Loading...
  • Phase
  • The University Children's Hospital Zurich is one of three European centers able to use this new gene therapy in an international clinical phase I/II study to treat patients with Chronic Granulomatous Disease (EU-FP7 program NET4CGD). (innovations-report.de)
  • Leukemia
  • In the past, myelodysplastic syndromes were classified as a disease of low malignant potential and referred to as a pre-leukemia. (cancer.ca)
  • chronic
  • Using a new cellular model, innovative gene therapy approaches for the hereditary immunodeficiency Chronic Granulomatous Disease can be tested faster and cost-effectively in the lab for their efficacy. (innovations-report.de)
  • Due to a gene defect, phagocytes of patients with Chronic Granulomatous Disease are unable to kill ingested bacteria and fungi. (innovations-report.de)
  • Already about ten years ago, the team of Janine Reichenbach initiated the worldwide first clinically successful gene therapy study for the treatment of children with Chronic Granulomatous Disease - headed at that time by UZH's now emeritus Professor Reinhard Seger. (innovations-report.de)
  • CRISPR/Cas9-generated p47phox-deficient cell line for Chronic Granulomatous Disease gene therapy vector development. (innovations-report.de)
  • Although the deleterious role of non-adaptive fibrosis in chronic heart disease is acknowledged, its mechanisms are still unknown. (ahajournals.org)
  • Depression of the bone marrow may be due to toxicity or hypersensitivity, as from certain drugs and other toxic substances or from chronic kidney disease. (ecureme.com)
  • This discovery has significant implications for the processing of BMCs before administration of cell therapy and potentially in the treatment of patients with acute coronary syndromes, chronic ischemic and nonischemic cardiomyopathies, and peripheral vascular disease. (ahajournals.org)