• Epilepsy is a type of neurological disorder known for causing seizures. (healthline.com)
  • These findings could lead to novel therapeutics for a range of mitochondrial diseases, including neurological and muscular disorders and premature aging. (pewtrusts.org)
  • Transient receptor potential melastatin member 4 (TRPM4), a non-selective cation channel, mediates cell membrane depolarization in immune response, insulin secretion, neurological disorders, and cancer. (frontiersin.org)
  • Sometimes it is re-absorbed too quickly, and this may lead to conditions such as premature ejaculation. (onlineclinic.co.uk)
  • Initially, you will be prescribed a dosage of 30mg to help alleviate the symptoms of premature ejaculation. (onlineclinic.co.uk)
  • Topical use (applied to the skin) of Asian ginseng as part of a multi-ingredient preparation is promoted for premature ejaculation. (nih.gov)
  • Rapid (or premature) ejaculation is the most common male sexual function concern. (healthyplace.com)
  • The authors describe these observations about the biology of PTSD as "premature senescence. (medscape.com)
  • Cells age as part of the normal cell cycle process called senescence, which progressively advances through a limited number of divisions in the cell lifetime. (sciencedaily.com)
  • Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
  • Skin fibroblasts in WS patients demonstrate characteristics of cells in conditions of stress with slow growth rates, an elongated cell cycle, and an altered morphology that suggests stress-induced premature senescence transduced in part by the p38α MAP kinase signaling pathway. (medscape.com)
  • Despite treatment, premature mortality is increased in people with epilepsy . (healthline.com)
  • PROFILE OVERVIEW q In terms of the number of years of life lost (YLLs) due to Percent decline in age-specific mortality rate by sex from 1990-2010 in Angola premature death in Angola, diarrheal diseases, malaria, and lower respiratory infections were the highest ranking causes in 2010. (who.int)
  • 30 q This chart shows the decline in mortality rate at every age range. (who.int)
  • Years of life lost (YLLs) quantify premature mortality by weighting younger deaths more than older deaths. (who.int)
  • This premature mortality is mainly caused by atherosclerotic events. (bmj.com)
  • We constrained cause-specific fractions within every age-sex group to sum to total mortality based on draws from the uncertainty distributions. (nih.gov)
  • This decrease was largely due to decreases in mortality from diarrhoeal disease (from 2·5 to 1·4 million), lower respiratory infections (from 3·4 to 2·8 million), neonatal disorders (from 3·1 to 2·2 million), measles (from 0·63 to 0·13 million), and tetanus (from 0·27 to 0·06 million). (nih.gov)
  • Ischaemic heart disease, lower respiratory infections, stroke, diarrhoeal disease, malaria, and HIV/AIDS were the leading causes of years of life lost due to premature mortality (YLLs) in 2010, similar to what was estimated for 1990, except for HIV/AIDS and preterm birth complications. (nih.gov)
  • Werner syndrome (WS) is an autosomal recessive disorder that affects connective tissue throughout the body. (medscape.com)
  • An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin changes, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, baldness, and a high incidence of neoplastic disease. (bvsalud.org)
  • Premature ovarian failure is reduced function of the ovaries (including decreased production of hormones). (medlineplus.gov)
  • Ovarian failure that occurs before the age of 40 is considered premature ovarian failure. (medlineplus.gov)
  • Premature ovarian failure may be caused by genetic factors such as chromosome abnormalities. (medlineplus.gov)
  • Chemotherapy and radiation therapy can also cause premature ovarian failure. (medlineplus.gov)
  • FSH levels are higher than normal in women with premature ovarian failure. (medlineplus.gov)
  • Women with premature ovarian failure who want to become pregnant may be concerned about their ability to conceive. (medlineplus.gov)
  • Posttraumatic stress disorder (PTSD) may increase biomarkers of the aging process and of medical conditions, such heart disease, associated with advanced age and lead to premature death, a new literature review reveals. (medscape.com)
  • If telomeres are lost or damaged, then that can lead to premature aging events or age-related diseases such as cancer. (iu.edu)
  • NAARDEN, Netherlands-(BUSINESS WIRE)-Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, announces the appointment of Henk Schuring as Chief Regulatory and Commercialization Officer. (dutchnews.nl)
  • Prilenia is a clinical stage biotech startup founded in 2018 with the purpose of improving the lives of patients and their families by developing treatments for neurodegenerative and neurodevelopmental disorders. (dutchnews.nl)
  • This chapter describes the different parts of the female reproductive system: the organs involved in the process of reproduction, hormones that regulate a woman's body, the menstrual cycle, ovulation and pregnancy, the female's role in genetic division, birth control, sexually transmitted diseases and other diseases and disorders. (wikibooks.org)
  • These numbers are expected to double by 2050 because of the aging US population and the projected increase in chronic diseases, such as diabetes. (cdc.gov)
  • 9 The leading causes of blindness and vision impairment are primarily age-related eye diseases, such as diabetic retinopathy, age-related macular degeneration, cataract, and glaucoma. (cdc.gov)
  • More than 30 million adults aged 40 or older are affected by age-related eye diseases. (cdc.gov)
  • 3 Spondyloarthropathies are a group of various rheumatic diseases of which ankylosing spondylitis (ASp) and psoriatic arthritis (PsA) are the most frequently occurring disorders ( table 1 ). (bmj.com)
  • Studying telomerase regulation provides key insights into the mechanisms of these telomere diseases, as well as cancer and aging. (uab.edu)
  • In the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), we aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex. (nih.gov)
  • Also surplus production of reactive oxygen species can cause premature aging disorders, inflammations and lead to diseases including diabetes, cancer, and atherosclerosis. (pharmiweb.com)
  • Women generally have more work-related cases of carpal tunnel syndrome, tendonitis, respiratory diseases, infectious diseases, and anxiety and stress disorders. (cdc.gov)
  • In schizophrenia, there's evidence that some of the subtle abnormalities preceded the onset of the disorder by decades, whereas in PTSD, people appear to be doing normally until this unusual, traumatic event, so it allows us to gage the starting point with much more precision," said Dr Palmer. (medscape.com)
  • Progeria is an extremely rare disease in which children experience symptoms normally associated with advanced age, including hair loss, diminished subcutaneous fat, premature atherosclerosis and skeletal abnormalities. (sciencedaily.com)
  • Cerebrospinal fluid samples from 245 pediatric patients (median age 43 days), submitted for evaluations of possible sepsis or of neurologic symptoms, were tested for HHV-6 and HHV-7 DNA by polymerase chain reaction. (cdc.gov)
  • However, HHV-6 and HHV-7 DNA have been detected in CSF and other body fluids by polymerase chain reaction (PCR), which implicates these viruses in neurologic disorders. (cdc.gov)
  • Premature aging and frailty, weaker bones, neurologic disorders and cancer can also occur. (positivelyaware.com)
  • Aging, musculoskeletal disorders and work capacity. (cdc.gov)
  • The study on Aging, Musculoskeletal Disorders and Work Capacity was initiated in 2008 as an observational study directed to the factors either accelerating or retarding the effects of work and non-work factors on musculoskeletal health (MSH) in an aging employed population. (cdc.gov)
  • The UConn study on Aging, Musculoskeletal Disorders and Work Capacity provides a remarkable quantified picture of the status of the older population in manufacturing, and suggests both long-term health consequences that may occur if unattended, and also important key interventions in areas of likely impact. (cdc.gov)
  • He was a member of the consortium that identified the Lamin A gene as the cause of the accelerated aging disease Hutchinson-Gilford progeria syndrome and participated in the first National Institutes of Health - Progeria Research Foundation workshop. (wikipedia.org)
  • He also showed that progeria is a true representation of aging with respect to cellular signaling pathways, and truly recapitulates the normal aging process at the cellular level. (wikipedia.org)
  • In 2003, NHGRI researchers discovered that a mutation in LMNA causes the rare premature aging condition, progeria, formally known as known as Hutchinson-Gilford progeria syndrome. (sciencedaily.com)
  • This study highlights that valuable biological insights are gained by studying rare genetic disorders such as progeria. (sciencedaily.com)
  • Our sense from the start was that progeria had a lot to teach us about the normal aging process and clues about more general biochemical and molecular mechanisms. (sciencedaily.com)
  • The current study shows that the mutation that causes progeria strongly activates the splicing of lamin A to produce the toxic progerin protein, leading to all of the features of premature aging suffered by children with this disease. (sciencedaily.com)
  • The term progeria is derived from a Greek term meaning "before old age. (medscape.com)
  • Inflammatory joint disorders (IJD) are characterised by chronic inflammation of the joints and related tissues. (bmj.com)
  • Breast disorders occurring in pediatric patients range from congenital conditions to neonatal infections and from benign disorders such as fibroadenoma in females and gynecomastia in males to breast carcinoma and rhabdomyosarcoma . (medscape.com)
  • Mutations in genes for telomerase cause a wide spectrum of disorders including, premature aging syndromes. (uab.edu)
  • WS and several other progeroid syndromes are epigenetically distinct disorders. (medscape.com)
  • Human progeroid syndromes are linked with mutations in single genes accelerating some, but not all, features of normal aging. (medscape.com)
  • We separately estimated cause fractions by aetiology for diarrhoea, lower respiratory infections, and meningitis, as well as disaggregations by subcause for chronic kidney disease, maternal disorders, cirrhosis, and liver cancer. (nih.gov)
  • Temple syndrome (TS) is an imprinting disorder that was first described by Temple et al in 1991 in a report of a male aged 18 years with maternal uniparental disomy of chromosome 14. (bmj.com)
  • gestational age was it should be noted that premature rupture confirmed via ultrasonography. (who.int)
  • The severity of ROP was associated with earlier gestational age, lower birth weight, and oxygen supplementation. (hindawi.com)
  • ROP was initially associated with premature birth and shortly after with oxygen treatment. (hindawi.com)
  • A detailed history included the gender, the gestational age, the birth weight, the need for intubation and blood transfusion, and the appearance of sepsis. (hindawi.com)
  • Occytes are present at birth, and age as a woman ages. (wikibooks.org)
  • Effects on babies include withdrawal symptoms, premature birth, and low birth weight. (nationaldec.org)
  • Premature birth was common (30%) and feeding difficulties frequently reported (n = 22). (bmj.com)
  • Isotretinoin (Accutane), an oral medication for acne, can cause very serious side effects and must not be used by pregnant women or women of child-bearing age who are not taking birth control. (limamemorial.org)
  • This is a cross-sectional study based on data analysis of the medical records of six pairs of low birth weight preterm twins of both sexes, at two years of age, attended at the State Center for the Prevention and Rehabilitation of People with Disabilities - CEPRED, in Salvador-Bahia-Brazil. (bvsalud.org)
  • Research shows that people who eat more foods with vitamin A are less likely to develop age-related macular degeneration (AMD). (limamemorial.org)
  • and relieve various other health problems, such as respiratory and cardiovascular disorders, depression, anxiety, and menopausal hot flashes. (nih.gov)
  • Death usually occurs when patients are aged 30-50 years because of atherosclerosis or malignant tumors. (medscape.com)
  • [ 6 ] A prematurely aged appearance with gray hair and sclerodermatous cutaneous changes begins in the 20-30s in association with cataracts, diabetes mellitus, atherosclerosis, cancers, and osteoporosis. (medscape.com)
  • Trastorno autosómico recesivo que origina envejecimiento prematuro en adultos, se caracteriza por cambios esclerodérmicos de la piel, cataratas, calcificación subcutánea, atrofia muscular, tendencia a la diabetes mellitus, apariencia de viejo en la cara, calvicie, y alta incidencia de enfermedad neoplásica. (bvsalud.org)
  • 30 weeks of gestational age and cases where medical notes were unavailable or incomplete. (hindawi.com)
  • The primary exclusion criteria were cases where ROP developed in newborns of more than 30 weeks of gestational age and the cases where medical notes were unavailable or incomplete. (hindawi.com)
  • The infants were divided into two groups based on their gestational age. (hindawi.com)
  • May 16, 2003 - Fri 12:30PM - Dr. Vilhelm Bohr, NIA - Human Premature Aging Proteins: Werner and Cockayne, Links Between DNA Repair and Aging 3. (bio.net)
  • Usually starting at around 40 years of age, HD patients suffer from movement disorder, progressive functional and cognitive decline, psychiatric disturbances and behavioral symptoms. (dutchnews.nl)
  • Various measures, including estrogen (typically taken until about age 51, when menopause occurs on average), can relieve or reduce symptoms. (msdmanuals.com)
  • or develop the same symptoms that are associated with normal menopause (which occurs at about age 51), such as hot flashes, night sweats, or mood swings. (msdmanuals.com)
  • This syndrome represents an important model for aging, possibly allowing improved understanding of mechanisms and therapeutics of human aging. (medscape.com)
  • The hallmark of this syndrome is a striking disproportion between the patient's real age and the patient's appearance. (medscape.com)
  • Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila. (tufts.edu)
  • Mutations in BLM cause Bloom syndrome, a rare disorder associated with cancer predisposition and premature aging. (tufts.edu)
  • Wilson's disease is a genetic disorder whereby sufferers have too much copper in their systems. (bewellbuzz.com)
  • however, sun exposure has a synergistic effect on skin aging. (medscape.com)
  • Prolonged loss of muscle can lead to metabolic disorders, physical disability, loss of independence and premature death. (illinois.edu)
  • Researchers looked at 30 studies of the association between PTSD and one or more potentially fatal medical conditions known to increase in incidence with normal aging and to worsen with stress. (medscape.com)
  • We aimed to investigate the incidence and the severity of retinopathy of extremely premature infants and to evaluate the risk factors and outcome of the cases. (hindawi.com)
  • Budding of the breasts, or thelarche, usually occurs at approximately age 10-11 years in females. (medscape.com)
  • Age at menarche, the onset of first menstruation in females, indicates the start of reproductive maturity and is a commonly reported marker of pubertal timing. (nature.com)
  • The top five leading causes of YLDs in Angola are major depressive disorder, low back pain, iron-deficiency anemia, malaria, and chronic obstructive pulmonary disease. (who.int)
  • Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. (frontiersin.org)
  • Scientists attribute the link between chronic insomnia and skin disorders to the immunomodulatory or immune-altering effects induced by the release of excess glucocorticoids triggered by sleep debt and stress. (lifeextension.com)
  • Those younger than age 30 may have a chromosome analysis to check for problems. (medlineplus.gov)
  • In particular, like most GWAS for other complex traits, previous GWAS for age at menarche provided poor coverage for low-frequency variants and omitted sex chromosome data. (nature.com)
  • If the cause is a disorder that confers a Y chromosome, the risk of cancer of the ovaries is increased. (msdmanuals.com)
  • 7 An estimated 2.1 million children and adults younger than age 40 have an uncorrectable vision impairment or blindness. (cdc.gov)
  • Many health conditions occur in men at a younger age. (opensquares.org)
  • There are some sexual disorders that men experience at a younger age as well as at older age. (opensquares.org)
  • It is characterized by abnormal neovascularization of the retina of premature infants [ 3 ]. (hindawi.com)
  • This retrospective study was conducted in the Obstetrics and Gynecology and Neonatology Departments of Venizeleio General Hospital of Heraklion of Crete and involved 200 premature infants, between 2008 and 2017. (hindawi.com)
  • In our inclusion criteria, we selected 7 singleton premature infants and one twin case. (hindawi.com)
  • Bronchopulmonary dysplasia (BPD) is a breathing disorder in premature infants where the infants' lungs become irritated and do not develop normally. (cincinnatichildrens.org)
  • Although there is no nutritional indication to add complementary foods to the diet of a healthy term infant before 4 to 6 months of age, the American Academy of Pediatrics suggests that home-prepared infant foods from vegetables (i.e. spinach, beets, green beans, squash, carrots) should be avoided until infants are 3 months or older [Greer and Shannon 2005]. (cdc.gov)
  • The theory behind the treatment for the seasonal disorder is that humans also need a certain amount of UV light and that may not be available in sufficient quantities during the winter months when people tend to spend less time outdoors and the days are shorter. (wisegeek.com)
  • PTSD is unique in that, unlike schizophrenia, depression, and bipolar disorder, it is relatively simple to pinpoint when the condition started, said study coauthor Barton Palmer, PhD, a research psychologist in the San Diego Veterans Administration and professor of psychiatry at the UCSD. (medscape.com)
  • Although mitochondrial dysfunction is known to play an essential role in the pathophysiology of bipolar disorder (BD), there is a glaring gap in our understanding of how mitochondrial dysfunction can modulate clinical phenotypes. (bvsalud.org)
  • International HIV dementia scale (IHDS) was used to screen for the disorder. (who.int)
  • HIV-associated neurocognitive disorder is an umbrella diagnosis, and treatment of HAND is vital term, which includes asymptomatic neurocognitive im- especially in low and middle income (LMIC) pairment (ANI), mild neurocognitive disorder (MND), countries such as Ethiopia, where HAND related and HIV-associated dementia (HAD) in individuals health bur- den is highest (3). (who.int)
  • TPM tend to occur in slower growing cell types and are associated with older age at least in glioblastoma, thyroid cancer, and melanoma (4) suggesting that molecular features in certain cell types and older patients may drive the acquisition of these mutations. (uab.edu)
  • This could result in sunburn, premature aging of the skin and even skin cancer . (wisegeek.com)
  • My research interest is to understand the biology of aging and cancer. (iu.edu)
  • Adults over the age of 60 may experience an increased risk for epileptic seizures, as well as related complications. (healthline.com)
  • More than 7 million adults are affected by diabetic retinopathy, which is the leading cause of new cases of blindness in working age adults. (cdc.gov)
  • It may also occur with certain autoimmune disorders that disrupt the normal function of the ovaries. (medlineplus.gov)
  • When a young woman reaches puberty around age 10 to 13, a promary oocyte is discharged from one of the ovaries every 28 days. (wikibooks.org)
  • Mental & behavioral disorders cause. (who.int)
  • Reduced vision affects a person's ability to perform daily activities and increases a person's risk of other health problems and premature death. (cdc.gov)
  • 2 RA leads to severe pain, major disability and premature death. (bmj.com)
  • [ 3 ] However, many organs in patients with WS prematurely undergo changes that are usually associated with aging. (medscape.com)
  • Premature menopause does not imply that a woman is aging prematurely. (msdmanuals.com)
  • This continues until the woman reaches menopause, usually around the age of 50 years. (wikibooks.org)
  • one patient was described who survived until dying of acute heart failure at age 68 years. (medscape.com)
  • Early puberty was reported in 86% of cases with the mean age of menarche at 10 years and 2 months of age. (bmj.com)
  • The mean age of parents and children was 39.5 ± 5.5 and 10.20 ± 1.90 (years), respectively. (magiran.com)
  • In 2011, over 70 percent of mothers with children under 18 years of age were in the labor force. (cdc.gov)
  • The mean age was 42.5 years (1SD=12.2). (who.int)
  • The prevalence of HAND was 75.3% and the difference was significantly more in those above 40 years of age (65.8% vs. 80.7%, p=0.003). (who.int)
  • Conclusion: The occurrence of neurocognitive impairment was more pronounced in individuals aged 40 years and above who were HIV positive, compared to those below 40 years. (who.int)
  • The average age of patients at the time of diagnosis is 37 years. (medscape.com)
  • 15 rates were faster in those age groups between 1990 and 2010. (who.int)
  • Menopause and aging. (medlineplus.gov)
  • Premature menopause is the permanent end of menstrual periods before age 40. (msdmanuals.com)
  • To become pregnant, women with premature menopause may be given fertility treatments (such as using eggs from another woman implanted in their uterus). (msdmanuals.com)
  • Job stress has been linked with heart disease, muscle/bone disorders, depression, and burnout. (cdc.gov)
  • Other blood tests may be done to look for autoimmune disorders or thyroid disease. (medlineplus.gov)
  • Improve timely detection, treatment, and management of vision impairment and eye disorders. (cdc.gov)
  • Twenty-eight out of 32 men (mean age 59.5.7 ± 9.8, range: 41-78y) completed a one-month follow-up after treatment. (researchgate.net)
  • IJD comprise a broad range of related disorders of which rheumatoid arthritis (RA) and spondyloarthropathies are the most common. (bmj.com)
  • WS is the most common of the premature aging disorders. (medscape.com)
  • This breathing disorder is common in babies, born too early, whose lungs have not fully grown. (cincinnatichildrens.org)
  • In general, this is an adult-onset disorder, with the earliest sign the lack of a growth spurt during adolescence. (medscape.com)
  • We identify several new associations between rare protein-coding and X-linked variants with age at menarche in women of European ancestry. (nature.com)
  • 1% yielded no significant associations with age at menarche. (nature.com)
  • The attributable affect was not trivial, since such responsibilities affected more than half of the hourly workforce above the age of 55. (cdc.gov)
  • In the workforce, 75% of women are of reproductive age. (cdc.gov)
  • Background: Given the improvement in life expectancy of people living with HIV (PLWH) in sub-Saharan Afri- ca, the risk of asymptomatic HIV-associated neurocognitive disorder (HAND) has increased. (who.int)
  • In the context of medical and cosmetic skin health, providers can play a key role in counseling patients on tobacco cessation to minimize smoking-related dermatologic surgical complications and severity of skin disorders. (medscape.com)
  • They note that given the limited availability of studies with overlapping methods of outcome measures and the small samples sizes within several of the available studies, "it seems premature to draw firm conclusions. (medscape.com)
  • Developing epilepsy before the age of 12 increases this positive outcome. (healthline.com)
  • 1 RA affects approximately 1% of the general population worldwide and the prevalence increases with age. (bmj.com)
  • As the age of the working population increases, there is a need to understand a broad array of factors that contribute to the ability of older workers to productively remain at work. (cdc.gov)
  • And could pericytes provide similar benefits in aged mice? (illinois.edu)
  • Interestingly, extracellular vesicles derived from pericytes in culture were able to significantly improve myofiber size and collagen degradation in both adult and aged mice after immobilization. (illinois.edu)