• Dominant mutant alleles of SOS1 have recently been found to cause Noonan syndrome [3] and Hereditary Gingival Fibromatosis type 1 [4] . (bionity.com)
  • BACKGROUND AND OBJECTIVE:Activated potassium channels were found to be strongly correlated with gingival overgrowth (GO) phenotype as we reviewed syndromic hereditary gingival fibromatosis (HGF). (shengsci.com)
  • The aim of the present study was to explore the pathogenic role of aberrantly activated potassium channel in Hereditary Gingival Fibromatosis (HGF). (shengsci.com)
  • Hereditary gingival fibromatosis (HGF) is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity. (nature.com)
  • Hereditary gingival fibromatosis (HGF) is an inherited disease characterized by fibrous overgrowth with pathological, nonhemorrhagic, diffuse or focal, slowly progressive hyperplasia of the gingival tissue, resulting in fibromatous hyperplasia of the gingival tissue. (nature.com)
  • gingival alterations related to blood dyscrasias, with leukemia being the central blood disorder with gingival repercussion and, finally, gingival alterations of genetic origin or hereditary gingival fibromatosis. (cidentist.com)
  • Gum disease is most often linked to poor dental hygiene but can also involve hereditary factors. (britedental.com.au)
  • Known as gingival fibromatosis, this hereditary condition involves an overproduction of collagen that causes an overgrowth of gum tissue. (britedental.com.au)
  • In addition, the tendency of gum tissue to overgrow can be inherited (i.e., hereditary gingival fibromatosis - HGF) or there could be a systemic cause for the condition. (lamasdental.com)
  • Hereditary Gingival Fibromatosis (HGF) occurs when your gums overgrow your teeth. (familytreedentist.com)
  • Gingival Hyperplasia. (bvsalud.org)
  • Furthermore, a knock-in mouse model confirmed that heterozygous or homozygous mutations within Zfp513 (p.R250W) or Kif3c (p.R412H) alone do not led to clear phenotypes with gingival fibromatosis, whereas the double mutations led to gingival hyperplasia phenotypes. (nature.com)
  • Most HGF cases are nonsyndromic, with gingival hyperplasia as the single symptom. (nature.com)
  • Among them, we can mention Lichenoid Reactions and Gingival Hyperplasia. (cidentist.com)
  • Gingival hyperplasia induced by any of the drugs mentioned above is similar and occurs in 50% of patients treated with phenytoin, 30% with cyclosporine, and 20% with nifedipine, appearing more frequently in children and young people from the third month of treatment when a sufficient concentration of the drug has been reached in the gingival tissues. (cidentist.com)
  • One issue that can be addressed using these advanced procedures includes gingival hyperplasia (i.e., overgrown gum tissue). (lamasdental.com)
  • Certain diseases, hormonal imbalances and even pregnancy can trigger gingival hyperplasia. (lamasdental.com)
  • After treating the physiological cause of the overgrown gum tissue, gingival hyperplasia usually improves. (lamasdental.com)
  • Jones syndrome is an extremely rare disorder characterized by gingival fibromatosis and sensorineural hearing loss. (wikipedia.org)
  • SMA-PME is characterized by early-childhood-onset progressive lower motor neuron disease manifest typically between ages three and seven years as proximal lower-extremity weakness, followed by progressive myoclonic and atonic seizures, tremulousness/tremor, and sensorineural hearing loss. (nih.gov)
  • Desquamative Gingivitis is one of the main gingival abnormalities not related to plaque. (cidentist.com)
  • At the gingival level, there are receptors for estrogens and progesterone, which allows these hormones to exert different effects on the gingival tissue among which are vascular, cellular, microbiological, and immunological alterations that lead to an increase in the degree of gingivitis. (cidentist.com)
  • Necrotizing ulcerative gingivitis (GUN), which is more prevalent among homosexual men, is characterized by reddened gingiva with diffuse inflammation, and there is also the involvement of the interdental papilla (necrosis) and the gingival margin, even leaving areas of bone exposed due to the loss of tissues soft. (cidentist.com)
  • If treatment for overgrown gingival tissue is not sought, the likelihood of developing gum disease (i.e., gingivitis) increases. (lamasdental.com)
  • Necrotizing gingivitis is part of a spectrum of disease termed necrotizing periodontal diseases . (mdwiki.org)
  • Nevertheless, the functional roles of potassium channels in gingival fibrosis or gingival overgrowth remained uncovered. (shengsci.com)
  • For the most part, a gummy smile is caused by an overgrowth of the gingival tissue around the necks of the teeth, a short lip and small teeth. (lamasdental.com)
  • Gingival overgrowth. (lamasdental.com)
  • And it shows in everything: in the way this 23-year-old man -one of the 60 people in the world diagnosed with juvenile hyaline fibromatosis- speaks, writes, sings, acts and lives, expressing his thoughts and emotions in rhythm machine gun. (digismak.com)
  • The differential diagnosis of Winchester syndrome includes the following diseases. (medscape.com)
  • Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome. (medscape.com)
  • The Winchester syndrome: a nonlysosomal connective tissue disease. (medscape.com)
  • AIDS-like syndrome: AIDS-like disease (illness) (syndrome) ARC AIDS-related complex Pre-AIDS AIDS-related conditions Prodromal-AIDS 3. (cdc.gov)
  • Depending on the severity of each case, GF may result in significant functional and aesthetic disorders, mainly related to the difficulty of cleaning, speech and swallowing due to formation of large gingival tissue masses. (bvsalud.org)
  • Tangier disease is characterized by severe deficiency or absence of high-density lipoprotein (HDL) in the circulation resulting in tissue accumulation of cholesteryl esters throughout the body, particularly in the reticuloendothelial system. (nih.gov)
  • Typically, when we think of a movie-star's smile we visualize a set of straight, bright-white teeth with a minimal amount of gingival tissue (i.e., gum tissue) showing and contours that appear balanced with his or her upper lip. (lamasdental.com)
  • What Causes the Gingival Tissue to Overgrow? (lamasdental.com)
  • A gummy-looking smile can be the direct result of swollen gingival tissue. (lamasdental.com)
  • This plaque and tartar irritate the gingival tissue, leading to inflamed, red, tender gums that easily bleed. (lamasdental.com)
  • This is a rare genetic condition that causes a slow, progressive enlargement of the gingival tissue. (lamasdental.com)
  • The bacteria, plaque and tartar may build up beneath the overgrown gingival tissue, as the body's immune system attacks the bacteria, it also attacks this excess tissue. (lamasdental.com)
  • Soft tissue sarcoma (STS) is a disease in which cancer cells form in the soft tissues of the body, including the muscles, tendons, fat, blood vessels, lymph vessels, nerves and tissues around joints. (blogspot.com)
  • The broad abundance of gingival tissue is normally treated with a gingivectomy, as it creates great stylish outcomes. (imedpub.com)
  • ZNF513 combined with KIF3C regulates gingival fibroblast proliferation, migration, and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathways. (nature.com)
  • If the gum disease is allowed to progress, periodontitis may set in. (lamasdental.com)
  • Aggressive periodontitis, Fibrocellular proliferation, Gingival fibromatosis, Puberty onset, Vertical bone loss around first molars INTRODUTION Journal of Clinical and Diagnostic Research. (dokumen.tips)
  • 2011 Feb, Vol-5(1):152-154 Aggressive periodontitis is a group of infrequent types of peri- odontal diseases with rapid attachment loss and bone destruc- tion, which are initiated at a young age. (dokumen.tips)
  • Aggressive periodontitis is a group of infrequent types of periodon- tal diseases with rapid attachment loss and bone destruction, which are initiated at a young age. (dokumen.tips)
  • Періодонтит Periodontitis is a chronic inflammatory oral disease that progressively destroys the tooth-supporting apparatus. (msdmanuals.com)
  • In a review correlation between various treatment way to deal with periodontitis the board in light of the underlying and last gingival wellbeing, customary gingivectomy was demonstrated to find actual success in lessening pocket profundities and irritation contrasted with non-careful medicines in pockets estimated 3mm or more. (imedpub.com)
  • however, only two disease-causing genes, SOS1 and REST , inducing HGF have been identified at two loci, GINGF1 and GINGF5, respectively. (nature.com)
  • In its early stages gum disease presents as swollen or reddened gums, and at this point it is reversible. (britedental.com.au)
  • If not treated, gum disease can progress to a more serious condition that affects the gums and bones supporting the teeth and may lead to tooth loss. (britedental.com.au)
  • The Gingival Fibromatosis (GF) is described as a rare oral condition, clinically manifested by a slow, progressive, diffuse, and benign growth of gingival tissues. (bvsalud.org)
  • METHODS:Gingival tissues were collected from 9 HGF patients and 15 normal controls. (shengsci.com)
  • RESULTS:KCNQ1 was upregulated in gingival tissues derived from HGF patients and HGF gingival fibroblasts presented increased outward K+ currents than NHGFs. (shengsci.com)
  • Previously, we reported that anti-rheumatic drugs, both COX inhibitors and disease-modifying anti-rheumatic drugs inhibit proliferation of synoviocytes in vitro . (aaem.pl)
  • Based on these findings, it can be suggested that anti-epileptic drugs may have a disease-modifying effect on rheumatoid synovial proliferation. (aaem.pl)
  • Gingival fibroblasts were isolated, and outward K+ currents were detected by whole-cell patch-clamp analysis, transmembrane potential was determined by flow cytometry. (shengsci.com)
  • Normal human gingival fibroblasts (NHGFs) were transfected with KCNQ1 adenovirus or treated with KCNQ1 selective agonist ML277 and antagonist chromanol 293B. (shengsci.com)
  • ZNF513 , a transcription factor, binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival fibroblasts. (nature.com)
  • This condition can manifest itself in isolation, in combination with other systemic diseases or as a component of syndromes. (bvsalud.org)
  • Though a variety of factors such as microbial, environmental, and behavioral factors and systemic diseases are suggested to influence the risk of aggressive peri- odontitis, an individual genetic profile is a crucial factor, influencing the systemic or host response-related risk [2],[3]. (dokumen.tips)
  • Cardiorespiratory complications (restrictive lung disease, thickening and insufficiency of the mitral and aortic valves, left and/or right ventricular hypertrophy) are common causes of death, typically in early to middle adulthood. (nih.gov)
  • have a cobblestone area of granulomatous gingival hypertrophy when intestinal flare-ups occur. (msdmanuals.com)
  • Necropsy showed several flattened and smooth tumorous lesions on the inner aspects of the upper and lower lips, as well as multiple small, partly ulcerated nodules at the gingival margin of the upper and lower jaw ( Figure 1 , panel B). (cdc.gov)
  • An increased susceptibility to develop autoimmune diseases (celiac disease, vasculitis, thyroiditis, SLE, uveitis) and myeloproliferative disorders have also been reported. (biomedcentral.com)
  • Since the disease is prone to recurrence after surgery, HGF patients must undergo repeated surgical procedures of gingival resection, which brings a heavy psychological and economic burden to HGF patients and their families. (nature.com)
  • Having become an associate professor in 1993 and a professor in 1999, Serhat YALÇIN's fields of interest include Dental Implantology, Distraction, Temporomandibular Joint Diseases and Orthognathic Surgery. (dentram.com)
  • This paper proposes a review of the clinical features, diagnosis and treatment of gingival fibromatosis and reports a severe case of this condition that was surgically treated. (bvsalud.org)
  • The first is plaque-associated gum disease. (cidentist.com)
  • however, in the absence of bacterial plaque, these changes cannot give rise to periodontal disease. (cidentist.com)
  • There was no significant pain and the probing revealed little sub- gingival plaque and calculus.Routine hematological investigations revealed normal readings. (dokumen.tips)
  • Irritation due to plaque deepens the normal crevice (sulcus) between the tooth and gingiva, creating gingival pockets. (msdmanuals.com)
  • Henceforth, there have been conversations at times by which all teeth between the main molars are remembered for the strategy, particularly in careful crown protracting, to accomplish a stylishly satisfying gingival design mixing in agreeably the gingival forms of the maxillary foremost and back teeth. (imedpub.com)
  • Also, if this condition develops during pregnancy, once the baby is born, gingival enlargement correction via dental intervention is usually not necessary, as the condition resolves on its own. (lamasdental.com)
  • Dental/gingival morphologic attributes and peri-oral factors impact patient's grin outline. (imedpub.com)
  • The spectrum of ASAH1-related disorders ranges from Farber disease (FD) to spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME). (nih.gov)
  • B) Multinodular fissured masses at the gingival margin. (cdc.gov)
  • Glomerulosclerosis associated with chronic tubular injury usually results in slowly progressive chronic renal failure and end-stage renal disease between the second and fourth decades of life. (nih.gov)
  • The disease has a progressive course with aggravating bony-articular, ocular, and cutaneous changes. (medscape.com)
  • 027.8 Other 027.9 Unspecified OTHER BACTERIAL DISEASES (030-041) Excludes: bacterial venereal diseases (098. (cdc.gov)
  • It is provided as an additional code where it is desired to identify the bacterial agent in diseases classified elsewhere. (cdc.gov)
  • Necrotizing periodontal disease is caused by a mixed bacterial infection that includes anaerobes such as P. intermedia [5] and Fusobacterium as well as spirochetes , such as Treponema . (mdwiki.org)
  • Halaven also received orphan drug designation , which provides incentives such as tax credits, user fee waivers, and eligibility for exclusivity to assist and encourage the development of drugs for rare diseases. (blogspot.com)
  • In contrast to protein interaction networks, enriched gene ontology (GO) terms of AMI related genes were used to construct a gene ontology interaction (GOI) network, which can be used to simulate the functional interactions between differential expressed genes of disease. (frontiersin.org)
  • Proporciona un análisis completo de los genes involucrados en esta enfermedad utilizando secuenciación de próxima generación (NGS) para comprender completamente el espectro de genes relevantes involucrados. (igenomix.com)
  • Evidencia de enfermedad viral en la madre o el feto. (igenomix.com)
  • Rare Disease PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other information that address the public health impact and translation of genomic and other precision health discoveries into improved health outcomes related to rare diseases. (cdc.gov)
  • Congratulations, Max, and thank you SO MUCH for all you're doing for RASopathies and Rare Diseases! (rasopathiesnet.org)
  • Cutis verticis gyrata (CVG) is a rare disease, congenital or acquired, characterized by the redundancy of skin on scalp, forming thick skin folds and grooves of similar aspect to cerebral cortex gyri. (biomedcentral.com)
  • A new classification of periodontal and peri-implant diseases and conditions was proposed in June 2018, in a meeting jointly held by the American Academy of Periodontology and European Federation of Periodontology, with the aim to update the 1999 classification in use for 19 years. (bvsalud.org)
  • According to Kozlowski et al and Lemaitre et al, specific radiologic findings should be the major criteria for classification of this disease. (medscape.com)
  • CLASSIFICATION OF DISEASES AND INJURIES I. INFECTIOUS AND PARASITIC DISEASES (001-139) Includes: diseases generally recognized as communicable or transmissible as well as a few diseases of unknown but possibly infectious origin Excludes: acute respiratory infections (460-466) influenza (487. (cdc.gov)
  • Serious medical complications that are more common than in the general population and that also appear at unusually early ages include chronic obstructive pulmonary disease, diabetes mellitus as a result of insulin resistance, and cancer of a wide variety of types and anatomic sites. (beds.ac.uk)
  • Kaposi sarcoma-like disease has been observed in rhadinovirus-infected nonhuman primates (NHP), but only in the presence of immunodeficiency, induced, for instance, by co-infection with simian immunodeficiency virus ( 13 , 14 ). (cdc.gov)
  • Participants were treated with either Halaven or another chemotherapy drug called dacarbazine until their disease spread or until they were no longer able to tolerate the side effects of treatment. (blogspot.com)