• Inherited mutations give rise to congenital heart disease, the most common birth defect, and abnormalities of the adult heart are a leading cause of illness and death in industrialized countries. (cshlpress.com)
  • Cardiovascular disease (CVD) is a world-leading health problem and encompasses a broad spectrum of disorders, including diseases of the blood vessels, the heart muscle, the electrical conduction system, and congenital heart disease. (springer.com)
  • Get the latest updates from the congenital heart disease team at Medtronic. (medtronic.com)
  • Another issue is whether to consider many infectious diseases as chronic conditions. (cdc.gov)
  • These funds will make it possible to launch CYNBIOME, the first excellence network on microbiota and infectious diseases based on the Non-Human Primate (NHP) model. (pharmiweb.com)
  • microbiota composition plays a factor in the onset of numerous conditions including inflammatory diseases, such as Crohn's disease, infectious diseases, metabolic diseases, such as type 2 diabetes, auto-immune and central nervous system diseases. (pharmiweb.com)
  • More specifically, numerous studies suggest that the composition of the microbiome has a genuine influence on the response to immunotherapy drugs for treating cancer or infectious diseases, as well as to antivirals and vaccines. (pharmiweb.com)
  • To date, there is no NHP efficacy model for studying the microbiome, in particular in the context of infectious human diseases. (pharmiweb.com)
  • This will allow CYNBIOME to offer unique preclinical services in the field of microbiome and infectious diseases, centered on the use of the NHP model. (pharmiweb.com)
  • Cynbiose's partners for the CYNBIOME network are: ABL, AMA Research Solutions, Biose, Maat Pharma, Biofortis (Mérieux Nutrisciences Group), Viroscan3D and the BIOASTER academic research institutes, the laboratory CarMen, the International Center for Research in Infectious Diseases (CIRI), SFR Biosciences and the technological research platform Virnext. (pharmiweb.com)
  • It brings together regional stakeholders with complementary expertise to create a brand-new preclinical study service focused on microbiome and infectious diseases. (pharmiweb.com)
  • The construction of a regional reference center, which includes a confined facility managed by Cynbiose, will allow NHP models to be manipulated for studying microbiota and carrying out infectious challenges. (pharmiweb.com)
  • Supported by its 15 years of expertise, Biofortis is making its resources and high-performance metagenomic analysis tools available to take on the major challenges of microbiota in infectious diseases. (pharmiweb.com)
  • Genetic mechanisms of susceptibility to congenital and infectious lung diseases, focusing on developmental antecedents and the influence of environmental factors. (rochester.edu)
  • T. cruzi is the protozoan parasite that causes Chagas disease (American trypanosomiasis), the leading cause of infectious heart disease worldwide and the highest-impact parasitic disease in the Western Hemisphere . (findaphd.com)
  • However, in some specific infectious diseases, pulse rate does not increase as expected, a condition called relative bradycardia. (cdc.gov)
  • Although rare in the United States and minimally emphasized in medical schools, some infectious diseases are showing resurgence because of increased world emigration and the spread of resistant forms of disease. (medscape.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • US Centers for Disease Control and Prevention (CDC) recommendations are stressed, and promising experimental treatments are noted. (medscape.com)
  • It also announced a new database-driven collaboration with Pfizer looking at many disease areas, including a focus on gain-ing a better understanding of the genetic causes of lupus. (centerwatch.com)
  • That deal follows a partner-ship with Pfizer announced last summer to research potential genetic factors associated with inflammatory bowel disease. (centerwatch.com)
  • The better we understand the genetic heterogeneity of complex diseases, the faster we may be able to accelerate the pace of development for potential new treat-ments for the right patient subpopulation," Jose-Carlos Gutierrez-Ramos, Pfizer's head of biotherapeutics R&D, said in a statement. (centerwatch.com)
  • Our work involves population and family-based genetic studies, high throughput sequencing to identify disease genes, with a focus on coronary artery disease (CAD) and metabolic syndrome (MetS). (yale.edu)
  • My laboratory aims to investigate the molecular and genetic basis of neural circuit function and dynamics, to develop bioinformatic tools for analysis of high-content neural data, and to design rapid cellular and whole-organism screens for therapeutic drugs and genetic modulators affecting neural disease. (wpi.edu)
  • Causal impact of a full-gene deletion will be investigated in all organ systems by comparing phenotypic characteristics of KO-mice with wild-type control mice of the same genetic C57BL/6N background (Munoz-Fuentes et al. (springer.com)
  • We employ various approaches and methods of biochemistry and biophysics, molecular and cellular biology, and genetic and surgical mouse models, to dissect the convergent and divergent regulatory pathways. (rochester.edu)
  • With the growth of genetic engineering, mice have become increasingly common as models of human diseases, and this has stimulated the development of techniques to assess the murine cardiovascular system. (nih.gov)
  • This article is a review of exciting, recently generated genetic, biochemical and clinical data from studies that have examined the importance of the tissue kallikrein-kinin system in protection from hypertension, vascular remodeling and renal fibrosis. (nature.com)
  • Currently I am studying the molecular and genetic aspects of the vascular disease cerebral cavernous malformations (CCM). (uni-potsdam.de)
  • Molecular pathways involved in this disease have been described, however, the very onset or non-genetic triggers that cause CCM remain undetermined. (uni-potsdam.de)
  • The first results from a functional genetic catalogue of the laboratory mouse has been shared with the biomedical research community, revealing new insights into a range of rare diseases and the possibility of accelerating development of new treatments and precision medicine. (sciencedaily.com)
  • With its similarity to human biology and ease of genetic modification, the laboratory mouse is arguably the preferred model organism for studying human genetic disease. (sciencedaily.com)
  • The murine model has allowed for major advances in the field of the microbiome, but the results obtained using it cannot necessarily be transferred to humans, in particular because of the physiological and genetic differences between mice and humans. (pharmiweb.com)
  • The Laboratory for Biomechanics, Biolab, hosts a variety of equipment and experimental setups to facilitate the ongoing research in the field of cardiovascular and orthopaedic biomechanics of the department of Biomedical Engineering. (tue.nl)
  • My laboratory is engaged in system biology approaches to investigate cardiovascular diseases. (yale.edu)
  • Most recently, we have established techniques of high throughput gene editing and multiple parallel reporter assays in my laboratory and have successfully mapped the regulatory landscape of a number of GWAS disease genes. (yale.edu)
  • EPFL Laboratory of Multiscale Modeling of Materials, in Switzerland, has developed a flowing 3D model of the cardiovascular system that should allow for predictions of certain heart diseases before they become dangerous. (eurekalert.org)
  • He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
  • Our laboratory is interested in the understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease. (rochester.edu)
  • The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases. (rochester.edu)
  • The specific organ system changes that lead to the variation in laboratory test results and cardiovascular parameters are described briefly in the following sections. (medscape.com)
  • Using the disease(s) identified in the previous prompt, identify the most common laboratory and diagnostic test used to access the disease(s). (apaxresearchers.com)
  • The candidate will graduate with a clear understanding of mouse models of immunity and infection, cutting-edge molecular immunology technologies, as well as strong laboratory and transferrable skills. (findaphd.com)
  • Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine describes how recent advances in genetics, stem cell biology, and developmental biology are transforming the way we understand and treat heart disease. (cshlpress.com)
  • Genetics and transgenic models. (norecopa.no)
  • By recruiting more than thousand kindreds with early onset CAD and multiple metabolic risk factors for genetics and metabolic studies we have been able to map, identify and characterize a dozen of human disease genes for CAD and MetS, which have been reported in leading journals such as Nat Genet, Science, NEJM, Cell Metab, JCI, PNAS, AJHG, etc. (yale.edu)
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • Lifestyle choices and genetics have clearly been demonstrated to be significant contributors but cannot alone or even in combination account for all the risk of developing CV disease, or the individual variability in which people experience the condition. (nih.gov)
  • These extensive high-throughput data from IMPC mice provide a promising opportunity to explore genetics causing metabolic heart disease with an important translational approach. (springer.com)
  • Genetics of transcription factors and their role in aging and disease. (rochester.edu)
  • A Path to Primary Prevention of Coronary Artery Disease: Can We All Live to 100? (stanford.edu)
  • Advanced experimental mock loops are available in the lab, to mimic different parts of the cardio vascular system (e.g. systemic, pulmonary and coronary circulation). (tue.nl)
  • Goodman et al (3) note the chronic nature of HIV infection, but other important chronic infections exist, such as tuberculosis and hepatitis B and C. In our view these conditions, and their co-occurring illnesses, encumber all of the management challenges of important noninfectious diseases such as coronary heart disease, cancer, diabetes, or stroke-related disability (11,12). (cdc.gov)
  • The model incorporated population-representative data from India on multiple risk factors that affect myocardial infarction and stroke mortality, including hypertension, hyperlipidemia, diabetes, coronary heart disease, and cerebrovascular disease. (who.int)
  • In unadjusted models, phosphorus levels were associated with coronary artery calcium, and in multivariate models, phosphorus levels were significantly associated with the category of coronary artery calcium level. (medscape.com)
  • Patients identified as high risk with the lifetime risk approach were more likely to be younger, male, from ethnic minority groups, and have a positive family history of premature coronary heart disease than those identified with the 10 year QRISK2 score. (bmj.com)
  • Each visit includes: assessment of cardiovascular risk factors, screening for subclinical atherosclerosis by two-dimensional/three-dimensional ultrasound of carotid and femoral arteries, cardiac CT of coronary arteries and blood sampling. (bvsalud.org)
  • This study showing that severe acute respiratory syndrome coronavirus directly infects coronary artery plaques, producing inflammatory substances, really joins the dots and helps our understanding on why we're seeing so much heart disease in COVID patients," Peter Hotez, MD, professor of molecular virology and microbiology at Baylor College of Medicine in Houston, told Medscape. (medscape.com)
  • Giannarelli noted that influenza is also associated with an increased risk of cardiovascular events, but there has been no evidence to date that it directly affects coronary arteries. (medscape.com)
  • In a recent article published online in Nature Cardiovascular Research , Giannarelli and colleagues analyzed human autopsy tissue samples from coronary arterial walls of patients who had died from COVID in the early stages of the pandemic in New York. (medscape.com)
  • Experimental rodent models play a central role in cardiovascular disease research by effectively simulating human cardiovascular diseases. (springer.com)
  • Plos Biology 2013 11: e1001635) and may play a role in cardiovascular disorders and cancers. (rochester.edu)
  • Each heart chamber is modeled by means of the elastances that describe the contractility of the cardiac muscle and the unloaded volume, that is the blood volume contained in the chamber at zero-pressure. (wikipedia.org)
  • Considering that different channels and temporal segments of a feature map extracted from the 12-lead electrocardiogram record contribute differently to cardiac arrhythmia detection, and to the classification performance, we propose a 12-lead electrocardiogram signal automatic classification model based on model fusion (CBi-DF-XGBoost) to focus on representative features along both the spatial and temporal axes. (frontiersin.org)
  • Doppler methods have been used to characterize and evaluate numerous cardiovascular phenotypes in mice and have been particularly useful in evaluating the cardiac and vascular remodeling that occur following transverse aortic constriction. (nih.gov)
  • We will base our model on the ex vivo culture of porcine superficial cardiac slices, comprising the epicardial layer and the underlying myocardial tissue (Epicardial/Cardiac-Tissue Slices, EpCardio-TS). (ukri.org)
  • This enabling model will contribute to further our understanding of the contribution of the epicardium to cardiac repair and improve the outcomes of therapies targeted to this tissue, reducing the burden to animals. (ukri.org)
  • Epicardial/Cardiac-Tissue Slice (EpCardio-TS) is an ex vivo model for the study of the epicardial cell reparative potential and the development of targeted therapeutic approaches. (ukri.org)
  • The Harmony Transcatheter Pulmonary Valve (TPV) System is indicated for use in the management of pediatric and adult patients with severe pulmonary regurgitation (i.e., severe pulmonary regurgitation as determined by echocardiography and/or pulmonary regurgitant fraction ≥ 30% as determined by cardiac magnetic resonance imaging) who have a native or surgically-repaired right ventricular outflow tract and are clinically indicated for surgical pulmonary valve replacement. (medtronic.com)
  • The immune system, our body's way of protecting us from infections, plays a key role in cardiac development, composition, and function. (findaphd.com)
  • A new proteomic risk model for cardiovascular disease was found to be more accurate than current methods of measuring cardiac risk, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. (news-medical.net)
  • Not only did the study indicate this model was more accurate compared to current approaches, the researchers were able to identify several proteins, like cartilage intermediate layer protein 2 (CILP2), that can be used in future research to identify cardiac risk or be the target for novel therapies. (news-medical.net)
  • CONCLUSIONS: Apparently healthy individuals without cardiac 18F-FDG uptake have higher HOMA-IR and higher prevalence of MetS traits, cardiovascular risk factors, and early atherosclerosis. (bvsalud.org)
  • We performed computed tomography and electrocardiography for all patients: no patients were given a diagnosis of cardiac disease. (cdc.gov)
  • and how various cutting-edge technologies and models are being employed to study heart biology, uncover disease-related processes, and identify therapeutic targets. (cshlpress.com)
  • We have developed expertise in in vivo investigation of lipid and glucose metabolism, insulin secretion and sensitivity, and vascular biology and in human physiological studies, leading to discovery of attractive drug targets that have been either patented or being investigated for their utility in treatment of fatty liver disease and diabetes in 2 clinical trials in the outlier populations of Fars/Iran. (yale.edu)
  • Understanding the mechanisms by which mechanical forces regulate the development and healing of connective tissues and the pathogenesis of disease is becoming one of the foremost problems at the intersection of biomechanics and cell biology-it has spawned the field of mechanobiology. (wpi.edu)
  • We will utilize techniques from engineering, chemistry and biology to address these research areas, including chemical modifications to alter drug-material interactions, small molecule and macromolecule conjugates to direct cell fate, and multi-cellular tissue/disease systems for paracrine signaling and direct cell-cell interactions. (wpi.edu)
  • Kamm has long been instrumental in developing research activities at the interface of biology and mechanics, formerly in cell and molecular mechanics, and now in engineered living systems. (selectbiosciences.com)
  • He was the Chair of the Bioengineering Division of the American Society of Mechanical Engineers (ASME), the first non-MD President of the International Society for Applied Cardiovascular Biology, and the Secretary of the Executive Committee of the Biomedical Engineering Society (BMES), for which he served on the Board of Directors for 10 years. (pitt.edu)
  • 2012) Elected President, International Society for Applied Cardiovascular Biology (ISACB). (pitt.edu)
  • 2006) Named to Executive Council of the International Society for Applied Cardiovascular Biology (ISACB). (pitt.edu)
  • The research, which generated over 20 million pieces of data, has found 360 new disease models and provides 28,406 new descriptions of the genes' effects on mouse biology and disease. (sciencedaily.com)
  • How can workplace health promotion professionals address job stress as a modifiable risk factor for heart disease and other chronic diseases? (cdc.gov)
  • Despite this, occupational stress is rarely addressed in the design of comprehensive health promotion efforts aimed at reducing risk factors for chronic diseases. (cdc.gov)
  • It is well established that both acute and chronic stress can be detrimental to health and wellbeing by directly increasing the risk of several chronic diseases and related health problems. (mdpi.com)
  • A full pipeline of diagnosis and prognosis the risk of chronic diseases using deep learning and Shapley values: The Ravansar county anthropometric cohort study. (cdc.gov)
  • An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system. (mcw.edu)
  • The measurement of mechanical properties of biological tissues is essential for describing the constitutive behaviour of these tissues in computer models. (tue.nl)
  • In our lab we use precisely engineered, two-dimensional and three-dimensional constructs as model systems to study the effects of external internal (cell-generated) forces on cell behavior, matrix biochemistry, and the biomechanics of soft tissues and biomaterials. (wpi.edu)
  • In addition to being expressed in immune cells, TLRs are expressed in other tissues, such as those of the cardiovascular system. (medscape.org)
  • In this project we will develop a model based on leftover pig heart tissues to mimic in a dish the behaviour of the epicardium after stimulation. (ukri.org)
  • Yet, the mouse shares a similar developmental trajectory to the human heart and a comparable four-chamber morphology that greatly enhances its translational value as a model organism, despite the substantial differences in size (Krishnan et al. (springer.com)
  • We would like to make the CYNBIOME structure a unique network that connects a translational model with technological tools, scientific and industrial expertise, and specialized partners for the preclinical study of microbiota in NHP models. (pharmiweb.com)
  • Heart disease is the primary cause of on-duty deaths in firefighters, but little is known about their lipid profile. (cdc.gov)
  • The number of deaths caused by cardiovascular diseases in 2008 is estimated at 17 million. (ni.com)
  • Background We simulated tobacco control and pharmacological strategies for preventing cardiovascular deaths in India, the country that is expected to experience more cardiovascular deaths than any other over the next decade. (who.int)
  • Methods and Findings A microsimulation model was developed to quantify the differential effects of various tobacco control measures and pharmacological therapies on myocardial infarction and stroke deaths stratified by age, gender, and urban/rural status for 2013 to 2022. (who.int)
  • Conclusions Smoke-free laws and substantially increased tobacco taxation appear to be markedly potent population measures to avert future cardiovascular deaths in India. (who.int)
  • Despite the rise in co-morbid cardiovascular disease risk factors like hyperlipidemia and hypertension in low- and middle-income countries, tobacco control is likely to remain a highly effective strategy to reduce cardiovascular deaths. (who.int)
  • It is estimated that up to 23 percent of heart disease related deaths per year could be prevented if the levels of job strain in the most stressful occupations were reduced to average levels seen in other occupations (Karasek and Theorell, 1990). (cdc.gov)
  • Age-specific death rates are based on data on deaths by age, gender and cause of death, as generated by the Member States from their death registration systems. (who.int)
  • Experimental gastrointestinal models of human diseases. (norecopa.no)
  • The cardiovascular system and models for human diseases. (norecopa.no)
  • The molecular basis of human diseases, including but not limited to the most common single-gene cause of intellectual disability and autism, Fragile X Syndrome, and the development of therapeutics. (rochester.edu)
  • This new model was found to be more accurate in identifying those at risk of future cardiovascular disease, as compared to both the 2013 ACC/AHA Pooled Cohort Equation (PCE)-;which provides a set of guidelines for best practices in measuring cardiovascular risk-;and a modified PCE that included estimated glomerular filtrate rate (eGFR). (news-medical.net)
  • In addition, HEARTS in the Americas can serve as a model for more comprehensive, effective, and sustainable noncommunicable disease prevention and treatment practices. (paho.org)
  • What resources can help health promotion professionals overcome barriers to addressing job stress in chronic disease prevention initiatives? (cdc.gov)
  • For the future workforce, incorporating occupational health and safety principles into undergraduate and graduate health promotion curricula would be extremely useful to ensure that chronic disease prevention efforts address workplace stressors as one of many factors affecting employee health and wellbeing. (cdc.gov)
  • Pregnancy complications, such as preeclampsia (PE), can reveal a subclinical predisposition for the development of future disease that may help identify women who could benefit from early CVD and CKD prevention strategies. (bvsalud.org)
  • Annex 4 to this document sets out the challenges to and opportunities for promoting access to affordable diagnostics, screening and early diagnosis as part of a comprehensive approach to the prevention and control of noncommunicable diseases. (who.int)
  • I'm Loretta Jackson-Brown and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Center for Disease Control and Prevention. (cdc.gov)
  • Marcy l ' Etoile, France, January 28, 2020 - Cynbiose, a service company specializing in the development and commercialization of innovative preclinical models, today announces that it has procured financing of €1.9 million ($2.1M) under the third phase of the French Program 'Investment for the Future' (PiA3). (pharmiweb.com)
  • Disease, United States, 2011-2020. (cdc.gov)
  • The model uses a combination of Machine Learning (ML) and a GlobalData proprietary algorithm to process data points from the Drugs, Clinical Trials, Regulatory Milestones, Company, and Financial databases. (globaldata.com)
  • Page said more than 80% of those custom-ers have consented to donate their data to R&D-a cohort that enables researchers to connect clinical data on how patients feel and how their diseases progress from their genomic side. (centerwatch.com)
  • Products that seek to provide deeper health insights, like the Apple Watch, have the potential to be significant in new clinical care models and shared decision making between people and their healthcare providers. (apple.com)
  • Chronic progressive cardiovascular (CV) disease, in all its clinical manifestations, is the most significant cause of morbidity and mortality in many developed countries and, increasingly, in countries experiencing economic growth and prosperity. (nih.gov)
  • Each of these articles explores different data sources, and despite the variation in disease and condition combinations selected, these articles show the ability of many US federal datasets to address and better characterize the scope of MCC as well as incorporate important MCC-related issues such as the effect of MCC on the cost of clinical care and the extent of clinical care use. (cdc.gov)
  • How do you deal with complex clinical manifestations of conditions, such as signs (visually observable patient abnormalities), symptoms (abnormal perceptions of illness that only the patients can report, such as pain, itching, fatigue, depressive feelings), and syndromes (clusters of signs, symptoms, and other clinical phenomena that may or may not be indicative of a specific underlying disease)? (cdc.gov)
  • Since our nanoparticle is relatively nonspecific for the target organ, it is known to be extremely safe, and thus can be the first clinical oriented drug delivery system in the field of cardiology. (escardio.org)
  • Experimental and clinical evidence implicate an imbalance between endogenous vasoconstrictor and vasodilator systems in the development and maintenance of hypertension. (nature.com)
  • Although much has been learned about TLR activation in cellular components of the cardiovascular system, the role individual TLR family members have in the pathophysiology of cardiovascular diseases and hence in clinical practice remains to be defined. (medscape.org)
  • This clinical sign could help clinicians to diagnose this disease. (cdc.gov)
  • and micro- and macrovascular disease (e.g. retinopathy, and (vi) clinical information systems (7) . (who.int)
  • In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. (hindawi.com)
  • We also found that the virus persists in these foam cells that could be responsible for long-term, low-grade inflammation in the vasculature that could contribute to the long-term cardiovascular manifestations in patients who have recovered from COVID," she said. (medscape.com)
  • This is why the IMPC is aiming to build a complete database that systematically details the functions of all areas of the mouse genome, including neurological, metabolic, cardiovascular, respiratory and immunological systems. (sciencedaily.com)
  • Nursing performance facing this unwanted human re- e n t i l a t i o n i sponse is considered essential for the maintenance and control of vital signs, cardiovascular monitoring, gas exchange and respiratory pat- tern, as well as constant surveil ance aimed at signs of hypoventilation p o n t a n e o u s V and inadequate ventilation. (bvsalud.org)
  • Total number of death among 30-70 years due to specific cause (cardiovascular diseases, cancer, chronic respiratory disease and diabetes) per 10,000. (who.int)
  • Unconditional probability of dying between the exact ages 30 and 70 years from CVDs, cancers, diabetes, or chronic respiratory diseases. (who.int)
  • The ICD codes to be included in the calculation are: cardiovascular disease: I00-I99, Cancer: C00-C97, Diabetes: E10-E14, or Chronic respiratory diseases: J30-J98. (who.int)
  • Disruption of normal circadian rhythms are associated with diseases of the central nervous system, immune system dysfunction, cancer and cardiovascular and metabolic disorders. (centerwatch.com)
  • The innate immune system detects highly conserved, relatively invariant structural motifs of pathogens. (medscape.org)
  • TLRs could, therefore, be a key link between cardiovascular disease development and the immune system. (medscape.org)
  • Most microorganisms encountered by healthy individuals are recognized initially by defense mechanisms that are not antigen-specific, a response mediated by the so-called innate immune system. (medscape.org)
  • In contrast to adaptive immunity, in which specific antigen receptors are generated by somatic hypermutation and selection, in the innate immune system germline-encoded receptor proteins recognize specific patterns that are shared by groups of pathogens, but not the host. (medscape.org)
  • Scientists at Iowa State University are poised to take a significant step forward in human health by transferring a human immune system into pigs. (iastate.edu)
  • Cardioimmunology: Dissecting immune mechanisms underlying infection-driven heart disease. (findaphd.com)
  • The successful candidate will combine cutting-edge transcriptomics and proteomics with transgenic mouse models to further dissect the role of immune cells infiltrating the heart during T. cruzi infection. (findaphd.com)
  • Our study shows a remarkable ability of the virus to hijack the immune system," she points out. (medscape.com)
  • PET-scanning and development of models for studies of neurological disorders. (norecopa.no)
  • The team also identified new candidate genes for diseases with an unknown molecular mechanism, including an inherited heart disease called 'Arrhythmogenic Right Ventricular Dysplasia' that affects the heart muscle, and Charcot-Marie-Tooth disease, which is characterised by nerve damage leading to muscle weakness and an awkward way of walking. (sciencedaily.com)
  • In preparation of his upcoming two-day CARD (Long Term Microgravity: A Model for Investigating Mechanisms of Heart Disease) experiment run, starting tomorrow, Jeff Williams replaced the batteries in the CDL HLTA BP (Cardiolab Holter Arterial Blood Pressure) instrument. (nasa.gov)
  • the slices will be subjected to treatments to simulate the aftermath of heart disease and stimulated with known therapeutic substances to assess the capacity of our system to reproduce what has been observed in the animal models. (ukri.org)
  • Chinese Americans are disproportionately affected by modifiable cardiovascular disease (CVD) risk factors such as diabetes and high blood pressure (4,5). (cdc.gov)
  • We are now fully characterizing this protein and evaluating its utility as a drug target for diabetes, dyslipidemia, and fatty liver disease. (yale.edu)
  • HEARTS in the Americas Initiative is the regional adaptation that envisions HEARTS as the model for cardiovascular disease risk management, including hypertension and diabetes, in primary health care in the Americas by 2025. (paho.org)
  • The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, funded this study. (medscape.com)
  • Chronic kidney disease (CKD) is a strong cardiovascular risk factor and is often accompanied by hypertension and diabetes. (news-medical.net)
  • Diabetes mellitus is one of the most prevalent chronic required in the health care system and by the patients to diseases. (who.int)
  • We evaluated the lipid profile in relation to other cardiovascular disease risk factors in 321 firefighters at a baseline examination. (cdc.gov)
  • Kwon SC, Wyatt LC, Li S, Islam NS, Yi SS, Trinh-Shevrin C. Obesity and Modifiable Cardiovascular Disease Risk Factors Among Chinese Americans in New York City, 2009-2012. (cdc.gov)
  • We used the Racial and Ethnic Approaches to Community Health Across the US (REACH US) Risk Factor Survey from 2009 through 2012 to examine the association between body mass index (BMI, calculated as kg/m 2 ) and 3 cardiovascular disease risk factors among Chinese Americans in New York City. (cdc.gov)
  • Survey items were adapted from the Behavioral Risk Factor Surveillance System interview (7). (cdc.gov)
  • Environmental exposures are presumed to contribute to the risk of developing CV disease and, in some cases such as air pollution, there is compelling evidence to support that likelihood. (nih.gov)
  • However, current approaches to environmental hazard assessment do not specifically address CV bioactivity and hazards, despite growing evidence that environmental exposures contribute to the onset, risk, or progression of chronic CV disease. (nih.gov)
  • Hereditary DNA sequence variants play a role in the transmission of disease risk in almost all of them (Basson et al. (springer.com)
  • In order to address stress effectively as a risk factor for chronic disease, workplace health promotion professionals need to broaden their focus to include institutional strategies aimed at controlling workplace stressors at their source. (cdc.gov)
  • 1) Do published risk scores applied to EHD yield accurate estimates of cardiovascular risk? (healthpartners.com)
  • We assessed calibration and discrimination for 4 risk scores: published versions of FRS and PCE and versions obtained by refitting models using a subset of the available EHD. (healthpartners.com)
  • and model refitting does not meaningfully improve the accuracy of risk estimates. (healthpartners.com)
  • Objective To develop, validate, and evaluate a new QRISK model to estimate lifetime risk of cardiovascular disease. (bmj.com)
  • Cox proportional hazards models in the derivation cohort to derive risk equations accounting for competing risks. (bmj.com)
  • Age-sex centile values for lifetime cardiovascular risk compared with 10 year risk estimated using QRISK2 (2010). (bmj.com)
  • Of the 10% of patients in the validation cohort classified at highest risk with either the lifetime risk model or the 10 year risk model, only 18 385(14.5%) were at high risk on both measures. (bmj.com)
  • 1 National policies now support targeting of interventions to reduce risk of cardiovascular disease among high risk patients. (bmj.com)
  • This is because age has such a dominant effect in calculating absolute cardiovascular risk. (bmj.com)
  • 9 10 11 12 Lifetime risks which measure the cumulative risk of developing a disease during the remainder of an individual's life 13 would reflect this relatively high risk and, given that lifetime risk estimates provide assessment over the full life course, they may provide a more appropriate assessment of future risks than estimates limited to 10 years, particularly at younger ages. (bmj.com)
  • Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. (eurekamag.com)
  • Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. (eurekamag.com)
  • In a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. (eurekamag.com)
  • With the model, they evaluated 4,628 unique proteins to find which could most closely help identify risk of cardiovascular disease. (news-medical.net)
  • Of those thousands of proteins evaluated, researchers used machine learning methods to choose 32 proteins that comprised their proteomic risk model. (news-medical.net)
  • Those specific proteins were determined to best help indicate a patient's risk level of heart attack, heart failure, stroke, or even cardiovascular death in those with CKD. (news-medical.net)
  • The ability to personalize risk assessment for individual patients with CKD is the first step toward scaling this for larger health systems. (news-medical.net)
  • Those in the highest measure of predicted risk had an observed incident cardiovascular event rate of 60 percent over 10 years. (news-medical.net)
  • The reliable identification of such high-risk individuals with no prior history of cardiovascular disease will undoubtedly be of great interest to patients and their providers for preventative care measures. (news-medical.net)
  • 2023). Proteomic cardiovascular risk assessment in chronic kidney disease. (news-medical.net)
  • INTRODUCTION: Life expectancy of patients with psoriasis is reduced by 4-5 years due to cardiovascular disease with an increased risk of myocardial infarction at an earlier age compared with the general population. (bvsalud.org)
  • This increased risk is independent of traditional cardiovascular risk factors and higher in moderate-to-severe forms of psoriasis. (bvsalud.org)
  • BACKGROUND: Cardiovascular (CVD) and chronic kidney disease (CKD) in women have unique risk factors related to hormonal status and obstetric history that must be taken into account. (bvsalud.org)
  • The findings may not only explain the link between COVID and the increased risk of cardiovascular events but mark a starting point for new therapeutic approaches. (medscape.com)
  • Giannarelli says it's important for doctors and patients to be aware of an increased cardiovascular risk after a SARS-CoV-2 infection and to pay extra attention to traditional risk factors, such as blood pressure and cholesterol. (medscape.com)
  • Hotez added that the increased risk of cardiovascular events with influenza has also been reported to be prolonged after the acute infection. (medscape.com)
  • That response induced the secretion of key proatherogenic cytokines, such as interluekin-6 and interleukin-1 beta, which have been implicated in the pathogenesis of atherosclerosis and in an increased risk of cardiovascular events. (medscape.com)
  • Advanced insight into the use and limitation of animal models in biomedical research. (norecopa.no)
  • A third research agreement with Reset Therapeutics will study circadian clock genes and ultimately improve therapeutic development for diseases related to molecu-lar clocks. (centerwatch.com)
  • In growing the database, we were able to engage corporate customers in research and we accelerated the pace of discovery in 2015, which validated our R&D model," said Emily Drabant Conley, director of business development for 23andMe. (centerwatch.com)
  • From that research, Genentech expects to identify new drugs for Parkinson's disease, along with evidence for existing therapies in its pipeline. (centerwatch.com)
  • The overall objectives of my research are to develop clinically translatable tissue regeneration and drug delivery strategies, and three-dimensional, in vitro human disease models using biologically-derived biomaterials. (wpi.edu)
  • Animal models have many facets that mimic various disease conditions in humans representing the importance for its tremendous use in biomedical research (Mukherjee et al. (springer.com)
  • Horizons in World Cardiovascular Research. (novapublishers.com)
  • The new disease models are being made available to the biomedical community to aid their research. (sciencedaily.com)
  • However, the vast majority of the mouse genome remains poorly understood, as scientists tend to focus their research on a few specific areas of the genome linked to the most common inherited diseases. (sciencedaily.com)
  • Our research is advancing improvements in healthcare - treatment, diagnosis and care - improving the health of people locally and impacting national and international health agendas in areas such as neglected tropical diseases, cancer research, palliative medicine, mental health and global public health. (findaphd.com)
  • Standardized Health data and Research Exchange (SHaRE): promoting a learning health system. (cdc.gov)
  • This ability should enable signals to be generated and applied to ECs (endothelial cells) or bilayer culture systems containing ECs and VSMCs ( vascular smooth muscle cells) seeded in a transparent test chamber or any geometry that allows observation under the microscope, recording of flow parameters and cell harvest after treatments. (ni.com)
  • He is also designing a small diameter tissue engineered vascular graft to treat cardiovascular diseases. (pitt.edu)
  • Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. (uni-potsdam.de)
  • Signaling transduction mechanisms in the vascular system. (rochester.edu)
  • Influenza vaccination can reduce the incidence of cardiovascular ally during the past decade but is far behind the targeted national disease (CVD) in the US. (cdc.gov)
  • While some population-based subscales that represent multiple features of providing health system models have adopted a structured and pro- patient-centred care consistent with the chronic care active approach to help reduce the incidence and burden model. (who.int)
  • Relative bradycardia is a characteristic physical finding in some intracellular bacterial infections, viral infections, and noninfectious diseases ( 4 ). (cdc.gov)
  • Furthermore, we are presenting not yet associated loss-of-function genes affecting both, metabolism and the cardiovascular system, such as the RING finger protein 10 ( Rfn10 ), F-box protein 38 ( Fbxo38 ), and Dipeptidyl peptidase 8 ( Dpp8 ). (springer.com)
  • We leverage modern techniques of functional genomics, epigenetics, transcriptomics, proteomics, gene editing and model-driven experimentation to understand the underlying causes of atherosclerosis and metabolic syndrome and discover therapeutic targets. (yale.edu)
  • One of our groundbreaking discoveries was the identification of founder mutations in the DYRK1B gene, underlying atherosclerosis, metabolic syndrome, and fatty liver disease. (yale.edu)
  • Phosphorus levels correlate with atherosclerosis in both animal models and humans with advanced chronic kidney disease, but whether this relationship exists among individuals with normal kidney function is unknown," write Robert N. Foley, from the Cardiovascular Special Studies Center, United States Renal Data System, and the University of Minnesota in Minneapolis, and colleagues. (medscape.com)
  • and (3) serve as a model for understanding atherosclerosis in other chronic inflammatory diseases. (bvsalud.org)
  • Our findings link cardiovascular autonomic parameters to brain activity changes involved in the elaboration of nociceptive information, thus beginning to elucidate underlying brain mechanisms associated with the reciprocal relationship between autonomic and pain-related systems. (frontiersin.org)
  • Current models are based on simplified in vitro systems (isolated epicardial cells) or on small animal models of cardiovascular diseases. (ukri.org)
  • EpCardio-TS provides the complexity of a multicellular preparation with physiological and electrical properties similar to the whole heart, combined with the simplicity of an in vitro system. (ukri.org)
  • Given a set of parameters that have a physical meaning (e.g. resistances to blood flow), it allows to study the changes in blood pressures or flow rates throughout the cardiovascular system. (wikipedia.org)
  • Modifying the parameters, it is possible to study the effects of a specific disease. (wikipedia.org)
  • This website is provided by the Agency for Toxic Substances and Disease Registry (ATSDR) ONLY as an historical reference for the public health community. (cdc.gov)
  • Global Hearts is the flagship initiative of the World Health Organization to reduce the burden of cardiovascular diseases, the leading cause of death and disability worldwide. (paho.org)
  • The goal of implementing these innovative and pragmatic solutions is to create a more effective health system and shift the focus of cardiovascular and hypertension programs from the highly specialized care level to primary health care. (paho.org)
  • Cardiovascular diseases cause a high mortality rate worldwide and represent a major burden for health care systems. (springer.com)
  • Nowadays, cardiovascular diseases are still among the top causes of mortality and morbidity in the world (the 2012 World Health Report). (ni.com)
  • Pharmacological therapies could also be considerably more potent with further health system improvements. (who.int)
  • A vast body of international scientific literature has established a strong causal association between job stress and cardiovascular diseases (CVD) and other chronic health conditions. (cdc.gov)
  • First and foremost, workplace health promotion specialists need education on the substantial role of occupational stress in the development of chronic disease, and what can be done at the organizational level to control exposure to stressors. (cdc.gov)
  • Describe the main health care providers for the cardiovascular and circulatory department. (apaxresearchers.com)
  • We found marginal improvement in influenza vaccination during the past hold income less than $50,000, and no health insurance had a decade among adults with cardiovascular disease, lagging far behind the lower prevalence of vaccination. (cdc.gov)
  • In this capacity, she has worked across federal and private partners to execute evidence-based strategies to prevent cardiovascular diseases and improve health. (cdc.gov)
  • Assessment of Care for Chronic Conditions (PACIC) vidual, society and the health care system (2) . (who.int)
  • Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene knockout models by a global network of mouse clinics. (springer.com)
  • Although duplex ultrasonic echo-Doppler instruments are being applied to mice, dedicated Doppler systems are more suitable for some applications. (nih.gov)
  • These 360 new disease models that we've identified in mice represent the first steps of a hugely important international project. (sciencedaily.com)
  • HNMT is expressed in the central nervous system, where it may play a critical regulatory role because its deficiency is related to aggressive behaviour and abnormal sleep-wake cycles in mice [ 4 ]. (hindawi.com)
  • Rodents as a model for urological disorders. (norecopa.no)
  • The IVIS Spectrum CT enables longitudinal workflows to characterize disease progression and therapeutic effect in animals throughout the complete experimental time frame with both quantitative CT and optical reconstructions. (lu.se)
  • www.cdc.gov/pcd/issues/2022/22_0154.htm Preventing Chronic Disease. (cdc.gov)
  • Terry Meehan, IMPC Project Coordinator at European Bioinformatics Institute (EMBL-EBI) said: "Mouse models allow us to speed up patient diagnosis and develop new therapies. (sciencedaily.com)
  • The newsletter will inform patients about different body systems, including their structure, function, and different diseases that affect that system. (apaxresearchers.com)
  • Patients will learn how a disease is diagnosed in a particular system and the type of doctor they would see if they have an ailment within a body system. (apaxresearchers.com)
  • Dr Smedley added: "In addition to a better understanding of the disease mechanism and new treatments for rare disease patients, many of the lessons we learn here will also be of value to precision medicine, where the goal is to improve treatment through the customisation of healthcare based on a patient's genomic information. (sciencedaily.com)
  • Subjects Patients aged 30-84 years who were free of cardiovascular disease and not taking statins between 1 January 1994 and 30 April 2010: 2 343 759 in the derivation dataset, and 1 267 159 in the validation dataset. (bmj.com)
  • Harmony™ TPV is the first FDA-approved transcatheter valve system specifically designed to treat severe pulmonary regurgitation in patients with a native or surgically-repaired right ventricular outflow tract (RVOT) - offering your patients a minimally invasive treatment option. (medtronic.com)
  • We showed that relative bradycardia was a common characteristic for 54 patients with PCR-confirmed mild-to-moderate coronavirus disease in Japan. (cdc.gov)
  • 39°C) for patients with coronavirus disease (COVID-19) has been reported ( 2 , 3 ), but the association between fever and pulse rate has not been investigated. (cdc.gov)
  • Predicted pulse rate over body temperature (red line) based on final random intercept model for relative bradycardia in patients with mild-to-moderate coronavirus disease, Japan. (cdc.gov)
  • This tool is widely used to assess the "level of CCM-congruent activities that patients worldwide, people living with the disease do not always receive" ( 8 ). (who.int)
  • The authors also provide a conceptual model for standardizing data approaches to the analyses of MCC. (cdc.gov)
  • Chronic itch in the elderly is a common problem that is often multifactorial due to physiological changes in ageing skin, including impaired skin barrier function, and changes in immunological, neurological, and psychological systems associated with age. (hindawi.com)
  • As a former Senior Vice President for Science and Quality at the American College of Cardiology, Dr. Wright oversaw the development of guidelines, performance measures and appropriate use criteria to include the National Cardiovascular Data Registry. (cdc.gov)
  • Recently the company announced a deal with Genentech , in which 23andMe will se-quence genomes to help find more effective treatments for Parkinson's disease. (centerwatch.com)
  • The beneficial actions of kinins in renal and cardiovascular disease are largely mediated by nitric oxide and prostaglandins, and extend beyond their recognized role in lowering blood pressure to include cardioprotection and nephroprotection. (nature.com)
  • cardiovascular and renal diseases), have a devastating effect on those affected and their family members. (who.int)
  • SFX-01 is under development for the treatment of human epidermal growth factor receptor 2 (her2) negative metastatic breast cancer, chronic kidney disease, glioblastoma, juvenile myelomonocytic leukaemia (JMML), rhabdomyosarcoma, autism spectrum disorder (ASD) Phenotype 2, colorectal cancer. (globaldata.com)
  • Such as in the field of cancer chemotherapy, an appropriate drug delivery system could enhance the therapeutic effects of these promising drugs by eliminating the unfavourable side effects. (escardio.org)
  • Role of cancer stem cell interactions with their microenvironment in disease progression. (rochester.edu)
  • Inflammatory conditions (e.g., allergy, asthma, and autoimmune diseases) have long been thought to be mainly mediated by the activation of histamine receptor 1 (H1R). (hindawi.com)
  • He is currently studying the biomechanical progression of aortic aneurysms by modeling the mechanical forces that act on the degenerating vessel wall. (pitt.edu)
  • Rödel CJ , Abdelilah-Seyfried S. A zebrafish toolbox for biomechanical signaling in cardiovascular development and disease. (uni-potsdam.de)
  • To facilitate the development of computer models using specialised software, the lab hosts a numerical area for computation and visualisation purposes. (tue.nl)
  • Development of therapies for rare disease lags far behind, with over half of diagnosed rare diseases still having no known causative gene. (sciencedaily.com)
  • The role of antioxidants in disease and the development of novel strategies to manipulate them therapeutically. (rochester.edu)
  • Subsequent molecular and physiological studies in human mutation carriers and animal models have allowed us to unravel novel functions of the identified genes, to delineate their cognate pathways and to discover new targets for pharmaceutical intervention. (yale.edu)
  • Hence, we can observe and study cellular and molecular processes that are dysfunctional under disease condition. (uni-potsdam.de)
  • Statins are known to improve pulmonary arterial hypertension (PAH) by their anti-inflammatory and anti-proliferative effects in animal models. (escardio.org)
  • This volume is a valuable reference for cardiologists, geneticists, and cell and developmental biologists interested in this complex, vital organ and the future of cardiovascular medicine. (cshlpress.com)