Diseases of muscle. Medical search. Frequent questions

The main signs and symptoms of MEB includes: Muscle dystrophies: muscle weakness, hypotonia, muscle atrophy Ocular abnormalities: lack of visual response, severe myopia, glaucoma Central nervous system abnormalities: intellectual disability, cortical malformation The most prevalent signs of MEB is infants being born floppy. (wikipedia.org)
In general, they manifest severe muscle weakness and retarded motor development. (wikipedia.org)
The muscle weakness affects facial muscles apart from skeletal muscles. (wikipedia.org)
Peripheral muscle weakness is commonly found in patients with chronic obstructive pulmonary disease (COPD) and may play a role in reducing exercise capacity. (nih.gov)
The purposes of this study were to evaluate, in patients with COPD: (1) the relationship between muscle strength and cross-sectional area (CSA), (2) the distribution of peripheral muscle weakness, and (3) the relationship between muscle strength and the severity of lung disease. (nih.gov)
In summary, the strength/muscle cross-sectional area ratio was not different between the two groups, suggesting that weakness in COPD is due to muscle atrophy. (nih.gov)
In COPD, the distribution of peripheral muscle weakness and the correlation between quadriceps strength and the degree of airflow obstruction suggests that chronic inactivity and muscle deconditioning are important factors in the loss in muscle mass and strength. (nih.gov)
DM1 is the most common muscular dystrophy in adults, and one of several genetic conditions that cause muscle wasting and progressive weakness. (medindia.net)
The disease is characterised by progressive muscle weakness, exercise intolerance and cramps. (nutraingredients.com)
Progressive weakness of the arms and legs, along with kyphoscoliosis, continues through late disease progression. (hindawi.com)
4 Cross-sectional studies have typically demonstrated muscle weakness 5 and reduced endurance, 6 particularly of the lower limbs, in COPD compared with age-matched controls. (bmj.com)
We envision that this concept, transferring a naturally occurring process within muscle to membrane vehicles, could revolutionize delivery of therapeutic material to skeletal muscle to improve genetic conditions such as muscular dystrophy and conditions associated with muscle loss and weakness," Doug Millay, PhD, a scientist at Cincinnati Children's, said in a statement. (scienceboard.net)
It's not easy to distinguish between the dozens of subtypes of limb girdle muscular dystrophy - a rare, genetic muscle disease characterized by weakness in the hips and shoulders that causes difficulty walking and lifting the arms. (sflorg.com)
People with PAD use their ankle flexors more to compensate for hip muscle weakness," Kakihana said. (feelgoodnatural.com)
In patients with muscle weakness, especially children, a program of physical therapy is useful to help prevent the contractures that can complicate the disease when patients do not fully move their joints. (medscape.com)
in others (eg, certain cases of Charcot-Marie-Tooth disease type 1A (CMT1A) and inherited brachial plexus neuropathy [IBPN]/hereditary neuralgic amyotrophy [HNA]), proximal weakness predominates. (medscape.com)

Understanding the structure and dynamics of the muscle sarcomere, the small molecular machines that power heart and skeletal muscles, at unprecedented detail will boost our understanding of fundamental muscle biology and allow analysing processes like ageing and muscle diseases with previously unknown insight. (kcl.ac.uk)
The MSTN gene provides instructions for making a protein called myostatin, which is active in muscles used for movement (skeletal muscles) both before and after birth. (medlineplus.gov)
Skeletal muscles symptoms vary from mild stiffness to obvious pain upon walking or an inability to stand. (breathinglabs.com)
When WMD affects the skeletal muscles, it can be treated with supplemental selenium and vitamin E, and animals should respond within 24 hours. (breathinglabs.com)

Muscle-eye-brain (MEB) disease, also known as muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A3 (MDDGA3), is a kind of rare congenital muscular dystrophy (CMD), largely characterized by hypotonia at birth. (wikipedia.org)

Before discussing the effects of acupuncture on such pain, it is important to clarify the conditions that are collectively called 'rheumatic' as some rheumatic diseases respond well to acupuncture whilst others seem to respond less well. (healthy.net)

citation needed] The other signs include joint and/or spinal rigidity, reduced muscle mass, hyporeflexia, muscular contracture, spasticity, muscle atrophy and spinal deformities. (wikipedia.org)
Detailed information on myotonic muscular dystrophy, a common form of muscular disease that affects adults and children. (medindia.net)
Duchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood. (hindawi.com)
In this paper we constructed a simple mathematical model to investigate the role of the immune response in muscle degeneration and subsequent regeneration in the mdx mouse model of Duchenne muscular dystrophy. (hindawi.com)
Duchenne muscular dystrophy (DMD) is a lethal, X-chromosome muscle wasting disease affecting approximately one in 3,500 boys [ 1 , 2 ]. (hindawi.com)
The X chromosome-linked mutation resulted in mice ( mdx mice) with high serum levels of muscle enzymes and with histological lesions comparable to those seen in human muscular dystrophy. (hindawi.com)
Lee is co-founder of Vita Therapeutics Inc., a Baltimore, Maryland-based cell engineering company, that hopes to bring muscle stem cell treatments to market for muscle wasting disorders, including muscular dystrophy. (hopkinsmedicine.org)
In a second set of experiments, the researchers transplanted the muscle stem cells into mice genetically engineered with a mutation in the dystrophin gene, which results in Duchenne muscular dystrophy, a muscle wasting disorder in mice and humans. (hopkinsmedicine.org)
April 28, 2023 -- Researchers have created a lentiviral gene therapy vector capable of targeting muscle cells to treat the rare disease Duchenne muscular dystrophy (DMD) in mice. (scienceboard.net)
Researchers at Washington University School of Medicine in St. Louis have developed an approach that could help doctors distinguish between the many subtypes of limb girdle muscular dystrophy, a rare, genetic muscle disease. (sflorg.com)
Unfortunately, no comprehensive catalog exists yet of all the variants of all the genes linked to limb girdle muscular dystrophy, and whether each of those variants can cause disease or is harmless. (sflorg.com)
Weihl is chief of the neuromuscular diseases section and treats people with muscular dystrophy at Barnes-Jewish Hospital. (sflorg.com)
In principle, the same approach could be used to resolve variants of unknown significance for many other genes associated with limb girdle muscular dystrophy, vastly simplifying and speeding up the process of diagnosing this complex disease. (sflorg.com)
Our team is working on the molecular and cellular actors involved in human muscle regeneration , in muscle ageing and in muscular dystrophies including oculopharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). (institut-myologie.org)
Some of the diseases of the muscular system are anecdotal and easily solvable (such as contractures), but others occur congenitally and can lead to the death of the patient in a few years. (muysalud.com)
Before entering fully into the most widespread diseases of the muscular system, we find it interesting to contextualize these diseases from an epidemiological point of view. (muysalud.com)
Although it's more of a "bone pain", lumbago falls into the category of the most common muscular diseases due to its origin in this system. (muysalud.com)
According to the National Library of Medicine of the United States , contractures and cramps are included within the group of muscular diseases. (muysalud.com)

This is corroborated by biopsy findings of muscle fibre atrophy and muscle fibre shift from type I to type II fibres. (bmj.com)
Obestatin signalling counteracts glucocorticoid-induced skeletal muscle atrophy via NEDD4/KLF15 axis. (institut-myologie.org)
Rationale: Locomotor muscle atrophy develops in patients with chronic obstructive pulmonary disease (COPD) partly because of increased protein degradation by the ubiquitin-proteasome system. (maastrichtuniversity.nl)
The degree of autophagy correlates with severity of muscle atrophy and lung function impairment. (maastrichtuniversity.nl)

The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
Centers for Disease Control and Prevention. (cdc.gov)
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
And I'm representing the Clinician Outreach and Communication Activity, COCA for the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
Dr. Petersen is a Medical Officer in the Division of Reproductive Health at the Centers for Disease Control and Prevention, CDC. (cdc.gov)

Adding exercise to genetic treatment for myotonic dystrophy type 1 (DM1) was more effective in reversing fatigue than giving the treatment alone, as per the study in a mouse model of the disease. (medindia.net)
It's encouraging that exercise makes a noticeable difference on its own and in combination with a genetic treatment specifically tailored for the disease," says Thurman M. Wheeler, MD, an investigator in the department of Neurology at MGH and at Harvard Medical School. (medindia.net)
The disease is caused by a gain-of-function mutation that leads to the expression of higher levels of a genetic element called an expanded microsatellite CUG repeat. (medindia.net)
Writing in Cell , scientists at Cincinnati Children's Hospital Medical Center recently shared details of their attempt to develop a new way to get genetic material to muscle cells to correct the root cause of DMD. (scienceboard.net)
AAVs can only carry genetic payloads of up to 4.8 kilobytes, compared to 8 kilobytes for lentiviruses, which limits the diseases that they can treat. (scienceboard.net)
But gene therapies are on the horizon, and such therapies are targeted to specific genetic variants, so pinpointing the genetic roots of each patient's disease has taken on a new importance. (sflorg.com)
The RareGuru disease database is regularly updated using data generously provided by GARD , the United States Genetic and Rare Disease Information Center. (rareguru.com)
Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)

The IAL aims to synergise the expertise in muscle and neuromuscular diseases of French teams and the expertise in immunology and inflammation of the Brazilian teams . (institut-myologie.org)

In proof-of-concept experiments, Johns Hopkins Medicine scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people. (hopkinsmedicine.org)
These muscle stem cells could potentially be developed as treatments for many types of muscle disorders," says Lee. (hopkinsmedicine.org)
There are more than 150 disorders that affect muscles, bones, and joints. (muysalud.com)
Infections, metabolic disorders, or autoimmune diseases can trigger them. (muysalud.com)
Skeletal muscle tissue, which makes up 50 percent of the body, is easily accessible and biopsies of muscle are relatively harmless to the donor, so we think it may be an alternative source of neural-like cells that potentially could be used to treat brain or spinal cord injury, neurodegenerative disorders, brain tumors and other diseases, although more studies are needed. (wakehealth.edu)

The skeleton (which includes bones, ligaments, tendons, and cartilage) and muscles that are attached to it make up the musculoskeletal system . (cdc.gov)

Over the past 2 decades, there has been increasing interest in the extrapulmonary manifestations of chronic obstructive pulmonary disease (COPD). (bmj.com)
Staging criteria for COPD (chronic obstructive pulmonary disease) include symptoms and lung function parameters, but the role of reduced inspiratory muscle strength related to disease severity remains unclear. (portlandpress.com)
Therefore the present study tested whether inspiratory muscle strength is reduced in COPD and is related to disease severity according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria and assessed its clinical impact. (portlandpress.com)
Dietary therapy is the mainstay of management of chronic kidney disease (CKD) is cats. (vin.com)
Behçet disease is chronic blood vessel inflammation (vasculitis) that can cause painful mouth and genital sores, skin lesions, and eye problems. (msdmanuals.com)
Mycetoma is a chronic, progressively destructive inflammatory disease of the skin, subcutaneous and connective tissue, muscle and bone. (who.int)

In January of 2013, I was diagnosed with advanced Graves' disease, a complicated autoimmune disorder that affects thyroid hormone (TSH) in the bloodstream. (breakingmuscle.com)
Immunoglobulin G4-related disease (IgG4-RD) is an uncommon immune disorder that usually affects multiple tissues and organs with tumor-like masses and/or painless enlargement. (msdmanuals.com)
Ebola diseases (EBOD) are rare, but severe and often fatal viral diseases that affects humans and other primates. (who.int)
The disease commonly affects young adults, particularly men aged between 20 and 40 years.2 Infection is thought to be acquired by traumatic inoculation of fungi or bacteria into the subcutaneous tissue following minor trauma or a penetrating injury, commonly thorn pricks. (who.int)

Our second presenter is Dr. Katherine Fleming-Dutra is a Medical Epidemiologist with the National Center for Emerging and Zoonotic Infectious Diseases at CDC. (cdc.gov)
Dr. Fleming-Dutra is a Pediatrician and Pediatric Emergency Medicine Physician and has focused on infectious diseases epidemiology in her career at CDC. (cdc.gov)
It can be difficult to clinically distinguish Ebola diseases symptoms from other infectious diseases such as malaria, typhoid fever and meningitis. (who.int)

The green color marks a muscle stem cell protein called PAX7. (hopkinsmedicine.org)
Patients with the rare disease have alterations in a protein that helps keep muscle cells intact. (scienceboard.net)
For one gene commonly involved in the disease, the researchers created the protein that would be made from that gene's instructions. (sflorg.com)
Then, she assessed where each variant protein was located on muscle cells, using a fluorescent antibody. (sflorg.com)
Effects of high housing and low training on the expression of hypoxiainducible factor-1α and vascular endothelial growth factor protein in skeletal muscle of rats. (sciendo.com)
This protein normally limits muscle growth, ensuring that muscles do not grow too large. (medlineplus.gov)
Methods: Muscle biopsies were obtained from two cohorts of control subjects and patients with COPD and the numbers of autophagosomes in the vastus lateralis and tibialis anterior muscles, the levels of LC3B protein lipidation, and the expression of autophagy-related genes were measured in the vastus lateralis muscle. (maastrichtuniversity.nl)
Recently, mutations in the muscle protein myopalladin have been linked to the pathogenesis of cardiomyopathy. (wichita.edu)
Most cases of Charcot-Marie- Tooth (CMT) disease are caused by mutations in the peripheral myelin protein 22 gene (PMP22), including heterozygous duplications (CMT1A), deletions (HNPP), and point mutations (CMT1E). (bvsalud.org)

Similar observations were made whether or not patients had been exposed to systemic corticosteroids in the 6-mo period preceding the study, although there was a tendency for the quadriceps strength/thigh muscle CSA ratio to be lower in patients who had received corticosteroids. (nih.gov)
Debate continues as to the relative importance of systemic and local factors in the aetiology of skeletal muscle dysfunction in COPD. (bmj.com)
Loss of lean body mass and muscle vitality not only impairs mobility, but also contributes to worsening of a large range of systemic disease outcomes. (nih.gov)
The proposed studies seek to fill this knowledge gap by investigating the hypothesis that arsenic impairs muscle progenitor cell function and differentiation to promote declines in muscle quality and composition, as well as disrupt communication of healthy muscle metabolism with systemic organs. (nih.gov)
These are imbalances extrinsic to the muscle, but which damage it due to a systemic imbalance. (muysalud.com)
[ 72 , 73 ] In addition to its positive effects on refractory muscle and skin disease, IVIG has been reported to be beneficial for other systemic manifestations, including severe esophageal dysfunction. (medscape.com)
Dr. Kaplan's research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity. (nih.gov)

Dear Colleagues, Many studies have shown that autoimmune diseases disproportionately affect women - nearly 80 percent of those with an autoimmune disease are women. (nih.gov)

Typically, a predilection exists for distal limbs as the site of disease onset and more severe symptoms and signs. (medscape.com)
When symptoms are present, the most common signs and symptoms of Zika virus disease include fever, rash, joint pain and conjunctivitis. (cdc.gov)
Other symptoms include muscle pain and headache. (cdc.gov)
Ebola diseases symptoms can be sudden. (who.int)
A person infected with an Ebolavirus cannot spread the disease until they develop symptoms. (who.int)

However, whether actual NAD+ deficiency exists in human disease, and whether NAD+ boosters could have curative effects in patients with degenerative diseases, has remained elusive. (nutraingredients.com)
In a pair of new interviews, he said he suffers from inclusion-body myositis (IBM), a degenerative disease that slowly weakens his muscles. (991thewhale.com)
White muscle disease is caused by a deficiency of selenium or vitamin E. It is a degenerative muscle disease found in all large animals, including sheep and goats. (breathinglabs.com)

Researchers at Johns Hopkins Medicine have discovered that blocking an ion channel increases muscle function and survival in mice with severe Duchenne. (scienceboard.net)
The most severe form of the muscle damage is rhabdomyolysis , which may lead to severe kidney damage, kidney failure and death. (aboutlawsuits.com)
Although other kinds of mouth sores are very common (for example, cold sores caused by the herpes simplex virus), the sores caused by Behçet disease tend to last longer and be more severe. (msdmanuals.com)
Bed rest is often valuable for those with severe inflammation of the muscles. (medscape.com)
With this report we hope to raise awareness that a subset of patients with this clinical entity are predisposed to severe cardiac disease. (elsevierpure.com)

"Our results are a proof-of-principle that NAD+ deficiency exists in humans and that NAD+ boosters can delay progression of mitochondrial muscle disease" , Suomalainen-Wartiovaara comments. (nutraingredients.com)
Immunosuppressive therapy, such as treatment with glucocorticoids, improves muscle strength and prolongs ambulation in DMD patients but does not prevent disease progression [ 3 , 12 ]. (hindawi.com)
However, even for CMT1 a heated debate has focused on the relative contribution of axonal versus demyelinative damage to the disease manifestations and progression. (medscape.com)
Given its slow progression, painless nature, ignorance about the disease and its causes, and scarcity of medical and health facilities in the areas where it occurs, many patients present late with advanced disease, when amputation may be the only available treatment. (who.int)

The research team, led by Gabsang Lee, Ph.D. , D.V.M., professor of neurology and member of the Institute for Cell Engineering at Johns Hopkins Medicine, coaxed IPS cells to turn into muscle stem cells using a nutrient-rich broth. (hopkinsmedicine.org)
Further studies are planned, Lee says, to examine the recipe further to determine which ingredients may be key to brewing the muscle stem cells. (hopkinsmedicine.org)
The team reported that when they injected the muscle stem cells into the mouse muscles, the cells moved to an area of the muscles known as the niche, where other natural muscle stem cells are typically found, and stayed there for more than four months. (hopkinsmedicine.org)
The research team then used two different methods to determine if the muscle stem cells would repair damaged tissue. (hopkinsmedicine.org)
In one method, the researchers transplanted the muscle stem cells into mice genetically engineered and bred without an immune system to avoid rejection of the transplanted cells. (hopkinsmedicine.org)
They then exposed the animals to a muscle-degrading toxin and radiation to eliminate muscle stem cells already existing within the mouse. (hopkinsmedicine.org)
At the site of the toxin and radiation damage in the muscle tissue, the researchers found that the transplanted human muscle stem cells developed into myoblasts, a kind of muscle construction cell that repairs damage by fusing together and developing the microfibers that characterize normal muscle. (hopkinsmedicine.org)
They also found that some of the transplanted human muscle stem cells migrate to the niche and behave like muscle stem cells naturally found within the mouse. (hopkinsmedicine.org)
The researchers found that transplanted muscle stem cells traveled to the muscle niche area. (hopkinsmedicine.org)
The targeting was enabled by two proteins, known as fusogens, that coordinate membrane fusion and mediate entry of stem cells into mature muscle cells. (scienceboard.net)
More precisely we are working on RNA metabolism , muscle regeneration , muscle stem cells , and fibrosis , with the final aim of developing innovative therapeutic approaches. (institut-myologie.org)
Scientists at Wake Forest Baptist Medical Center have taken the first steps to create neural-like stem cells from muscle tissue in animals. (wakehealth.edu)
In the current research, the team isolated neural precursor cells from in vitro adult skeletal muscle of various species including non-human primates and aging mice, and showed that these cells not only survived in the brain, but also migrated to the area of the brain where neural stem cells originate. (wakehealth.edu)

7 Skeletal muscle dysfunction seems to be clinically relevant in COPD, as loss of skeletal muscle mass and strength are associated with poor health status, 8 increased healthcare use 9 and even mortality, 2 10 independent of lung function parameters. (bmj.com)
Here are 10 of the most common and clinically interesting muscle diseases. (muysalud.com)

Connect with other caregivers and patients with Hereditary continuous muscle fiber activity and get the support you need. (rareguru.com)

Niacin, a vitamin B3 form improves NAD+ levels and improves muscle strength and performance in patients with the progressive muscle disease, mitochondrial myopathy, according to an international team of scientists. (nutraingredients.com)
The team found that NAD+ levels are lower in both the blood and muscle of mitochondrial myopathy patients. (nutraingredients.com)
All statins carry warnings about the potential risk of serious muscle injury, known as myopathy. (aboutlawsuits.com)
Rippling muscle disease (RMD) has previously been reported as a skeletal myopathy that was attributed to a defect in the sarcomere. (elsevierpure.com)

This study, carried out by researchers at the Massachusetts General Hospital (MGH) and collaborators, has implications for patients who experience fatigue due to genetics-related musculoskeletal diseases as well as other types of illness-induced fatigue. (medindia.net)
This study provides preliminary answers to at least two questions: How effective should scientists expect gene therapy for this disease will be in actual patients? (medindia.net)
While it seems like common sense that exercise would help patients suffering from muscle weaknesses, some clinicians and researchers wondered if it could also have the opposite effect and actually hasten patients' decline. (medindia.net)
Niacin restored NAD+ in the muscle of the patients to the normal level and improved strength of large muscles and mitochondrial oxidative capacity. (nutraingredients.com)
Typically by the age of 12, DMD patients require the use of a wheelchair due to the loss of lower limb muscle strength. (hindawi.com)
The histology and time course of the disease in mdx mouse model are very different from those in DMD patients: relatively normal life span and overall fitness compared to progressive physical impairment leading to death in DMD patients [ 7 ]. (hindawi.com)
BRG1 is activated in certain patients with hypertrophic cardiomyopathy, its level correlating with disease severity and MHC changes. (ca.gov)
Certainly, a surprisingly high proportion of patients with COPD terminate exercise complaining of muscle effort. (bmj.com)
PAD patients should ask for an expert, such as a physical therapist, to evaluate their gait and the strength of their hip flexors and other muscles. (feelgoodnatural.com)
Purpose To review the prevalence of preoperative and postoperative intorsion in patients with strabismus and Graves' eye disease (GED), and to correlate the intorsion with coexisting superior rectus (SR) and superior oblique (SO) muscle enlargement as a possible mechanism causing intorsion in these patients. (bmj.com)
Conclusions Preoperative SR and/or SO muscle enlargement appear to be a primary contributing factor relating to preoperative and postoperative intorsion in patients with GED-associated strabismus. (bmj.com)
Objectives: To investigate whether autophagy is enhanced in locomotor muscles of stable patients with COPD, to quantify autophagy-related gene expression in these muscles, and to identify mechanisms of autophagy induction. (maastrichtuniversity.nl)
Measurements and Main Results: Autophagy is enhanced in the locomotor muscles of patients with COPD as shown by significantly higher numbers of autophagosomes in affected muscles as compared with control subjects. (maastrichtuniversity.nl)
Conclusions: Autophagy is significantly enhanced in locomotor muscles of stable patients with COPD. (maastrichtuniversity.nl)
Inpatient care is needed for patients with fulminant dermatomyositis with muscle and/or internal organ involvement. (medscape.com)
Rehabilitative exercise is also recommended for both adult and pediatric patients in order to maintain muscle strength, even during the course of active muscle disease. (medscape.com)
Recently, an analysis of 195 patients with polymyositis and dermatomyositis looked to determine predictors of response to rituximab, and found that antisynthetase and anti-Mi2 autoantibodies, as well as lower disease damage and juvenile-onset disease, were predictors of clinical improvement with rituximab. (medscape.com)
PMP22-Related neuropathies and other clinical manifestations in Chinese han patients with charcot-marie-tooth disease type 1. (bvsalud.org)
During the 2018-2020 Ebola virus disease (EVD) outbreak caused by Zaire ebolavirus in the Democratic Republic of the Congo, the first-ever multi-drug randomized control trial was conducted to evaluate the effectiveness and safety of drugs used in the treatment of EVD patients under an ethical framework developed in consultation with experts in the field and the DRC. (who.int)

PROJECT DESCRIPTION / ABSTRACT Declines in muscle quality and impaired metabolism are major contributing factors to cardiovascular disease morbidity and mortality. (nih.gov)

Inspiratory muscle strength, as reliably assessed by TwPmo, decreased with increasing severity of COPD and should be considered as an important factor in rating disease severity and to reflect burden in COPD. (portlandpress.com)

Immune/inflammatory-mediated mechanisms, which result in muscle cell death and/or mechanisms leading to fibrosis, may be important initiators of lesions in dystrophin-deficient muscle. (hindawi.com)
The level of delivery to the diaphragm was high enough to drive reduced central nucleation, a marker for muscle degeneration, and fibrosis in dystrophic mice. (scienceboard.net)

This longitudinal study was designed to document the extent of change in body composition (including muscle mass, fat mass and bone mineral composition) in older men and women, identify possible clinical conditions that accelerate these changes and examine the health impact of these changes on strength, endurance, disability and weight-related diseases of old age. (bmj.com)

The disease can affect both the skeletal and cardiac muscles. (breathinglabs.com)
Cardiac muscle damage is often permanent. (breathinglabs.com)

Nursing Central , nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/730620/all/rippling_muscle_disease. (unboundmedicine.com)

MEB is an autosomal recessive disease inherited from parents. (wikipedia.org)
Myostatin-related muscle hypertrophy has a pattern of inheritance known as incomplete autosomal dominance. (medlineplus.gov)

Although not diagnostic of muscle disease, a CK and γ glutamyl transpeptidase measurement can help guide the clinical plan and follow-up for seeking and obtaining a definitive diagnosis. (jabfm.org)
A CK measurement might help avoid these unnecessary tests and guide the clinical workup toward muscle disease. (jabfm.org)
Clinical characteristics documented included age, gender, horizontal and vertical deviation, subjective torsional deviation, specific extraocular muscles (EOMs) operated upon, EOM enlargement on CT/MRI scans and width and thickness of SO, SR group and inferior rectus (IR). (bmj.com)
Pre-clinical and clinical studies have demonstrated that dedifferentiated smooth muscle cells (SMCs) are the main contributor to NF. (gla.ac.uk)

Muscle mass and strength in obstructive lung disease: a smoking gun? (bmj.com)
12 The investigators retrospectively used baseline lung function criteria to divide the Health ABC cohort into those with obstructive lung disease (OLD) and controls. (bmj.com)

Aging effect on skeletal muscle lipid metabolism-related regulation factor. (sciendo.com)

We predict that it is from disuse and blood flow restriction to the muscles," Kakihana said. (feelgoodnatural.com)
Effects of blood flow restriction training on skeletal muscle morphology and strength in elderly. (sciendo.com)

Large populations of lymphocytes, macrophages, and neutrophils are present in DMD muscle tissue [ 10 ]. (hindawi.com)
Variants that reduce the production of functional myostatin lead to an overgrowth of muscle tissue. (medlineplus.gov)
When people want to burn their body fat to cut the calories, actually they put the lean muscle tissue in to a danger situation since it is very easy to lose unless protectant steroid is applied. (pharmaceuticalsteroids.com)

The muscles, bones and joints are usually called collectively the musculo-skeletal system. (healthy.net)
In the world, about 1.710 million people have at least one disorder of the muscles , bones, joints, or all of these elements at the same time. (muysalud.com)
The NIAMS Update is a digest on the latest scientific news and resources on diseases of the bones, joints, muscles, and skin. (nih.gov)

In COPD, quadriceps strength and muscle CSA correlated positively with the FEV1 expressed in percentage of predicted value (r = 0.55 and r = 0. (nih.gov)
In older people, as in COPD, sarcopaenia (loss of muscle mass and strength associated with ageing) is independently associated with disability and mortality. (bmj.com)

The deer (or bear) tick, Ixodes dammini, which normally feeds on the white-footed mouse, the white-tailed deer, other mammals, and birds, is responsible for transmitting Lyme disease bacteria to humans in the northeastern and north-central United States. (cdc.gov)
Research in the eastern United States has indicated that, for the most part, ticks transmit Lyme disease to humans during the nymph stage, probably because nymphs are more likely to feed on a person and are rarely noticed because of their small size (less than 2 mm). (cdc.gov)
Tick larvae are smaller than the nymphs, but they rarely carry the infection at the time of feeding and are probably not important in the transmission of Lyme disease to humans. (cdc.gov)

The structure of entire sarcomeres is unknown, yet a precise molecular understanding of how the entire sarcomere machine forms and functions are required to fully understand its role in health, disease and ageing. (kcl.ac.uk)
The group will solve the structure of the sarcomere at near-atomic resolution, unravel the fundamentals of its force-driven assembly and turnover in health and ageing, and develop the foundations for future basic and translational research including the design and development of new agents to mitigate muscle disease and ageing. (kcl.ac.uk)

http://www.EFTUniverse.com In this EFT Tapping demonstration session, Dawson Church, Phd begins tapping with an EFT Workshop participant with neck injuries which quickly turn to tapping about her feelings around her Inclusion body myositis (IBM) inflammatory muscle disease diagnosis. (eftuniverse.com)
As millions of Americans are prescribed popular statin drugs, which include brand name medications like Lipitor and Zocor, a new study suggests that more of those individuals will suffer inflammatory muscle conditions that may be caused by side effects of the cholesterol drugs. (aboutlawsuits.com)

In dystrophin-deficient skeletal muscle, for example, mechanical injury and proteolysis may be important factors but do not fully explain DMD pathogenesis. (hindawi.com)
Barresi, R. & Campbell, K.P. Dystroglycan: from biosynthesis to pathogenesis of human disease. (nature.com)

After administering the lentivirus to mice, the researchers detected micro-dystrophin in 5% to 25% of the muscle cells in limb muscles and 77% to 90% of muscle cells in the diaphragm. (scienceboard.net)

However, a number of studies have linked the drugs to an increased risk of potentially serious injuries, including muscle damage, kidney problems and diabetes. (aboutlawsuits.com)
Others develop muscle problems from injuries or infections. (phoenixchildrens.org)
These muscle injuries occur when the muscle is stretched or damaged beyond normal for a limited time. (muysalud.com)

THURSDAY, May 7, 2015 (HealthDay News) - Exercises to strengthen the hips may ease calf pain for people with peripheral artery disease (PAD), a new study suggests. (feelgoodnatural.com)
Using a 3-D motion analysis system, the researchers compared the walking patterns of seven healthy people to those of 16 older people with moderate peripheral artery disease. (feelgoodnatural.com)
The study revealed those with peripheral artery disease had abnormal walking patterns. (feelgoodnatural.com)

Effects of roxburgh rose powder on oxidative stress in skeletal muscle of overtrained rats. (sciendo.com)

The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
Early diagnosis of muscle disease can help prevent both acute and long-term sequelae of many muscle diseases. (jabfm.org)

Our model suggests that the immune response contributes substantially to the muscle degeneration and regeneration processes. (hindawi.com)
As the name suggests, these conditions derive from the passing of time and the use of the muscles throughout life. (muysalud.com)

became the Director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) in February, 2021. (nih.gov)

Dystrophin deficiency does not always produce muscle degeneration at all life stages, in all muscle phenotypes, or in all animal models [ 8 ]. (hindawi.com)

Studies have suggested that otherwise healthy individuals who begin taking statins to reduce their risk of heart disease, may actually face an increased risk of diabetes, which itself increases the risk of cardiovascular disease. (aboutlawsuits.com)

White Muscle Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "White Muscle Disease" by people in this website by year, and whether "White Muscle Disease" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "White Muscle Disease" by people in Profiles. (uchicago.edu)
If you are raising sheep and goats in Michigan, or other selenium-deficient areas, you need to take measures to prevent white muscle disease. (breathinglabs.com)
White muscle disease can be prevented by supplementing selenium and vitamin E in areas where soils are deficient. (breathinglabs.com)

Observations of activated immune cell infiltrates in dystrophic muscle suggest that the immune/inflammatory response may play a role in exacerbating the disease [ 8 - 12 ]. (hindawi.com)

The research team plans to study the use of the cells in mouse models of other muscle-related conditions for their potential use in sports medicine, trauma, and age-related muscle loss. (hopkinsmedicine.org)

Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. (nature.com)

We review the potential primary role of skeletal muscle insulin resistance in the pathophysiology of the metabolic syndrome, showing that in lean, young, insulin-resistant individuals, impaired muscle glucose transport and glycogen synthesis redirect energy derived from carbohydrate into hepatic de novo lipogenesis, promoting the development of atherogenic dyslipidemia and NAFLD. (nih.gov)

Anatomy74

Organisms17

Diseases22

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology2

Phenomena and Processes65

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena7

Technology, Industry, Agriculture1

Information Science3

Health Care2

Weakness16

Skeletal muscles4

Congenital1

Rheumatic diseases1

Muscular18

Atrophy4

Centers for Diseas5

Genetic8

Neuromuscular diseases1

Disorders5

Ligaments1

Chronic6

Affects4

Infectious3

Protein9

Systemic7

Autoimmune diseases1

Symptoms5

Degenerative3

Severe5

Progression4

Stem cells13

Clinically2

Hereditary1

Myopathy4

Patients19

Morbidity and morta1

Severity1

Fibrosis2

Bone1

Cardiac2

Rippling1

Autosomal2

Clinical4

Obstructive2

Metabolism1

Blood flow restriction2

Tissue3

Bones3

COPD2

Humans3

Sarcomere2

Inflammatory muscle2

Pathogenesis2

Limb1

Injuries3

Peripheral3

Oxidative1

Diagnosis2

Suggests2

20211

Phenotypes1

Cardiovascular disease1

White Muscle5

Dystrophic1

Conditions1

Regeneration1

Lean1