Disease tumors cell cycle. Medical search. Frequent questions

Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. (mdpi.com)
The tumor microenvironment (TME) promotes BCSC survival and cancer progression, and targeting the TME can aid in successful immunotherapy. (hindawi.com)
DNA sequencing in men with metastatic castration-sensitive prostate cancer revealed alterations in certain signaling pathways that predict worse overall survival and shorter progression time to castration-resistant disease. (oncologynurseadvisor.com)
Metabolic reprogramming plays an important role in tumor progression and antitumor immunity. (medsci.org)
Mice lacking the tumor suppressors p16(Ink4a) (Cdkn2a, cyclin-dependent kinase inhibitor 2a), p19(Arf) (an alternative reading frame product of Cdkn2a,), and p27(Kip1) (Cdkn1b, cyclin-dependent kinase inhibitor 1b) result in malignant progression of epithelial cancers, sarcomas, and melanomas, respectively. (koreamed.org)
Participant must have radiographic evidence of disease progression based on RECIST criteria following the most recent line of treatment. (uclahealth.org)
Biochemical recurrence (eg, CA-125 in ovarian carcinoma) only is not considered as disease progression. (uclahealth.org)
Platinum-resistant disease, defined as progression or relapse within 6 months after the completion of platinum-based therapy, is eligible. (uclahealth.org)
Platinum sensitive disease, defined as disease which progress after 6 or more months after the completion of platinum-based therapy and primary platinum refractory disease, defined as progression while on the upfront platinum-based therapy, is not eligible. (uclahealth.org)
While some patients experience spontaneous regression or differentiation of the tumor, others are affected by rapid and fatal tumor progression despite increasingly intensive treatment strategies [ 9 ]. (biomedcentral.com)
T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
We find that the circadian clock drives rhythms in components of the cell cycle, which provides a mechanism for effects of circadian disruption on cancer progression. (irbbarcelona.org)
This effect is mediated by downregulation of the key cell cycle progression factors cyclin B1, cyclin D1, CDK1, CDK4, and survivin, the latter also constituting an essential inhibitor of apoptosis, underlying additionally the onset of apoptosis. (uandes.cl)
These ANN ment, cell-cycle progression, drug treat- with different dyes. (lu.se)
Of course we refer models were trained using 63 SRBCT ment or disease progression. (lu.se)
Important steps during cancer progression are tumor growth and subsequent metastasis. (umassmed.edu)
MCCB researchers focus on a number of different steps in tumor progression and metastasis, using both disease and developmental models. (umassmed.edu)
The lab aims to elucidate advantages these metabolic alterations can play in the growth and progression of tumors, and how these changes can be exploited to selective target cancer cells, such as selectively inducing the accumulation of toxic metabolites to poison cancer cells within the tumor. (umassmed.edu)
The Mercurio group is interested in the initiation and progression of epithelial-derived tumors (carcinomas), especially aggressive, poorly differentiated tumors. (umassmed.edu)
Two highly homologous master kinases, the tumour suppressors ATM and ATR (Tel1 and Mec1 in yeast), coordinate cell cycle progression with repair during HR. Despite their importance, our molecular understanding of these apical coordinators has been limited, in part due to their large sizes. (imperial.ac.uk)
Here, cycles of fasting for 2 days in the absence of other treatments are shown to delay the progression of several tumor types in mice and, in some cases, to be as effective as toxic chemotherapy drugs. (kingdomfasting.com)
However, the combination of fasting and chemotherapy was much more effective than either alone and delayed the progression of a variety of tumors, including breast cancer and glioma, reduced the number of organs affected by melanoma metastases, and promoted long-term cancer-free survival in up to 40% of mice with neuroblastomas. (kingdomfasting.com)
In mice injected with human breast and ovarian cancer cells, fasting cycles promoted survival extension by protecting the mice from chemotherapy while causing a strong inhibition of tumor progression. (kingdomfasting.com)
Cycles of starvation were as effective as chemotherapeutic agents in delaying progression of different tumors and increased the effectiveness of these drugs against melanoma, glioma, and breast cancer cells. (kingdomfasting.com)
However, to the best of our knowledge whether frankincense, pine needle and geranium essential oils have any effect on the progression of BC in MCF-7 cells remains unclear. (spandidos-publications.com)
Further data demonstrated that frankincense, pine needle and geranium essential oils induced apoptosis, but did not affect cell cycle progression. (spandidos-publications.com)
In conclusion, the present study indicated that frankincense, pine needle and geranium essential oils were involved in the progression of BC cells possibly through the AMPK/mTOR pathway. (spandidos-publications.com)
However, whether frankincense, pine needle and geranium essential oils have any effect on progression of BC in MCF-7 cells remains unclear. (spandidos-publications.com)
CCN5 is a matricelluar protein, which has a role in cell proliferation, angiogenesis, and progression of certain cancers. (tufts.edu)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
The presence of metastatic disease in 15% of the MCA/MWCNTexposed mice compared to 1.6% in the MCA-exposed group suggests that carbon nanotube s also induce cancer progression. (cdc.gov)
The presentation will include a discussion of the mechanism of MWCNT-induced tumor promotion and progression as well as work in progress to examine the dose response of MWCNT-induced tumor promotion. (cdc.gov)
Thankfully, there was no progression of disease on therapy. (medscape.com)

These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors. (ukessays.com)
Through these processes, the SMARCB1 protein and other SWI/SNF subunits are thought to act as tumor suppressors. (goldenhelix.com)
However, the Bergmann Lab has discovered a novel class of tumor suppressor genes: non-autonomous tumor suppressors. (umassmed.edu)
Hinck's lab has identified a family of cellular proteins that help regulate cell proliferation and migration and act as breast tumor suppressors. (ucsc.edu)

Heterozygous mutation of Trp53 decreases p53 and results in attenuated apoptosis and G1-S checkpoint control, allowing Brca1Delta11/Delta11 cells to proliferate. (nih.gov)
describe the impact of human papillomaviruses on cell cycle and apoptosis. (cdc.gov)
If a cell has an error in its DNA that cannot be repaired, it may undergo self-destruction ( apoptosis ). (medlineplus.gov)
Apoptosis is a common process throughout life that helps the body get rid of cells that no longer work or that it doesn't need. (medlineplus.gov)
Apoptosis protects the body by removing genetically damaged cells that could lead to cancer, and it plays an important role in the development of the embryo and the maintenance of adult tissues. (medlineplus.gov)
Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
In contrast, no significant alteration of apoptosis in the BCa cells with downregulated LAPTM5 was noticed. (spandidos-publications.com)
ASncmtRNA knockdown with an antisense oligonucleotide induces massive apoptosis in tumor cell lines, without affecting healthy cells. (uandes.cl)
This work adds to the elucidation of the molecular mechanisms behind cell cycle arrest preceding tumor cell apoptosis induced by ASncmtRNA knockdown. (uandes.cl)
Normally, cells which have lost a classical tumor suppressor gene become highly proliferative and resistant to apoptosis, thus permitting autonomous tumor growth. (umassmed.edu)
TRAIL, Tumor necrosis factor Related Apoptosis Inducing Ligand). (uni-muenchen.de)
As described in the literature, wildtype p53 leaded to an increase in intrinsic cell death, whereas different p53 mutations reduced apoptosis. (uni-muenchen.de)
As a next step we studied the influence of cell cycle arrest induced by p53 activation on TRAIL apoptosis sensitivity (Ehrhardt/Wachter et al. (uni-muenchen.de)
2013). Cell cycle arrest was induced in tumor cell lines and patient samples in G0, G1 or G2 with cytostatic drugs, phase-specific inhibitors or RNA interference against cyclinB and E. Molecular or biochemical arrest at any point of the cell cycle augmented the rate of apoptosis by TRAIL. (uni-muenchen.de)
The extrinsic apoptosis by TRAIL was increased in senescent tumor cells. (uni-muenchen.de)
The impact of the p53 status of tumor cells on extrinsic apoptosis signaling should be considered, especially in the context of therapeutic approaches that aim to restore p53 function to enable cell death. (uni-muenchen.de)
In 4T1 breast cancer cells, short-term starvation resulted in increased phosphorylation of the stress-sensitizing Akt and S6 kinases, increased oxidative stress, caspase-3 cleavage, DNA damage, and apoptosis. (kingdomfasting.com)
Consistent with the in vitro activities, frankincense essential oil was effective in inhibiting tumor growth and inducing tumor cell apoptosis in a human BC mouse model. (spandidos-publications.com)
Moreover, it was also reported that extracts from pine needle inhibited apoptosis of the normal cells induced by a hydroxyl radical ( 11 ). (spandidos-publications.com)
Moreover, we elucidated the regulatory AMPK/mTOR pathway involving essential oils in BC cell proliferation, invasion and apoptosis development. (spandidos-publications.com)
In other situations the response is cell cycle arrest or programmed cell death (apoptosis), providing a barrier to further tumour development that the tumour may ultimately circumvent through the acquisition of a mutation in one of the genes within the stress-response pathway. (southampton.ac.uk)
Normally, these cells are eliminated by apoptosis. (medscape.com)
The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
A recent paper from this study concerning apoptosis and cell cycle control genes identified caspase 8 as a possible susceptibility gene. (cdc.gov)

Interestingly, the 1p36 region is frequently deleted not only in NB, but also in other human cancer types, including those of neural, epithelial and hematopoietic origin, indicating that the same tumor suppressor genes might be involved in a broad range of human cancers [ 11 ]. (biomedcentral.com)
1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
Metastasis suppressor genes inhibit one or more steps required for metastasis without affecting primary tumor formation. (umassmed.edu)
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

About 8% of cases are hereditary, and approximately half of these are associated with germline mutations of the breast tumor suppressor gene BRCA1 (refs. (nih.gov)
There are an increasing number of reports showing that mutations in the ATG genes were identified in various human diseases such as neurodegenerative diseases, infectious diseases, and cancers. (nature.com)
Here, we review the major advances in identification of mutations or polymorphisms of the ATG genes in human diseases. (nature.com)
Similarly, in 112 osteosarcomas who underwent exome or whole genome sequencing, another report found a median of 38 mutations per tumor. (biomedcentral.com)
Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers. (koreamed.org)
Cancer is a complex genetic disease caused by abnormal alteration (mutations) in DNA sequences that leads to dyregulation of normal cellular processes thereby driving tumor growth. (intechopen.com)
Herein we selected a Mendelian genetics form of familial cancer such as hereditary tumor syndromic endocrine neoplasias caused by highly penetrant germline mutations leading to pheochromocytoma-paraganglioma syndromes. (intechopen.com)
Multiple endocrine neoplasia syndrome type 1 (MEN-1), loss-of-function germline mutations in the tumor suppressor gene MEN1 increase the risk of developing pituitary, parathyroid and pancreatic islet tumors, and less commonly thymic carcinoids, lipomas and benign adrenocortical tumors. (intechopen.com)
In the case of multiple endocrine neoplasia type 2 (MEN 2), gain-of-function germline mutations clustered in specific codons of the RET proto-oncogene increase the risk of developing medullary thyroid carcinoma (MTC), phaeochromocytoma and parathyroid tumors. (intechopen.com)
Although most mutations in SMARCB1 primarily occur de novo, familial cases have been reported and if inherited leads to a condition called rhabdoid tumor predisposition syndrome (RTPS). (goldenhelix.com)
During tumor growth, normal cellular pathways that prevent growth and protect genome integrity are often blocked due to mutations. (umassmed.edu)
Angela Brooks is developing computational and experimental approaches to determine which mutations in cancer cells are functionally important. (ucsc.edu)
Mutations leading to colony-stimulating factor-1 receptor (CSF-1R) loss-of-function or haploinsufficiency cause CSF1R-related leukoencephalopathy (CRL), an adult-onset disease characterized by loss of myelin and neurodegeneration, for which there is no effective therapy. (bvsalud.org)
However, familial studies have identified a few carriers of pathogenic CSF1R mutations that remain asymptomatic even in their seventh decade of life, raising the possibility that the development and severity of disease might be influenced by environmental factors. (bvsalud.org)

Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
This includes the analysis of genes in germline stem cell proliferation and differentiation. (ncl.ac.uk)
MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 in BCa cells. (spandidos-publications.com)
Furthermore, previous studies suggested that knockdown of LAPTM4B , another important subtype of the LAPTM family inhibited proliferation of hepatocellular carcinoma ( 11 ), prostate ( 12 ) and breast cancer cells ( 13 ). (spandidos-publications.com)
Apoptotic death is preceded by proliferation blockage, suggesting that these transcripts are involved in cell cycle regulation. (uandes.cl)
Our results suggest that ASncmtRNA targeting blocks tumor cell proliferation through reduction of essential cell cycle proteins, mediated by mitochondrial and nuclear miRNAs. (uandes.cl)
Instead, the mutant cells influence the behavior of neighboring wild-type (non-mutant) cells and promote their proliferation and increased apoptotic resistance, causing non-autonomous overgrowth. (umassmed.edu)
In the present study, we assessed the possible effects of frankincense, pine needle and geranium essential oils on cell viability, proliferation, migration and invasion as well as the possible mechanisms. (spandidos-publications.com)
In the present study, we clearly revealed that frankincense, pine needle and geranium essential oils suppressed cell viability, proliferation, migration and invasion in human BC MCF-7 cells. (spandidos-publications.com)
Major factors that may contribute to the proliferation of the leiomyoma are the decrease in the protein CCN5 and the expression of the gene HBP1--both of which are components of the Wnt signaling pathway, a fundamental pathway in normal development and in disease. (tufts.edu)
We have also developed interests in other pathways which regulate gene transcription and cancer cell proliferation in response to stress and changes in cell metabolism. (southampton.ac.uk)
Role of CtBP transcriptional repressors in cancer cell proliferation and survival In common with p53, CtBP1 and CtBP2 proteins were discovered through their physical association with a viral oncoprotein. (southampton.ac.uk)

When the cell cycle proceeds without control, cells can divide without order and accumulate genetic errors that can lead to a cancerous tumor . (medlineplus.gov)
Genetic abnormalities associated with MDS block differentiation of hematopoietic stem and progenitor cells. (medscape.com)
Thus, it has become particularly important to understand the genetic basis of putative human autophagy-related diseases. (nature.com)
With the completion of the Human Genome Project in 2003 and the International HapMap Project in 2005, researchers now have a powerful set of research tools, including the high-speed DNA sequencing technology that make it possible to identify the genetic contributions to specific diseases, even if they are rare. (nature.com)
Table 1 summarizes the association between genetic variants of autophagy-related genes and selected human diseases. (nature.com)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
Our MPhil, MD and PhD in Genetics look at the causes of genetic disease. (ncl.ac.uk)
We explore genetic disease at the molecular and cellular level and its treatment. (ncl.ac.uk)
This is to identify mechanisms where genetic variability contributes to developing cardiovascular disease. (ncl.ac.uk)
We work on large scale studies on the genetic basis of common diseases with complex causes. (ncl.ac.uk)
To understand how B-Raf itself is regulated, we combined mass spectrometry with genetic approaches to map its interactome in MCF-10A cells as well as in B-Raf deficient murine embryonic fibroblasts (MEFs) and B-Raf/Raf-1 double deficient DT40 lymphoma cells complemented with wildtype or mutant B-Raf expression vectors. (uni-wuerzburg.de)
Considering this genetic defect and the frequent genomic alterations of the NBPF1 locus in several cancer types, we hypothesized that NBPF1 is a tumor suppressor. (biomedcentral.com)
The dysregulation results genetic mutation related diseases. (ukessays.com)
Besides cancer, some miRNAs genes cause or contribute in many inherited and genetic based diseases. (ukessays.com)
As miRNAs proposed to control the expression up to one third of all genes and possibly utilised as diagnostic and prognostic marker for many genetic based diseases. (ukessays.com)
Recent high-impact research has shown the genomic/genetic differences between cancer and normal cells using methods such as next-generation sequencing [ 1 , 2 ]. (intechopen.com)
Malignant transformation of germ cells is the result of a multistep process of genetic changes. (medscape.com)
An important development in cancer research over the past 2 decades has been the recognition that genetic changes drive the pathogenesis of tumors of both adulthood and childhood. (medscape.com)
An international consortium of brain tumor epidemiological studies (BTEC) was organized so that brain tumor risks associated with genetic susceptibility and specific exposures can be evaluated in the combined studies. (cdc.gov)

Multicellular organisms, especially long-living animals, face the challenge of cancer, which occurs when cells fail to regulate their growth within the normal program of development. (wikipedia.org)
The main reason is that the regulation mechanism of the tumor cell cycle is damaged, which leads to uncontrolled cell growth. (hindawi.com)
How do genes control the growth and division of cells? (medlineplus.gov)
A variety of genes are involved in the control of cell growth and division. (medlineplus.gov)
explains the growth of cancerous tumors. (medlineplus.gov)
More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
The T category informs about tumor growth, depth and stage of adjacent tissues invasion. (biorxiv.org)
1500 cells/µL without growth factor support within 1 week prior to obtaining the hematology values at Screening. (uclahealth.org)
Decreased expression of NBPF1 in neuroblastoma cell lines with loss of 1p36 heterozygosity and the marked decrease of anchorage-independent clonal growth of DLD1 colorectal carcinoma cells with induced NBPF1 expression further suggest that NBPF1 functions as tumor suppressor. (biomedcentral.com)
1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
Furthermore, we established a BCa cell model with downregulated LAPTM5, revealing a significantly delayed growth rate in the BCa cells with knockdown of LAPTM5. (spandidos-publications.com)
Moreover, cell cycle arrest at G0/G1 phase was triggered by decreased LAPTM5 as well, which could lead to delayed BCa cell growth. (spandidos-publications.com)
As proof-of-concept, we show that in vivo knockdown of ASncmtRNAs results in drastic inhibition of tumor growth in a xenograft model of MDA-MB-231 subcutaneous tumors, further supporting this approach for the development of new therapeutic strategies against breast cancer. (uandes.cl)
Genetically, MRTs typically demonstrate abnormalities in the SMARCB1 gene located on chromosome 22, which influences the SWI/SNF chromatin remodeling complex that is involved in regulating cell cycle, growth, and differentiation (2). (goldenhelix.com)
As the tumor grows, hypoxia induces the expression of growth factors that stimulate blood vessel formation into and around the tumor, further promoting growth. (umassmed.edu)
It works by slowing or stopping the growth of cancer cells. (guidechem.com)
Its mechanism of action involves slowing or halting the growth of cancer cells. (guidechem.com)
The therapy causes DNA breaks, inhibiting DNA replication and shutting down the cell cycle to prevent tumour growth. (pharmaceutical-technology.com)
The mechanisms by which cells control their growth and size are poorly understood and represent a fundamental unsolved problem in cell biology. (ucsc.edu)
Doug Kellogg's lab is working to elucidate these mechanisms, using biochemistry, genetics, and mathematical modeling to understand signaling networks that are required for control of cell size and cell growth. (ucsc.edu)
The first suggests that fetal gonocytes whose development into spermatogonia is blocked may undergo abnormal cell division and then invasive growth mediated by postnatal and pubertal gonadotrophin stimulation. (medscape.com)
A subsequent in vivo multiwalled carbon nanotube (MWCNT) whole body inhalation exposure study further demonstrated that MWCNTs promoted the growth of DNA damaged (initiated) lung cells to form lung adenomas and adenocarcinomas. (cdc.gov)
The protein is involved in cellular growth and development and has an important role in regulating the cell cycle. (msdmanuals.com)
In the pituitary, adrenocorticotropic hormone-producing adenomas are the most common tumor (33%), whereas tumors that secrete prolactin (24%) or growth hormone (19%) are slightly less common. (msdmanuals.com)
In addition, NV651 decreased tumour growth in xenograft-mouse model. (lu.se)
For example, in addition to promoting sleep, melatonin can also stop tumor growth and protect against the spread of cancer cells. (cdc.gov)
Laboratory animals whose days and nights were disrupted in scientific experiments had reduced levels of melatonin and increased rates of cancer or tumor growth. (cdc.gov)

Additionally, forced expression of NBPF1 in two p53-mutant neuroblastoma cell lines also resulted in a G1 cell cycle arrest and CDKN1A upregulation. (biomedcentral.com)
In mouse models of neuroblastoma, fasting cycles plus chemotherapy drugs-but not either treatment alone-resulted in long-term cancer-free survival. (kingdomfasting.com)
We could confirm the increased polyploidy upon Mps1 inhibition in neuroblastoma cell lines and PDX model, leading to mitotic catastrophe activating the caspase-dependent mitochondrial apoptotic pathway. (lu.se)

Due to the large tumor load in advanced patients, drug resistance is easy to occur during chemotherapy. (hindawi.com)
Therefore, improving the early diagnosis rate, chemotherapy drug sensitivity, reducing tumor recurrence, and improving disease prognosis are the focus of diagnosis and treatment research at the present stage [ 8 , 9 ]. (hindawi.com)
Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
BCSCs can develop into many cell types and repopulate heterogeneous tumors following conventional chemotherapy or radiotherapy [ 4 , 6 ]. (hindawi.com)
Although clinical trials testing the effect of fasting in cancer treatment are still in the early stages, they suggest that fasting cycles may boost the efficacy of chemotherapeutic agents and could be as effective as chemotherapy drugs in the killing of specific tumor cells. (kingdomfasting.com)
Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. (kingdomfasting.com)
These studies suggest that multiple cycles of fasting promote differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy of certain chemotherapy drugs in the treatment of various cancers. (kingdomfasting.com)
Finally, it is not known whether DR would also protect cancer cells from chemotherapy. (kingdomfasting.com)
Chemotherapy is the choice of treatment for multicentric lymphoma, approximately 70% to 95% of the cases achieve remission, period in which the patients do not present signs of disease, and because in most of the cases chemotherapy is well tolerated, a good quality of life is maintained during the remission time. (vin.com)
This resistance may be present because of the emergence of tumor cells that are more inherently resistant to chemotherapy. (vin.com)
Anticipated to undergo 3 cycles of chemotherapy (solid tumour cancer participants) OR autologous stem cell transplantation (haematological cancers - HSCT participants). (who.int)
Timing of intervention: Solid tumours - from mucositis daily questionnaire (MDQ) score >1 in first cycle of chemotherapy to end of cycle 3. (who.int)
Gut distress determined by the Mucositis Daily Questionnaire (MDQ) for up to 3 cycles of chemotherapy and calculated as area under the curve and adjusted per cycle (AUC MDQ/cycle) [The MDQ is assessed daily for the duration of each treatment cycle up to a maximum of 3 full cycles. (who.int)
AUC for solid tumour patients will be assessed over the 3rd full cycle of chemotherapy after starting medicinal cannabis. (who.int)

Tight regulation of this process ensures that a dividing cell's DNA is copied properly, any errors in the DNA are repaired, and each daughter cell receives a full set of chromosomes. (medlineplus.gov)
Disruption of normal regulation of the cell cycle can lead to diseases such as cancer. (medlineplus.gov)
studies on cell cycle regulation and genome instability. (ncl.ac.uk)
We investigated by real-time quantitative RT-PCR the expression profile of a panel of genes important in cell cycle regulation. (biomedcentral.com)
1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
A large number of experimental studies show that the mutation and regulation of long non-coding RNAs (lncRNAs) are associated with various human diseases. (biomedcentral.com)
Long non-coding RNAs (lncRNAs) play an increasingly important role in some fundamental biological processes such as translational regulation, cell cycle regulation, epigenetic regulation, splicing, differentiation, and immune response [ 5 ]. (biomedcentral.com)
In addition, they are investigating how cell cycle-regulation of chromatin proteins helps to coordinate the condensation of chromosomes with their segregation during mitosis. (umassmed.edu)
As a clinical-stage, biopharmaceutical company, we develop innovative cancer medicines based on cell cycle, transcriptional regulation, epigenetics and mitosis biology. (cyclacel.com)
Some Example Projects: Regulation of HDM2 and HDMX proteins The HDM2 oncoprotein is the major negative regulator of p53 function in the cell. (southampton.ac.uk)
Recent work has shown that these proteins are also involved in hormonal regulation of breast cancer cells. (ucsc.edu)

Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
Researchers in this group are identifying mechanisms that account for the loss of differentiation and the highly aggressive behavior of these tumors, and exploiting these mechanisms to improve prognosis and therapy. (umassmed.edu)
During his postdoc, he carried out research to determine the role of Kruppel-like factor 2 (KLF2) during osteoblast (OB) differentiation of dental pulp-derived stem cells (DPSC). (nih.gov)
During the cellular differentiation process, cellular metabolism alters as the cell prepares for ongoing changes. (nih.gov)
Simultaneous measurements of glycolysis and oxidative phosphorylation in live cells revealed that OB differentiation decreased the oxygen consumption rate, which indicates reduced ATP production and mitochondrial respiration. (nih.gov)
Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)

A third hypothesis is that as a unicellular organism divided, the daughter cells failed to separate, resulting in a conglomeration of identical cells in one organism, which could later develop specialized tissues. (wikipedia.org)
Studies have found that E2F1 is highly expressed in a variety of tumor tissues and cells and plays a role of oncogenic gene [ 10 - 13 ]. (hindawi.com)
Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
But for the most part, normal tissues and 9 cell lines). (lu.se)
Subsequently, normal cell-cell interactions between the tumor and surrounding tissues and immune cells begin to breakdown, leading to invasion and eventual metastasis to distant sites. (umassmed.edu)
The Kim lab investigates how various metabolic pathways, such as amino acid biosynthesis pathways, in a tumor cell relative to normal tissues. (umassmed.edu)
Cyclophilin overexpression is a common event in fibrotic tissues playing a key role in different stages of the fibrotic process, including inflammation, hepatocyte death, and activation of the hepatic stellate cells leading to increased collagen production. (lu.se)
Stage 1B1 cervical cancer indicates that the tumor appears clinically to be confined to the tissues of the cervix, and is less than 4 cm in diameter. (cdc.gov)
Only 3 benign breast tumour tissues (12.5%) and none of the healthy breast tissue specimens were HPV-DNA-positive. (who.int)

Abstract: Uterine leiomyoma, frequently known as fibroid, is a benign smooth muscle tumor that occurs in women between the ages of 30-55 years old. (tufts.edu)
As you know, at around the time, almost 10 years ago, some of these neoadjuvant trials had not mandated biopsy, so we had patients with benign tumors or different types of histologies. (medscape.com)

Western blotting validated the anti-inflammatory effects of melatonin by downregulating interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels via the extracellular regulated kinase (ERK)/nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 (HO-1) signaling pathway. (biomedcentral.com)

Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. (biorxiv.org)

enumerate the multiple, distinct receptor homologs and binding proteins encoded by poxviruses that target tumor necrosis factor. (cdc.gov)
Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. (springer.com)
In addition, proteome analysis of NBPF1-overexpressing DLD1 cells identified 32 differentially expressed proteins, of which several are implicated in carcinogenesis. (biomedcentral.com)
We demonstrated that NBPF1 exerts different tumor suppressive effects, depending on the cell line analyzed, and provide new clues into the molecular mechanism of the enigmatic NBPF proteins. (biomedcentral.com)
To achieve this ordering, many cell cycle-regulatory proteins are expressed exclusively when their functions are needed. (umassmed.edu)
These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)

No single epidemiological study of brain tumors has adequate statistical power to evaluate most gene-environment or gene-gene interactions. (cdc.gov)

A study of 424 patients with mCSPC treated at a tertiary care center revealed that alterations in the androgen receptor (AR), TP53, cell-cycle, MYC oncogenic signaling pathways occur more commonly in tumors with worse overall survival and decreased time to castration-resistant disease, whereas alterations in the SPOP and MNT pathways occur more frequently in tumors with a better prognosis, according to findings published in Clinical Cancer Research . (oncologynurseadvisor.com)
Among men with high-volume disease, the highest-ranking pathways were the NOTCH, cell-cycle, and epigenetic modifiers pathways. (oncologynurseadvisor.com)
After adjusting for disease volume and other genomic pathways, the researchers found that the rates of castration resistance differed by 1.5-fold and up to 5-fold according to alterations in the AR, SPOP (inverse), TP53, cell-cycle, WNT (inverse), and MYC pathways. (oncologynurseadvisor.com)
Overall survival (OS) rates varied from 2- to 4-fold according to alterations in the AR, SPOP (inverse), WNT (inverse), and cell-cycle pathways. (oncologynurseadvisor.com)
GSEA analysis found STARD12 and STARD14 were associated with glycolysis, oxidative phosphorylation and tumor related signaling pathways. (medsci.org)
In single celled organisms these pathways are generally involved in ensuring the survival and replication of the individual cell. (southampton.ac.uk)
Stress-response pathways play a key role in the patho-physiology and treatment of many diseases, including cancer.At almost every stage of the development of a tumour, cells are exposed to some form of stress. (southampton.ac.uk)
Many current and prospective treatments for cancer work by either inhibiting, or re-activating stress response pathways.Our work focuses on the role of regulators of gene transcription in the response of cancer cells to stress. (southampton.ac.uk)
A particular interest of our work has been how HDM2 and HDMX protein synthesis is controlled in response to cell-signalling pathways in different cell types, and how this affects p53 function in these cells. (southampton.ac.uk)
Several pathways involved in cell cycle and DNA repair were affected upon NV651 treatment. (lu.se)

Participant must have at least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 criteria (by local Investigator) (Eisenhauer, 2009). (uclahealth.org)
A pair of studies presented at the AACR Annual Meeting 2019 demonstrated encouraging clinical outcomes with two different chimeric antigen receptor (CAR) T-cell therapies for patients with advanced solid tumors. (aacr.org)
Given the success of CAR T-cell therapies for blood cancers, the most anticipated next step in the field is the development of this type of immunotherapy for solid tumors. (aacr.org)
Developing CAR T-cell therapies for solid tumors, however, has been challenging, and researchers in the field have had several failed attempts. (aacr.org)
This recent review article summarizes the challenges with developing CAR T-cell therapy for solid tumors and strategies to overcome the hurdles, and lists some of the ongoing clinical trials in which CAR T cells that target tumor antigens, including GD2, CEA, and EGFR, are being currently tested against a variety of solid tumors. (aacr.org)
Data presented here at the conference have demonstrated that it is possible to develop CAR T-cell therapies for solid tumors that are not only safe but also yield clinical benefit for patients. (aacr.org)
If this approach is successful, 2 million patients with mesothelin-expressing solid tumors per year in the United States will be eligible for this treatment," said Prasad S. Adusumilli, MD , who presented the study. (aacr.org)
This article in Cancer Discovery reviews the types of solid tumors that express mesothelin, and the potential of mesothelin-directed CAR T-cell therapy to treat such malignancies. (aacr.org)
A Phase 1/2, Open-label, Multi-center Study to Investigate the Safety, Pharmacokinetics, and Efficacy of Fadraciclib (CYC065), an Oral CDK2/9 Inhibitor, in Subjects with Advanced Solid Tumors and Lymphoma. (cyclacel.com)
We had, I believe, 11 out of 24 patients with a partial response - about 46% of patients who had a partial response by the response evaluation criteria in solid tumors (RECIST) criteria - which was quite encouraging, with a relatively short duration of therapy. (medscape.com)

Although hundreds of genes are known to be mutated in cancers our understanding of mutational events in cancer cells remains incomplete ( Futreal PA et al, 2004 ). (intechopen.com)
The case studies on six diseases, including cancers and non-cancers, further demonstrate the effectiveness of our method in real-world applications. (biomedcentral.com)
The U.S. Food and Drug Administration has approved two CAR T-cell therapies for blood cancers so far: tisagenlecleucel (Kymriah) for treating certain patients with acute lymphoblastic leukemia or non-Hodgkin lymphoma (NHL), and axicabtagene ciloleucel (Yescarta) for treating certain adults with NHL. (aacr.org)
The p53 tumour suppressor protein is a key component of one such stress-response pathway, and virtually all cancers loose functionality of the p53-stress response pathway. (southampton.ac.uk)
This data will allow for analysis of the selected steroid hormones and related binding protein that can be used to assist in disease diagnosis, treatment, and prevention of diseases, such as Polycystic Ovary Syndrome (PCOS), androgen deficiency, certain cancers, and hormone imbalances. (cdc.gov)
Deaths from sporadic cancers (i.e. cancers for which no recognized exposure accounts for tumour development) may be prevented by screening or earlier diagnosis. (who.int)

Challenges include finding the right target to direct the T cells, the ability to expand in an often-immunosuppressive tumor microenvironment, yielding an effective antitumor response, and avoiding adverse side effects. (aacr.org)

This study aimed to explore the potential targets and molecular mechanisms of HNK on metastatic BCSC (mBCSC)-cell cycle arrest and the impact of the TME. (hindawi.com)
Recurrent tumors are highly aggressive, potentially cross-drug resistant, highly metastatic, and have a poor prognosis. (hindawi.com)
The study compared genomic alterations according to clinical phenotypes: high- vs low-volume disease and de novo vs metastatic recurrence. (oncologynurseadvisor.com)
The authors pointed out that genomic landscape studies of tumor DNA profiling in prostate cancer in general have excluded metastatic castration-sensitive tumors. (oncologynurseadvisor.com)
Instead, most studies have focus on localized disease or metastatic castration-resistant disease. (oncologynurseadvisor.com)
During EMT, cells will undergo transformation from epithelial phenotype to mesenchymal phenotype ( 14 ) and many characteristics of cells will change including loss of cell-cell adhesion and acquisition of aggressive and metastatic ability ( 15 ). (spandidos-publications.com)
Using an interventional radiology procedure, the investigators injected IcasM28z CAR T cells directly into the pleural cavity in 21 patients with malignant pleural disease (19 with malignant pleural mesothelioma, one with metastatic lung cancer, and one with metastatic breast cancer). (aacr.org)
However especially metastatic diseases and relapses still require the development of new therapeutic modalities. (uni-muenchen.de)
Treatment protocols for nonseminoma testicular cancer are provided below, including recommendations for treatment of stage I-III disease, second-line recommendations for metastatic disease, and recommendations for persistent or recurrent disease. (medscape.com)

Lymphoma and ovarian tumors also occur at lower frequencies. (nih.gov)
Tumors include Ewing sarcoma (EWS), neu- while Ewing sarcomas are aggres- roblastoma (NB), rhabdomyosarcoma (RMS) and Burkitt lym- rently used in tumor diagnosis do sive enough to warrant treatment phomas (BL, subset of non-Hodgkin lymphoma). (lu.se)

However, the molecular mechanisms of action of HNK in BCSCs, as well as its effects on the cell cycle, remain unclear. (hindawi.com)
Finally, the interaction between HNK and two HNK-targets regulating the cell cycle was analyzed using molecular docking analysis. (hindawi.com)
The patient was referred to the University of California San Diego (UCSD) Moores Cancer Center Molecular Tumor Board (MTB). (biomedcentral.com)
The identification of causal or predictive variants/genes/mechanisms for disease-associated traits is characterized by 'complex' networks of molecular phenotypes. (researchgate.net)
Using a combination of cell culture models, molecular biology approaches, and in vivo modeling, the Lewis lab is characterizing the roles of novel factors involved in tumor dissemination. (umassmed.edu)
Their research projects emphasize molecular cell biology but they derive from the analysis and clinical behavior of carcinomas. (umassmed.edu)
Dr. Jyoitirindra Maity has focused on cellular and molecular biology in rare disease models and cancer and stem cell modeling throughout his career. (nih.gov)
Cancer research at UC Santa Cruz includes faculty in a wide range of departments, including Applied Math and Statistics, Biomolecular Engineering, Chemistry and Biochemistry, Electrical Engineering, Microbiology and Environmental Toxicology, and Molecular, Cell, and Developmental Biology. (ucsc.edu)

Most patients have tumor metastasis and recurrence within 2 years, and the 5-year survival rate is 20%-40% [ 2 ]. (hindawi.com)
Breast cancer stem cells (BCSCs) play a critical role in chemoresistance, metastasis, and poor prognosis of breast cancer. (hindawi.com)
is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
The most frequent tumor suppressor miRs were miR-126, miR-199b and miR-22 and the hypoexpression of these miRs was associated with distant metastasis, worse prognosis and a higher risk of disease relapse (worse disease-free survival). (biorxiv.org)
Analysis of the changes of migration and invasion, showed significant reduced LAPTM5 suppressed cell metastasis. (spandidos-publications.com)
Increasing evidence suggested EMT was involved in cancer invasion, metastasis ( 16 ) and the malignancy of tumors ( 17 ), often marked by reduction of E-cadherin and induction of N-cadherin ( 18 ). (spandidos-publications.com)
Forced expression of HOTAIR in epithelial cancer cells induces genome-wide Polycomb repression complex 2 (PRC2) to retarget to a more similar pattern of embryonic fibroblasts, leading to gene expression changes, and increase cancer invasion and metastasis. (biomedcentral.com)

The presence of p53 in tumor cell lines and xenograft tumor cells resulted in augmented, unaffected or decreased cell death. (uni-muenchen.de)

J.C. Manson and R.M. Barron describe the diagnosis of transmissible spongiform encephalopathies, the appearance of new strains, and the nature of host susceptibility to disease. (cdc.gov)
Accurate prediction of lncRNA-disease associations can provide a new perspective for the diagnosis and treatment of diseases. (biomedcentral.com)
Furthermore, MWCNT inhalation increased the incidence of serosal tumors consistent with the diagnosis of sarcomatous mesothelioma from 2% in the MCA-exposed mice to 9% in the MCA/MWCNT, a 4.5 fold increase. (cdc.gov)
His blood center, Dr. Katz told Medscape Infectious Diseases , is developing a policy to give informational materials to all prospective donors at registration that asks them to not donate blood if they have or ever had a diagnosis of CFS. (medscape.com)

A membrane would then form around each nucleus (and the cellular space and organelles occupied in the space), thereby resulting in a group of connected cells in one organism (this mechanism is observable in Drosophila). (wikipedia.org)
These tumors are characterized by an unusual combination of mixed cellular elements similar to but not typical of teratomas and can originate at any anatomic location. (goldenhelix.com)
WRN critically regulates autophagy in various cellular stresses, including starvation, endoplasmic reticulum (ER) stress conditions to rescue the cell, and basal situations to restore proper cellular function. (nih.gov)
Examples include exposure to toxic compounds or radiation, loss of contact with other cells or the extra-cellular matrix, lack of oxygen (hypoxia), acidic pH, the activation of oncogenes, induction of cellular senescence, oxidative damage or depletion of essential metabolites. (southampton.ac.uk)
CtBP activity is modified by UV radiation and glycolytic metabolism, suggesting that CtBPs regulate cell survival in response to cellular stress. (southampton.ac.uk)
According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)

Ovarian cancer is the most fatal malignant tumor of the female reproductive tract [ 1 ]. (hindawi.com)
Anti-Müllerian hormone (AMH) or Müllerian-inhibiting substance, a dimeric glycoprotein secreted by granulosa cells of the preantral and small antral ovarian follicles. (cdc.gov)

Breast cancer stem cells (BCSCs) are one of the main factors driving chemoresistance, thereby contributing to poor prognosis and clinical outcomes [ 3 - 5 ]. (hindawi.com)
Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the miRs in order to use them in clinical practice. (biorxiv.org)
However, a fascinating feature of NB is its remarkable biological heterogeneity, which is evident in the broad variety of clinical courses of the disease. (biomedcentral.com)
In a phase I clinical trial , a team of researchers from Memorial Sloan Kettering Cancer Center tested whether mesothelin-directed CAR T cells that they developed would be safe and effective in patients with malignant pleural disease from mesothelioma and lung and breast cancer. (aacr.org)
Applying cutting-edge science to address the unmet clinical needs for infectious disease control on a global scale. (imperial.ac.uk)
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)
Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)
Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)
A second press release [2] has indicated stem cell source, resulting in widespread excitement that the program is planning to move forward very rapidly, with all of the patients being enrolled in the Correspondence to: Roger A. Barker, John van Geest Centre first quarter of 2016 and interim results being shared for Brain Repair, Department of Clinical Neurosciences, Univer- in October 2016. (lu.se)

Multiple endocrine neoplasia, type 4 (MEN 4) is an autosomal dominant syndrome characterized by adenomas and sometimes hyperplasia of the parathyroid glands and tumors of the pancreatic islet cells and/or pituitary gland. (msdmanuals.com)

Lung cancer is the first leading diagnosed malignant tumor globally [ 1 ]. (medsci.org)

Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
Here, we show that ASncmtRNA knockdown induces cell death preceded by proliferative blockage in three different human breast cancer cell lines. (uandes.cl)
The treatment also induces an increase in the microRNA hsa-miR-4485-3p, whose sequence maps to ASncmtRNA-2 and transfection of MDA-MB-231 cells with a mimic of this miRNA induces cyclin B1 and D1 downregulation. (uandes.cl)
While it is well understood that doxorubicin activates p53 and induces cell-cycle arrest, we observed that cell-cycle arrest disabled inactivation of anti-apoptotic Bcl-2-family members by vincristine. (uni-muenchen.de)

Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumor. (medscape.com)

This event explains the presence of multiple derangements observed in the bone marrow that involve several cell lineages. (medscape.com)
As the affected cell lines continue to divide and to provide the marrow with dysplastic cells, bone marrow dysfunction becomes apparent. (medscape.com)
Osteosarcoma is the most common primary bone tumor in children and young adults. (biomedcentral.com)
The classical presentation of PHPT is a clinically overt pattern of recurring nephrolithiasis associated with frank hypercalcemia and low serum phosphate, invalidating bone disease, deep weakness, and reduced life expectancy. (snmjournals.org)
Subsequently, he joined the NIAMS as a visiting postdoctoral fellow and works on translational bone tumor research related to melorheostosis disease. (nih.gov)
Cortical bone-derived stem cells (CBSCs) are reportedly essential for osteogenic lineages, bone maintenance and repair. (biomedcentral.com)
Camilla Forsberg studies how the different types of blood cells develop from hematopoietic stem cells in the bone marrow. (ucsc.edu)
Estradiol levels decline greatly with age, and this decrease is associated with increased risk for cardiovascular disease, cognitive impairment, and bone fractures in older women. (cdc.gov)

Forced expression of NBPF1 in HEK293T cells resulted in a G1 cell cycle arrest that was accompanied by upregulation of the cyclin-dependent kinase inhibitor p21 CIP1/WAF1 in a p53-dependent manner. (biomedcentral.com)
Consequently, when cell cycle arrest was deactivated by adding caffeine, the antitumor activity of TRAIL was decreased. (uni-muenchen.de)
Activation of p21 or p16 therefore causes cell cycle arrest. (medscape.com)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)

A major focus of this work is to define mechanisms that control the genesis and function of cancer stem cells with an emphasis on the role of integrin and VEGF signaling. (umassmed.edu)
The Shaw lab investigates mechanisms by which carcinoma cells acquire the ability to metastasize, with a focus on breast cancer. (umassmed.edu)
We aim to suppress mechanisms of resistance and reactivate the body's own cell death mechanisms to destroy cancer cells. (cyclacel.com)
Further analyses seek to define the Wnt signaling mechanisms and are focused on our lab's unique organotypic model of leiomyoma, in which human fibroid tumors are grown in immune-compromised mice. (tufts.edu)

However, most female Brca1Delta11/Delta11 Trp53+/- mice develop mammary tumors with loss of the remaining Trp53 allele within 6-12 months. (nih.gov)
Unlike preexisting embryonic stem cell-based knockout mice, our mouse models are free from selectable markers or other external gene insertions, permitting more precise study of cell cycle-related diseases without confounding influences of foreign DNA. (koreamed.org)
Experiments in simple organisms, human cells, and mice indicated that these effects of fasting were caused by changes inside and outside cells that increased the death of tumor but not normal cells, a process termed differential stress sensitization. (kingdomfasting.com)
By contrast, a limited exposure to a severely restricted diet (short-term starvation or fasting) can protect yeast, mammalian cells, mice, and possibly patients from the toxic effects of oxidative and chemotherapeutic agents without causing chronic weight loss (10-14). (kingdomfasting.com)
In the experimental autoimmune encephalomyelitis (EAE) model, p53 loss of function, specifically in oligodendrocytes, did not affect the EAE disease severity and had no effect on demyelination in the spinal cord of the mice. (bvsalud.org)
Tumors that developed in mice deficient in INK4A were enhanced by the topical application of carcinogens and ultraviolet light. (medscape.com)
Twenty three percent of the filtered air controls, 27% of the MWCNT-exposed, and 52% of the methylcholanthrene (MCA) followed by air-exposed mice, had a mean of 1.3, 1.3 and 1.4 lung tumors per mouse, respectively. (cdc.gov)
By contrast, 91% of the mice exposed to MCA followed by inhaled MWCNTs (MCA/MWCNT) had an average of 3.24 tumors per mouse. (cdc.gov)

1 Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 10/9N105, Bethesda, Maryland, USA. (nih.gov)
The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics. (ncl.ac.uk)

To reproduce, true multicellular organisms must solve the problem of regenerating a whole organism from germ cells (i.e., sperm and egg cells), an issue that is studied in evolutionary developmental biology. (wikipedia.org)
BMC Cell Biology, 9 , 45. (springer.com)
Cyclacel is a pioneer in the field of cell cycle biology to treat cancer. (cyclacel.com)
In June 2018, Dr. Maity became a research associate in the Vascular Biology and Stem Cell Research Laboratory in the department of Pharmaceutical Sciences at Texas Tech University Health Sciences Center, Amarillo. (nih.gov)

However, direct evidence of the connections between ATG gene dysfunction and human diseases has emerged only recently. (nature.com)
1. Artelt P, Grannemann R, Stocking C, Friel J, Bartsch J, Hauser H. The prokaryotic neomycin-resistance-encoding gene acts as a transcriptional silencer in eukaryotic cells. (koreamed.org)
We research gene expression control during development and misregulated in diseases. (ncl.ac.uk)
Because of the influence on different cell cycle processes, SMARCB1 is understood to be a tumor suppressor gene. (goldenhelix.com)
In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
The authors used artificial neural croarrays is to study changes in gene ex- .nature organ the tumor arose from, how big it networks (ANNs) to identify gene-ex- pression that accompany changes in is, and what it looks like after it has pression signatures associated with spe- cell physiology, such as during develop- been imbedded in wax and colored cific subtypes of tumors. (lu.se)
The chromosomal locus for HBP1 (7q22.3) is deleted in many fibroid tumors and HBP1 is thus a potential fibroid suppressor gene. (tufts.edu)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
The vast majority of these cells did not divide, suggesting that the transgene was indeed regulated in a similar fashion as the endogenous GFAP gene. (lu.se)

The International Germ Cell Cancer Consensus Group (IGCCCG) developed a risk classification for advanced nonseminoma testicular cancer based on identifying clinically independent prognostic features, including extent of disease and levels of serum tumor markers. (medscape.com)

MDS is a clonal disorder of myeloid stem cells. (medscape.com)

In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
In vitro genotoxicity investigations have shown that high aspect ratio carbon nanotube s induce cell cycle disruption and errors in chromosome number. (cdc.gov)

Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)

HBP1, an HMG Box transcription factor, is a cell cycle inhibitor and a transcriptional repressor of the Wnt signaling pathway. (tufts.edu)
The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
Treatment with the novel cyclophilin inhibitor NV651, presented a potent antiproliferative effect in HCC cell lines via cell cycle perturbations arresting cells in the mitotic phase. (lu.se)

J.L. Whitton gives an overview of the adaptive CD8+ T-cell immune response in the context of virus infections. (cdc.gov)
Besides, administration of concentrated extracts of Morinda citrifolia in tumor containing animals increased the immune response of the animals with a concomitant reduction in tumor burden 7 . (nature.com)
Overall, these findings highlight the potential of HNK as an immunotherapeutic agent for mBCSCs by modulating the tumor immune environment. (hindawi.com)
STARD14 was negatively associated with the infiltration of CD8+T cells, while positively with CCL28 and immune checkpoints, including CTLA4 as well as PD-L2. (medsci.org)
LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
In-depth biological analysis of connected genes in ANDnet and XORnet revealed genes that are related to energy metabolism, cell cycle control (AATF), immune system response, and several cancer types. (researchgate.net)

Finally, although XMRV was initially discovered in tumor tissue of a subset of patients with prostate cancer (according to results published in March 2006 in PLoS Pathogens ), other studies have had varied results in finding the virus in prostate tumors. (medscape.com)

It is beneficial in the therapy of patients with coronary heart disease (CHD), neurodegenerative disorders and carcinoma. (spandidos-publications.com)
To explain the origin of occult carcinoma in situ cells, 2 models have been proposed. (medscape.com)
[ 3 ] This abnormality is found in occult carcinoma in situ lesions as well as more advanced disease. (medscape.com)
What's New in the Field of Neoadjuvant Therapy and Renal Cell Carcinoma? (medscape.com)
Welcome to season 2 of Medscape's InDiscussion series on renal cell carcinoma (RCC). (medscape.com)

G. Screaton and J. Mongkolsapaya explain potential roles of T-cell responses in dengue hemorrhagic fever. (cdc.gov)

I was actually surprised there were not more dramatic genomic differences between de novo and relapsed disease," said study co-senior author Philip Kantoff, MD, a medical oncologist and Chair of the Department of Medicine at Memorial Sloan Kettering Cancer Center in New York. (oncologynurseadvisor.com)
We did not find any obvious genomic reason to explain the differences in docetaxel sensitivity between high- and low-volume disease," Dr Kantoff said. (oncologynurseadvisor.com)
The cell carrying this abnormality is relatively protected against apoptotic death because of the oncogenic effect of CCND2, leading to re-initiation of cell cycle and genomic instability. (medscape.com)

Colorectal cancer (CRC) is a multifactorial disease commonly diagnosed worldwide, with high mortality rates. (biorxiv.org)

Although MEN 4 involves the same primary organs as MEN 1 (parathyroids, pancreas, and pituitary), patients tend to present later in life and have a more indolent course of disease than those with MEN 1. (msdmanuals.com)

review our current understanding of the pathogenesis of Ebola and Marburg filoviruses, paying particular attention to the factors that contribute to lethal disease. (cdc.gov)
C. Dye and S. Siddell discuss the pathogenesis of feline coronavirus, an animal disease model that has provided insights into the study of the newly recognized disease, severe acute respiratory syndrome. (cdc.gov)
However, these experimental results do not directly demonstrate that defects in autophagy contribute to pathogenesis of human diseases. (nature.com)

In other groups, generally parasites, a reduction of multicellularity occurred, in number or types of cells (e.g., the myxozoans, multicellular organisms, earlier thought to be unicellular, are probably extremely reduced cnidarians). (wikipedia.org)
The patient's tumor showed 68% reduction in positron emission tomography (PET) avidity, lasting 31 months after therapy initiation, when a solitary recurrence occurred, was resected, and treatment continued. (biomedcentral.com)

During this stage of germ cell development, aberrant chromatid exchange events associated with crossing over can occur. (medscape.com)

As an alternative, the clone may progressively deteriorate, and the appearance of marrow may return to normal as healthy stem cells repopulate it. (medscape.com)
We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. (ncl.ac.uk)
His research focused on dental pulp stem cells (DPSC) and autophagy. (nih.gov)
Kim uses stem cells and mouse models of cancer to examine how lncRNAs are involved in epigenetic reprogramming. (ucsc.edu)

Approximately 40% of those affected with leukemia will have Acute Myeloid Leukemia (AML), a cancer of the BM and blood wherein blood cells are unable to develop or function normally, are overproduced at an immature stage of development and overtake any normal elements remaining in the BM and blood. (aiche.org)

History of unstable cardiovascular disease including myocardial infarction or cerebrovascular accident, crescendo history of angina or heart failure. (who.int)

Anatomy18

Organisms10

Diseases56

Chemicals and Drugs74

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes62

Disciplines and Occupations1

Information Science4

Health Care3

Progression34

Suppressors4

Apoptosis25

Suppressor genes8

Mutations14

Proliferation13

Genetic19

Growth27

Neuroblastoma3

Chemotherapy14

Regulation12

Differentiation6

Tissues9

Benign2

Necrosis factor-alpha1

Expressed in tumor tissue1

Proteins6

Brain tumors1

Pathways10

Solid tumors10

Cancers6

Microenvironment1

Metastatic9

Lymphoma2

Molecular8

Metastasis7

Xenograft1

Diagnosis4

Cellular6

Ovarian2

Clinical10

Pancreatic1

Malignant tumor1

Induces4

Primary tumor1

Bone8

Arrest4

Mechanisms4

Mice8

Genetics2

Biology4

Gene10

Testicular cancer1

Clonal1

Induce2

Genes in human1

Inhibitor3

Immune6

Subset1

Carcinoma5

Roles1

Genomic3

Commonly1

Pituitary1

Pathogenesis3

Reduction2

Occur1

Stem cells4

Acute Myeloid1

Cardiovascular disease1