Disease tumor cell. Medical search. Frequent questions

Importantly, immune constituents of the tumor microenvironment (TME) can influence therapy response and cancer progression. (mdpi.com)
Analysis of immune biomarkers will focus on Jak2/STAT3 driven processes such as the percentage of MDSC, T cell subset analysis and inflammatory cytokines both systemically and in the tumor microenvironment. (bmj.com)
Challenges include finding the right target to direct the T cells, the ability to expand in an often-immunosuppressive tumor microenvironment, yielding an effective antitumor response, and avoiding adverse side effects. (aacr.org)
One of the reasons that cancer is so difficult to prevent is the complex interaction between individual cancer cells and the tumor microenvironment. (medicalnewstoday.com)
In order to improve the tissue hypoxia in the tumor microenvironment, it is required to normalize very leaky and immature tumor vasculature. (nii.ac.jp)
It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. (scienceopen.com)
Cancer-associated fibroblasts (CAFs) are a major cellular component of tumor microenvironment in most solid cancers. (elifesciences.org)

Also, expression of chemokines or treatment with poly(I:C) decreased tumor growth. (nih.gov)

These results are exciting because of the possible implications for a patient population that currently has the poorest possible prognosis going into treatment, those with malignant brain tumors that have recurred after initial treatment," said James Vredenburgh, M.D., a brain cancer specialist at Duke's Preston Robert Tisch Brain Tumor Center and lead researcher on the study. (sciencedaily.com)
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown for the first time that malignant brain tumors arise directly from brain stem cells. (dkfz.de)
Overproduction of Tlx in mice stimulates the development of malignant brain tumors from brain stem cells. (dkfz.de)
For many years now, the subventricular zone has been suspected to be the origin of specific malignant brain tumors called gliomas, the most deadly type of which is glioblastoma. (dkfz.de)

Yang Y, Huang Z, Niu X, Xu H, Li Y, Liu W. Clinical characteristics and risk factors analysis of lung metastasis of benign giant cell tumor of bone. (medscape.com)
Rosario M, Kim HS, Yun JY, Han I. Surveillance for lung metastasis from giant cell tumor of bone. (medscape.com)
Pulmonary metastasis of benign giant cell tumor of bone. (medscape.com)
[ 115 ] Moreover, CK19 releasing cells were found to be detectable in up to 65 and 70% of CRC and breast cancer patients, respectively, and correlated with presence of metastasis and poor survival in breast cancer. (medscape.com)
These same cells cause metastasis, but their presence opens the possibility for blood-based diagnostics that can identify the presence of an existing tumor within the body. (medgadget.com)
Here we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal transition (EMT), an important step in the progression of primary tumors toward metastasis. (jci.org)
Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. (nii.ac.jp)
In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. (scienceopen.com)
Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis. (scienceopen.com)
There is increasing fascination with circulating tumor cells (CTCs) because of the purported part in breasts cancers metastasis and their potential like a "water biopsy" tool in breasts cancer analysis and management. (ampkpathway.com)

In particular, B-cell activating factor belonging to the TNF family receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) play critical roles in promoting B-cell survival at distinct stages of development by engaging a proliferation-inducing ligand (APRIL) and/or BAFF. (nih.gov)
Dysregulated signaling by TNFRSF members can promote B-cell survival and proliferation, causing autoimmunity and neoplasia. (nih.gov)
Epidermal growth factor receptor signalling contributes to osteoblastic stromal cell proliferation, osteoclastogenesis and disease progression in giant cell tumour of bone. (ox.ac.uk)
In functional studies EGF supported proliferation of GCTB stromal cells, and the addition of EGF and macrophage-colony stimulating factor promoted osteoclastogenesis. (ox.ac.uk)
CONCLUSION: In GCTB, EGFR signalling in neoplastic stromal cells may contribute to disease progression through promoting stromal cell proliferation and osteoclastogenesis. (ox.ac.uk)
In vivo, poly(I:C) treatment increased intratumoral chemokine expression, NK-cell activation and tumor infiltration, and proliferation of tumor-infiltrating T and NK cells. (nih.gov)
Proliferation of tumor parenchyma cells was decreased. (nih.gov)
Peripheral blood phenotyping data show increases in CD4+ and CD8+ T cell proliferation two weeks after anti-OX40 administration. (bepress.com)
These data provide evidence that anti-OX40 prior to surgery is safe and can increase activation and proliferation of CD4+ and CD8+ T cells in blood and tumor. (bepress.com)
Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
The tumors showed glandular proliferation or small nests with invasive growth (Figure 2(d) ). (hindawi.com)

A pair of studies presented at the AACR Annual Meeting 2019 demonstrated encouraging clinical outcomes with two different chimeric antigen receptor (CAR) T-cell therapies for patients with advanced solid tumors. (aacr.org)
Given the success of CAR T-cell therapies for blood cancers, the most anticipated next step in the field is the development of this type of immunotherapy for solid tumors. (aacr.org)
Developing CAR T-cell therapies for solid tumors, however, has been challenging, and researchers in the field have had several failed attempts. (aacr.org)
This recent review article summarizes the challenges with developing CAR T-cell therapy for solid tumors and strategies to overcome the hurdles, and lists some of the ongoing clinical trials in which CAR T cells that target tumor antigens, including GD2, CEA, and EGFR, are being currently tested against a variety of solid tumors. (aacr.org)
Data presented here at the conference have demonstrated that it is possible to develop CAR T-cell therapies for solid tumors that are not only safe but also yield clinical benefit for patients. (aacr.org)
If this approach is successful, 2 million patients with mesothelin-expressing solid tumors per year in the United States will be eligible for this treatment," said Prasad S. Adusumilli, MD , who presented the study. (aacr.org)
This article in Cancer Discovery reviews the types of solid tumors that express mesothelin, and the potential of mesothelin-directed CAR T-cell therapy to treat such malignancies. (aacr.org)
Researchers say T cells used in immunotherapy may be hindered by stress responses induced when encountering solid tumors. (medicalnewstoday.com)
Now, immunotherapy experts suggest that one reason immunotherapy may not always be effective could be the stress response encountered by T cells when they enter solid tumors. (medicalnewstoday.com)

They are potentially serious, since some mast cell tumors are malignant. (tuftscatnip.com)

Pancreatic neuroendocrine tumors can be benign (noncancerous) or malignant (cancerous). (medicinenet.com)
It tells you whether all abnormal cells were removed, and whether - or how fast - the cancerous mast cells may spread in the body. (dogsnaturallymagazine.com)
The researchers first confirmed that AGPS expression increased when normal cells turned cancerous. (scitechdaily.com)
Avastin, a relatively new type of drug that shrinks cancerous tumors by cutting off their blood supply, can slow the growth of the most common and deadly form of brain cancer, a pilot study conducted at Duke University Medical Center has found. (sciencedaily.com)
The researchers tested the effectiveness of Avastin in conjunction with a standard chemotherapy agent in patients with recurrent cancerous brain tumors called gliomas. (sciencedaily.com)
Although giant cell tumors are not cancerous, they are aggressive and can destroy the surrounding bone. (orthoinfo.org)
Some tumors are cancerous, or malignant. (cdc.gov)
Tumor antigens After a cell becomes cancerous, the immune system is often able to recognize it as abnormal and destroy it before it replicates or spreads. (msdmanuals.com)

CD40 is also essential for directing the humoral response to T-cell-dependent antigens. (nih.gov)
Our data indicate that certain GSL antigens, especially SGGLs, GD3, and OAc-GD3, are expressed in neural tumor cells and may be considered as tumor-associated antigens that represent important biomarkers for neural tumors. (karger.com)
After these initial studies had yielded such promising results, Lukas Bunse expects that vaccine-induced T-cell receptors targeting brain tumor antigens could be a promising approach to develop new immunotherapies against glioblastoma. (dkfz.de)
According to the scientist, it is also conceivable to generate T cell receptor transgenic cell therapies against patient-individual cancer antigens. (dkfz.de)

CAR T-cell therapy is a type of immunotherapy in which T cells are removed from a patient's body and genetically modified so that they can recognize the patient's cancer cells. (aacr.org)
The primary aim of cancer immunotherapy is to enhance immune cells to prevent cancer cells from escaping the immune system's control. (medicalnewstoday.com)
However, the researchers in the current study said that this natural T cell response to stress would actually harm the effectiveness of cancer immunotherapy when it comes to stopping tumors. (medicalnewstoday.com)
For immunotherapy to be effective, T cells must secrete cytokines, such as cytotoxic cytokines to kill tumor cells. (medicalnewstoday.com)
Scientists from the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim (UMM) successfully tested a new form of cellular immunotherapy against brain tumors in mice for the first time. (dkfz.de)
Our laboratory has a long-standing interest in immune signaling and cell metabolism underlying the differentiation and function of T cells, a central cell type in adaptive immunity and cancer immunotherapy. (stjude.org)

The only known risk factor for extragonadal germ cell tumors is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors, which are characterized by their location on the midline from the pineal gland to the coccyx. (medscape.com)
Combined AFP and β-hCG testing is an essential adjunct in the evaluation and treatment of nonseminomatous germ cell tumors, and in monitoring the response to therapy. (aafp.org)

It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
This case demonstrates the efficacy of Denosumab in stabilizing the progression of giant cell tumo r of bone but also highlights the need for further investigation into cumulative dose-related side effects and long term treatment planning as patients currently have no other treatment options once stability is achieved. (scitechnol.com)
We also determined that the percentage of human lung tumor tissues positive for Brachyury expression increased with the stage of the tumor, indicating a potential association between Brachyury and tumor progression. (jci.org)
The selective expression of Brachyury in tumor cells and its role in EMT and cancer progression suggest that Brachyury may be an attractive target for antitumor therapies. (jci.org)
Recent data have expanded the concept that inflammation is a critical component of tumour progression. (scienceopen.com)
2.33 gene and following HER2 protein overexpression is connected with significantly reduced disease-free survival (DFS) and OS in the lack of HER2-targeted therapy (73 74 Similarly individuals with HER2+ CTCs have already been reported to possess worse progression-free survival (PFS) and OS in comparison to individuals with HER2? (ampkpathway.com)

Is Islet Cell Tumor a Neuroendocrine Tumor? (medicinenet.com)
Is an Islet Cell Tumor a Neuroendocrine Tumor? (medicinenet.com)
An islet cell tumor, also known as a pancreatic neuroendocrine tumor , forms in hormone-producing cells (islet cells) of the pancreas. (medicinenet.com)

We investigated the expression of immune checkpoints (ICs) on lymphoid populations within the CRC TME and compared with cells from normal colon tissues using samples from 50 patients with varying disease stages. (mdpi.com)
The cells release those granules into the tissues to destroy the "invader. (dogsnaturallymagazine.com)
Mesenchymal tumors include structures arising from mesodermal-derived precursor cells that develop into cartilage, bone, or other connective tissues. (newhopemedicalcenter.com)
The study of tissues and cells under a microscope. (cdc.gov)
Furthermore, we found Brachyury to be overexpressed in various human tumor tissues and tumor cell lines compared with normal tissues. (jci.org)
Brachyury expression in human lung tumor tissues. (jci.org)
Mast cells are found in all tissues of the body, but are concentrated in the skin, respiratory tract and digestive tract. (tuftscatnip.com)
A procedure in which a sample of blood is examined to measure the amounts of certain substances released into the blood by organs, tissues , or tumor cells in the body. (vicc.org)
The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. (vicc.org)
Cells from malignant tumors can invade nearby tissues. (cdc.gov)
C. Peterson, M. Ringne´r / Artificial Intelligence in Medicine 28 (2003) 59-74 structure and function, cellular metabolism, development of cells and tissues, and response of organisms to their environments. (lu.se)
If such interaction patterns can be measured for various kinds of tissues and the corresponding data can be interpreted, potential clinical benefits are obvious and novel tools for diagnostics, identification of candidate drug targets, and predictions of drug effectiveness for e.g. cancer diseases will emerge. (lu.se)
Since genes are composed of a given alphabet (A, T, C, G) with fixed pairing properties A-T and C-G, probes can be constructed that attract gene transcripts extracted from cell tissues and cultures. (lu.se)

OX40, GITR, and 4-1BB), can enhance T cell immunity in tumor-bearing hosts. (bepress.com)
In this experiment, we found that apelin normalizes tumor vasculature, resulting in improvement of drug delivery and tumor immunity. (nii.ac.jp)
This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention. (scienceopen.com)
Chapman NM, Chi H . Metabolic adaptation of lymphocytes in immunity and disease. (stjude.org)

The five-year survival rate for people with these tumors is exceptionally poor due to a lack of effective therapies to target these cancer cells. (mayo.edu)
Pancreatic cancer (PCa) is resistant to cytotoxic therapies, and the profound immune suppressive nature of this disease renders patients non-responsive to immunologic therapies. (bmj.com)
The U.S. Food and Drug Administration has approved two CAR T-cell therapies for blood cancers so far: tisagenlecleucel (Kymriah) for treating certain patients with acute lymphoblastic leukemia or non-Hodgkin lymphoma (NHL), and axicabtagene ciloleucel (Yescarta) for treating certain adults with NHL. (aacr.org)
They found that the two drugs together halted tumor growth up to twice as long as comparative therapies. (sciencedaily.com)
In the pilot study, the researchers found that dual therapy with Avastin and the chemotherapy drug irinotecan either shrank the tumors or restricted their growth in nearly all cases for up to three months longer than comparative therapies. (sciencedaily.com)
When the tumor recurs after treatment, there are no standard therapies," Vredenburgh said. (sciencedaily.com)
To find new, more effective treatment options for those affected, doctors and scientists are testing numerous immunotherapeutic approaches, including so-called "adoptive" T-cell therapies: This involves isolationg T cells from the patient, modifying them in the culture dish and transferring them back to the patient. (dkfz.de)
Much more advanced in clinical development than T-cell receptor transgenic cells are cellular therapies using so-called CAR-T (chimeric antigen receptor) cells, which have already been approved for the treatment of various leukemias and lymphomas. (dkfz.de)
At that time, the oncology community had little enthusiasm for the use of T-cell therapies to treat cancer. (childrensnational.org)
Production of transforming growth factor-β in the immediate vicinity of tumors normally thwarts tumor-directed therapies by having devastating effects on T-cell function in vivo. (childrensnational.org)
Other radiation therapies affect the tumor - and likely the tissue around it too. (mayoclinic.org)
To tailor CRC treatment, it is essential to first model this heterogeneity by defining subtypes of patients with homogeneous biological and clinical characteristics and second match these subtypes to cell lines for which extensive pharmacological data is available, thus linking targeted therapies to patients most likely to respond to treatment. (tudelft.nl)
By matching the identified subtypes to cell line panels that have been pharmacologically characterized, it opens up new possibilities for the development and application of targeted therapies for defined CRC patient sub-populations. (tudelft.nl)

[ 1 , 2 ] In extragonadal germ cell tumors, no evidence of a primary malignancy is present in either the testes or ovaries by radiologic imaging or physical examination. (medscape.com)
Controversy remains regarding the origin of extragonadal germ cell tumors. (medscape.com)
The classic theory suggests that germ cell tumors (GCTs) in these areas are derived from local transformation of primordial germ cells misplaced during embryogenesis. (medscape.com)
According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)
Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumor. (medscape.com)
During this stage of germ cell development, aberrant chromatid exchange events associated with crossing over can occur. (medscape.com)
Malignant transformation of germ cells is the result of a multistep process of genetic changes. (medscape.com)
Childhood extracranial germ cell tumors form from germ cells in parts of the body other than the brain. (cigna.com)
A germ cell is a type of cell that forms as a fetus develops. (cigna.com)
This summary is about germ cell tumors that form in parts of the body that are extracranial (outside the brain). (cigna.com)
Extracranial germ cell tumors are most common in adolescents, with rates in this age group lower for females than males. (cigna.com)
For information on intracranial (inside the brain) germ cell tumors, see Childhood Central Nervous System Germ Cell Tumors Treatment. (cigna.com)
Childhood extracranial germ cell tumors may be benign or malignant. (cigna.com)
Childhood extracranial germ cell tumors are grouped as gonadal or extragonadal extracranial tumors. (cigna.com)
Malignant extracranial germ cell tumors are tumors that form outside the brain. (cigna.com)
Gonadal germ cell tumors form in the gonads (testicles and ovaries). (cigna.com)
Testicular germ cell tumors are divided into two main types, seminoma and nonseminoma. (cigna.com)
Testicular germ cell tumors usually occur before the age of 4 years or in adolescents and young adults. (cigna.com)
Testicular germ cell tumors in adolescents (11 years and older) and young adults are different from those that form in early childhood. (cigna.com)
Ovarian germ cell tumors are more common in adolescent girls and young women. (cigna.com)
Most ovarian germ cell tumors are benign mature teratomas (dermoid cysts). (cigna.com)
Extragonadal extracranial germ cell tumors form in areas of the body other than the brain or gonads (testicles and ovaries). (cigna.com)
Most extragonadal extracranial germ cell tumors form along the midline of the body. (cigna.com)
In children younger than 11 years, extragonadal extracranial germ cell tumors usually occur at birth or in early childhood. (cigna.com)
In older children, adolescents, and young adults (11 years and older), extragonadal extracranial germ cell tumors are often in the mediastinum. (cigna.com)
Extragonadal germ cell tumors form from developing sperm or egg cells that travel from the gonads to other parts of the body. (vicc.org)
When cells that are meant to form sperm in the testicles or eggs in the ovaries travel to other parts of the body, they may grow into extragonadal germ cell tumors . (vicc.org)
Benign extragonadal germ cell tumors are called benign teratomas . (vicc.org)
These are more common than malignant extragonadal germ cell tumors and often are very large. (vicc.org)
Age and gender can affect the risk of extragonadal germ cell tumors. (vicc.org)
Signs and symptoms of extragonadal germ cell tumors include breathing problems and chest pain. (vicc.org)
Malignant extragonadal germ cell tumors may cause signs and symptoms as they grow into nearby areas. (vicc.org)
Imaging and blood tests are used to diagnose extragonadal germ cell tumors. (vicc.org)

In this review, we present a current understanding of the functions of and distinctions between APRIL/BAFF signaling by their respective receptors expressed on particular B-cell subsets. (nih.gov)
Receptor discordance NXY-059 identifies variations in receptors of major tumor and metastatic CTCs or tumors. (ampkpathway.com)
Cytokines transmit their message by attaching to specific molecules called receptors on the surface of another cell. (msdmanuals.com)

diagnostic prediction of small round blue cell tumors (SRBCT) of childhood and determining the estrogen receptor (ER) status of sporadic breast cancer. (lu.se)

The lab's investigators explore how the metastatic behavior of tumor cells is regulated to discover new treatments for lung, liver and pancreatic cancers. (mayo.edu)
The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
Circulating tumor cells offer the possibility of "liquid biopsies" that only require a simple blood draw to screen for cancers. (medgadget.com)
The researchers said they found that T cells that are subjected to the environment of solid cancers undergo a stress response that limits their abilities, hindering their capability to eliminate the tumors. (medicalnewstoday.com)
This article focuses mainly on nonmelanoma skin cancers, with an emphasis on rare benign and malignant epithelial, dermal, and adnexal tumors. (medscape.com)

The goal of our alternative treatments for granular cell tumors is to stimulate the spontaneous regression of cancer cells and ultimately light your path toward remission. (newhopemedicalcenter.com)
Objectives Granular cell tumors are rare neoplasms of neural origin. (medscape.com)
We present the largest case series to date comprising 50 patients with benign and atypical soft tissue granular cell tumors in an effort to better define the pathologic features in this subset of lesions. (medscape.com)
Methods All cases of soft tissue granular cell tumors from the Ohio State Medical Center and the Medical College of Wisconsin over a 10-year period were reviewed for histologic and clinical findings. (medscape.com)
Conclusions Compared with granular cell tumors overall, the soft tissue subset shows a larger average size and higher propensity for incomplete resections, with atypical features being relatively common. (medscape.com)
Our findings suggest that soft tissue granular cell tumors may be slightly more aggressive than their dermal or organ-confined counterparts. (medscape.com)
Granular cell tumors (GCTs) are rare lesions believed to be of neural origin. (medscape.com)

Tumors that belong to this group are: Desmoplastic small-round-cell tumour Ewing sarcoma/PNET Neuroblastoma Medulloblastoma Rhabdomyosarcoma Synovial sarcoma Carcinoid tumor Mesothelioma Small cell lung cancer Wilms' tumour Retinoblastoma[citation needed] Small-cell lymphoma Hepatoblastoma- only the anaplastic form has round blue cells, the more common fetal and embryonal types do not Merkel cell carcinoma Mesenchymal chondrosarcoma Endometrial stromal condensation may mimic a small-blue-round-cell tumour. (wikipedia.org)
Malignant granular cell tumor (MGCT) is a high-grade mesenchymal tumor of Schwann cell origin. (newhopemedicalcenter.com)
Overexpression of Brachyury in human carcinoma cells induced changes characteristic of EMT, including upregulation of mesenchymal markers, downregulation of epithelial markers, and an increase in cell migration and invasion. (jci.org)
Conversely, inhibition of Brachyury resulted in downregulation of mesenchymal markers and loss of cell migration and invasion and diminished the ability of human tumor cells to form lung metastases in a xenograft model. (jci.org)
The concept of tumor cell plasticity highlights the significance of re-activation of developmental programs that are closely correlated with epithelial-mesenchymal transition, acquisition properties of cancer stem cells, and trans-differentiation potential during drug exposure. (scienceopen.com)
Epithelial-mesenchymal transitions in development and disease. (scienceopen.com)
Despite the mesenchymal nature of these tumors, they rarely occur in the soft tissue, and as a result, this subset is not well characterized. (medscape.com)

Protein markers commonly used for circulating tumor cells investigations. (medscape.com)
Engineers at the University of Michigan have developed a high speed microfluidic chip that can separate circulating tumor cells (CTCs) from whole blood and analyze them. (medgadget.com)

The aim was to determine whether EGFR protein expression contributes to the aggressiveness and recurrence potential of giant cell tumour of bone (GCTB), an osteolytic primary bone tumour that can exhibit markedly variable clinical behaviour. (ox.ac.uk)
First described by Cooper and Travers in 1818, giant cell tumors (GCTs) of bone have been labeled the most challenging benign bone tumors. (medscape.com)
In the United States and Europe, GCTs represent approximately 5% of all primary bone tumors and 21% of all benign bone tumors. (medscape.com)
[ 1 ] In China, GCTs have been estimated to account for 20% of all primary bone tumors. (medscape.com)
Giant-cell tumor of bone: analysis of two hundred and eight cases in Chinese patients. (medscape.com)
Primary Bone Tumors: Epidemiologic Comparison of 9200 Patients Treated at Beijing Ji Shui Tan Hospital, Beijing, China, With 10 165 Patients at Mayo Clinic, Rochester, Minnesota. (medscape.com)
the SH3BP2 protein is particularly important for the function of cells involved in the replacement of old bone tissue with new bone (bone remodeling) and certain immune system cells. (medlineplus.gov)
which are cells that break down bone tissue during bone remodeling. (medlineplus.gov)
An excess of these bone-destroying cells contributes to the destruction of bone in the upper and lower jaws. (medlineplus.gov)
We present a case of locally recurring giant cell tumor (GCT) of the bone in the cervical spine of a 12-year-old girl. (scitechnol.com)
Denosumab is an excellent treatment for non-resectable and recurrent GCT of the bone, it only eliminates giant cells, leaving the stromal cells to reactivate the GCT of the bone after a period of halting Denosumab. (scitechnol.com)
A giant cell tumor of bone is a type of benign (noncancerous) tumor that has a wide range of behaviors. (orthoinfo.org)
Treatment for a giant cell tumor almost always involves surgery to remove the tumor and prevent damage to the bone near the affected joint. (orthoinfo.org)
Many types of bone tumors and other conditions (including normal bone) contain giant cells. (orthoinfo.org)
The diagnosis of giant cell tumor of bone is made when a large number of giant cells are seen among a background of other abnormal cells. (orthoinfo.org)
While most bone tumors occur in the flared area near the ends of the body's long bones (metaphysis), giant cell tumors occur almost exclusively in the end portion of the long bones (epiphysis), directly next to the joints. (orthoinfo.org)
In rare cases, a patient can have multiple giant cell tumors in different bones, a condition called multi-centric giant cell tumor of bone. (orthoinfo.org)
While giant cell tumors are typically benign (noncancerous), they can grow quickly and destroy bone close to a joint. (orthoinfo.org)
Giant cell tumors of bone are not inherited. (orthoinfo.org)
This is different than an isolated, single giant cell tumor of bone. (orthoinfo.org)
Occasionally, the bone weakened by the tumor breaks and causes the sudden onset of severe pain. (orthoinfo.org)
Reproduced from Lewis VO, Aboulafia AJ: Giant cell tumor of bone. (orthoinfo.org)
X-ray shows a giant cell tumor in the lower end of the radius bone in the wrist. (orthoinfo.org)
Recurrent giant cell tumour of the bone is a difficult to treat and mutilating disease. (bjmo.be)
An overview of giant cell tumour of the bone is given. (bjmo.be)
Recent advances in the management of GCT developing in Paget's disease of bone. (jocr.co.in)
Paget's disease of bone (PDB) is a disease of elderly characterised by disorganised bone remodelling. (jocr.co.in)
A 40 yr old gentleman presented with back pain and on evaluation was diagnosed as a case of polyostotic pagets disease of bone. (jocr.co.in)
GCT- PDB is a rare phenomenon occuring mainly in polyostotic pagets disease of bone and is associated with more severe manifestations of the disease. (jocr.co.in)
Paget's disease is a disease of elderly seen commonly after the fifth decade of life characterized by remodelling of bone in a disorganized manner. (jocr.co.in)
We present a case of GCT developing in the background of polyostotic Paget's disease of bone. (jocr.co.in)
Bone biopsy from the iliac region revealed numerous multinucleated giant cells with haphazard new bone formation and diagnosis of polyostotic Paget's disease was confirmed. (jocr.co.in)
The bone is a common site for metastatic disease. (massgeneral.org)
Bone metastases, or bone mets, occur when cancer cells from a primary tumor spread to the bone. (massgeneral.org)
Metastatic bone tumors of the skeleton are caused when cancer from another part of the body spreads to the bones. (massgeneral.org)
Cancer spreading to the bones from elsewhere is much more common than cancer that begins in the bones (primary bone tumors). (massgeneral.org)
The most common kinds of metastatic bone tumors of the skeleton begin with prostate, breast, thyroid, lung, or kidney cancer. (massgeneral.org)
With many patients, the primary tumor is not identified, so staging studies and biopsy are necessary to rule out a primary malignant bone tumor. (massgeneral.org)

Most pancreatic neuroendocrine tumors (islet cell tumors) are functional tumors. (medicinenet.com)
What are the stages of pancreatic neuroendocrine tumors? (medicinenet.com)
What are the signs or symptoms of pancreatic neuroendocrine tumors? (medicinenet.com)
Carriers of germinal VHL mutations have an increased prevalence of kidney cysts and ccRCC as well as hemangioblastoma , pheochromocytoma and pancreatic neuroendocrine tumors . (bvsalud.org)

1 Program on Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. (nih.gov)
It was concluded that circulating epithelial cells may be present in patients with benign inflammatory colon which were detectable by CTC assays. (medscape.com)
The body produces mast cells as an inflammatory and histamine response. (dogsnaturallymagazine.com)
Activation of mast cells can result in classic signs of allergy, including edema (swelling), warmth, redness and attraction of other inflammatory cells to the site. (tuftscatnip.com)
Inflammatory bowel disease and sensitive digestive systems that may require special diets are present in some Bernese. (bmdca.org)
For dendritic cell-mediated extrinsic control of T cell differentiation, we focus on metabolic and inflammatory pathways (see Du Nature 2018). (stjude.org)
In fact, clear cell acanthoma possesses a similar staining pattern to inflammatory dermatoses such as psoriasis vulgaris, lichen planus, and discoid lupus erythematosus and might be a localized form of inflammatory eruption rather than a neoplasm. (medscape.com)

This metastatic behavior of tumor cells is the single most important factor affecting survival, as 90% of mortality is due to metastatic invasion. (mayo.edu)
Using an interventional radiology procedure, the investigators injected IcasM28z CAR T cells directly into the pleural cavity in 21 patients with malignant pleural disease (19 with malignant pleural mesothelioma, one with metastatic lung cancer, and one with metastatic breast cancer). (aacr.org)
Metastatic disease is responsible for the majority of human cancer deaths. (jci.org)
Discordance between your ER and/or PR position of major and metastatic tumors is definitely observed (83-85). (ampkpathway.com)
In children, metastatic skeletal tumors are usually due to neuroblastoma, leukemia or Ewing's sarcoma. (massgeneral.org)
Metastatic tumors from the kidney or thyroid are usually very vascular (made of blood vessels) whereas tumors from prostate, breast and lung are less so. (massgeneral.org)
Staging studies are usually done to determine the extent of the metastatic disease and plan the most appropriate treatment. (massgeneral.org)
Chemotherapy, use of hormones and palliative radiation therapy, that is radiation to treat the symptoms not cure, are other options used to care for patients with metastatic disease. (massgeneral.org)
Metastatic disease is very serious, but advances in cancer care mean that many patients still have significant amounts of quality time for themselves and their families. (massgeneral.org)
These patients living with metastatic disease have a phenomenal amount of inner strength and hope. (massgeneral.org)

Here, a pancreatic cancer cell is degrading a fluorescent matrix (green) as it migrates. (mayo.edu)
The Tasmanian devil faces extinction due to devil facial tumour disease (DFTD), a highly transmittable clonal form of cancer without available treatment. (nature.com)
The Tasmanian devil is an endangered Australian species, restricted to the island state of Tasmania 1 , and threatened with extinction due to a contagious and transmissible "parasitic" form of cancer known as devil facial tumour disease (DFTD) 2 , which has killed ~80% of the devil population since emerging in 1996 1 . (nature.com)
The objective of this prospective study was to assess the prognostic impact of isolated tumor cells (ITC, defined as cell deposits ≤ 0.2 mm) in loco-regional LN of stage I & II colon cancer patients. (biomedcentral.com)
This study provides compelling evidence that ITC in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival. (biomedcentral.com)
Those high-risk stage II colon cancer patients feature at least one of the follwing characteristics: pT4 tumor, poorly differentiated histology, presence of lymphovascular invasion, localized perforation, bowel obstruction or less than 12 lymph nodes (LN) analyzed [ 4 , 6 ]. (biomedcentral.com)
While uncertainty persists regarding the explanation of the high recurrence-rate in node negative colon cancer, there is emerging evidence that the appearance of isolated tumor cells (ITC) and micro-metastases in LN could be associated with worse prognosis [ 8 - 14 ]. (biomedcentral.com)
Therefore, a few research groups have been evaluating the sentinel lymph node (SLN) procedure in colon cancer to allow a more thorough investigation of a few LN with high probability of hiding tumor infiltrates. (biomedcentral.com)
To evaluate in vivo activity of BMS-911543, we used a genetically engineered PCa model with conditional expression of mutant KrasG12D, tp53R270H , and Brca1 alleles in pancreatic cancer cells (Brca1-KPC mice). (bmj.com)
The modified T cells, when reintroduced into the patient's body, multiply and attack cancer cells. (aacr.org)
In a phase I clinical trial , a team of researchers from Memorial Sloan Kettering Cancer Center tested whether mesothelin-directed CAR T cells that they developed would be safe and effective in patients with malignant pleural disease from mesothelioma and lung and breast cancer. (aacr.org)
The CAR T cells the team developed, called IcasM28z, target the cell-surface protein, mesothelin, which is expressed on the majority of cancer cells. (aacr.org)
Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
[ 115-117 ] In cancer cell line spike-in experiments, this method was capable of detecting one cancer cell per 5 ml blood. (medscape.com)
Also, cathepsin D or MUC1 secreting cells were successfully detected in breast cancer patients but not in healthy controls. (medscape.com)
Illustration of an aggressive cancer cell. (scitechdaily.com)
In a newly published study, researchers tested the effects of reducing ether lipids on human skin cancer cells and primary breast tumors, finding that inactivating an enzyme critical to the formation of ether lipids substantially reduced the aggressiveness of the cancer cells. (scitechdaily.com)
Researchers have long known that cancer cells metabolize lipids differently than normal cells. (scitechdaily.com)
Cancer cells make and use a lot of fat and lipids, and that makes sense because cancer cells divide and proliferate at an accelerated rate, and to do that, they need lipids, which make up the membranes of the cell," said study principal investigator Daniel Nomura, assistant professor in UC Berkeley's Department of Nutritional Sciences and Toxicology. (scitechdaily.com)
In the study, Nomura and his team tested the effects of reducing ether lipids on human skin cancer cells and primary breast tumors. (scitechdaily.com)
They then found that inactivating AGPS substantially reduced the aggressiveness of the cancer cells. (scitechdaily.com)
The cancer cells were less able to move and invade," said Nomura. (scitechdaily.com)
The researchers also compared the impact of disabling the AGPS enzyme in mice that had been injected with cancer cells. (scitechdaily.com)
The researchers determined that inhibiting AGPS expression depleted the cancer cells of ether lipids. (scitechdaily.com)
They also found that AGPS altered levels of other types of lipids important to the ability of the cancer cells to survive and spread, including prostaglandins and acyl phospholipids. (scitechdaily.com)
This study sheds considerable light on the important role that AGPS plays in ether lipid metabolism in cancer cells, and it suggests that inhibitors of this enzyme could impair tumor formation," said Benjamin Cravatt, professor and chair of chemical physiology at The Scripps Research Institute, who is not part of the UC Berkeley study. (scitechdaily.com)
Because of the estimated large volume, many cancer registries do not register basal cell skin cancer except for selected sites, such as skin of the external genital organs (for example, vulva, penis, scrotum). (cdc.gov)
An early cancer that is present only in the layer of cells in which it began. (cdc.gov)
Classification of childhood cancer based on tumor histology. (cdc.gov)
A classification system used by tumor or cancer registries to code the site and the histology of the cancer, usually from a pathology report. (cdc.gov)
Selective HIF2A Inhibitors in the Management of Clear Cell Renal Cancer and Von Hippel-Lindau-Disease-Associated Tumors. (bvsalud.org)
Von Hippel-Lindau ( VHL ) loss is the hallmark event characterizing the clear cell renal cancer subtype (ccRCC). (bvsalud.org)
Real-time PCR was performed for Brachyury on lung tumor tissue cDNA from 80 lung cancer patients of the indicated stages of disease. (jci.org)
In new research published in the journal Cancer Research , researchers explain how the stress response experienced by T cells can reduce their effectiveness at restricting tumor growth. (medicalnewstoday.com)
When a T cell encounters cancer cells, PERK can react to the stressors, such as lack of glucose, an important nutrient for cells. (medicalnewstoday.com)
When T cells are under stress (like when they must fight cancer cells), PERK causes T cells to stop secreting proteins in order to protect and help the T cell survive. (medicalnewstoday.com)
In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
In this treatment, we identified that CD44 is up-regulated under the hypoxia and this molecule supports stemness of cancer stem cells and induces drug resistance of cancer cells. (nii.ac.jp)
Journal Article] DNA damage enhanced by the attenuation of SLD5 delays cell cycle restoration in normal cells but not in cancer cells. (nii.ac.jp)
Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. (scienceopen.com)
A pancreatic neuroendocrine tumor (NET) is a type of cancer that forms tumors in the pancreas. (hopkinsmedicine.org)
This is a surgery that removes cells so they can be checked under a microscope to look for cancer. (hopkinsmedicine.org)
A goal of cancer research is to reveal cell subsets linked to continuous clinical outcomes to generate new therapeutic and biomarker hypotheses. (elifesciences.org)
RAPID was also validated to find known risk-stratifying cells and features using published data from blood cancer. (elifesciences.org)
Scientists from the divisions of Professor Dr. G nther Sch tz and Professor Dr. Peter Lichter at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have recently shown in mouse brains that brain stem cells in the subventricular zone are characterized by a specific molecule: Protein Tlx, a transcription factor, which stimulates the activity of various genes. (dkfz.de)
Lukas Bunse, a scientist at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and a physician at the University Medical Center Mannheim, relies on the comparatively new concept of "T cell receptor transgenic cells" in his current study: To this end, brain tumor patients were first inoculated with an antigenic fragment of the protein NLGN4X (Neuroligin4X). (dkfz.de)
In this way, they succeeded in producing large numbers of T cells with identical specificity, all of which recognize the cancer antigen NLGN4X. (dkfz.de)
In melanoma, the malignant black skin cancer, such T-cell receptor transgenic T cells have already been shown to prolong the lives of some patients. (dkfz.de)
Altered cellular metabolism is a hallmark of cancer, and much of the published literature has focused on neoplastic cell-autonomous processes for these adaptations. (elifesciences.org)
We demonstrate that exosomes secreted by patient-derived CAFs can strikingly reprogram the metabolic machinery following their uptake by cancer cells. (elifesciences.org)
We find that CAF-derived exosomes (CDEs) inhibit mitochondrial oxidative phosphorylation, thereby increasing glycolysis and glutamine-dependent reductive carboxylation in cancer cells. (elifesciences.org)
Through 13C-labeled isotope labeling experiments we elucidate that exosomes supply amino acids to nutrient-deprived cancer cells in a mechanism similar to macropinocytosis, albeit without the previously described dependence on oncogenic-Kras signaling. (elifesciences.org)
Using intra-exosomal metabolomics, we provide compelling evidence that CDEs contain intact metabolites, including amino acids, lipids, and TCA-cycle intermediates that are avidly utilized by cancer cells for central carbon metabolism and promoting tumor growth under nutrient deprivation or nutrient stressed conditions. (elifesciences.org)
We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
Because family physicians are assuming a greater role in caring for patients with cancer, an understanding of tumor markers is becoming increasingly important. (aafp.org)
Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
T-cells seek out and destroy cancer cells or virus-infected cells, protecting the body from infection and malignancy. (childrensnational.org)
DNRII-LSTs were resistant to normally inhibitory concentrations of TGF-β in vitro and retained their ability to kill the cancer cells. (childrensnational.org)
Proton Beam delivers high-dose radiation directly into the tumor, rendering the cancer cells unable to reproduce. (mayoclinic.org)
Proton beam renders the cancer cells unable to reproduce. (mayoclinic.org)
We use a combination of experimental systems including mouse genetics, cellular immunology and biochemistry, as well as models of cancer, infection an autoimmune disease. (stjude.org)
Cancer begins in your cells when the genetic material, or DNA, is damaged or changed. (cdc.gov)
Devil Facial Tumor Disease, A Potential Model of the Cancer Stem-Cell Process? (cipps.org.au)
Background Colorectal cancer (CRC) is a heterogeneous and biologically poorly understood disease. (tudelft.nl)
Metastases after age 30 are usually adenocarcinoma (a type of cancer that involves the cells lining the walls of different organs in the body). (massgeneral.org)
Tracking Translation of Human Genome Discoveries into Prevention and Control of Common Chronic Diseases: The Action is in Cancer! (cdc.gov)
We searched PHGKB for published translational studies, guidelines and recommendations and implementation tools and studies for the top common chronic diseases: cancer, heart disease/stroke, diabetes, arthritis and Alzheimer's disease. (cdc.gov)
As shown in the accompanying graphs, we found that cancer accounted for most of the "action" for potential genomics translation into healthcare and disease prevention. (cdc.gov)
There were almost 31,000 articles in cancer, more than the number of articles for all the other diseases combined. (cdc.gov)
the cancer field has 34 entries compared to only 2 for all other diseases combined. (cdc.gov)

While HIF1A acts as a tumor suppressor and is frequently lost through inactivating mutations /14q chromosome deletions, HIF2A acts as an oncogene promoting the expression of its target genes ( VEGF , PDGF, CAIX Oct4, among others). (bvsalud.org)
To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)
We used whole-transcriptome shotgun sequencing (RNA-seq) to compare the S. pneumoniae transcriptome in biofilms, bacteria dispersed from biofilms after exposure to IAV, febrile-range temperature, or ATP, and planktonic cells grown at 37°C. Compared with biofilm bacteria, actively dispersed S. pneumoniae, which were more virulent in invasive disease, upregulated genes involved in carbohydrate metabolism. (lu.se)
In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
Epidemiologic studies are crucial in genomics not only to document associations between genes and diseases but to assess the relationship in terms of risks and interactions among genes and environmental factors. (cdc.gov)
PHGKB users can more fully examine these results looking at specific genes and diseases, and retrieving articles, systematic reviews, and meta-analyses. (cdc.gov)

When your vet tests the cells within the lump or lesion, she'll be able to tell you whether an MCT is benign or malignant. (dogsnaturallymagazine.com)
As with all tumors, whether benign or malignant, the paradigm of comprehension depends on identifying the cell or cell layer of origin. (medscape.com)

This meant that while you could trap a lot of CTCs you could only get a bit of genetic information out of them, or you could do a complete sequencing but this could be performed on only a few viable cells. (medgadget.com)
They then performed genetic sequencing on these cells and discovered that patients can shed CTCs that are quite different from each other and that up to 50% of the CTCs displayed stem cell-like properties, a particularly interesting finding. (medgadget.com)
One strong risk factor for the disease is a rare genetic disorder known as multiple endocrine neoplasia type 1 syndrome (MEN1 syndrome). (hopkinsmedicine.org)
These treatments target specific genetic characteristics of the tumor cells. (msdmanuals.com)
The genetic characteristics of tumors. (msdmanuals.com)

Bristol-Myers Squibb) would elicit anti-tumor activity against PCa and decrease immune suppressive features of the disease. (bmj.com)

In contrast, fucosyl-GM1 was not found to restrict to small cell lung carcinoma cells. (karger.com)
We examined TLR3- and TLR7-expressing pancreatic adenocarcinomas, squamous cell carcinomas of head and neck and lung carcinomas. (aacrjournals.org)

Clear cell tumors were also found in both ovaries. (hindawi.com)
These cells later become sperm in the testicles or eggs in the ovaries. (cigna.com)

EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. (scienceopen.com)

Breathing in 1,1,1-trichloroethane may also cause fatty changes in the liver, swelling of liver cells, and noncancerous tumors. (cdc.gov)

Long term evolution of Paget's disease increases the risk of various malignant tumors like osteosarcoma, fibrosarcoma, chondrosarcoma, malignant fibrous histiocytoma and very rarely locally aggressive tumor like Giant Cell Tumour (GCT) [1]The reported cases of GCT complicating Paget's occur mainly in polyostotic disease [2]. (jocr.co.in)

To characterize biomarkers in neural tumors, we analyzed the acidic lipid fractions of 13 neural tumor cell lines using enzyme-linked immunoabsorbent assay (ELISA) and high-performance thin-layer chromatography (HPTLC) immunostaining. (karger.com)

Extragonadal germinal cell tumors (EGGCTs) are rare tumors that predominantly affect young males. (medscape.com)

Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)
In the adult brain, the Tlx protein is responsible for generating new neurons from tissue stem cells. (dkfz.de)
As a result, cell division activity in the subventricular zone increased, the cells left their habitual environment called stem cell niche, and started forming glioblastoma-like tissue lesions. (dkfz.de)
Our data suggest that disease is caused by pneumococci that are primed to move to tissue sites with altered nutrient availability and to protect themselves from the nasopharyngeal microflora and host immune response. (lu.se)
It is found in large quantities in glioblastoma cells, but is virtually undetectable in healthy brain tissue. (dkfz.de)
In other words, the tumor should be surrounded on all sides by a nice rim of normal tissue, so that when examining the margins of the removed tissue under the microscope, the entire tumor is in the center, and the margins of the tumor contain no tumor cells. (tuftscatnip.com)
Proton beam therapy destroys tumor cells while sparing healthy brain tissue. (mayoclinic.org)
Proton beams can be targeted more precisely, allowing doctors to attack a tumor with high doses of radiation while preserving the surrounding healthy tissue. (mayoclinic.org)
Delivers radiation directly into the tumor, leaving surrounding tissue intact. (mayoclinic.org)
GCTs of the soft tissue are rare and not well characterized, representing only 0.5% of all soft tissue tumors. (medscape.com)

A patient with a recurrent giant cell tumour of the jaw is reported. (bjmo.be)

Based on studies in animals and a few reports in humans, 1,1,1-trichloroethane may lead to liver disease and changes to proteins in the liver. (cdc.gov)

Unfortunately, up to 20 % of stage I & II disease patients will develop recurrence within five years after diagnosis. (biomedcentral.com)
If you suspect a mast cell tumor, take your dog to the vet for diagnosis so that you can decide on the best treatment option. (dogsnaturallymagazine.com)
Testing for the beta subunit of human chorionic gonadotropin (β-hCG) is an integral part of the diagnosis and management of gestational trophoblastic disease. (aafp.org)
However the value of these procedures is with Abrams needle was performed in all limited in establishing the cause of PE that patients except those with an obvious clini- results from either malignant or nonma- cal diagnosis of congestive heart failure or lignant diseases. (who.int)
The treatment and diagnosis of many cutaneous tumors is continually changing, and the role of clinicians (eg, primary care physicians, dermatologists, plastic surgeons, pathologists) focuses on an accurate diagnosis and a thorough understanding of the clinical sequelae. (medscape.com)
In addition, these rare cutaneous tumors are often difficult to diagnose based solely on the physical examination findings, and the proper diagnosis relies on excisional biopsy with histologic studies. (medscape.com)
Eleven (21.6%) cases showed evidence of cytologic atypia and fulfilled the criteria for a diagnosis of atypical giant cell tumor. (medscape.com)

All sera had high titers of antibodies of the IgM isotype against SGPG (titers over 1:3,200), especially in tumors such as meningiomas, germinomas, orbital tumors, glioblastomas, medulloblastomas, and subependymomas. (karger.com)
With a pilot mass cytometry dataset of 2 million cells from 28 glioblastomas, RAPID identified tumor cells whose abundance independently and continuously stratified patient survival. (elifesciences.org)
Glioblastomas are the most aggressive of all brain tumors. (dkfz.de)

Most of these tumors are benign teratomas in the sacrum or coccyx. (cigna.com)

In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)

A malignant skin tumor composed of cells similar to those from the basal cell layer of the epidermis. (cdc.gov)
Once inserted, the barrel of the syringe is pulled back a few times, aspirating cells from the skin tumor into the hub of the needle. (tuftscatnip.com)

Distribution of giant cell tumors according to age and sex of patient. (medscape.com)
Giant cell tumors usually occur in young adults, and are slightly more common in females. (orthoinfo.org)
Giant cell tumors are named for the characteristic way they look when viewed under the microscope. (orthoinfo.org)
When viewed microscopically, the tumors consist of many unusually large or "giant" cells. (orthoinfo.org)
Formed by the fusion of several cells, giant cells show multiple nuclei when viewed under a microscope. (orthoinfo.org)
Illustration shows a giant cell tumor at the lower end of the thighbone. (orthoinfo.org)
Most giant cell tumors occur in patients between 20 and 40 years of age. (orthoinfo.org)
In rare cases, a giant cell tumor may spread, or metastasize , to the lungs. (orthoinfo.org)
The cause of giant cell tumors is unknown. (orthoinfo.org)
The most common symptom of a giant cell tumor is pain in the area of the tumor. (orthoinfo.org)
Your doctor will perform a thorough physical examination and use X-rays and other tests to diagnose a giant cell tumor. (orthoinfo.org)
On X-ray, a giant cell tumor appears as a destructive (lytic) lesion next to a joint. (orthoinfo.org)
X-rays from the front ( left ) and side ( right ) show a giant cell tumor in the lower end of the thighbone. (orthoinfo.org)
Development of Giant cell tumour in PDB (GCT-PDB) is extremely rare and little is known about its etiopathogenesis and management. (jocr.co.in)
Variants of the clear cell acanthoma have been noted and include polypoid, giant, multiple, and eruptive. (medscape.com)

Here we describe the results from a phase Ib clinical trial (NCT02274155) in which 17 patients with locally advanced head and neck squamous cell carcinoma (HNSCC) received a murine anti-human OX40 agonist antibody (MEDI6469) prior to definitive surgical resection. (bepress.com)
Our work suggests that increases in the tumor-reactive CD103+ CD39+ CD8+ TIL could serve as a potential biomarker of anti-OX40 clinical activity. (bepress.com)
T cell metabolism has already been shown to influence T cell therapy efficacy in the clinical setting. (medicalnewstoday.com)
A robust metabolic function of T cells is found in patients with better clinical response. (medicalnewstoday.com)
This expanded knowledge of tumor cell plasticity contributes to developing novel therapeutic strategies or combination therapy regimens using available anticancer drugs, which are likely to improve patient outcomes in clinical practice. (scienceopen.com)
Mast cell tumors can usually be diagnosed using a technique called fine needle aspiration," explains Michael Stone, DVM, clinical assistant professor at the Cummings School of Veterinary Medicine at Tufts University. (tuftscatnip.com)
However, a consistent increase in tumor marker levels, coupled with lack of clinical improvement, may indicate treatment failure. (aafp.org)
Four of the seven patients with active disease achieved clinical responses that were complete and ongoing in two patients for more than four years, including in one patient who achieved only a partial response to unmodified tumor-directed LSTs. (childrensnational.org)
primary tumors and significantly reduced the risk of relapse and prolonged the DFS (81 82 Clinical trials are underway testing the utility of CTCs as a therapy decision-making tool in such instances of noticed discrepancy in HER2 positivity between your major tumor and CTCs. (ampkpathway.com)
Typically, the clinical presentation of clear cell acanthoma is a solitary nodule in the lower extremities. (medscape.com)

Signs and symptoms are often caused by the growth and spread of the tumor. (medicinenet.com)
The signs or symptoms are either caused by the growth of the tumor and/or by the hormones produced by the tumor. (medicinenet.com)
Nonseminomas are usually large and cause signs or symptoms of disease. (cigna.com)

In histopathology, a small-blue-round-cell tumour (abbreviated SBRCT), also known as a small-round-blue-cell tumor (SRBCT) or a small-round-cell tumour (SRCT), is any one of a group of malignant neoplasms that have a characteristic appearance under the microscope, i.e. consisting of small round cells that stain blue on routine H&E stained sections. (wikipedia.org)

They are termed "atypical" because they don't contain the granules that are so characteristic of most mast cells. (tuftscatnip.com)
These atypical mast cell tumors often spontaneously regress over time, usually four to 24 months after they're diagnosed. (tuftscatnip.com)

The IL-6/Jak2/STAT3 axis also mediates expansion of myeloid-derived suppressor cells (MDSC). (bmj.com)

Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. (bepress.com)
A few studies have reported tumors coexisting with SMBTs, such as endometrioid adenocarcinoma [ 4 ] and squamous cell carcinoma [ 5 ]. (hindawi.com)
Inhalation of 1-BP produced alveolar/bronchiolar adenomas and carcinomas in female mice, adenomas of the large intestine in female rats, and keratoacanthoma/squamous cell carcinoma of the skin in male rats. (cdc.gov)
and 3.73 (1.44) ppm for keratoacanthoma +squamous cell carcinoma of the skin. (cdc.gov)
SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)

Detecting phosphotyrosine epitopes pY1068 and -pY1173 indicated active EGFR signalling, and finding EGFR ligands EGF and transforming growth factor-α restricted to cells of the monocytic lineage suggested paracrine EGFR activation in stromal cells. (ox.ac.uk)
We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
Other studies have investigated specific lipid signaling pathways, but what makes AGPS stand out as a treatment target is that the enzyme seems to simultaneously regulate multiple aspects of lipid metabolism important for tumor growth and malignancy. (scitechdaily.com)
common current treatment normally offers only six to 12 weeks of halted growth before the tumor grows and spreads, ultimately destroying cognitive and physical function and leading to death. (sciencedaily.com)
Avastin may be effective in treating gliomas because these tumors have a high concentration of vascular endothelial growth factor, a protein that stimulates development of new blood vessels in a process known as angiogenesis. (sciencedaily.com)
New blood vessels spur a tumor's growth and ability to spread, so researchers are interested in cutting off angiogenesis to slow tumors down. (sciencedaily.com)
They said that by manipulating various proteins in the stress response pathway within T cells, it is possible to overcome the T cell's intrinsic stress response and enable the immune system to fight against further tumor growth. (medicalnewstoday.com)
Previous studies have shown that T cells without PERK were better at controlling tumor growth when transfused into tumor-bearing hosts. (medicalnewstoday.com)
Many of the cysts and the low papillary growth lesions were lined by tall columnar mucinous or cuboidal ciliated serous cells (Figure 2(b) ). (hindawi.com)
Nuclear stratification was noted, but no invasive growth was apparent in these cystic tumors. (hindawi.com)
Such non-mutational processes are largely driven by tumor cell plasticity, which renders tumor cells insusceptible to the drug-targeted pathway, thereby facilitating the tumor cell survival and growth. (scienceopen.com)
The first suggests that fetal gonocytes whose development into spermatogonia is blocked may undergo abnormal cell division and then invasive growth mediated by postnatal and pubertal gonadotrophin stimulation. (medscape.com)
While Rothman does not dismiss the possibility that RF radiation affects the growth and development of tumor cells, he would direct more attention to the "most important health effect of using mobile telephones," which, he states, "is likely to be the result of behavioral change related to attention span. (microwavenews.com)

Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)

In this study, we report the cell-autonomous antiproliferative and cytotoxic activities exhibited by the spider peptide gomesin (AgGom) and gomesin-like homologue (HiGom) in DFTD cells. (nature.com)
The screening of a novel panel of AgGom-analogues revealed that, unlike changes in the hydrophobicity and electrostatic surface, the cytotoxic potential of the gomesin analogues in DFTD cells lies on specific arginine substitutions in the eight and nine positions and alanine replacement in three, five and 12 positions. (nature.com)
This observation prompted us to characterise the cell-autonomous cytotoxic and anti-proliferative profile of gomesin in DFTD cells and in comparison, to non-transformed (healthy) Tasmanian devil fibroblasts (FIBS). (nature.com)

In a just-released commentary , Ken Rothman , one of the best-known names in epidemiology, explores two of the most contentious issues related to mobile phone health risks: (1) If cell phones do lead to an increased incidence of brain tumors, when would we expect to begin to see it? (microwavenews.com)
Rothman, the founder and editor emeritus of Epidemiology, has long been involved in cell-phone health research. (microwavenews.com)
Last Sunday, two days after his commentary was posted on the Epidemiology Web site, the New York Times kicked off a special report -"Driven to Distraction"- on the well-documented hazards of using a cell phone or some other wireless gadget while behind the wheel. (microwavenews.com)
With respect to RF radiation, Anders Ahlbom and the other members of ICNIRP's epidemiology committee highlight the absence of a tumor link in the short or intermediate term in their review. (microwavenews.com)

According to the TNM classification system micro-metastases are defined as tumor deposits of 0.2 mm to ≤ 2 mm in diameter, labeled as pN1(mi), and ITC as either single tumor cells or clusters of tumor cells of 0.2 mm or less, labeled as pN0(i+) [ 15 ]. (biomedcentral.com)
When a tumor forms in one of these clusters, it's called a pancreatic NET, or islet cell carcinoma. (hopkinsmedicine.org)

Six patients had multicentric disease. (medscape.com)
Immunohistochemistry and quantitative polymerase chain reaction were used to analyze tumor samples from 172 HCC patients. (nih.gov)
Comparison of tumor biopsies before and after treatment reveals an increase of activated, conventional CD4+ tumor-infiltrating lymphocytes (TIL) in most patients and higher clonality by TCRβ sequencing. (bepress.com)
[ 116 , 118 ] However, a recent report found that CK19 releasing cells could also be detected in patients with benign colon diseases such as diverticulosis and Crohn's disease. (medscape.com)
In addition, we have analyzed serum antibody titers against SGPG, GD3, and OAc-GD3 in patients with neural tumors by ELISA and HPTLC immunostaining. (karger.com)
Nevertheless, tumor markers can play a crucial role in detecting disease and assessing response to therapy in selected groups of patients. (aafp.org)
They engineered T-cells, essential players in the body's own immune system, to strip tumors of their self-preservation skill and were able to hold Hodgkin lymphoma at bay in patients with relapsed disease for more than four years. (childrensnational.org)
What's more, they infused patients with the tumor-directed T-cells without requiring "pretreatment" chemotherapy. (childrensnational.org)
In the dose-escalation study, eight patients with Epstein Barr virus-positive Hodgkin lymphoma received as few as 2 and as many as 12 doses of between 2 × 107 and 1.5 × 108 cells/m2 of specially engineered T-cells. (childrensnational.org)
Seven of the eight patients treated had active disease at the time of T-cell infusion. (childrensnational.org)
Discordance in HER2 position between primary tumor and CTCs reports are variable in the order of 15-35% in MBC (75 79 80 HER2 discordance has also been reported in EBC patients. (ampkpathway.com)
primary tumors had HER2+ CTCs and 1 of 3 (33%) patients with HER2+ primary tumors had HER2? (ampkpathway.com)
Disease in any organ can cause exuda- of combining both procedures in the diag- tive PE through a variety of mechanisms nosis of TB and malignancy in patients with including infection, malignancy, immuno- exudative PE. (who.int)
Fields et al reviewed 500 patients with Merkel cell carcinoma in a single-institution study. (medscape.com)

The presence of ITC was associated with a significantly worse disease-free survival (hazard ratio = 4.73, p = 0.005). (biomedcentral.com)
These stromal cells have been previously shown by our group to rely on STAT3 signaling for survival, and secrete cytokines involved in MDSC generation. (bmj.com)
Due to the critical significance of early and accurate detection in improving the survival rate of a patient with a malignant granular cell tumor, an oncologist will order a number of diagnostic tests to produce rapid correct findings. (newhopemedicalcenter.com)
We introduce a machine learning algorithm, Risk Assessment Population IDentification (RAPID), that is unsupervised and automated, identifies phenotypically distinct cell populations, and determines whether these populations stratify patient survival. (elifesciences.org)
To date, no tumor marker has demonstrated a survival benefit in randomized controlled trials of screening in the general population. (aafp.org)

Remodel the surrounding tumor stroma by protease secretion to escape into adjacent blood vessels. (mayo.edu)

So, the research team forced expression of a dominant-negative TGF-β receptor type 2 (DNRII) onto LMP-specific T-cells (DNRII-LSTs) that were specially designed to seek out proteins derived from the Epstein Barr virus and destroy tumor cells expressing them. (childrensnational.org)

Provided the function of CTC in development to metastases it isn't surprising the fact that hormone receptor position of CTCs could also change from that of the principal tumor. (ampkpathway.com)

Mast cells are a component of the immune system. (tuftscatnip.com)
WASHINGTON -Tumors have come up with ingenious strategies that enable them to evade detection and destruction by the immune system. (childrensnational.org)
The study team writes that their findings underscore the potential utility of expressing DNRII when battling other tumors that have learned to evade the immune system. (childrensnational.org)

This is a common location for the tumors to occur. (orthoinfo.org)
Most often, the tumors occur close to the knee joint - either in the lower end of the femur or the upper end of the tibia. (orthoinfo.org)
The tumors occur spontaneously. (orthoinfo.org)
Rear end paralysis can occur for a number of reasons (spinal embolism, back injuries / pinched nerves, cervical disc disease, spondylosis, etc. (bmdca.org)
A degenerative joint disease like HD (Hip Dysplasia, see below), ED causes arthritic changes to occur in the elbow joint. (bmdca.org)

We also underscore how new findings and conceptual insights into TNFRSF signaling are facilitating the understanding of B-cell malignancies and autoimmune diseases. (nih.gov)
Cutaneous tumors encompass a vast array of malignancies, from neuroendocrine to lymphoid. (medscape.com)
Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)

Anatomy21

Organisms11

Diseases82

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes49

Disciplines and Occupations1

Information Science4

Health Care6

Microenvironment7

Decreased tumor growth1

Malignant brain tumors4

Metastasis10

Proliferation13

Solid tumors9

Mast cell tumors are malignant1

Cancerous8

Antigens4

Immunotherapy6

Nonseminomatous germ cell t2

Progression7

Islet cell3

Tissues13

Immunity4

Therapies13

Germ33

Receptors3

Small round blue1

Cancers5

Granular Cell Tumors7

Mesenchymal7

Circulating Tumor Cells2

Bone38

Neuroendocrine tumors4

Inflammatory7

Metastatic10

Cancer72

Genes6

Benign or malignant2

Genetic5

Anti-tumor activity1

Lung2

Ovaries2

Induces1

Noncancerous1

Aggressive tumor1

Biomarkers1

Extragonadal1

Tissue10

Recurrent1

Humans1

Diagnosis7

Glioblastomas3

Teratomas1

Recurrence1

Skin tumor2

Giant15

Clinical10

Symptoms3

Neoplasms1

Atypical2

Suppressor1

Squamous cell carc5

Growth13

Carcinomas1

Cytotoxic3

Epidemiology4

Clusters2

Patients14

Survival5

Blood vessels1

Destroy1

Metastases1

Immune system3

Occur5

Malignancies3