• Disintegrins are a family of small proteins (45-84 amino acids in length) from viper venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion. (wikipedia.org)
  • Disintegrin-like proteins are found in various species ranging from slime mold to humans. (wikipedia.org)
  • Some other proteins known to contain a disintegrin domain are: Some snake venom zinc metalloproteinases consist of an N-terminal catalytic domain fused to a disintegrin domain. (wikipedia.org)
  • ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. (frontiersin.org)
  • A Disintegrin and Metalloproteases (ADAM), originally named metalloproteinases disintegrin cystein-rich (MDC), are membrane-anchored cell surface proteins containing both disintegrin and metalloproteinase domains. (frontiersin.org)
  • A family of cellular proteins related to snake venom disintegrins. (jax.org)
  • The A disintegrin and metalloproteinases are a new gene family of proteins having a metalloprotease domain with matrix metalloproteinases and play an important role in the chondrocyte development process. (elsevierpure.com)
  • SVEVs isolated from lyophilized venoms collected from four different species of snakes ( Agkistrodon contortrix contortrix , Crotalus atrox , Crotalus viridis and Crotalus cerberus oreganus ) were analyzed by mass spectrometry-based proteomic, which allowed the identification of proteins belonging to eight main functional protein classes such as SVMPs, serine proteinases, PLA 2 , LAAO, 5′nucleotidase, C-type lectin, CRISP and Disintegrin. (nature.com)
  • Furthermore, D-Pen mainly regulated A disintegrin and metalloprotease 10 (ADAM10) expression via melatonin receptor 1 (MTNR1α) and the downstream PKA/ERK/CREB pathway. (figshare.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) in samples from Serum, plasma, tissue homogenates and other biological fluids. (isogem.org)
  • Description: A sandwich ELISA kit for detection of A Disintegrin And Metalloproteinase With Thrombospondin 5 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (isogem.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) in samples from tissue homogenates, cell lysates or other biological fluids. (isogem.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human A Disintegrin And Metalloproteinase With Thrombospondin 5 (ADAMTS5) in tissue homogenates, cell lysates and other biological fluids. (isogem.org)
  • Description: Quantitativesandwich ELISA kit for measuring Human A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) in samples from serum, plasma, cell culture supernates, tissue homogenates. (master-sistemisanitari-medicinenonconvenzionali.org)
  • Proteases produced by macrophages, such as matrix metalloproteinases and members of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, play potential roles in regulating atherosclerotic plaque stability. (cardiff.ac.uk)
  • Figure 3 A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 activity before and after treatment for acute rejection in a liver transplant recipient. (wjgnet.com)
  • Endogenous inhibitors of angiogenesis include thrombospondin 1 (TSP-1) and a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1), and their aberrant expression may contribute to the diabetes-related dysregulation of retinal vascular homeostasis and vasculopathies ( 7 , 8 ). (spandidos-publications.com)
  • GLPG1972/S201086 is a disintegrin and metalloproteinase with thrombospondin motif-5 (ADAMTS-5) inhibitor in development as an osteoarthritis disease-modifying therapy. (lu.se)
  • To Study the Role of Plasma Von Willebrand Factor Antigen (vWF) to A Disintegrin-like and Metalloproteinase With Thrombospondin Type-1 Motifs 13 (ADAMTS-13) Activity Ratio as a Predictor of Development of Extrahepatic Organ Failure in Acute on Chronic Liver Failure (ACLF) Patients. (who.int)
  • Analysis of published microarray data identified a network of genes up-regulated by HVECs in response to TSST-1 that includes the sheddase, a disintegrin and metalloproteinase 17 (ADAM17). (perfectusbiomed.com)
  • Y IL-1 expected a disintegrin and metalloproteinase 17 (ADAM17)-dependent shedding of your ligand neuregulin-1 (NRG-1). (ezh2inhibitor.com)
  • Small Disintegrins: 49-51 amino acids, 4 disulfide bonds Medium Disintegrins: 70 amino acids, 6 disulfide bonds Large Disintegrins: 84 amino acids, 7 disulfide bonds Dimeric Disintegrins: 67 amino acids, 4 intra-chain disulfide bonds Snake Venom Metalloproteinases: 100 amino acids, 8 disulfide bond Disintegrins evolved via gene duplication of an ancestral protein family, the ADAM family. (wikipedia.org)
  • Therefore, we analyzed the expression of A disintegrin and metalloproteinases and matrix metalloproteinases in several kinds of cartilaginous bone tumors at the messenger RNA level and immunohistochemical protein level and ascertained their relationships to the histologic degree of malignancy. (elsevierpure.com)
  • Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases. (southampton.ac.uk)
  • Here, we identified a disintegrin and a metalloproteinase domain 9 (ADAM9) protein as an important host factor for SARS-CoV-2 entry. (flutrackers.com)
  • Here, we identify a disintegrin and metalloproteinase domain 9 (ADAM9) protein as a co-factor of ACE2 important for SARS-CoV-2 entry, even for the variants of concern, and show that ADAM9 interacts with Spike to aid virus entry. (flutrackers.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat A Disintegrin And Metalloprotease 9 (ADAM9) in Tissue homogenates, cell lysates and other biological fluids. (scalegen.com)
  • Description: Quantitativesandwich ELISA kit for measuring Human A Disintegrin And Metalloprotease 9, ADAM9 in samples from serum, plasma, tissue homogenates, cell culture supernates, asciticfluid. (scalegen.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human A Disintegrin And Metalloprotease 9 (ADAM9) in samples from Tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (agctsequencing.com)
  • Description: This Human A Disintegrin And Metalloprotease 9 (ADAM9) ELISA Kit employs a two-site sandwich ELISA to quantitate ADAM9. (agctsequencing.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human A Disintegrin And Metalloprotease 9 (ADAM9) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (pharmas-eu.org)
  • ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). (thermofisher.com)
  • Matrix metalloproteinase-7 and adam-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy. (ualberta.ca)
  • En contraste con las proteínas ADAM, que residen en las MEMBRANAS CELULARES, las proteasas ADAMTS se segregan y actúan en la MATRIZ EXTRACELULAR. (bvsalud.org)
  • Structurally, ADAM7 consists of an N-terminal domain, followed by a zinc metalloproteinase domain, a disintegrin domain, and a large C-terminal domain that contains a transmembrane region. (wikipedia.org)
  • Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma. (ox.ac.uk)
  • Binding of mAbs to one epitope bin in the C-terminal disintegrin-like domain efficiently reduces the proteolytic activity of ADAMDEC1. (ox.ac.uk)
  • A unique mAb, also recognizing the disintegrin-like domain, stimulates the caseinolytic activity of ADAMDEC1 while having no significant effect on the proteolysis of carboxymethylated transferrin. (ox.ac.uk)
  • Using two different mAbs binding the disintegrin-like domain, we developed a robust, quantitative sandwich ELISA and demonstrate secretion of mature ADAMDEC1 protein by primary human macrophages. (ox.ac.uk)
  • Disintegrins act as receptor antagonists, inhibiting aggregation induced by ADP, thrombin, platelet-activating factor and collagen. (wikipedia.org)
  • Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. (wikipedia.org)
  • Description: A sandwich ELISA kit for detection of A Disintegrin And Metalloprotease 9 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
  • It has been suggested that these proteinases are able to cleave themselves from the disintegrin domains and that the latter may arise from such a post-translational processing. (wikipedia.org)
  • Molecules containing both disintegrin and metalloprotease domains are known as ADAMs. (embl.de)
  • Figure 1 Plasma a disintegrin-like and metalloproteinase with throm-bospondin type-1 motifs 13 activity before and after living-related liver transplantation. (wjgnet.com)
  • We cloned a disintegrin and metalloprotease 12 (ADAM12) as a specific enzyme to shed HB-EGF in the heart and found that dominant-negative expression of ADAM12 abrogated this signaling. (nih.gov)
  • Small, medium, large, and dimeric disintegrin family are found only in the family Viperidae, suggesting duplication and diversification about 12-20 million years ago. (wikipedia.org)
  • Reverse transciptase-polymerase chain reaction and real-time quantitative reverse transciptase-polymerase chain reaction of the expression of the A disintegrin and metalloproteinase family in cartilaginous bone tumors demonstrated that A disintegrin and metalloproteinase 28 messenger RNA levels in grade I chondrosarcoma were significantly higher than those in enchondroma (P = .009). (elsevierpure.com)
  • Disintegrins work by countering the blood clotting steps, inhibiting the clumping of platelets. (wikipedia.org)
  • The role of disintegrin in preventing blood coagulation renders it of medical interest, particularly with regard to its use as an anti-coagulant. (wikipedia.org)
  • The metalloprotease-disintegrin ADAM8 is highly expressed in GBM tumor and immune cells and correlates with poor. (uni-marburg.de)
  • A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. (embl.de)
  • Moreover, positive immunoreactivity of A disintegrin and metalloproteinase 28 was observed in 12 (59%) of 22 patients with grade I chondrosarcoma and in 21 (91%) of 23 patients with grade II chondrosarcoma, respectively. (elsevierpure.com)
  • In contrast, only 2 (9%) of 21 cases of enchondromas demonstrated positive staining for A disintegrin and metalloproteinase 28. (elsevierpure.com)
  • Disintegrins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • The disintegrin and metalloproteinase ADAM17, also known as tumor necrosis factor alpha converting enzyme, is expressed in adipocytes, and elevated levels of expression have been linked to obesity and insulin resistance. (usda.gov)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1) were tested 20 times on one plate, respectively. (biomatik.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
  • This assay has high sensitivity and excellent specificity for detection of A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1). (biomatik.com)
  • No significant cross-reactivity or interference between A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1) and analogues was observed. (biomatik.com)
  • Aggrecanases belong to ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. (mobitec.com)
  • A disintegrin and metalloprotease 12 (ADAM12) has been associated with tumor development and progression. (mdpi.com)
  • These included CpG sites in the disintegrin and metalloprotease 12 ( ADAM12 ) and alpha-actinin 1 ( ACTN1 ) genes and near the adhesion G protein-coupled receptor F1 ( ADGRF1 ) gene and long noncoding ribonucleic acid (RNA) LINC01132 . (news-medical.net)
  • ENSEMBL annotation of mouse reference assembly GRCm39, protein_coding, a disintegrin and metallopeptidase domain 29 [Source:MGI Symbol;Acc:MGI:2676326]. (jax.org)
  • Various studies reported a disintegrin and metalloprotease 33 (ADAM33) as an important susceptibility gene for asthma, which is frequently detected among certain populations. (nih.gov)
  • A disintegrin and metalloprotease 33 ( ADAM33 ) has been identified as a susceptibility gene for asthma and single nucleotide polymorphisms (SNPs) in this gene have been associated with excessive decline of lung function in individuals with asthma. (atsjournals.org)
  • A disintegrin and metalloprotease 33 ( ADAM33 ) has been identified as an asthma susceptibility gene ( 1 ). (atsjournals.org)
  • Description: This Human A Disintegrin And Metalloprotease 9 (ADAM9) ELISA Kit employs a two-site sandwich ELISA to quantitate ADAM9. (agctsequencing.com)
  • Proteolytic processing of PrP C generates N- and C-terminal fragments which play crucial roles both in the pathophysiology of prion diseases and in transducing physiological functions of PrP C . A-disintegrin-and-metalloproteinase 10 (ADAM10) has been proposed by cell culture experiments to be responsible for both shedding of PrP C and its α-cleavage. (biomedcentral.com)
  • A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the Muscle Satellite Cell Pool. (peprotech.com)
  • Disintegrins contain an RGD (Arg-Gly-Asp) or KGD (Lys-Gly-Asp) sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of fibrinogen to the receptor-glycoprotein complex of activated platelets. (wikipedia.org)
  • Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors. (bvsalud.org)
  • The metalloprotease-disintegrin ADAM8 is critically involved in the progression of pancreatic cancer. (uni-marburg.de)
  • Also, a term starts with "a disintegrin and metalloprot" might have spVar in a varienty of form. (nih.gov)
  • It has been suggested that these proteinases are able to cleave themselves from the disintegrin domains and that the latter may arise from such a post-translational processing. (wikipedia.org)
  • The beta subunit contains a disintegrin at the N-terminal extremity. (wikipedia.org)