify immunoglobulin light chains. (unm.edu)
  • An ultrasensitive technique, RNAscope, has been recently introduced which can identify light chains in cases of B cell LPDs. (unm.edu)
  • [ 2 ] The term has been associated with various glomerular abnormalities that are caused by the deposition of these monoclonal immunoglobulins (or their heavy-chain or light-chain subunits) and are broadly classified into 2 categories, organized or nonorganized, depending on the pattern of deposition. (medscape.com)
  • It has been demonstrated the involvement of branched-chain amino acids (BCAA) on obesity and related metabolic disorder. (ironmagazine.com)
  • Overview of Hereditary Metabolic Disorders Hereditary metabolic disorders are inherited genetic conditions that cause metabolism problems. (msdmanuals.com)
  • This disorder is one of the most common inherited disorders of metabolism, particularly among people of Northern European descent. (msdmanuals.com)
  • To detect disorders of hormone production that may affect baby's metabolism, response to infection, ability to regulate salt levels and sex characteristics. (kkh.com.sg)
  • We investigated the effects of branched-chain amino acids (BCAA) on obesity and on glucose/fat homeostasis in mice fed on a high-fat (45%) diet. (ironmagazine.com)
  • The BCKD enzyme is a multimeric enzyme complex with four components, branched-chain keto acid decarboxylase alpha and beta subunits (E1 α and E1 β ), dihydrolipoyl transacylase (E2) subunit, and dihydrolipoamide dehydrogenase (E3) subunit. (nature.com)
  • Refsum disease (RD) is a neurocutaneous syndrome that is characterized biochemically by the accumulation of phytanic acid in plasma and tissues. (medscape.com)
  • Refsum disease is a recessive disorder characterized by defective peroxisomal alpha-oxidation of phytanic acid. (medscape.com)
  • The most characteristic histologic lesion of light chain deposition disease (LCDD) is nodular glomerulosclerosis, which must be distinguished from diabetic glomerulosclerosis by using electron microscopy. (medscape.com)
  • In rare cases, symptoms of this disorder are not recognized early in life, and the condition is not diagnosed until adulthood. (medlineplus.gov)
  • As a result, these fats are not converted to energy, which can lead to the characteristic signs and symptoms of this disorder such as lethargy and hypoglycemia. (medlineplus.gov)
  • The complement system is also activated, and chemo-attracted neutrophils cause local inflammation and tissue damage. (bdbiosciences.com)
  • These are further divided into at least 10 subtypes (4 kappa and 6 lambda) based on the amino acid sequence in the variable region of the polypeptide chain. (medscape.com)
  • Evaluate malignancies and hematologic disorders for diagnostic or prognostic purposes. (agt-info.org)
  • The resultant chimeric immune systems were demonstrated to be immunologically tolerant to heart tissue from the HSC donor, providing a safe platform for HSC transplantation as a means to solid organ transplantation. (stanford.edu)
  • The mechanisms and treatment of persistent post-coronavirus disease 2019 (COVID-19) smell and taste disorders are still challenges. (wjgnet.com)
  • Improved mechanisms of targeted drug delivery to specific tissues could have far-reaching applications, from better directed anti-cancer treatments to common antibiotics. (databasefootball.com)
  • Ultrasensitive RNAscope is a reliable assay in the detection of clonality in FFPE tissue, particularly where fresh tissue is not available for flow cytometry. (unm.edu)
  • A tissue microarray (TMA) was constructed using 1.6 mm diameter tissue punches of 31 FFPE tissue blocks from 27 cases (figure 1) which were previously characterized as marginal zone lymphoma (MZL) by a combination of morphology, IHC, and/or flow cytometry. (unm.edu)
  • A handful of fungi have the unique ability to hijack the nervous systems of an insect host, invading its tissue and directing its movement while slowly eating the organism from the inside. (databasefootball.com)
  • Any disturbance of this structure of the haemoglobin molecule, reduces the capacity of the haemoglobin to carry oxygen to the tissues , but also disturbs the whole structure of the red blood cell containing the haemoglobin. (thalassaemia.org.cy)
  • The main effect of aniline by any route of exposure is a blood disorder in which oxygen delivery to the tissues is impaired. (cdc.gov)
  • The challenge will address three blood disorders that exact an enormous toll on populations around the globe. (scinfo.org)
  • These long chains weave together to produce the flexible tissues that our lives depend on - including skin, lungs, and blood vessels. (mit.edu)
  • Haemoglobin disorders or haemoglobinopathies are a group of conditions affecting the molecule haemoglobin which is contained in the red blood cells. (thalassaemia.org.cy)
  • Summary: Kimura disease is a rare chronic inflammatory disorder mimicking malignancy. (ajnr.org)
  • Kimura disease is a chronic inflammatory disorder of unknown origin that mimics a malignant lesion both clinically and on images (1) . (ajnr.org)
  • For ultrasensitive ISH RNAscope assay, 4 µ thickness tissue sections were hybridized using kappa and lambda probes, incubated overnight, counterstained with hematoxylin, cover-slipped and reviewed blindly without knowledge of prior flow cytometry results. (unm.edu)
  • And because they increase in concentration as they move up the food chain, PBTs can reach dangerous levels in living organisms, even when released in minute quantities. (ghanabusinessnews.com)
  • The major pathway of free radical leakage is the electron transport chain inside the damaged mitochondria. (stanford.edu)
  • Immunohistochemistry (IHC) or in situ hybridization (ISH) are commonly used to assess light chain restriction in formalin fixed, paraffin embedded (FFPE) tissues. (unm.edu)
  • Research more strongly supports the theory that the disease is caused by an interaction between antibodies produced to fight the group A streptococcus bacteria and the heart tissue. (encyclopedia.com)
  • ANSWER: ALD is an uncommon genetic disorder affecting about 1 in 20,000 people. (sunjournal.com)
  • MPS II is a genetic disorder. (mountsinai.org)
  • There are several IFB-related disorders and incidence can range from 0 to 100% of a crop, with severity ranging from no brown flesh to browning of the entire fruit flesh. (mdpi.com)
  • First, beta-secretases cut the APP's chain of amino acids at a certain distance outside the cell membrane. (mcgill.ca)