• This study has 2 objectives: (1) to report the experiences of the Plastic Surgery Service of São Lucas Hospital of the Pontifical Catholic University of Rio Grande do Sul (Porto Alegre, RS, Brazil) in the reconstruction of nasal mass losses that resulted from tumor resection and (2) to describe the most commonly used skin flaps used for defect repair according to the anatomic subunit. (rbcp.org.br)
  • I am also interested in mechanisms of carcinogenesis, particularly as they relate to squamous cell carcinoma of the skin and a spontaneously regressing tumor called keratoacanthoma. (yale.edu)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
  • Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma. (uchicago.edu)
  • these include leukemia and most forms of carcinoma in situ. (wikipedia.org)
  • Key entities on the differential diagnosis include melanoma in situ (use melanocyte markers), and Bowen disease (positive for AE1:AE3). (surgpath4u.com)
  • Cylindromas, also known as cutaneous or dermal cylindromas, are rare and benign skin appendage tumors. (medscape.com)
  • Cylindromas are appendage tumors previously thought to be of apocrine differentiation. (medscape.com)
  • BSS has been described as an autosomal dominant disease characterized by the development of multiple skin appendage tumors such as cylindromas, trichoepitheliomas, and spiradenomas, with a variable preponderance of any of the aforementioned subsets. (medscape.com)
  • Tumors or cancer of the SKIN . (lookformedical.com)
  • Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. (uchicago.edu)
  • Salivary gland-type tumors of the breast: a spectrum of benign and malignant tumors including "triple negative carcinomas" of low malignant potential. (uchicago.edu)
  • I am studying skin cancer, particularly squamous cell carcinoma and keratoacanthoma. (yale.edu)
  • Bowen's disease is a sunlight induced skin disease considered either as an early stage or intraepidermal form of squamous cell carcinoma . (wikidoc.org)
  • When advanced basal cell carcinoma and squamous cell carcinoma invade cartilage (classically the pinna) or bone (e.g. mandible) there is a higher risk of chondroradionecrosis or osteoradionecrosis. (cancer.org.au)
  • Prediction of Microvascular Invasion in Hepatocellular Carcinoma with Expert-inspiration and Skeleton Sharing Deep Learning. (cdc.gov)
  • The appendages of the skin - nails, hair, sebaceous glands, apocrine and eccrine glands - can also have diseases that, although in most cases do not lead to serious damage to health, are annoying and unpleasant for those affected and sometimes lead to psychological distress. (sdam-svou-kvartiru.ru)
  • A lesion through the skin or a mucous membrane resulting from loss of tissue, usually with inflammation. (theodora.com)
  • Vulvar Paget disease may appear as a dermatitis (eczema, psoriasis), lichen sclerosis, thus, there may be a delay in biopsying and treating the lesion. (surgpath4u.com)
  • Although not specific to atopic dermatitis, affected skin exhibits white dermatographism (ie, appearance of a white line when the lesion is stroked). (medscape.com)
  • [14] Approximately 3 to 90 days after the initial exposure (average 21 days) a skin lesion, called a chancre , appears at the point of contact. (ipfs.io)
  • Nasal cavity tumefactive fibroinflammatory lesion mimicking recurrent mucoepidermoid carcinoma. (uchicago.edu)
  • Development of a Skin-Directed Scoring System for Stevens-Johnson Syndrome and Epidermal Necrolysis: A Delphi Consensus Exercise. (harvard.edu)
  • The outer part (epidermis) contains skin cells, pigment, and proteins. (medlineplus.gov)
  • With aging, the outer skin layer (epidermis) thins, even though the number of cell layers remains unchanged. (medlineplus.gov)
  • Mammary Paget disease is the colonization of the epidermis by an underlying ductal carcinoma of the breast i.e. a secondary process. (surgpath4u.com)
  • In contrast to mammary Paget disease where it is a secondary disease process (colonization of the epidermis by an underlying ductal carcinoma of the breast). (surgpath4u.com)
  • In this disorder, the major protection of the epidermis from UV radiation, mechanical damage and chemically by acidic and alkaline substances that maintain the structure and elasticity of the skin 2, 5 . (ijpsr.com)
  • Researchers have noted an MYB-NFIB gene fusion, which provides a new genetic link between dermal cylindroma and adenoid cystic carcinoma. (medscape.com)
  • There are also the so-called apocrine sweat glands which are only found in certain regions of the skin and whose function is the secretion of fragrances. (lifeafterjob.com)
  • Those who wish to continue their work in dermatology departments and/or specialized outpatient skin clinics can, as a fully trained dermatologist, attend the Training center to continue working or to apply to specialist departments in other clinics. (sdam-svou-kvartiru.ru)
  • and MELANOMA and non-melanoma skin cancers of the head and neck. (lookformedical.com)
  • Acral lentiginous melanoma is a kind of skin melanoma , and it is also known as subungual melanoma. (wikidoc.org)
  • Acral lentiginous melanoma is a kind of skin cancer, and it is also know as a skin cancer that manifests under the nail. (wikidoc.org)
  • A Non-Invasive Interpretable Diagnosis of Melanoma Skin Cancer Using Deep Learning and Ensemble Stacking of Machine Learning Models. (cdc.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The skin and cartilage of the ear are subject to the same insults as similar tissues found elsewhere in the body. (medscape.com)
  • The first signs of the disease usually are thickened nails or neonatal teeth. (findzebra.com)
  • Pachyonychia congenita (PC) is a rare inherited condition that primarily affects the nails and skin. (findzebra.com)
  • A rare autosomal dominant disorder that affects the nails and skin is hypertrophic nail dystrophy, oral leukokeratosis, and palm plantar keratoderma. (ijpsr.com)
  • Keratin is a protein found in nails, hair and skin that forms tough fibers for strength. (ijpsr.com)
  • Although nails are a skin appendage, they have their own signs and symptoms which may relate to other medical conditions. (wikidoc.org)
  • Deformity or disease of the nails may be referred to as onychosis . (wikidoc.org)
  • Half and half nails refer to a change in the appearance of the nails due to internal diseases and nutritional deficits. (wikidoc.org)
  • The eccrine sweat glands belong to the skin appendages, just like nails and hair. (lifeafterjob.com)
  • Anatomic extent of lymph node metastases as an independent prognosticator in node-positive major salivary gland carcinoma: A study of the US SEER database and a Chinese multicenter cohort. (uchicago.edu)
  • Patients who have AN associated with malignancies also have skin changes involving the scalp, areolae, and eyelids. (medscape.com)
  • One must also look for secondary involvement from adjacent malignancies (secondary extramammary Paget disease). (surgpath4u.com)
  • Other lesions reported with BSS include parotid basal cell adenomas, organoid nevi, syringomas, and basal cell carcinomas. (medscape.com)
  • Clinical features suggestive of paraneoplastic AN include the development of AN in nonobese elderly persons and the rapid extensive progression of florid skin lesions in unusual locations, such as the mucosal membranes, palms, and soles of the feet. (medscape.com)
  • Atopic dermatitis, also known as eczema, is a systemic disease that manifests as intensely pruritic, erythematous, skin lesions. (medscape.com)
  • Extramammary Paget disease (EMPD) is clinically and histologically identical to mammary Paget disease of the nipple, however, important differences must be noted. (surgpath4u.com)
  • Lloyd J, Flanagan AM. Mammary and extramammary Paget's disease. (surgpath4u.com)
  • Also common are pinkish rough patches (actinic keratosis) which have a small chance of becoming a skin cancer. (medlineplus.gov)
  • Generations of clinicians, skin biologists, residents, and educators have acclaimed Fitzpatrick's as the most authoritative and complete guide to dermatologic basic sciences, histopathology, diagnosis, and treatment. (edu.au)
  • Pathology is the study and diagnosis of disease through examination of organs , tissues , cells and bodily fluids . (bionity.com)
  • This classic yet cutting-edge text is supported by the expert insights of more than 500 internationally respected contributors, and it covers everything dermatologists need to know about skin, dermatologic signs of underlying disease, and the management of all skin diseases, including acne, skin cancer, and psoriasis. (edu.au)
  • IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies Chen J, Murphy M, Singh K, Wang A, Chow R, Kim R, Cohen J, Ko C , Damsky W. IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies. (yale.edu)
  • Inverse psoriasis is particularly subject to irritation from rubbing and sweating because of its location in skin folds and tender areas. (jcadonline.com)
  • Treatment of inverse psoriasis can be difficult and requires a different approach to the more common cutaneous forms of the disease due to the sensitivity of skin in the susceptible areas. (jcadonline.com)
  • The use of BoNTA in inverse psoriasis might act at the neuroglandular junction level to reduce local sweating and prevent the consequent skin maceration and secondary infection. (jcadonline.com)
  • Growths such as skin tags , warts , brown rough patches (seborrheic keratoses), and other blemishes are more common in older people. (medlineplus.gov)
  • Bowen's disease is a sunlight induced skin disease considered an early stage for of skin cancer. (wikidoc.org)
  • Ablation of Cancer Stem Cells by Therapeutic Inhibition of the MDM2-p53 Interaction in Mucoepidermoid Carcinoma. (uchicago.edu)
  • ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas. (uchicago.edu)
  • When treating a patient who has undergone previous radiotherapy, the clinician (e.g. general practitioner or skin cancer specialist) should consult the radiation oncologist on the patient's history to ascertain the dose and location of prior radiation. (cancer.org.au)
  • The presence of advanced ovarian cancer is often suspected on clinical grounds, but it can be confirmed only pathologically by removal of the ovaries or, when the disease is advanced, by sampling tissue or ascitic fluid. (medscape.com)
  • The inflammation is first seen as erythema (skin redness), then dry desquamation (skin peeling) and finally, moist desquamation (patchy or confluent superficial ulceration). (cancer.org.au)
  • Allergies and autoimmune diseases are also possible culprits. (sdam-svou-kvartiru.ru)
  • Pharmacological control of autoimmune diseases and inflammatory processes of various origins also plays an important role in dermatological therapy: Glucocorticosteroids, immunosuppressants, biologics, cytokines and systemic immunomodulators, among others, are used here. (sdam-svou-kvartiru.ru)
  • Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined to represent a paraneoplastic syndrome. (medscape.com)
  • In this review, we have discussed the keratinization that occurs in the stratum corneum that follows mutation in the keratin gene "rare disease" pachyonychia congenital an autosomal dominant disorder or hereditary syndrome by any one of a missense mutation in keratin genes such as KRT6A, KRT6B, KRT16 and KRT17. (ijpsr.com)
  • The vulvar squamous epithlium contains large cells with pale blue cytoplasm consistent with extramammary Paget disease. (surgpath4u.com)
  • Sandu N. Extramammary Paget Disease: eMedicine. (surgpath4u.com)
  • Herpes simplex is a viral disease caused by Herpes simplex viruses . (wikidoc.org)
  • Skin Manifestations. (edu.au)
  • There is limited treatment for this disease, only for the clinical manifestations. (ijpsr.com)
  • While the compound microscope had been invented approximately 150 years prior, Virchow was one of the first prominent physicians to emphasize the study of manifestations of disease which were visible only at the cellular level. (bionity.com)
  • In the broadest sense, nearly all research which links manifestations of disease to identifiable processes in cells, tissues, or organs can be considered experimental pathology. (bionity.com)
  • Infectious diseases of the external ear have been covered in other articles and are not discussed here. (medscape.com)
  • The primary stage classically presents with a single chancre (a firm, painless, non-itchy skin ulceration ) but there may be multiple sores. (ipfs.io)
  • A new technique has been presented that results in an acceleration of delayed primary healing with full thickness skin and subcutaneous tissue coverage. (who.int)
  • As new research techniques, such as electron microscopy, immunohistochemistry , and molecular biology have expanded the means by which biomedical scientists can study disease, the definition and boundaries of investigative pathology have become less distinct. (bionity.com)
  • Lichen planus is an inflammatory disease that affects the skin and the mouth. (wikidoc.org)
  • A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. (edu.sa)
  • Atherosclerosis is a disease affecting arterial blood vessels and it can cause changes to the nail beds. (wikidoc.org)
  • A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. (lookformedical.com)
  • An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
  • However, the density with which the skin is covered with sweat glands varies greatly from area to area. (lifeafterjob.com)
  • Another difference is that these sweat glands are only found in certain areas of the skin, including genital organs, nipples and armpits. (lifeafterjob.com)
  • Important diseases of the sweat glands primarily affect the quantity of secreted fluid: If there is no sweat production at all, this is called Anhidrosis but if it is increased, there is one Hyperhidrosis in front. (lifeafterjob.com)
  • CONCLUSION: We seek to highlight the need for screening for CMYP13 in patients expressing the typical phenotype of the disease even in the absence of Lumbee Native American ancestry, and to raise awareness to possible complications like malignant hyperthermia in Bailey-Bloch congenital myopathy. (bvsalud.org)
  • Patients suffering from the systemic form of lupus require special attention from dermatologists to manage their chronic disease. (sdam-svou-kvartiru.ru)
  • SYN: Curling u.. decubitus u. a chronic u. that appears in pressure areas of skin overlying a bony prominence in debilitated patients confined to bed or otherwise immobilized, due to a circulatory defect. (theodora.com)
  • The majority of NB patients present with high-risk disease for which current therapies are ineffective. (jcancer.org)
  • While patients with low and intermediate risk disease have an excellent prognosis, most patients present with metastatic high-risk disease. (jcancer.org)
  • Irritable bowel syndrome in patients with virus type 1-infected patients with periodontal disease. (delvv.com)
  • Physical findings are uncommon in patients with early disease. (medscape.com)
  • Patients with more advanced disease may present with ovarian or pelvic mass, ascites, pleural effusion, or abdominal mass or bowel obstruction. (medscape.com)
  • [ 1 ] The disease usually manifests in childhood and is more commonly observed in families with a history of asthma, allergic rhinitis , and other atopic disorders. (medscape.com)
  • Childhood and adolescent tracheobronchial mucoepidermoid carcinoma (MEC): a case-series and review of the literature. (uchicago.edu)
  • Skin cancers are also common and usually located in sun-exposed areas. (medlineplus.gov)
  • Loss of nasal mass is mainly caused by resection of skin cancers. (rbcp.org.br)
  • Some systemic diseases lead to a variety of clinical pictures, which also or mainly manifest themselves on the skin. (sdam-svou-kvartiru.ru)
  • Acanthosis nigricans (AN) manifests as a hyperpigmented, velvety thickening of the skin that usually occurs in the intertriginous zones, including the axillae, groin, neck, and inframammary folds. (medscape.com)
  • This disease shows hypertrophic dystrophy in toenails and fingernails, plantar keratoderma, oral leukokeratosis, cysts, and follicular hyperkeratosis in the hair follicles. (ijpsr.com)
  • Digital clubbing is a deformity of the fingers and fingernails that is associated with a number of diseases, mostly of the heart and lungs. (wikidoc.org)
  • Keratin 16 is a type I intermediate filament protein present on the tongue, hair follicle and a part of glabrous skin 1 . (ijpsr.com)
  • [3] While secondary disease is known for the many different ways it can manifest, symptoms most commonly involve the skin, mucous membranes , and lymph nodes . (ipfs.io)
  • It presents typically as a solitary erythematous patch with excoriations and accentuated skin markings, which are caused by prolonged and repeated scratching. (jcadonline.com)
  • Carcinoma, Mucoepidermoid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Carcinoma, Hepatocellular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • Upon examination, some persons only manifested discrete, small, skin-coloured growths, while the proband manifested an expansion of multiple large growths on the nose and numerous dome-shaped papules on the scalp. (medscape.com)
  • Lichen planus is an inflammatory disease that affects the skin and the oral mucosa . (wikidoc.org)