AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Metabolic Syndrome XObesity, AbdominalObesityDietSyndromeWaist CircumferenceWaist-Hip RatioBody Mass IndexRisk FactorsInsulin ResistancePrevalenceCross-Sectional StudiesBlood GlucoseDiabetes Mellitus, Type 2OverweightTriglyceridesAbdominal FatCardiovascular DiseasesAdiposityDyslipidemiasBody WeightObesity, MorbidAdipose TissueAnthropometryIntra-Abdominal FatAsian Continental Ancestry GroupMetabolic DiseasesCholesterol, HDLLipidsInsulinHypertensionDietary FatsDiet, ReducingFatty LiverAdiponectinBlood PressureSex FactorsBody CompositionBody ConstitutionBody Fat DistributionChinaLogistic ModelsNew OrleansDiabetes MellitusRepublic of KoreaCohort StudiesPediatric ObesityTaiwanBiological MarkersWeight LossAbdomenDown SyndromeLife StyleOdds RatioC-Reactive ProteinGlucose IntoleranceProspective StudiesAge FactorsGlucose Tolerance TestJapanHypertriglyceridemiaCholesterolDiet, High-FatLeptinFollow-Up StudiesRisk AssessmentFastingCase-Control StudiesCholesterol, LDLHyperlipidemiasBrazilFood HabitsIncidenceDiet, Fat-RestrictedLinear ModelsHealth SurveysUnited StatesEnergy IntakeArecaBody HeightDiet, MediterraneanTime FactorsComorbidityMultivariate AnalysisNephrotic SyndromeEatingEuropean Continental Ancestry GroupQuestionnairesAdipokinesEnergy MetabolismPolycystic Ovary SyndromeLipid MetabolismDietary CarbohydratesSex DistributionLongitudinal StudiesInflammationIranSjogren's SyndromeHyperglycemiaIndia
InsulinHypertensionDisordersType 2 diabetHepaticAdiposeDyslipidemiaInflammationAbstractAbdominal obesityMetSHyperinsulinemiaOverweightChanges in the gut microbiotaEtiology2021MechanismsMale Wistar ratsNAFLDAlterationsEndocrine2017Cardiovascular and metabolicPhenotypePrevalence of obesitySecretionGlucoseLiverAnti-obesityExcessDietaryDiabetes mellitusNutritionPathwaysRatsInflammatory diseasesSkeletal muscle massTherapeuticCardiacDifferentiallyLipidObese ratFattyPatients with metabolicIncreasesMultifactorialAbnormalitiesComplicationsObstructiveTreat obesitySigns of metabolicChronic diseasesAdiposityMiceProcesses2023Lead to obesityInjury inducedTreatment of obesityAdditionallyRisk of obesityCauses of obesityDevelopment of obesityAccumulation
Insulin26
Hypertension6
Disorders14
  • Obesity can induce type 2 diabetes mellitus, dyslipidemia, cardiovascular disease and other chronic disorders with high social and health costs. (benthamscience.com)
  • As per the Institute for Health Metrics and Evaluation, in the U.S, Ischemic heart disease, neonatal disorders, stroke, lower respiratory infections, diarrhea, road injuries, and chronic obstructive pulmonary disease (COPD) accounted for more than 1 million deaths each worldwide in the year 2017. (straitsresearch.com)
  • My studies show the promising potential of functional foods against life-style associated metabolic disorders. (edu.au)
  • Obesity and associated metabolic disorders (e.g., cardiovascular disease and type 2 diabetes) are major public health concerns. (iasvn.org)
  • A research review found that ginger could benefit obesity and related metabolic disorders. (medicalnewstoday.com)
  • We then reviewed whether the reported changes in gut bacterial members found to be established by complex carbohydrates would benefit or harm the cardiometabolic and immunological health of the host taking into account the alterations in the microbiome composition and abundance known to be associated with obesity and its associated disorders. (frontiersin.org)
  • The current systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders. (frontiersin.org)
  • Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR. (frontiersin.org)
  • Since 2007, Dr. Farese's laboratory has studied the role of lipid metabolism in the central nervous system, particularly in neurodegenerative disorders such as Frontotemporal Dementia (FTD). (harvard.edu)
  • Acquired or inherited defects associated to environmental factors in any part of this system can lead to metabolic disorders such as the syndrome X which is presently a frequent syndrome in industrialized countries. (erudit.org)
  • In addition, if necessary, specific treatment of the metabolic disorders is required. (erudit.org)
  • Risk for obesity and metabolic disorders begins during perspective can inform more effective and sustainable gestation (1). (cdc.gov)
  • Feeding low-protein diets to pregnant rats produces a increased more than in children not exposed to tobacco in broad spectrum of disorders in their offspring (7): hyper- utero. (cdc.gov)
  • Another study found pregnancy has been associated with low birth weight, a that smoking during the 12 months before birth of a child marker of risk for obesity and other metabolic disorders was associated with adolescent overweight (21). (cdc.gov)
Type 2 diabet14
  • Obesity was firstly described in 2000 as a cardiometabolic disease, even before Metabolic Syndrome, type 2 diabetes mellitus and coronary disease were considered as such. (benthamscience.com)
  • metabolic syndrome, type 2 diabetes, cardiovascular lesions and malignancies. (benthamscience.com)
  • This combination increases the risk of development of cardiovascular disease, fatty liver and type 2 diabetes. (edu.au)
  • Studies showed that monosodium glutamate (MSG) induces raised echelons of oxidative stress, and excessive hepatic lipogenesis is concomitant to obesity and type 2 diabetes mellitus (T2DM). (diabeets.com)
  • The study concluded by saying, "High hepatic fat content is associated with metabolic syndrome, Type-2 diabetes mellitus, and coronary heart disease. (ndtv.com)
  • 26 120 180 ] Body mass index (BMI) has been widely used to indicate the level of obesity, though recent studies have found that abdominal or visceral adiposity (vs subcutaneous), as reflected in the waist-to-hip ratio or waist circumference, is a strong criteria for predicting the risk of developing metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). (surgicalneurologyint.com)
  • describe how low skeletal muscle mass and abdominal obesity additively increase the risk of incident type 2 diabetes, independently from glycometabolic parameters. (tomwademd.net)
  • Type 2 diabetes mellitus is one of the most common diseases in occidental society and it is associated with a high cardiovascular risk, not only due to the classical factors but also to a chronic low-grade inflammation [ 1 ]. (biomedcentral.com)
  • Ingestion of polyunsaturated fatty acids (PUFAs) has been proposed to influence several chronic diseases including coronary heart disease (CHD) and type-2 diabetes (T2D). (biomedcentral.com)
  • Type 2 diabetes (T2D) is a major health concern in the United States with an estimated 18.3 million adults having physician-diagnosed diabetes, an additional 7.1 million adults having undiagnosed diabetes and about 81.5 million having prediabetes, also referred to as metabolic syndrome [ 1 ]. (biomedcentral.com)
  • Based on long-term trials of 6-12 months, researchers state that high-protein diets are "thought to also prevent obesity and obesity-related diseases, such as metabolic syndrome, nonalcoholic fatty liver disease, type 2 diabetes, and cardiovascular diseases. (medscape.com)
  • ABSTRACT The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. (who.int)
  • There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. (who.int)
  • 11), altered liver structure and function (12), altered naire data from 8,765 children aged 5 to 7 years, smoking gene expression (13), and possibly type 2 diabetes mel- after pregnancy was not associated with childhood obesity litus (10). (cdc.gov)
Hepatic9
  • 6 Weight loss induced by diet and exercise has also been shown to be effective in resolving NASH and improving hepatic fibrosis. (xiahepublishing.com)
  • Together, these data indicate that glucocorticoids recruit peripheral endocannabinoid signaling to promote metabolic dysregulation, with hepatic endocannabinoid signaling being especially important for changes in lipid metabolism. (iasvn.org)
  • CB 1 R −/− mice are also protected against the CORT-induced increase in ( G ) liver weight, ( H ) plasma cholesterol, ( I ) alanine aminotransferase (ALT), ( J ) triglycerides, and ( K ) hepatic triglycerides. (iasvn.org)
  • The study titled, "The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content" was published in the Journal of Hepatology and it was conducted by a team of researchers from Ben Gurion University of Negev. (ndtv.com)
  • The researchers found that Mediterranean diet significantly reduced hepatic fat- the fat that accumulates around the liver, pancreas and the heart. (ndtv.com)
  • Mediterranean diet was found to be more effective at reducing hepatic fat, as compared to all other diets with similar calorie budgets. (ndtv.com)
  • In the CENTRAL 18-month intervention trial, a Mediterranean/low-carbohydrate diet induced a greater decrease in hepatic fat content than a low-fat diet, conferring beneficial health effects that were beyond the favorable effects of visceral fat loss. (ndtv.com)
  • In the literature, there is a link that NAFLD is the hepatic component of the metabolic syndrome diagnosis ( Takahashi & Fukosato, 2014 ). (nursingcenter.com)
  • Low hepatic ATP, hyperuricemia, and hepatic lipid accumulation reported in metabolic syndrome (MetS) patients may reflect insufficient hepatic O 2 delivery, potentially accounting for the sympathetic overdrive associated with MetS. (surgicalneurologyint.com)
Adipose8
  • Furthermore, the independent association of systemic adipokine levels with knee osteoarthritis severity supports a role for adipose-associated inflammation in the molecular pathogenesis of obesity-induced osteoarthritis. (biomedcentral.com)
  • Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity. (harvard.edu)
  • report on studies with male mice indicating that the metabolic benefits of intermittent fasting result in part from promotion of histone acetylation in lipid oxidation genes of muscle and adipose tissue. (tomwademd.net)
  • Additionally, hyperinsulinemia-induced lipid storage was shown to promote adipose tissue-specific inflammation and a subsequent acute phase response [22, 23]. (encyclopedia.pub)
  • Reduction of PPAR-γ expression and generation of a pro-inflammatory environment by increased lipocalin-2 expression in white adipose tissue may contribute to stress-induced glucose intolerance. (biomedcentral.com)
  • This study aims to unveil biological markers that establish the molecular basis of stress-induced glucose intolerance, with a special emphasis on the visceral white adipose tissue (vWAT). (biomedcentral.com)
  • There are several factors that act and interact in the regulation of food intake and energy deposition, contributing to the development and maintenance of obesity, including: endocrinal, adipose, intestinal and neuronal factors 2 . (bvsalud.org)
  • However, adipose tissue growth also has limits, and the excess of energy induces inflammation, helped by the ineffective intervention of the immune system. (medscape.com)
Dyslipidemia1
Inflammation9
  • The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well understood, but may include systemic inflammation associated with increased adiposity. (biomedcentral.com)
  • Longitudinal changes in musculoskeletal function and inflammation were compared with endpoint neurobehavioral and osteoarthritic disease states. (biomedcentral.com)
  • The cell model exhibited the key NASH disease phenotypes of hepatocyte injury, steatosis, inflammation, and fibrosis. (xiahepublishing.com)
  • Diet is important in the development of metabolic syndrome assisted by increased oxidative stress and inflammation. (edu.au)
  • ABSTRACT There is accumulating evidence suggesting that inflammation is the bridging link between cardiovascular disease and metabolic syndrome. (who.int)
  • 7 Moreover, these rats enjoy better glucose tolerance, reduced oxidative stress and decreased serum levels of proinflammatory cytokines, suggesting that metabolic syndrome and systemic inflammation are ameliorated in such rats. (bmj.com)
  • This suggests that improving glycemic control might reduce the inflammatory response supporting the link between inflammation and glucose metabolic disturbance. (biomedcentral.com)
  • Inflammation is now thought to contribute to the development of a variety of chronic diseases, including T2D. (biomedcentral.com)
  • The so-called "metabolic inflammation" (also known as meta-inflammation) distinguishes T2D from T1D. (encyclopedia.pub)
Abstract1
  • Award from the Society of Comparative Endocrinology - SCE for the abstract "Effect of The Stage Of Chronic Kidney Disease On Serum Total Thyroxine In Cats. (rossu.edu)
Abdominal obesity1
  • Meanwhile, they found that there was no significant difference between the weight loss effects of these diets, but that the Mediterranean diet, when consumed in combination with exercise, lead to the maximum loss in abdominal obesity or excess fat around the stomach area. (ndtv.com)
MetS9
  • AIM OF THE STUDY: This study aims to evaluate the efficacy of garlic on the components of metabolic syndrome (MetS) in metabolic disease patients. (bvsalud.org)
  • Diet-induced obesity in C57BL/6 mice triggers common features of human metabolic syndrome (MetS). (scienceopen.com)
  • Each component of the MetS is an independent risk factor for cardiovascular disease and together enhances and compounds the atherosclerotic risk in the individual. (kauveryhospital.com)
  • It is the pathophysiologic aspects of obesity coupled with MetS that leads to changes in hemodynamics, atherosclerosis and calcification, myocardial metabolism, microvascular dysfunction that culminates in myocardial infarction and heart failure. (kauveryhospital.com)
  • This theoretical concept is supported by experimental results in animals fed a high fructose diet to induce MetS. (surgicalneurologyint.com)
  • This is strongly reinforced by the fact that MetS is cured in a matter of days in a significant percentage of patients by diet, bariatric surgery, or endoluminal sleeve, all of which would decrease splanchnic oxygen demand by limiting nutrient contact with the mucosa and reducing the nutrient load due to loss of appetite or dietary restriction. (surgicalneurologyint.com)
  • 180 ] While obesity is a risk factor for MetS, the fact that not all obese patients develop MetS or T2DM[ 25 106 186 196 203 230 266 ] suggests that adiposity may not be etiologic. (surgicalneurologyint.com)
  • The term MetS, or originally Syndrome X, was proposed to foster a coherent clinical approach to management and therapeutic intervention. (surgicalneurologyint.com)
  • A large number of clinical studies have demonstrated that a significant percentage of patients with MetS have durable remission of comorbidities within days of bariatric surgery, calorie restriction (diet), or implantation of an endoluminal plastic sleeve that prevents nutrient contact with the proximal gastrointestinal mucosa, as discussed below. (surgicalneurologyint.com)
Hyperinsulinemia1
  • The ovarian androgen excess may be because of an interaction between obesity-related, chronic hyperinsulinemia with genetic factors predisposing to the development of ovarian hyperandrogenism. (scienceopen.com)
Overweight15
  • The obesity epidemic has resulted in more overweight/obese women before and during pregnancy. (karger.com)
  • The current obesity epidemic has resulted in an increasing number of overweight and obese women entering pregnancy [ 1 ]. (karger.com)
  • In another 12-week, single-blind, randomized, controlled trial 20 , 60 overweight subjects consumed a diet consisting of 2000 kcal/daily for 12 weeks, and were equally randomized into two groups receiving either green tea capsules three times daily, or placebo. (totalhealthmagazine.com)
  • Avoidance of overweight from adolescence onwards is likely important for cardiovascular disease prevention. (nature.com)
  • A notable feature of the global obesity epidemic is the appearance of overweight and obesity in childhood and early adulthood. (nature.com)
  • Furthermore, the WHO outlined overweight as a "body mass index (BMI) more than or equivalent to 25, and obesity as a BMI above or equally 30" [13] . (diabeets.com)
  • Although undernutrition is often associated with refugee status, concerns are increasing about overweight/obesity among refugees resettling to developed countries. (cdc.gov)
  • 7 - 9 Overweight and obesity are frequently assumed to be associated with assimilation to a U.S. lifestyle (increased availability of high-calorie foods, reduced physical activity), compounded by lack of nutritional education. (cdc.gov)
  • However, one study identified a population of African children who had a high prevalence of overweight/obesity at the time of arrival, 5 and other data have identified overweight/obesity and associated medical consequences in the newly arriving Iraqi population. (cdc.gov)
  • 10 This trend may reflect the overall rising global prevalence of overweight/obesity and/or the changing socioeconomic status of newly arriving refugees. (cdc.gov)
  • Obesity and overweight affect, worldwide, over 1.7 billion people and is associated with premature mortality, chronic diseases and increase in health costs. (bvsalud.org)
  • Although a person is at risk for During gestation, risk factors for obesity include maternal obesity throughout his life, we focus on specific develop- diet, overweight, and smoking. (cdc.gov)
  • This study was conducted to verify the responses of a multi-professional intervention on anthropometric, body composition, and food profile in adolescents with overweight or obesity. (bvsalud.org)
  • Dietary transition refers to consuming foods with high energy density and low nutritional value, which are contributing causes of overweight, obesity, and NCDs 3 . (bvsalud.org)
  • As a result, the evidence presented above shows a relationship between lower levels of PA and elevated consumption of industrialized foods (processed and ultra-processed foods) that are associated to overweight and especially obesity. (bvsalud.org)
Changes in the gut microbiota2
  • Dietary supplementation with complex carbohydrates is known to alter the composition of gut microbiota, and optimal implementation of the use of these so called "prebiotics" could be of great potential in prevention and possibly treatment of obesity and associated cardiometabolic and inflammatory diseases via changes in the gut microbiota. (frontiersin.org)
  • Against this background, several researches have been carried out to identify potential strategies to induce specific changes in the gut microbiota composition towards microbial species with high fermentative activity. (springer.com)
Etiology5
  • The etiology of this disease is complex and multifaceted, and numerous genetic and environment risk factors have been identified that modify disease incidence and severity. (biomedcentral.com)
  • Hence, different factors in the etiology of the disease are shown to contribute differentially to CAN manifestations. (encyclopedia.pub)
  • Interestingly, metabolic inflammatory processes are evident in the cardiovascular, neuronal, and neurovascular systems, indicating their possible involvement in the etiology of cardiac autonomic dysfunction in the metabolic syndrome [33-35]. (encyclopedia.pub)
  • Characterized as a chronic disease with a multifactorial etiology, environmental factors and a genetic predisposition appear to be the main cofactors 1 . (bvsalud.org)
  • This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
20211
  • Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL), and Google scholar were searched till December 25, 2021 for identifying the relevant studies that have shown the effects of garlic on components of metabolic syndrome in metabolic disease patients. (bvsalud.org)
Mechanisms9
  • While awaiting the release of new drugs, topiramate, alone or combined with phentermine, has been proposed as a novel anti-obesity drug, showing relevant effects not only on weight loss but also on cardiometabolic alterations and biomarkers, even though new studies should clarify the mechanisms of these findings. (benthamscience.com)
  • BACKGROUND: The aim of this study was to investigate the common gene signatures and potential molecular mechanisms of bladder urothelial carcinoma (BLCA) and metabolic syndrome (MS). METHODS: Transcriptome data for BLCA and MS were obtained from the Gene Expression Omnibus (GEO) database. (bvsalud.org)
  • The specific mechanisms by which GCs modulate these processes remain largely unknown, but GCs increase production of endocannabinoids-potent central and peripheral regulators of appetite, energy balance, and metabolism. (iasvn.org)
  • This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
  • Further investigation into this exciting field promises to shed insights into the mechanisms of health and disease and provide new therapeutic options. (medscape.com)
  • The molecular mechanisms underlying this obesity-induced cardiac phenotype disorder are not well understood. (kauveryhospital.com)
  • In Endocrine Reviews , Akalestou and others survey mechanisms of weight loss after obesity surgery, which include changed food selection. (tomwademd.net)
  • Li and colleagues identify mechanisms that may account for the weight-loss-inducing effects of berberine. (tomwademd.net)
  • Chronic stress is associated with increased risk of glucose intolerance and cardiovascular diseases, albeit through undefined mechanisms. (biomedcentral.com)
Male Wistar rats2
  • To induce metabolic syndrome, young male Wistar rats were fed with a high-carbohydrate high-fat diet for 16 weeks while corn starch served as control diet. (edu.au)
  • Forty male wistar rats weighing 180-250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). (researchgate.net)
NAFLD5
  • Nonalcoholic fatty liver disease (NAFLD) is an umbrella term that comprises a large spectrum of liver injuries, varying in severity but all leading to fibrosis. (xiahepublishing.com)
  • Nonalcoholic fatty liver disease (NAFLD) is a globally observed metabolic disease with high prevalence both in adults and children. (mdpi.com)
  • Nonalcoholic fatty liver disease (NAFLD) is fast becoming a disease of first-world countries, where high fat food is rarely a scarcity, and lives continue to become more sedentary. (nursingcenter.com)
  • Nonalcoholic steatohepatitis (NASH) is a deadly subset disease of those diagnosed with NAFLD. (nursingcenter.com)
  • Both NAFLD and its progression into NASH are seen almost simultaneously, with at least some of the components of metabolic syndrome. (nursingcenter.com)
Alterations2
  • For diet-driven alterations of gut microbial composition particularly the type and proportion of complex indigestible carbohydrates that reach the colon turn out to be of great importance ( 18 , 19 , 21 - 24 ). (frontiersin.org)
  • Her lab also studies how the normal function of the brain changes in response to alterations in body weight including obesity (excess body weight) and anorexia/cachexia (insufficient body weight), and how these changes in the brain contribute to the development of commonly associated diseases like diabetes. (exeter.ac.uk)
Endocrine5
  • Simple measures of gestational weight gain provide insufficient detail of the underlying physiological and metabolic adaptations occurring in pregnancy, and should be complemented by measures of body composition, metabolic and endocrine responses. (karger.com)
  • The predominance of central, viscerally deposited fat may alter the immunological, metabolic and endocrine milieu. (benthamscience.com)
  • She is also an active researcher and her interests include endocrine physiology and endocrine and metabolic diseases of dogs and cats. (rossu.edu)
  • Today I link to the web page, An Endocrine Society Thematic Issue: Obesity 2023 . (tomwademd.net)
  • However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)
20172
  • Early Career Author Prize 2017 from Experimental Physiology to the first author (Marcus Machado) - Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome. (rossu.edu)
  • Prevalence of obesity and severe obesity among adults: United States, 2017-2018. (msdmanuals.com)
Cardiovascular and metabolic1
  • Further, waste products from coffee production are a potential source for new interventions in diet-induced cardiovascular and metabolic diseases. (edu.au)
Phenotype2
  • Similarly, a neutral, peripherally restricted CB 1 receptor antagonist (AM6545) was able to attenuate the metabolic phenotype caused by chronic corticosterone, suggesting a peripheral mechanism for these effects. (iasvn.org)
  • Subjects with T2D, especially those with LDL phenotype B and obesity, have higher levels of inflammatory biomarkers. (biomedcentral.com)
Prevalence of obesity1
Secretion2
  • It was also discovered that MIN6 pancreatic β-cells and human primary islets containing β-cells secrete asprosin and that secretion is induced by palmitate in a dose-dependent manner. (wikipedia.org)
  • We know that short-chain fatty acids increase secretion of immunoglobulins, induce regulatory T-cell tissue repair, promote antimicrobial peptides and mucus production, and basically optimize intestinal function and the intestinal barrier integrity. (medscape.com)
Glucose8
  • In vitro study showed that exendin-4 (the active ingredient of exenatide) attenuated HUVECs injury induced by high glucose, with improving cell viability and attenuating cell apoptosis. (hindawi.com)
  • Exendin-4 also significantly alleviated the increased malondialdehyde (MDA), nitrotyrosine content, and inducible nitric oxide synthase (iNOS) expression induced by high glucose in HUVECs. (hindawi.com)
  • Nevertheless, a third group reported in 2019 that they had identified the receptor for asprosin, an olfactory receptor family GPCR expressed on liver hepatocytes, and showed that plasma asprosin levels increased with fasting and high fat diet, and that asprosin stimulated glucose release in normal mice (thereby confirming the original study) but that mice lacking this receptor were unable to respond to asprosin by releasing glucose. (wikipedia.org)
  • One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
  • The myocardium is capable of sustained function using fuels not limited to acetate, glucose or long-chain fatty acids - it is indeed a metabolic omnivore. (kauveryhospital.com)
  • This review is focused on the fate of dietary glucose under conditions of chronically high energy (largely fat) intake, evolving into the metabolic syndrome. (medscape.com)
  • Dietary lipids favor their metabolic processing, saving glucose, which additionally spares amino acids. (medscape.com)
  • Obesity results from a combination of factors that occur exhibit low birth weight and glucose intolerance -- a mul- at different stages during a person's lifetime. (cdc.gov)
Liver4
  • To better understand nonalcoholic steatohepatitis (NASH) disease progression and to evaluate drug targets and compound activity, we undertook the development of an in vitro 3D model to mimic liver architecture and the NASH environment. (xiahepublishing.com)
  • Coffee pulp and spent coffee considered as waste products of coffee manufacturing industries attenuated cardiovascular remodelling and non-alcoholic fatty liver disease. (edu.au)
  • A study has showed one of the most ideal diets to reduce fat accumulation in the liver is the Mediterranean diet. (ndtv.com)
  • Fatty liver disease is on the rise and the study has indicated that one of the most ideal diets to reduce fat accumulation in the liver is Mediterranean diet, which is also low in carbs and rich in fresh fruits and vegetables, as well as healthy sources of fats like olive oil, seeds and nuts. (ndtv.com)
Anti-obesity3
  • Atta-ur-Rahman, M. Iqbal Choudhary , " Anti-Obesity Drug Discovery and Development ", Bentham Science Publishers (2014). (benthamscience.com)
  • Research has shown that essential oils may exert anti-obesity effects. (medicalnewstoday.com)
  • A 2019 study found spearmint essential oil to be an anti-obesity agent that might be safer than synthetic drugs. (medicalnewstoday.com)
Excess8
  • There is growing evidence that early development of obesity increases cardiovascular risk later in life, but less is known about whether there are effects of long-term excess body weight on the biological drivers associated with the atherosclerotic pathway, particularly adipokines, inflammatory and endothelial markers. (nature.com)
  • Sinha S, Haque M (September 04, 2022) Obesity, Diabetes Mellitus, and Vascular Impediment as Consequences of Excess Processed Food Consumption. (diabeets.com)
  • Dietary phosphate excess often leads to phosphate toxicity, ultimately potentiating kidney disease development. (diabeets.com)
  • Unhealthy diets leading to an excessive calorie intake coupled with sedentary lifestyles are the most common causes of obesity and excess weight. (kauveryhospital.com)
  • Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
  • Moreover, overnutrition overwhelms inherent mitochondrial capacity for scavenging excess ROS produced by metabolic processes promoting further upregulation of proinflammatory processes through NF-κB pathways [30]. (encyclopedia.pub)
  • In the Southern region the prevalence of excess weight was 56.8% for males and 51.6% in females as well as being the region with the highest percentage of obesity: 15.9% of men and 19.6% of women. (bvsalud.org)
  • We are not prepared for excess dietary energy, our main defenses being decreased food intake and increased energy expenditure, largely enhanced metabolic activity and thermogenesis. (medscape.com)
Dietary5
  • High susceptibility to dietary obesity was associated with increased osteoarthritic changes in the knee and impaired musculoskeletal force generation and motor function compared with controls. (biomedcentral.com)
  • The Dietary Guidelines for Americans recommend a Mediterranean diet for promoting health and minimizing disease. (medscape.com)
  • Short-term dietary supplementation with BO and FO improved biomarkers associated with T2D/metabolic syndrome. (biomedcentral.com)
  • Conversely, dietary changes could be more effective to induce lasting changes in the composition of gut microbiota. (springer.com)
  • Within this context, the prebiotic effect of dietary fibres might be a feasible strategy to prevent T2D, through the modulation of metabolic response. (springer.com)
Diabetes mellitus2
Nutrition5
  • The nutrition during the cure is based on a low-irritant, calorie-reduced, predominantly alkaline diet, avoiding animal protein and fat, and almost salt-free. (rosenalp.de)
  • Usually, the first-line intervention is a combination of nutrition, physical activity, and behavior change support, not just diet. (medscape.com)
  • Esposito L, Fisher JO, childhood nutrition and obesity should be examined from Mennel a JA, Hoelscher DM, Huang TT. (cdc.gov)
  • First, prenatal and early life perspectives on nutrition and obesity from gestation to experiences influence the trajectory of weight into adult- adolescence. (cdc.gov)
  • infancy, childhood, and adolescence that may lead to Therefore, examining childhood nutrition and obesity from -- or prevent -- obesity. (cdc.gov)
Pathways4
  • Recent evidence shows that glucocorticoids possess the ability to increase endocannabinoid signaling, which is known to regulate appetite, energy balance, and metabolic processes through both central and peripheral pathways. (iasvn.org)
  • GO and KEGG analysis showed that genes regulated by E2 and/or HFD are mainly responsible for immune response, inflammatory response and metabolic pathways. (scienceopen.com)
  • and several changes to gut integrity, immunity, and pathways that are derivatives toward diseases and even promoting translocation of gut bacteria. (medscape.com)
  • Among microbial metabolites, short-chain fatty acids (SCFA) are modulators of different metabolic pathways. (springer.com)
Rats4
  • In highii carbohydrate, high-fat fed rats, leuprolide treatment worsened metabolic syndrome symptoms and cardiovascular function, and orchidectomy produced greater responses. (edu.au)
  • A recent study of diet-induced obesity in rats provides some confirmation of this idea. (bmj.com)
  • 5 Rats fed a diet high in fats and sugar were injected intraperitoneally with bilirubin or vehicle for 14 days. (bmj.com)
  • With the aim of gaining insights into the latter, this study examined the metabolic profile of young adult male rats that were exposed to chronic unpredictable stress. (biomedcentral.com)
Inflammatory diseases3
  • Therefore, it has been suggested that the modulation of gut microbiota could be a reliable tool to prevent metabolic and inflammatory diseases. (springer.com)
  • Clinically, I am interested in the consequences of inflammatory diseases on the CNS, vasculitides as well as treatment of connective tissue diseases. (edu.au)
  • My research interests are in several areas including chronic inflammatory diseases such as atherosclerosis and rheumatoid arthritis. (edu.au)
Skeletal muscle mass1
  • It was observed an improvement in skeletal muscle mass, resting metabolic rate, as well as the consumption of fresh foods/g and processed food/kcal after the intervention period. (bvsalud.org)
Therapeutic4
  • The first step in the therapeutic strategy against obesity should be the correct diagnosis of its causes and the promotion of lifestyle changes including physical exercise and a healthy diet. (benthamscience.com)
  • Since the naringin is a flavanone plant with lots of beneficial and therapeutic properties, the growing number of diseases across the globe is expected to boost the growth of this market. (straitsresearch.com)
  • Plant-based diets provide potential therapeutic approaches to metabolic syndrome. (edu.au)
  • Therapeutic intervention favours at present diet and exercise prescriptions. (erudit.org)
Cardiac4
  • Rapid correction of the hypercapnia can alkalinize the cerebrospinal fluid, which may cause seizures, and can induce a metabolic alkalosis, placing the patient at risk for cardiac dysrhythmias. (medscape.com)
  • This is especially true of patients who may be at high risk for additional complications, e.g. those with metabolic syndrome, diabetes, or cardiac, cerebrovascular or other neurological diseases. (ersjournals.com)
  • Obesity-related changes in cardiac structure and function have been referred to as the 'cardiomyopathy of obesity. (kauveryhospital.com)
  • It constitutes the major cause of silent cardiovascular events in patients without overt cardiac disease. (encyclopedia.pub)
Differentially1
  • Editor's choice in Experimental Physiology - Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome. (rossu.edu)
Lipid3
  • The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. (harvard.edu)
  • Bob Farese Jr. is an expert in how lipid synthesis and storage may lead to disease-and an accomplished amateur photographer. (harvard.edu)
  • Schweitzer and colleagues describe weight loss and blood lipid as well as HbA1c improvements resulting from a short-term workplace-based diet and exercise program (Pritkin). (tomwademd.net)
Obese rat1
  • In this project, I used a diet-induced obese rat model for examining the nutraceutical effects of some potential functional foods. (edu.au)
Fatty3
  • A NASH-like environment was induced by addition of medium containing free fatty acids and tumor necrosis factor-α. (xiahepublishing.com)
  • Therefore, we can say that the short-chain fatty acid derivative from the intestinal microbiome does have central nervous system-related effects. (medscape.com)
  • In obesity, the myocardium abnormally utilises fatty acids and shows an impaired ability to shift away from this increased fatty acid utilization. (kauveryhospital.com)
Patients with metabolic1
  • We carried out a cross-sectional study of 195 patients with metabolic syndrome. (who.int)
Increases5
  • These results indicate that diet-induced obesity increases the risk of symptomatic features of osteoarthritis through changes in musculoskeletal function and pain-related behaviors. (biomedcentral.com)
  • however, there is currently no comprehensive explanation for why obesity increases the risk of osteoarthritis at different sites throughout the body. (biomedcentral.com)
  • In premenopausal women, ovarian hyperandrogenism likely increases risk by inducing chronic anovulation and progesterone deficiency. (scienceopen.com)
  • We hypothesize that POPS will yield positive effects compared to Usual Head Start, and that the combined intervention (POPS + IYS) addressing behaviors well-known to be associated with obesity risk, as well as self-regulatory capacity, will be most effective in preventing excessive increases in child adiposity indices (body mass index, skinfold thickness). (biomedcentral.com)
  • Epidemiological studies show that chronic stress increases the risk of diabetes and metabolic syndrome [ 2 ]. (biomedcentral.com)
Multifactorial2
  • Obesity is a multifactorial disease that is currently developing a threatening tendency towards becoming the main cause of chronic disease in the world. (benthamscience.com)
  • Causes of obesity are multifactorial and include genetic predisposition and behavioral, metabolic, and hormonal influences. (msdmanuals.com)
Abnormalities2
  • CB 1 R signaling is required for GC-mediated metabolic abnormalities. (iasvn.org)
  • Abnormalities in myocardial fuel substrate selection in obesity have been noted. (kauveryhospital.com)
Complications2
  • ETHNOPHARMACOLOGICAL RELEVANCE: Metabolic diseases are the major causes of macrovascular and microvascular complications which lead to morbidity and mortality. (bvsalud.org)
  • In the United States, obesity and its complications cause as many as 300,000 premature deaths each year, making it second only to cigarette smoking as a preventable cause of death. (msdmanuals.com)
Obstructive3
  • A subset of these patients has concurrent symptoms of excessive daytime sleepiness attributable to their nocturnal breathing disorder and is classified as having obstructive sleep apnoea/hypopnoea syndrome (4-5% of the middle-aged population). (ersjournals.com)
  • In moderate-to-severe obstructive sleep apnoea/hypopnoea syndrome, treatment with continuous positive airway pressure has been shown to be effective. (ersjournals.com)
  • The epidemiology of obstructive sleep apnoea (OSA)/hypopnoea syndrome (OSAHS) has been described in a significant number of studies. (ersjournals.com)
Treat obesity2
  • 10 The stimulation of BAT can potentially increase total daily energy expenditure (i.e. burn more calories) and is seen as a possible target to treat obesity. (totalhealthmagazine.com)
  • Sciacovelli and associates report on the successful use of semaglutide to treat obesity induced by resection of craniopharyngioma. (tomwademd.net)
Signs of metabolic1
  • In particular, widely used beverage coffee showed relevant actions against most signs of metabolic syndrome. (edu.au)
Chronic diseases2
  • Some researchers believe that essential oils may also help counteract more than 20 chronic diseases and health conditions that obesity may contribute to. (medicalnewstoday.com)
  • Data source adequately treat many chronic diseases consequences. (cdc.gov)
Adiposity1
Mice2
  • In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet. (biomedcentral.com)
  • Female C57BL/6J mice were fed either a 10% kcal fat or a 45% kcal fat diet from 9 to 54 weeks of age. (biomedcentral.com)
Processes2
  • Ultimately, obesity results from a long-standing imbalance between energy intake and energy expenditure, including energy utilization for basic metabolic processes and energy expenditure from physical activity. (msdmanuals.com)
  • Interestingly, comparisons between type 1 and type 2 diabetic individuals further confirm the fact that CAN processes in T2D start earlier than the onset of overt metabolic impairment [2]. (encyclopedia.pub)
20231
  • Read our special collection of journal articles, published in 2022-2023, focused on obesity! (tomwademd.net)
Lead to obesity1
  • abilities are intensified to specific maternal and environ- mental exposures that can lead to obesity (2). (cdc.gov)
Injury induced1
  • Recent evidence has indicated that the vascular endothelial injury induced by hyperglycemia is associated with the enhanced nitrooxidative stress both in vivo and in vitro [ 3 - 6 ]. (hindawi.com)
Treatment of obesity1
  • The Intra-oral Alimentary Satiety Device can be considered a safe and effective method which, together with a hypocaloric diet, shows satisfactory results, thus proving to be an important auxiliary option in the treatment of obesity. (bvsalud.org)
Additionally1
Risk of obesity2
  • Their offspring tend to have higher birth weights and more body fat, and carry an increased risk of obesity later in life. (karger.com)
  • 11 Several factors have been identified that increase the risk of obesity among refugees, including length of stay in the host country 12 - 14 , level of acculturation to U.S. lifestyles 15 - 17 , existing cultural beliefs and values 18 , and poor quality of housing. (cdc.gov)
Causes of obesity1
  • Future research should take into account the different causes of obesity and its adverse health conditions, which in turn have drastic effects on the microbiome balance. (frontiersin.org)
Development of obesity1
Accumulation1
  • Environmental medicine studies how the accumulation of environmental substances in the body may cause disease, and detoxification therapy utilizes cleansing the body as its central treatment. (encyclopedia.com)