• Success has been particularly limited in adult-onset neurodegenerative diseases, for which no disease-modifying drug yet exists. (nature.com)
  • In this study, we sought to understand the disease stages and therapeutic hypotheses studied in clinical trials conducted in neurodegenerative diseases to date. (nature.com)
  • Defects in ubiquitin-dependent proteolysis have been shown to result in a variety of human diseases, including cancer, neurodegenerative diseases, and metabolic disorders. (nih.gov)
  • Identifying a particular interaction that contributes to a disease and then finding ways to disrupt it, can be a painstaking and incredibly slow process," explains Dr. Lorraine Kalia, who is also a staff neurologist at UHN and a scientist at U of T's Tanz Centre for Research in Neurodegenerative Diseases, in the Temerty Faculty of Medicine. (worldhealth.net)
  • Growing evidence indicates that gut microbiota plays a critical role in regulating the progression of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD), but the molecular mechanism underlying such microbe-host interaction is still unclear. (hku.hk)
  • Inhibiting the ability of the bacteria to secrete such proteins may be a preventative treatment for neurodegenerative diseases. (hku.hk)
  • Neurodegenerative diseases are caused by protein aggregation in the neurons. (hku.hk)
  • Studies in the last few years have suggested that gut bacteria may play an important role in the pathogenesis of neurodegenerative diseases. (hku.hk)
  • This is consistent with the observation that drinking green tea has beneficial effects in preventing neurodegenerative diseases," said Dr Chenyin WANG, the first author of the paper. (hku.hk)
  • This research opens a new direction to develop preventative measures for neurodegenerative diseases by targeting bacterial curli production in the human gut. (hku.hk)
  • Emerging studies suggest a correlation between elevated plasma homocysteine (hcy) levels and the risk of atherosclerosis, vascular disorders, and neurodegenerative diseases, including Parkinson's disease (PD). (lu.se)
  • As palliative treatments for Alzheimer's disease proliferate, the focus of therapeutics turns to drugs withthe potential to alter course. (psychiatrist.com)
  • Evidence is reviewed, suggesting that there is biological plausibility to utilizinganti-inflammatory agents, antioxidants, free-radical scavengers, estrogen preparations, and perhaps cholinomimetics.This range of possibilities leads to an optimistic assessment of the likelihood for altering the courseor delaying the onset of Alzheimer's disease. (psychiatrist.com)
  • Hypometabolism as a therapeutic target in Alzheimer's disease. (greenmedinfo.com)
  • The pathology of Alzheimer's disease (AD) is characterized by cerebral atrophy in frontal, temporal, and parietal regions, with senile plaques, dystrophic neurites, and neurofibrillar tangles within defined areas of the brain. (greenmedinfo.com)
  • The proposed research programme is unique in terms of generating a tuneable, multipurpose, microwave, continuous, atmospheric pressure, flow reactor for the efficient conduct of various chemical reactions for the synthesis of Leucettamines to be used against Alzheimer's disease. (europa.eu)
  • The timeliness of MICRO-THERAPY is a response to demand for new ways to produce chemicals for the therapeutic activities against Alzheimer's disease. (europa.eu)
  • Furthermore, the research team found that curli also promoted neurodegeneration in animal models of Alzheimer's disease, Amyotrophic lateral sclerosis, and Huntington's disease, suggesting that the bacteria-secreted curli may have detrimental effects in a range of neurodegenerative disorders. (hku.hk)
  • The β-amyloid (Aβ) peptide is the major constituent of amyloid plaques in Alzheimer's disease (AD) brain and is likely to play a central role in the pathogenesis of this devastating neurodegenerative disorder. (jneurosci.org)
  • Although the etiology of Alzheimer's disease (AD) is not completely understood, the study of disease genes that cause AD has revealed important clues about the pathogenesis of this disorder. (jneurosci.org)
  • Among these substrates, the amyloid precursor protein (APP) has been the most studied, as generation of aggregation-prone amyloid β-protein (Aβ) is a defining feature of Alzheimer's disease (AD). (ku.edu)
  • Substrate-based chemical probes-synthetic peptides and peptidomimetics-have been critical to unraveling the complexity of γ-secretase, and small drug-like inhibitors and modulators of γ-secretase activity have been essential for exploring the potential of the protease as a therapeutic target for Alzheimer's disease. (ku.edu)
  • The neurofibrillary tangles (NFTs) generated by self-aggregation of anomalous forms of tau represent a neuropathological hallmark of Alzheimer's disease (AD). (unboundmedicine.com)
  • Alzheimer's disease (AD), the most common cause of dementia (major neurocognitive disorder), is taking up more space as society ages. (bvsalud.org)
  • Allopregnanolone, a first-in-class regenerative therapeutic, has the potential to delay neurodegeneration in early Alzheimer's disease (AD) by promoting endogenous systems of renewal and repair, early clinical data show. (medscape.com)
  • In presenting the findings at the 16th Clinical Trials on Alzheimer's Disease (CTAD) conference, study investigator Roberta Brinton, PhD, with The Center for Innovation in Brain Science at the University of Arizona in Tucson, gave a "whirlwind tour of decades of research" into allopregnanolone - "from discovery to translation to now in clinical trials. (medscape.com)
  • Work in preclinical animal models suggests allopregnanolone may reduce some of the hallmarks of Alzheimer's disease, like amyloid plaque buildup, and even have an effect on learning and memory," Edelmayer explained. (medscape.com)
  • The early clinical data reported at CTAD builds off that initial work, "demonstrating that there may be the potential for delaying disease progression and treating Alzheimer's disease with this type of approach," she said. (medscape.com)
  • 16th Clinical Trials on Alzheimer's Disease (CTAD) conference: Abstract OC10. (medscape.com)
  • We identified articles for review primarily by conducting a Medline search using the subject headings dementia, mild cognitive impairment, Alzheimer's disease, vascular dementia, frontotemporal dementia, and Lewy body dementia . (cdc.gov)
  • Articles included in this review were primarily identified through a Medline search of the terms dementia, mild cognitive impairment, Alzheimer's disease, vascular dementia, frontotemporal dementia, Lewy body dementia, mental disorders, and stigma . (cdc.gov)
  • Northwestern Medicine scientists have uncovered a new mechanism by which mutations in a gene parkin contribute to familial forms of Parkinson's disease. (news-medical.net)
  • After the initial discovery, Northwestern scientists tried to understand the function of these contacts in Parkinson's disease. (news-medical.net)
  • However, they also found that in some forms of Parkinson's disease, lysosomes cannot serve as a 'helping hand' to mitochondria because the contacts between the two organelles are disrupted. (news-medical.net)
  • This results in dysfunctional mitochondria and ultimately degeneration of vulnerable neurons in Parkinson's disease. (news-medical.net)
  • Findings from this study suggest that dysregulation of mitochondria-lysosome contacts contributes to the Parkinson's disease pathophysiology,' said Krainc, the study's corresponding author. (news-medical.net)
  • We propose that restoring such mitochondria-lysosome contacts represents an important new therapeutic opportunity for Parkinson's disease. (news-medical.net)
  • The title of the study is 'Parkin regulates amino acid homeostasis at mitochondria-lysosome contact sites in Parkinson's disease. (news-medical.net)
  • Parkinson's disease (PD) can be considered as a multi-system disorder affecting the regulation of several neurotransmitters in the brain. (drexel.edu)
  • NEW YORK, September 21, 2003 - New research from Memorial Sloan Kettering Cancer Center (MSKCC), Cornell University, and The University of Connecticut describes a novel way of producing therapeutic nerve cells that can cure mice with Parkinson's-like disease. (mskcc.org)
  • In a study published in Nature Communications, a team led by Krembil Brain Institute Senior Scientists, Drs. Lorraine Kalia and Suneil Kalia, and University of Toronto (U of T) Professor, Dr. Philip M. Kim, identified a protein-protein interaction that contributes to Parkinson's disease. (worldhealth.net)
  • In this study, the researchers took an alternate approach by looking for protein-protein interactions that may be promoting the accumulation of a-syn in Parkinson's disease. (worldhealth.net)
  • We tested the peptide in multiple experimental models of Parkinson's disease, and we consistently found that it restored endolysosomal function, promoted a-syn clearance and prevented cell death," he said. (worldhealth.net)
  • Nonetheless, our findings are very exciting because they suggest a new avenue for developing treatments for Parkinson's disease and other neurodegenerative conditions. (worldhealth.net)
  • NEW YORK, NY - The Michael J. Fox Foundation for Parkinson's Research today announced $3.5 million in total funding to nine research studies aiming to advance understanding of the LRRK2 gene, a promising therapeutic target for Parkinson's disease. (michaeljfox.org)
  • First linked to Parkinson's disease in 2004, the LRRK2 gene is now believed to be the most common genetic contributor to the disease. (michaeljfox.org)
  • Parkinson's disease (PD) is one severe debilitating neurological disease that results from massive and progressive degenerative loss of dopaminergic neurons in the substantial nigra, and new cell therapy appeal hopeful functional recovery of injured dopaminergic neuronal system and cure of PD. (omicsonline.org)
  • Background: Deep Brain Stimulation (DBS) is an established treatment for motor symptoms in Parkinson's disease (PD). (lu.se)
  • The aberrant metabolism of H 2 S is involved in the pathogenesis of several skin diseases, such as vascular disorders, psoriasis, ulcers, pigment disorders, and melanoma. (hindawi.com)
  • Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. (frontiersin.org)
  • The abnormal morphology and dysfunction of mitochondria have been proven as the principal mechanisms in the pathogenesis of cardiovascular diseases, such as heart failure, myocardial infarction, atherosclerosis, and hypertension ( 4 - 6 ). (frontiersin.org)
  • In the last few decades, a better knowledge of the inflammatory pathways involved in the pathogenesis of Inflammatory Bowel Disease (IBD) has promoted biological therapy as an important tool to treat IBD patients. (mdpi.com)
  • The authors collected the evidence for roles of aging on pathogenesis of COPD and considered future therapeutic strategy for COPD based on this senescence hypothesis. (dovepress.com)
  • A therapeutic interfering particle is an antiviral preparation that reduces the replication rate and pathogenesis of a particular viral infectious disease. (wikipedia.org)
  • To investigate PASC pathogenesis , studies of MA10-infected mice were extended from acute disease through clinical recovery. (bvsalud.org)
  • A national survey was performed to gain insight into current approaches towards enteral feeding during therapeutic cooling. (bmj.com)
  • hence, approaches that enhance mitochondrial activities have a promising therapeutic potential for these conditions. (tigem.it)
  • Overall, these data support the potential use of miR-181a/b downregulation as an innovative mutation-independent therapeutic strategy for IRDs, which can be effective both to delay disease progression and to aid gene-specific therapeutic approaches. (tigem.it)
  • In this review, we summarize the latest research progress on H 2 S-mediated effects, focusing on the most recent results and mechanism of the antioxidant effect of H 2 S in various skin diseases, to provide new insights into further exploration of its therapeutic targets. (hindawi.com)
  • We annotated targets and eligibility criteria for 3238 neurodegenerative disease trials registered at ClinicalTrials.gov from 2000 to 2020. (nature.com)
  • Though often linked to disease initiation, not progression, these targets were tested mostly at symptomatic disease stages. (nature.com)
  • Our goals were to characterize clinical trials across major neurodegenerative disease indications, identifying correlations and temporal trends, particularly with regards to disease stages and molecular targets of drugs. (nature.com)
  • Two programs aim to identify drug targets for clinically important subtypes of type 2 diabetes, which affects more than 37 million people in the United States alone, and one program aims to unravel the genetic roots of cardiac fibrosis, or scarring of the heart, which occurs in many cardiovascular diseases that can lead to heart dysfunction and failure. (broadinstitute.org)
  • The two diabetes programs will aim to identify therapeutic targets for both non-weight mediated insulin resistance and loss of beta cell function. (broadinstitute.org)
  • The alliance will utilize state-of-the-art genetics and genomics methods to interrogate subtypes of diabetes and, with Broad's Center for the Development of Therapeutics , probe the relationships between genes and pathways that could be therapeutic targets using large-scale cell screens. (broadinstitute.org)
  • The team aims to identify and validate genes that could serve as therapeutic targets to inhibit or possibly reverse fibrosis - a condition that has few effective therapies. (broadinstitute.org)
  • It is not intended to support research focused on understanding normal biology, disease processes, generating lists of putative new targets, identifying new therapeutic uses for existing compounds, or identifying mechanism of action for therapeutic leads. (nih.gov)
  • Optogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. (frontiersin.org)
  • With the recent discovery that mTOR inhibitors extend the lifespan of mice, sirolimus and other rapamycin analogs (rapalogs) are emerging as therapeutic targets for the treatment and prevention of age-related diseases. (medscape.com)
  • It also set targets including that of reducing the disease burden by at least 50% by 2010 and by 75% by 2015. (who.int)
  • Therefore, combining automated annotation and deep manual curation of clinical trial registrations from ClinicalTrials.gov, we set out to map the landscape of clinical trials and their therapeutic interventions and to test correlations and trends over the past 2 decades. (nature.com)
  • However, clinical trials of these agents for cardiovascular diseases were hardly approved to carry out, even less to evaluate their clinical effectiveness and safety. (frontiersin.org)
  • This review focuses on the role of ubiquitin-dependent degradation in human disease and potential clinical applications that are being developed to exploit the cells natural proteolytic machinery to treat diseases. (nih.gov)
  • The Broad Institute of MIT and Harvard today announced a new research alliance with Novo Nordisk aimed at addressing critical unmet clinical needs in diabetes and cardiometabolic diseases. (broadinstitute.org)
  • Studies suggest the potential clinical use of these quinolines and of their derivatives to inhibit tau aggregation and possible therapeutic routes for AD. (unboundmedicine.com)
  • The apoptosis in health and disease clinical and therapeutic aspects, Even, which shows of already local a l in reputable request, were driven for moving those new projections of Girgenti and Syracuse, of which the strata 'm us upward to a geological present in solid wine. (singlewheel.com)
  • Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria. (bmj.com)
  • METHODS: Forty two patients with confirmed multiple sclerosis, selected as having a very active disease on clinical and MRI criteria were randomised to receive either mitoxantrone (20 mg intravenously (IV) monthly) and methylprednisolone (1 g iv monthly) or methylprednisolone alone over six months. (bmj.com)
  • CONCLUSION: In this selected group of patients with multiple sclerosis with very active disease, mitoxantrone combined with methylprednisolone was effective in improving both clinical and MRI indices of disease activity over a period of six months whereas methylprednisolone alone was not. (bmj.com)
  • This study aimed to evaluate the informed consent process, therapeutic misconception and motivation for participation among Egyptians participating in clinical trials. (who.int)
  • Investigators need to emphasize the distinction between research and clinical care to address the high rate of therapeutic misconception. (who.int)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • In this review, we discuss recent advances in understanding H 2 S and its antioxidant effects on skin pathology, the roles of altered H 2 S metabolism in skin disorders, and the potential value of H 2 S as a therapeutic intervention in skin diseases. (hindawi.com)
  • The potential for disease modification through early intervention against root molecular causes of disease remains largely unexplored. (nature.com)
  • Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. (dovepress.com)
  • Intervention with therapeutic interfering particles can be prophylactic (to prevent or ameliorate the effects of a future infection), or a single-administration therapeutic (to fight a disease that has already occurred, such as HIV or COVID-19). (wikipedia.org)
  • Early intervention with antiviral EIDD-2801 reduced chronic disease , and early anti-fibrotic agent (nintedanib) intervention modified early disease severity . (bvsalud.org)
  • Aggressive surgical intervention is the major therapeutic modality for patients with necrotizing fasciitis and should be performed as early as possible. (medscape.com)
  • We hope this review will provide perspectives on mitochondrial-targeted therapeutics in cardiovascular diseases. (frontiersin.org)
  • And now-as Professor of the Department of Experimental Therapeutics at the University of Texas M.D. Anderson Cancer Center-spices are the subject of many experiments in my laboratory, where my colleagues and I are discovering the molecular and biochemical secrets behind the therapeutic power of these ancient medicines, and conducting human studies to put those secrets to use in the battle against cancer . (naturalnews.com)
  • Such chemical probes and therapeutic prototypes will be reviewed here, with concluding commentary on the future directions in the study of this biologically important protease complex and the translation of basic findings into therapeutics. (ku.edu)
  • The goal of this Funding Opportunity Announcement (FOA) is to support translational research that provides strong justification for later stage therapeutics development and preclinical efforts in health-related outcomes relevant to the National Institute of Diabetes and Digestive and Kidney Diseases. (nih.gov)
  • The objective of this FOA is to stimulate early-stage preclinical validation of therapeutic leads (that need not be finalized therapeutics, henceforth called "therapeutic leads") such as small molecules or non-viral biologics that are not currently a focus within the biotechnology and pharmaceutical industries. (nih.gov)
  • At the end of the project period, a successful project will have provided a significant contribution to the data supporting the validity around a therapeutic such that it can advance further for later stage therapeutics development and preclinical efforts through other funding mechanisms, such as the Parent R01 or small business programs ( https://sbir.nih.gov/niddk/index ), spin-off companies, or licensing to or partnering with pharmaceutical companies. (nih.gov)
  • The development of effective therapeutics for disorders of the nervous system has been challenging in comparison with other areas such as cancer and cardiovascular disease ( Schoepp, 2011 ). (frontiersin.org)
  • Geroprotectors are therapeutics that affect the root cause of aging and age-related diseases, and thus prolong the life-span of animals. (dovepress.com)
  • According to the research report, the global diverticulitis disease market was valued at USD 1.56 billion in 2022 and is expected to reach USD 3.86 billion by 2032, to grow at a CAGR of 8.91% during the forecast period. (newstechzone.com)
  • The latest research on the Pruritus Therapeutic market provides a comprehensive overview of the market for the years 2022 to 2028. (menafn.com)
  • The most recent research on the Pruritus Therapeutic industry offers a thorough overview of the business from 2022 to 2028. (menafn.com)
  • General recommendations and organism-specific therapeutic regimens for osteomyelitis (as shown in the radiograph below) are provided. (medscape.com)
  • General recommendations and organism-specific therapeutic regimens for necrotizing fasciitis are provided below, including those for Streptococcus pyogenes , methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S aureus (MRSA), and Clostridium species. (medscape.com)
  • Neurodegenerative disease is on the rise globally due to aging populations 1 , highlighting a need for effective therapeutic interventions. (nature.com)
  • Further optimization of nonpathogenic myelin-derived peptides can be expected to lead the way to the development of an effective therapeutic vaccination protocol as a strategy for the prevention of total paralysis after incomplete spinal cord injury. (jci.org)
  • Targeting curli production in the gut may represent a general therapeutic approach to prevent or slow down the progression of protein aggregation diseases. (hku.hk)
  • severe acid buildup in body), meet the cat's nutrient and energy requirements, normalize serum phosphorus, maintain hydration and electrolyte balance, and slow the progression of the disease. (vin.com)
  • Although restriction of dietary protein has been demonstrated to slow progression of kidney disease in rats and humans, no definitive studies have been performed in cats, which are obligate carnivores. (vin.com)
  • Dr. Wing Lee and colleagues will attempt to identify drug-like chemical compounds that can bind to and stabilize the structure of the mutated myocilin, which subsequently may delay the onset of the disease or slow down disease progression by correcting abnormal changes at molecular level. (brightfocus.org)
  • Hence, the disease onset or progression may be delayed. (brightfocus.org)
  • So mitochondria-targeted therapy is suggested to be a potential treatment strategy for cardiovascular diseases. (frontiersin.org)
  • Therefore, patients with cardiovascular diseases would fail to achieve the desired outcomes by using these mitochondrial-targeted drugs ( 5 ). (frontiersin.org)
  • He is also an institute member and director of the Cardiovascular Disease Initiative at the Broad. (broadinstitute.org)
  • Despite significant advances in therapeutic techniques ischemic cardiovascular disease remains the leading cause of mortality and heart failure in most countries [1]. (immune-source.com)
  • Inhibiting certain interactions has emerged as a promising approach to treat diseases such as stroke and cancer. (worldhealth.net)
  • Using a multipronged approach that includes collaboration between the research teams, the funded projects will help accelerate LRRK2 therapeutic development efforts. (michaeljfox.org)
  • Conclusion This survey concludes that there is no uniform approach to nutrition during therapeutic cooling in neonates within the UK. (bmj.com)
  • Here, we outline these topics and review the evidence assessing psychotherapy and related modalities as therapeutic options in patients with IBD. (medscape.com)
  • Researchers from Weill Cornell Medicine and New York-Presbyterian have demonstrated that patients with Crohn's disease have an overabundance of a type of gut bacteria called adherent-invasive Escherichia coli (AIEC), which promotes inflammation in the intestine. (genengnews.com)
  • Adherent-invasive E. coli are enriched in the intestinal microbiota of patients with Crohn's disease (CD) and promote intestinal inflammation," the researchers wrote. (genengnews.com)
  • Thanks to NIAID prioritization of these threats, we're able to advance some very promising preclinical molecules towards the clinic and move closer to our goal of providing effective treatments for patients suffering from this devastating disease. (uvm.edu)
  • Chronic obstructive pulmonary disease (COPD) progresses very slowly and the majority of patients are therefore elderly. (dovepress.com)
  • It is for this purpose that the present work proposes: to discuss about the influence of music as a therapeutic potential for Alzheimer's patients. (bvsalud.org)
  • TB360 trade name] must not be used in patients with severe liver disease (see section 4.3). (who.int)
  • Palliative care is provided to patients when the disease has already reached an incurable stage. (who.int)
  • Though cases occur across the Americas, the disease currently has no approved treatments, but thanks to support from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH), a potential new therapy is on the horizon. (uvm.edu)
  • I'm extremely grateful to the NIH for this opportunity to develop a potential frontline treatment for this deadly disease," he added. (uvm.edu)
  • These findings indicate that the a-syn-CHMP2B interaction is a potential therapeutic target for the disease, as well as other conditions that involve a buildup of a-syn, such as dementia with Lewy bodies. (worldhealth.net)
  • The endolysosomal pathway is underexplored, so it was not an obvious place to look for potential disease-related protein-protein interactions. (worldhealth.net)
  • The therapeutic potential of BACE will also be considered. (jneurosci.org)
  • This collaboration has the potential not only to accelerate our understanding of the diseases, but also potentially enable scientific advancements in disease-modifying interventions - a true game changer in addressing cardiometabolic diseases. (broadinstitute.org)
  • We are interested in therapeutic potential of neural stem cell in transplantation treatment against PD, the midbrain-derived neural stem cells (mNSCs) were studied by in vitro culture in focusing on their proliferative, differentiation and neurotrophic properties and in comparing with hippocampus-derived NSCs (hNSCs). (omicsonline.org)
  • In addition to key driving factors, the report discusses restraints, potential growth opportunities, challenges, and barriers likely to affect the Diverticulitis Disease Market. (newstechzone.com)
  • This finding of a weak spot in the gut bacteria may lead to more targeted therapies for Crohn's disease, according to the researchers. (genengnews.com)
  • Neurodegenerative disease is increasingly prevalent and remains without disease-modifying therapies. (nature.com)
  • For both patient populations, there are no safe and effective therapies for reversing disease. (broadinstitute.org)
  • It is expected that there is significant novelty in the target, small molecule, or non-viral biologic and in how the resulting therapeutic would differentiate from existing therapies. (nih.gov)
  • Engaging the right target, at the right disease stage, could be an important determinant of success. (nature.com)
  • For these reasons, MJFF has identified LRRK2 as a high-priority therapeutic target, investing nearly $17 million to date for a broad and integrated strategy to drive critical LRRK2-related initiatives at every stage of drug development. (michaeljfox.org)
  • Thus, BACE is a prime drug target for the therapeutic inhibition of Aβ production in AD. (jneurosci.org)
  • A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies. (bvsalud.org)
  • And studies that analyze dietary patterns and disease-so-called population or epidemiological studies-have linked high spice intake to low rates of chronic disease. (naturalnews.com)
  • There is increasing evidence that psychological stress and associated mood disorders are linked with, and can adversely affect the course of, inflammatory bowel disease (IBD). (medscape.com)
  • [ 1-3 ] The inflammatory bowel diseases (IBDs) - Crohn's disease (CD) and ulcerative colitis (UC) - were classified as psychosomatic disorders, with early studies reporting a close association between IBD and psychiatric diagnoses. (medscape.com)
  • This includes outcomes relevant to diabetes and other endocrine and metabolic diseases, liver and other digestive diseases, nutritional disorders, obesity, kidney and urological diseases, and hematologic diseases. (nih.gov)
  • In summary, the Swarm is a novel high-throughput all-optical system capable of collecting information-dense data from optogenetic assays in both heterologous and iPS cell-derived models, which can be leveraged to drive diverse therapeutic discovery programs for nervous system disorders and other disease areas involving excitable cells. (frontiersin.org)
  • A new class of therapeutic agents called pharmacological chaperones has recently emerged to treat protein misfolding disorders, which are diseases caused by the presence or accumulation of misfolded proteins. (brightfocus.org)
  • Adequate nutrition during therapeutic cooling for ischaemic injury in the newborn is important in minimising long-term neurological morbidity. (bmj.com)
  • The present invention relates to a family of S-substituted quinazoline derivatives that inhibitors of the enzyme phosphodiesterase 7 (PDE7), useful for the treatment or prevention of diseases mediated by said enzyme, especially inflammatory, neurodegenerative, neurological, psychiatric and/or autoimmune diseases. (justia.com)
  • The S-substituted quinazoline derivatives of the present invention are, therefore, useful for the treatment or prevention of diseases mediated by said enzyme PDE7, especially inflammatory, neurodegenerative, neurological, psychiatric and/or autoimmune diseases. (justia.com)
  • Patent application PCT WO2010/133742 discloses that the compounds with a quinazoline nucleus described in patent application WO2008/113881 are useful for the treatment of neurodegenerative and/or neurological diseases. (justia.com)
  • Importantly, therapeutic inhibition of β-secretase would decrease production of all forms of Aβ, including the pathogenic Aβ 42 . (jneurosci.org)
  • To reduce the risk of autoimmune disease while retaining the benefit of the immunization, we vaccinated the rats immediately after severe incomplete spinal cord injury with MBP-derived altered peptide ligands. (jci.org)
  • Patent application PCT WO2008/113881 discloses a family of compounds with a quinazoline nucleus that have dual inhibitory activity of enzymes PDE7 and PDE4 and are useful for the treatment of inflammatory or autoimmune diseases. (justia.com)
  • Spices, they have found, contain compounds that fight oxidation and inflammation, the two processes underlying most chronic diseases. (naturalnews.com)
  • To identify chemical compounds that can bind to myocilin carrying a disease-causing mutation Y437H, Lee and colleagues will make use of a new screening system called the Corning EPIC®, which will allow them to measure binding between compounds and Y437H mutant myocilin proteins. (brightfocus.org)
  • Celdara Medical and UVM Professor of Medicine Jason Botten, Ph.D., have received a Phase II Small Business Technology Transfer grant from the National Institute of Allergy and Infectious Diseases that will support the ongoing development of therapeutic antibodies for the treatment of Hantavirus Cardiopulmonary Syndrome - a severe respiratory disease caused by rodent-borne hantaviruses. (uvm.edu)
  • Research reported in this press release is supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award number R42AI132047-03. (uvm.edu)
  • It is recommended that consultation with an infectious diseases specialist and and orthopedic specialist be obtained to assist in management. (medscape.com)
  • Appropriate consultation with an infectious diseases specialist and an orthopedic surgeon, both with experience in dealing with infected prostheses, is highly recommended. (medscape.com)
  • Guidelines from the Infectious Diseases Society of America (IDSA) have provided guidance for management of osteomyelitis with prosthetic joints but not for other kinds of orthopedic hardware infections (though extrapolations can be made from the IDSA guidance). (medscape.com)
  • The funding - a Phase II Small Business Technology Transfer (STTR) grant - will support the ongoing development of therapeutic antibodies for the treatment of HCPS and the continued collaboration between Celdara Medical and Jason Botten, Ph.D., professor of medicine at the University of Vermont (UVM), scientific founder at Celdara Medical, and principal investigator. (uvm.edu)
  • The research conducted by Botten and his team has been instrumental in the ongoing development of HCPS therapeutic antibodies at Celdara Medical. (uvm.edu)
  • A method of mass-producing disease-fighting antibodies entirely within bacteria has been developed by a research group at The University of Texas at Austin. (utexas.edu)
  • Objectives To analyse simple national statistics and survival data collected in the central cardiac audit database after treatment for congenital heart disease and to provide long term comparative statistics for each contributing centre. (bmj.com)
  • Thus, therapeutic strategies to lower cerebral Aβ 42 levels are expected to be beneficial for the treatment or prevention of AD. (jneurosci.org)
  • In the second video of this two-part series, hear first-hand patient perspectives on the burden of Wilson disease along with expert discussion on the latest evidence and implications for treatment and management decision-making. (primeinc.org)
  • Disease areas Broad brings people together to advance the understanding and treatment of disease. (broadinstitute.org)
  • Taken together, this study has provided new evidence that mNSCs show the unique cell proliferation, cell survival, dopaminergic neuronal differentiation and neurotrophic properties, suggesting that midbrain-derived NSCs may present an ideal cell source or reliable tissue candidate for therapeutic cell transplantation or neuroprotective treatment of PD in human beings. (omicsonline.org)
  • This causes an increased risk of respiratory infection, lung cancer and chronic obstructive pulmonary disease (COPD) where effective treatment is not available. (dovepress.com)
  • Dr. Kazuhiro's review provides the molecular mechanism of COPD as accelerating aging lung disease and future prospect of anti- aging strategy, called geroprotector for the treatment of COPD. (dovepress.com)
  • Therapeutic relationships between Veterans and buprenorphine providers and effects on treatment retention. (cdc.gov)
  • Objective: To examine the extent to which there was any therapeutic relationship between Veterans and their initial buprenorphine provider and whether the presence of this relationship influenced treatment retention. (cdc.gov)
  • The primary exposure was a therapeutic relationship between the Veteran and buprenorphine provider, defined as the presence of a previous visit or medication prescribed by the provider in the 2 years preceding buprenorphine treatment initiation. (cdc.gov)
  • Conclusions: Veterans initiating buprenorphine frequently did not have a therapeutic history with their initial buprenorphine provider, but this relationship was not associated with treatment retention. (cdc.gov)
  • Future work should investigate how the quality of Veteran-provider therapeutic relationships influences opioid use dependence management and whether eliminating training requirements for providers might affect access to buprenorphine, and subsequently, treatment initiation and retention. (cdc.gov)
  • The authors of the article are as follows: Kazuhir Ito, Thomas Colley, Nicolas Mercado, Airways Disease Section, National Heart and Lung Institute, Imperial College London, UK. (dovepress.com)
  • The central cardiac audit database was established by the British Cardiac Society, the Society of Cardiothoracic Surgeons, and the British Paediatric Cardiac Association to provide national analysis of outcomes of cardiac surgery and therapeutic cardiac catheterisation. (bmj.com)
  • Collectively, these phototropic actions of allopregnanolone promote regenerative and disease modifying outcomes," said Brinton, founder and president of NeuTherapeutics, LLC, which is developing the drug. (medscape.com)
  • Their findings were published in the journal Cell Host and Microbe , in a paper entitled " Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation . (genengnews.com)
  • This murine model provides opportunities to identify pathways associated with persistent SARS-CoV-2 pulmonary disease and test countermeasures to ameliorate PASC. (bvsalud.org)
  • In cases involving rifampin-sensitive ​S aureus , the IDSA guidelines advocated adding rifampin at 450 mg PO q12hr if the patient can tolerate the medication and does not have significant liver disease. (medscape.com)
  • Pruritus can also be caused by medical conditions such as kidney failure, liver disease, thyroid disease, cancer, and diabetes. (menafn.com)
  • Furthermore, H 2 S donors and some H 2 S hybrids have been evaluated in many experimental models of human disease and have shown promising therapeutic results. (hindawi.com)
  • First, experimental drugs are often broadly categorized as "disease-modifying" if the hypothesis is one of disease modification, regardless of the quality of that hypothesis. (nature.com)
  • Despite high case fatality rates, there is vanishingly little therapeutic development activity. (uvm.edu)
  • Research areas Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. (broadinstitute.org)
  • Results Since April 2000 data have been received from all 13 UK tertiary centres performing cardiac surgery or therapeutic cardiac catheterisation in children with congenital heart disease. (bmj.com)
  • In 2000 the Department of Health funded the central cardiac audit database to collate data from all centres for congenital heart disease in the United Kingdom. (bmj.com)
  • The third program, focused on cardiac fibrosis, will leverage genetics, genomics, and machine learning to investigate the role of cardiac fibrosis in heart disease. (broadinstitute.org)
  • Therapeutic diets for chronic kidney disease are not necessarily equivalent, or are they? (vin.com)
  • Cats with IRIS stage 1 and 2 chronic kidney disease maintain body weight and lean muscle mass when fed food having increased caloric density, and enhanced concentrations of carnitine and essential amino acids. (vin.com)
  • Nutritional management goals for chronic kidney disease (CKD) in cats are to reduce risk of uremic crisis (ie. (vin.com)
  • Therapeutic kidney diets are considered indicated for cats in International Renal Interest Society (IRIS) Stage 2-4 CKD (ie. (vin.com)
  • Dr. Jean A Hall, College of Veterinary Medicine at Oregon State, Corvallis, Oregon in collaboration with researchers associated with Hill's Pet Nutrition, Inc. enrolled 28 adult cats with IRIS Stage 1 and 2 CKD and compared two commercially available therapeutic kidney diets in a prospective, randomized, 6-month feeding trial. (vin.com)
  • The goal of this study was to determine whether two different therapeutic kidney diets were appropriate for cats with either IRIS Stage 1 and 2 CKD. (vin.com)
  • Changing one metabolic pathway in one type of bacteria can have a big impact on intestinal inflammation," explained Monica Viladomiu, PhD, a postdoctoral associate in medicine in the division of gastroenterology and hepatology and the Jill Roberts Institute for Research in Inflammatory Bowel Disease at Weill Cornell Medicine. (genengnews.com)
  • If your dosages are changed, you may get repeated tests until your medicine levels fall into the therapeutic range. (medlineplus.gov)
  • Studies show that the biomedical view and the use of drugs often do not cover the problems arising from the disease, and the search for alternatives other than medication and exclusion of the patient is promising. (bvsalud.org)
  • For non-MRSA disease, 4-6 weeks of intravenous (IV) therapy or therapy with drugs with high oral bioavailability is preferred. (medscape.com)
  • This research is still in its early stages -- more work is definitely needed to translate this peptide into a viable therapeutic," cautions Dr. Lorraine Kalia. (worldhealth.net)
  • Our latest research report highlights the dynamic growth of the Diverticulitis Disease Market and provides comprehensive insights into the market trends, share, Industry growth and revenue projections for the forecast period up to 2032. (newstechzone.com)
  • Cite this: First-in-Class Regenerative Therapeutic for Alzheimer's Promising - Medscape - Oct 30, 2023. (medscape.com)
  • We previously reported that miR-181a/b downregulation boosts mitochondrial turnover in models of primary retinal mitochondrial diseases. (tigem.it)
  • Addressing these processes at the root, rather than simply treating the symptoms, would really change how we treat this disease. (broadinstitute.org)
  • Using analytical tools like Porter's five forces analysis, Industry Value chain analysis, and PESTEL analysis of the Pruritus Therapeutic market, the study provides insights into the industry. (menafn.com)
  • By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. (greenmedinfo.com)
  • However, a longer course may be indicated in any type of more complicated disease. (medscape.com)
  • This granular type of stimulation pattern provided powerful and specific therapeutic effects, free of noticeable side effects, in a PD animal model. (lu.se)
  • Interfering with this process, by either reducing the bacteria's food supply or eliminating a key enzyme in the process relieved gut inflammation in a mouse model of Crohn's disease. (genengnews.com)
  • Without propanediol dehydratase, the bacteria do not set off a cascade of inflammation in a mouse model of Crohn's disease. (genengnews.com)
  • More than four million people worldwide suffer from Crohn's disease. (genengnews.com)
  • In conclusion, this study suggests that therapeutic renal foods with good palatability, increased caloric density and enhanced concentrations of essential amino acids and L-carnitine may help cats with CKD maintain body weight and lean body mass. (vin.com)
  • References 1 JY Ting, D Manhas, SM Innis, S Albersheim, Elevated Triglycerides Levels in Two Infants With Hypoxic-ischemic Encephalopathy Undergoing Therapeutic Hypothermia and Receiving Parenteral Nutrition. (bmj.com)
  • It gives a comprehensive picture of the global Pruritus Therapeutic industry, considering all significant industry trends, market dynamics, competitive landscape, and market analysis tools such as Porter's five forces analysis, Industry Value chain analysis, and PESTEL analysis of the Pruritus Therapeutic market. (menafn.com)
  • Protein-protein interactions govern virtually all the inner workings of the cell, including breaking down disease-causing proteins. (worldhealth.net)
  • With no access to quality prevention and detection services, most women seek consultation only when the disease is already at an advanced stage. (who.int)