• Benign lesions include placental site nodule and hydatidiform moles while malignant lesions have four subtypes including invasive mole, gestational choriocarcinoma, placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). (wikipedia.org)
  • The cause of this disease is unknown but the identification of the tumor based on total beta-human chorionic gonadotropin (β-hCG) in the serum. (wikipedia.org)
  • Although this group of diseases are highly susceptible to chemotherapy, prognosis depends on the type of GTN and whether the tumor has spread to other areas of the body. (wikipedia.org)
  • Although risk factors may impact on the development of the tumor, most do not directly cause of disease. (wikipedia.org)
  • Placental side trophoblastic tumor (PSTT) is differentiated by low β-hCG levels because it is a neoplastic proliferation of intermediate trophoblastic cells. (wikipedia.org)
  • GTN includes complete hydatidiform mole (CHM), partial hydatidiform mole (PHM), invasive mole, choriocarcinoma, placental-site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). (medscape.com)
  • [ 2 ] The modified WHO prognostic scoring system is not applicable to patients with placental-site trophoblastic disease (PSTT) or epithelioid trophoblastic tumor (ETT). (medscape.com)
  • Tru-cut placental site trophoblastic tumor biopsy: A novel way for diagnosis. (peertechzpublications.org)
  • A Placental Site Trophoblastic Tumor (PSTT) is a rare form of gestational trophoblastic disease and usually manifests itself with abnormal uterine bleeding and elevated β-hCG serum levels even months or years after any antecedent pregnancy event. (peertechzpublications.org)
  • The patient performed a hysteroscopy with simultaneous tru-cut biopsy of the lesion under US guidance and a placental site trophoblastic tumor was diagnosed by histological examination. (peertechzpublications.org)
  • Placental Site Trophoblastic Tumor (PSTT) is a rare form of gestational trophoblastic disease accounting for about 1% - 2% of all trophoblastic tumors [1]. (peertechzpublications.org)
  • Although the most common cause of an elevated HCG level in females is pregnancy, occasionally, a HCG-secreting tumor is suspected and other conditions such as gestational trophoblastic disease (GTD), nontrophoblastic neoplasms, or a pituitary source of HCG, must be considered. (sheppard-arts.com)
  • A tumor that arises from the testis and is composed of neoplastic trophoblastic cells. (nih.gov)
  • Choriocarcinoma of the ovary is a highly malignant ovarian tumor which is characterized pathologically by the presence of trophoblastic malignant cells, and biochemically by the production of the pregnancy hormone human chorionic gonadotrophin (hCG) in the absence of an ongoing pregnancy. (atlasgeneticsoncology.org)
  • This disease is classified two types in origin, gestational choriocarcinoma and nongestational germ cell tumor. (atlasgeneticsoncology.org)
  • The levels of serum or urine beta-hCG are good tumor marker for the progression or remission of disease. (atlasgeneticsoncology.org)
  • Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells: cytotrophoblast (CT), intermediate trophoblast (IT), and syncytiotrophoblast (ST). The CT and IT tend to grow in clusters and sheets separated by ST. The typical pattern of choriocarcinoma has been called two cell pattern, biphasic-terms that reflect the relatively regular, alternating arrangement of CT and ST in the tumor interspread with intermediate trophoblast. (atlasgeneticsoncology.org)
  • Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis. (medscape.com)
  • Relapse rate of patients with low-risk gestational trophoblastic tumor initially treated with single-agent chemotherapy. (medscape.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental site trophoblastic tumors (PSTTs) and epithelioid trophoblastic tumors (ETTs). (johnshopkins.edu)
  • Since these tumors are derivatives of fetal trophoblastic tissue, approximately 50% of GTN cases are expected to originate from a male conceptus and carry a Y-chromosomal complement according to a balanced sex ratio. (johnshopkins.edu)
  • To evaluate the efficacy and toxicity of a regimen of etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine in patients with metastatic, high-risk gestational trophoblastic tumors. (elsevierpure.com)
  • All met the National Cancer Institute criteria for high-risk gestational trophoblastic tumors. (elsevierpure.com)
  • A malignant metastatic form of trophoblastic tumors. (umassmed.edu)
  • Performed by an interventional radiologist, selective embolization of the uterine artery is reported as a well-tolerated and effective treatment option for managing severe bleeding from residual uterine vascular malformations in patients with gestational trophoblastic tumors that have been treated. (medscape.com)
  • Typically, tumors are confined into the uterus and secrete lower levels of β-hCG compared with other Gestational Trophoblastic Neoplasia (GTN). (peertechzpublications.org)
  • Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. (mycancergenome.org)
  • Gestational trophoblastic tumors are sensitive to many antineoplastic agents, especially those that act in the S phase or the M phase of the cell cycle. (medscape.com)
  • What is the best protocol of single-agent methotrexate chemotherapy in nonmetastatic or low-risk metastatic gestational trophoblastic tumors? (medscape.com)
  • Roberts JP, Lurain JR. Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. (medscape.com)
  • The elevated HCG levels are also associated with trophoblastic diseases and certain nontrophoblastic neoplasms. (artronlab.com)
  • A number of conditions other than pregnancy including trophoblastic disease and certain nontrophoblastic neoplasms cause elevated levels of hCG. (mydiscountpill.com)
  • A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometrium and histologically characterized by hyperplasia of trophoblasts generalized cystic degeneration of chorionic villi and the presence of molar villi in the myometrium and/ or uterine blood vessels. (globalgenes.org)
  • The neoplastic disease may precede or follow FERTILIZATION. (nih.gov)
  • If metastases are present, signs and symptoms associated with the metastatic disease and more severe symptoms may be present. (wikipedia.org)
  • Other symptoms can develop in the case of metastatic disease. (medscape.com)
  • but the sequelae of HIV and/or AIDS, the resultant low CD4 counts, comorbidities, poor performance status and the extent of metastatic disease in patients receiving chemotherapy, compromise the prognosis and survival. (sun.ac.za)
  • The response to treatment is generally favourable but the associated complications of HIV, comorbidities, poor performance status and extent of metastatic disease in gestational trophoblastic neoplasm patients receiving chemotherapy, compromises the outcome and survival. (sun.ac.za)
  • CONCLUSIONS: Our findings support inclusion of chemotherapy combinations with investigational agents for advanced or metastatic disease. (bvsalud.org)
  • New onset of symptoms or a rising CEA warrants investigation with chest and abdominal CT to look for recurrent or metastatic disease that may be amenable to therapy. (health.am)
  • For patients with a rising CEA with unrevealing CT imaging, a PET scan is more sensitive for the detection of occult metastatic disease. (health.am)
  • Gestational trophoblastic neoplasia (GTN) is group of rare diseases related to pregnancy and included in gestational trophoblastic disease (GTD) in which abnormal trophoblast cells grow in the uterus. (wikipedia.org)
  • Gestational trophoblastic neoplasia (GTN) represents a spectrum of premalignant and malignant diseases that occur after abnormal fertilization. (medscape.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • 5-day methotrexate for women with metastatic gestational trophoblastic disease. (medscape.com)
  • Gestational trophoblastic neoplasia (GTN) is staged by the American Joint Committee on Cancer (AJCC) and the Féderation Internationale de Gynécologie et d'Obstétrique (FIGO) systems, based on the criteria below (see Table 1). (medscape.com)
  • Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. (medscape.com)
  • An estimated 30 - 40% of HIV-infected patients are likely to develop cancer during the progression of their disease. (sun.ac.za)
  • OBJECTIVE: Aim of our study was to evaluate whether the different laparotomic (ARH) or minimally invasive (laparoscopic and robotic) approaches (MIS) in FIGO stage IB1-IB2 cervical cancer, present different patterns of recurrence of the disease. (bvsalud.org)
  • Cancer is a major burden of disease worldwide. (health.am)
  • In many countries, cancer ranks the second most common cause of death following cardiovascular diseases. (health.am)
  • USCS are produced by the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI), in collaboration with the North American Association of Central Cancer Registries (NAACCR). (cdc.gov)
  • The objective of a cervical screening programme is to prevent invasive cancer of the cervix by detecting and treating pre-invasive disease of the cervix. (annals.edu.sg)
  • Cervical cancer is a preventable disease that affects nearly half a million women worldwide. (annals.edu.sg)
  • Testicular cancer represents 1% of adult neoplasms and 5% of urological tumours, with three to ten new cases per 100,000 males/per year in Western societies [ 6 ]. (uroweb.org)
  • To describe the prevalence of inadequate nutritional status of children and adolescents with malignant neoplasm at hospital admission in childhood cancer reference centers in Brazil. (bvsalud.org)
  • A benign or malignant neoplasm arising from tissues that do not include fluid areas. (mycancergenome.org)
  • ThromboembolismThromboembolism is the benign epub 7 tips whereby there is a command of heart or muscles is the health instances that is effective and stated by habit to be another agencies in the Expenses, application, complete blindness, arteries and disease. (ccctw.hk)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
  • A case report of effusion cytology of a mucinous neoplasm is illustrated. (sun.ac.za)
  • Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). (mycancergenome.org)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • Management of liver metastasis from gestational trophoblastic neoplasia. (medscape.com)
  • Renal metastases of gestational trophoblastic disease: a report of eight cases. (medscape.com)
  • Conclusions: Chemotherapy with etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine is well tolerated and highly effective for metastatic, high-risk gestational trophoblastic disease. (elsevierpure.com)
  • Is lack of response to single-agent chemotherapy in gestational trophoblastic disease associated with dose scheduling or chemotherapy resistance? (medscape.com)
  • It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. (curehunter.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Saving Lives, Protecting People Centers for Disease Control and Prevention. (cdc.gov)
  • The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. (cdc.gov)
  • Stage I - Disease confined to the uterus Stage II - GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament) Stage III - GTN extends to the lungs, with or without known genital tract involvement Stage IV - All other metastatic sites All types of gestational trophoblastic neoplasia originate from the placenta. (wikipedia.org)
  • Acquired Uniparental Disomy Regions Are Associated with Disease Outcome in Patients with Oral Cavity and Oropharynx But Not Larynx Cancers. (cdc.gov)
  • Patients who did not undergo full colonoscopy preoperatively should undergo colonoscopy within 3-6 months postoperatively to exclude other synchronous colorectal neoplasms and 1 year thereafter. (health.am)
  • Signs and symptoms of GTN will appear vary from person to person and depending upon the type of the disease. (wikipedia.org)
  • HCG is a hormone produced by trophoblastic tissue and it appears around the 8-9th day after ovulation, or around the 4th day after conception. (artronlab.com)
  • The epub 7 tips to becoming a of neoplasm intestines destroyed on the medical complication is of Breast effect, initially least in stateSaving an tissue of the remission of Leipzig to the yellow paradoxical use. (ccctw.hk)
  • Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. (lookformedical.com)
  • Ultrasonography, the preferred adjunct examination method and the differential diagnostic tool for gynecologic emergency, can reflect the change pattern of gynecological diseases in daytime and at night. (dovepress.com)
  • Rapid escalation of weekly intramuscular methotrexate for nonmetastatic gestational trophoblastic disease: a Gynecologic Oncology Group study. (medscape.com)
  • It can effectively diagnose gynecological diseases caused by acute abdominal pain in women, while exclude other causes without surgical treatment. (dovepress.com)