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  • Loci
  • We then related these data to results from GWAS for diseases, to find a set of disease-associated loci that are likely to have an underlying expression mechanism. (biomedcentral.com)
  • We integrated the current gold standard data with SNPs in disease-associated loci from the Wellcome Trust Case-Control Consortium (WTCCC) GWAS of seven common human diseases. (biomedcentral.com)
  • Approximately one-third of these disease-associated loci in the WTCCC GWAS were found to be consistent with an underlying expression change mechanism. (biomedcentral.com)
  • type 1 diabet
  • In this study, we aimed to characterise rapid progressors to type 1 diabetes among children recruited from the general population, on the basis of HLA-conferred disease susceptibility. (springer.com)
  • OBJECTIVE As data on the predictive characteristics of diabetes-associated autoantibodies for type 1 diabetes in the general population are scarce, we assessed the predictive performance of islet cell autoantibodies (ICAs) in combination with autoantibodies against insulin (IAAs), autoantibodies against GAD, and/or islet antigen 2 for type 1 diabetes in children with HLA-defined disease predisposition recruited from the general population. (diabetesjournals.org)
  • CONCLUSIONS Within the general population, the combination of HLA and autoantibody screening resulted in disease risks that are likely to be as high as those reported among autoantibody-positive siblings of children with type 1 diabetes. (diabetesjournals.org)
  • Type 1 diabetes is an immune-mediated disease that leads to the destruction of the pancreatic β-cells and eventually to total dependence on exogenous insulin. (diabetesjournals.org)
  • The current work represents data from the first 14 years of this study, assessing the predictive characteristics of DAAs in a population-derived cohort of children with HLA-conferred susceptibility to type 1 diabetes. (diabetesjournals.org)
  • obesity
  • We believe this project will shed light on the role of genetic variation in contributing to racial/ethnic health disparities for a number of chronic diseases, including common cancers, Type 2 diabetes, obesity, high blood glucose and other conditions. (healthcanal.com)
  • In Part 1 of this two-part post , I reviewed scientific evidence that the gut microbiome interacts with ingested chemicals to influence susceptibility to obesity and diabetes. (edf.org)
  • Infectious Diseases
  • Researchers in Australia's Centre for Innate Immunity and Infectious Diseases at the Monash Institute of Medical Research have identified a "new" protein, interferon epsilon (IFNe), that exists only in the female reproductive tract. (thebodypro.com)
  • Diabetes
  • 4 Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. (sciencemag.org)
  • The clinical manifestation of the disease is preceded by a preclinical phase, during which diabetes-associated autoantibodies (DAAs) can be detected in the peripheral circulation. (diabetesjournals.org)
  • traits
  • The researchers plan to genotype approximately 50,000 samples from African, Hispanic and Asian ancestries for a wide range of diseases and traits. (healthcanal.com)
  • neurodegenerative
  • The unprecedented breadth of GTEx donors and tissue types establishes a resource that scientists studying areas ranging from blood pressure to neurodegenerative disease would find invaluable. (eurekalert.org)
  • severe
  • The pathology was similar to that seen in CD2AP-null mice before the development of severe kidney disease at ∼3 to 4 weeks of age. (sciencemag.org)
  • The strategic application of these functional approaches is discussed and illustrated by analysis of the role of genetic variation in the tumour necrosis factor promoter region in determining susceptibility to severe malaria. (clinsci.org)
  • findings
  • Risley and her collaborators will take the findings from this important study and apply them to future works, using the genetically tractable fruit fly at different ages, to try and understand mechanisms of age-related disease susceptibilities and how to protect against them at the cellular level. (eurekalert.org)
  • antibodies
  • Mice with CD2AP haploinsufficiency developed glomerular changes at 9 months of age and had increased susceptibility to glomerular injury by nephrotoxic antibodies or immune complexes. (sciencemag.org)
  • Positivity for four antibodies was associated with the highest disease sensitivity (54.4%) and negative predictive values (98.3%) and the lowest negative likelihood ratio (0.5). (diabetesjournals.org)
  • biomarkers
  • Sordillo said the team will refine the list of biomarkers for metabolic stress that are most accurate in detecting increased risk of disease during early lactation, incorporate them into the app and test for effectiveness on dairy herds in Michigan. (cowsmo.com)
  • immune
  • They have recently discovered that cells from the immune system regulate X-chromosome Inactivation quite differently from all other adult cells, providing insight into the mechanisms behind sex-biased diseases. (eventbrite.com)
  • This can result in a compromised immune system and the development of various diseases. (cowsmo.com)
  • predictive
  • Predictive models estimate that by 2030, 1 in every 1,600 American adults will have been affected by the disease. (ucsd.edu)
  • patients
  • Analysis of pathophysiological conditions indicated that autophagy was substantially increased in glomeruli from mice with induced proteinuria and in glomeruli from patients with acquired proteinuric diseases. (jci.org)
  • thereby
  • With this algorithm, we can easily identify new drug targets, thereby deepening our understanding of diseases and unlock new therapies to treat it. (iran-daily.com)
  • research
  • Jane Burns, MD, professor in the UC San Diego School of Medicine and director of the Kawasaki Disease Research Center. (ucsd.edu)
  • This is the first successful analysis of whole genome sequence from a family that revealed a new gene implicated in KD susceptibility," said senior author Jane C. Burns, MD, professor and director of the Kawasaki Disease Research Center at UC San Diego School of Medicine and Rady Children's Hospital-San Diego. (ucsd.edu)
  • Previous research had not identified this gene as influencing susceptibility to KD. (ucsd.edu)