Myelodysplastic SyndromesMyeloproliferative DisordersBone MarrowJanus Kinase 2Primary MyelofibrosisMyelodysplastic-Myeloproliferative DiseasesPolycythemia VeraThrombocythemia, EssentialBone Marrow CellsAnemia, RefractoryBone Marrow NeoplasmsLeukemia, Myelomonocytic, ChronicBone Marrow TransplantationReceptors, ThrombopoietinAnemia, Refractory, with Excess of BlastsLeukemia, Myeloid, AcuteThrombocytosisBone and BonesSyndromeBone Marrow DiseasesLeukemia, MyeloidHematopoietic Stem CellsLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeAnemia, SideroblasticMutationLeukemia, Myelomonocytic, JuvenileBone Marrow ExaminationChromosomes, Human, Pair 5LeukemiaHematologic NeoplasmsSplenomegalyLeukemia, Myelogenous, Chronic, BCR-ABL PositiveProto-Oncogene Proteins c-cblPrognosisHematopoiesisKaryotypingAzacitidineBlast CrisisAnemia, AplasticChromosome AberrationsPhiladelphia ChromosomeBone RemodelingMegakaryocytesTreatment OutcomePreleukemiaMyeloid Progenitor CellsPancytopeniaHematologyTransplantation, HomologousMonosomyDNA Mutational AnalysisHematopoietic Stem Cell TransplantationJanus KinasesThalidomideAntigens, CD34Acute DiseaseMice, Inbred C57BLMegakaryocyte Progenitor CellsChromosomes, Human, Pair 7Colony-Forming Units AssaySTAT5 Transcription FactorDisease ProgressionCell Transformation, NeoplasticBone DensityMegakaryocyte-Erythroid Progenitor CellsGranulocytesMyelopoiesisFlow CytometryCytogenetic AnalysisMutation, MissenseNeoplasms, Second PrimaryCell DifferentiationCell ProliferationClonal EvolutionChromosome DeletionFusion Proteins, bcr-ablBlood Cell CountGranulocyte Precursor CellsAntineoplastic AgentsBone ResorptionPhenotypeHematologic DiseasesWhole-Body IrradiationErythropoietinCytogeneticsGene Knock-In TechniquesGranulocyte Colony-Stimulating FactorPoint MutationAmino Acid SubstitutionBone NeoplasmsImmunophenotypingProtein Kinase InhibitorsCells, CulturedProto-Oncogene ProteinsSurvival AnalysisTransplantation, AutologousBone Marrow PurgingNeoplasmsDown SyndromeTranslocation, Genetic