• Some connective tissue diseases such as lupus erythematosus are associated with a specific type of hepatitis. (cdc.gov)
  • This disorder may evolve into one of several major connective tissue diseases or to an overlap syndrome of the major connective tissue diseases. (medscape.com)
  • [ 10 ] Other authors propose that MCTD cases should not be distinguished from undifferentiated autoimmune rheumatic disease. (medscape.com)
  • We hypothesized that idiopathic NSIP is an autoimmune disease and the lung manifestation of undifferentiated connective tissue disease (UCTD), a recently described, distinct entity. (nih.gov)
  • Furthermore, these results show that the clinical entity idiopathic NSIP is different from idiopathic pulmonary fibrosis and appears to be an autoimmune disease. (nih.gov)
  • Unclassifiable ILDs, autoimmune ILDs, chronic hypersensitivity pneumonitis, sarcoidosis, myositis, Sjögren syndrome, coal worker pneumoconiosis, and idiopathic forms of interstitial pneumonias (eg, idiopathic nonspecific interstitial pneumonia [NSIP]) are among the diseases that may develop a progressive form of chronic fibrosing ILD. (medscape.com)
  • The mechanism whereby it affects autoimmune diseases is unknown. (medscape.com)
  • The dysregulation of its immunosuppressive functions is also implicated in the pathogenesis of autoimmune diseases, although their effect is mediated by the environment of other cytokines present. (wikipedia.org)
  • Sharp and colleagues first proposed mixed connective tissue disease (MCTD) as a separate autoimmune disorder. (medscape.com)
  • Mixed connective tissue disease has features of several autoimmune diseases. (medscape.com)
  • This diagnosis was changed to probable Pick’s disease. (ucl.ac.uk)
  • Physicians in the United States must be alert to the diagnosis of leishmaniasis in travelers returning from endemic areas. (aafp.org)
  • Physicians working for short periods in endemic areas often must make the diagnosis and should be aware of local disease patterns. (aafp.org)
  • This disease must be considered in at-risk patients, and family physicians should know the basics of diagnosis and where to go for more help. (aafp.org)
  • The process of getting a rare disease diagnosis can take several years. (nih.gov)
  • When we talk about early diagnosis, we're not talking about days, but rather hours and even minutes," said Michael Cooperstock, M.D., professor of child health in the Division of Pediatric Infectious Diseases at the MU School of Medicine, medical director of infection control at University of Missouri Health Care and senior author of the study. (sciencedaily.com)
  • [ 2 , 3 ] A comparison of the sensitivity and specificity of the above 3 sets of criteria along with a fourth set of criteria developed by Kahn et al demonstrated that the Kahn and Alarcon-Segovia criteria are the most sensitive and specific for disease diagnosis. (medscape.com)
  • Mixed connective tissue disease remains a controversial diagnosis. (medscape.com)
  • INTRODUCTION: The diagnosis and management of subacute thyroiditis (SAT) may be challenging, and more evidence on patient and disease characteristics is warranted. (bvsalud.org)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
  • However, Kenya has already drafted new legislation which covers the donation of organs and tissues from both living and deceased donors, and eight Member States8 intend to adopt new legal requirements. (who.int)
  • Myocardial tissue engineering strategies follow the idea of in vitro generation of myocardium-like structures for epicardial transplantation. (nih.gov)
  • West Nile Virus transmission through tissue transplantation, for instance, skin, muscle, or connective tissues, has not been identified, and the risk for transmission by this route is not known. (cdc.gov)
  • In 2011, the CDC assisted state and local health departments in an investigation of a cluster of West Nile Virus disease transmitted through solid organ transplantation. (cdc.gov)
  • Online learning and education surrounding all aspects of tissue donation, tissue banking, research, and transplantation. (aatb.org)
  • Organ and tissue donation and transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ or tissue. (who.int)
  • There is no information about reproductive tissue transplantation as a method of treating infertility in the African Region. (who.int)
  • https://en.wikipedia.org/wiki/Organ_transplantation. (who.int)
  • 4 World Health Assembly - Resolution WHA63.22 on Human organ and tissue transplantation, May 2010. (who.int)
  • Medical therapy targets control of disease activity in general and management of specific organ involvement, while monitoring for and mitigating the risks of complications either of the condition itself (eg, pulmonary hypertension, interstitial lung disease) or of its treatment (eg, infection). (medscape.com)
  • A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)
  • This includes studies of germ cell development and epigenetic effects that persist following fertilization, the uterine environment during implantation, as well as placental and organ formation and function and related development of chronic diseases after birth. (ohsu.edu)
  • Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition. (hindawi.com)
  • In 6 clusters of organ transplant-transmitted West Nile Virus infections reported to public health agencies in the United States, 12 of 16 recipients were infected. (cdc.gov)
  • Serious organ involvement included 47% of patients with renal disease, 54% with restrictive lung disease, and 29% with GI disease. (medscape.com)
  • Used for organ, tissue, or cell structure in disease states. (bvsalud.org)
  • Leiomyosarcoma is an aggressive soft tissue sarcoma that has significant high unmet medical need, especially for those patients who have relapsed or are refractory to current treatments. (prnewswire.com)
  • We assembled a database of museum armadillo tissue samples using the biodiversity information portals VertNet ( http://portal.vertnet.org ) and Arctos ( https://arctos.database.museum/home.cfm ), queried during December 2018-April 2019. (cdc.gov)
  • On March 13, 2020, the United States declared a national emergency to combat coronavirus disease 2019 (COVID-19). (cdc.gov)
  • A 2019 study looked at NAFLD-related death data from 2007 to 2016 in the United States. (healthline.com)
  • In a 27 August 2019 article in the Philadelphia Enquirer newspaper, Penn State entomologist Dave Biddinger commented on field trials using B. bassiana . (adirondackalmanack.com)
  • To prevent the spread of the coronavirus disease 2019 (COVID-19) pandemic, vaccines have been authorized for emergency use and implemented worldwide. (bvsalud.org)
  • Prednisone therapy is best prescribed in consultation with a pulmonary disease specialist. (medscape.com)
  • Nintedanib is indicated to slow the rate of decline in pulmonary function in patients who have interstitial lung disease (ILD) associated with scleroderma. (medscape.com)
  • These exposure levels put workers, particularly sand mover operators and T-belt operators who had the highest levels, at risk of silicosis and the other silica-related conditions of lung cancer, end-stage renal disease, chronic obstructive pulmonary disease, tuberculosis, and connective tissue disease. (cdc.gov)
  • Although rare, morbidity from cerebral disease, cardiomyopathy, myopericarditis, and pulmonary hypertension has been reported and is associated with a significant risk of mortality. (medscape.com)
  • Select laboratories have the capability to perform PCB analyses on human tissue. (cdc.gov)
  • Testing human tissue for PCB content, however, remains principally a research tool. (cdc.gov)
  • They compared performance of different antibodies on 44 different human tissue types and further identified bound proteins through techniques such mass spectroscopy at a scale not before undertaken. (sciencedaily.com)
  • The only accreditation program for tissue establishments, recognizing the highest commitment to the quality and safety of donated human tissue. (aatb.org)
  • We studied 28 consecutive patients with idiopathic interstitial pneumonia (IIP) enrolled in the University of California, San Francisco Interstitial Lung Disease Center who met prespecified criteria for UCTD, as follows: at least one clinical manifestation of connective tissue disease, serologic evidence of systemic inflammation in the absence of clinical infection, and absence of sufficient American College of Rheumatology criteria for another connective tissue disease. (nih.gov)
  • Many disease conditions-including obesity, arthritis and heart disease-- are affected by an ongoing inflammation even when there is no infection. (ohsu.edu)
  • The group is also looking at how prenatal nutrition regulates the inflammatory state in newborns, and whether chronic inflammation during pregnancy predisposes the offspring to obesity and diabetes. (ohsu.edu)
  • We further discuss how injuries alter tissue environments and how this primes mononuclear phagocytes to enforce this particular environment, for example, to support host defense and pathogen clearance, to support the resolution of inflammation, to support epithelial and mesenchymal healing, and to support the resolution of fibrosis to the smallest possible scar. (hindawi.com)
  • Chronic inflammation is a disease in which the inflammatory state persists and may result in tissue damage. (nih.gov)
  • The researchers examined the relationships between the inflammation biomarkers and both overall survival and disease-free survival. (nih.gov)
  • Ideally, inflammation rapidly clears pathogens and damaged tissue to return tissues to their previous healthy state. (dal.ca)
  • However, chronic inflammation can lead to inflammatory bowel disease, heart disease, arthritis, and hyperinflammatory conditions, such as seen in septic and severe COVID-19 patients. (dal.ca)
  • Using critical scientific equipment, Dr. Fairn and his research team are working to understand better the mechanisms of inflammation and its contributions to disease. (dal.ca)
  • Saturated fats and LDL-cholesterol are two of the major contributing factors responsible for Inflammation and Heart Disease, angina and subsequent myocardial infarction and death, as established by the first author beginning in the mid-1990s [1-4]. (bmj.com)
  • Anyone who suggests otherwise is either too unfamiliar with the "Inflammation and Heart Disease" and "Angina" Theories or simply does not understand them ( https://bjsm.bmj.com/content/51/15/1111.responses ) [5]. (bmj.com)
  • The mere measurement of lipids and markers of inflammation (CRP, IL-6, et cetera) through serum testing, correlate poorly with the extent and severity of coronary artery disease (CAD), and measurement of their change only moderately correlate with changes in CAD [6]. (bmj.com)
  • 4. 20/20 Segment on Heart Disease and Inflammation. (bmj.com)
  • The knockout model brain regions and peripheral tissues that were not used for the initial characterization were collected and stored for potential future studies. (michaeljfox.org)
  • Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)
  • This applied also to athyreotic subjects on thyroxine and to subjects on thyroxine plus carbimazole, suggesting that the mechanism is independent of thyroid tissue, uninfluenced by carbimazole, and probably operates via the peripheral metabolism of T4. (lu.se)
  • This review focused on the elucidation of paracrine crosstalk between MSCs and Mφs during musculoskeletal diseases and injury. (frontiersin.org)
  • In conclusion, MSCs in musculoskeletal system, mediated by the interaction between MSC paracrine and Mφs, have therapeutic potential in musculoskeletal diseases. (frontiersin.org)
  • none of the donor tissues were transplanted. (cdc.gov)
  • During July-August 2023, the United States has experienced above-average coastal sea surface temperatures and widespread heat waves [5]. (cdc.gov)
  • Hansen disease (leprosy) is an ancient pathology caused by 2 slow-growing intracellular bacilli, Mycobacterium leprae and M. lepromatosis ( 1 ). (cdc.gov)
  • Pathology samples from 1,000 mesothelioma patients will be used to build a Tissue Microarray, which will allow scientists to process and evaluate hundred of tumor cell samples at once. (survivingmesothelioma.com)
  • An immune-centric view assumes that a particular priming of phagocytes then causes a particular type of pathology in target tissues, conceptually similar to antigen-specific T-cell priming. (hindawi.com)
  • This slightly different perspective may somewhat shape our understanding of macrophage heterogeneity and tissue pathology but certainly also raise new questions for future research. (hindawi.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The future grantees will carry out their projects at universities and research centers across 18 EU Member States and other countries associated with Horizon Europe. (mpi-cbg.de)
  • Most large pediatric rheumatology centers in major cities have 5-15 active pediatric cases, although some studies estimate that mixed connective tissue disease occurs in 0.6% of all pediatric rheumatology patients. (medscape.com)
  • CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. (researchandmarkets.com)
  • Although mesenchymal stem cells (MSCs) have been shown as a novel approach in tissue regeneration, the therapeutic potential of MSCs mediated by the interaction between MSC-derived paracrine mediators and Mφs remains elusive. (frontiersin.org)
  • Compared with patients who did not have epitope spreading, patients with epitope spreading had a significantly lower prevalence of skin sclerosis (0% vs 44%, P = 0.004) and a higher prevalence of interstitial lung disease (46% vs 15%, P = 0.05). (medscape.com)
  • Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
  • Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease? (nih.gov)
  • and recall of stored tissues from donors found after donation to have been infected. (cdc.gov)
  • Guidelines for AATB accredited establishments to use in conjunction with the Standards for Tissue Banking and the Standards for Non-Anatomical Donation. (aatb.org)
  • Researchers found that cirrhosis was the top cause-specific death, followed by cardiovascular disease. (healthline.com)
  • The group speculates that the environment in the womb will hamper the cells' ability to respond to disease states later in the child's life and will lead to cardiovascular disease. (ohsu.edu)
  • This research team is determined to find the mechanisms in the fetus that lead to adult cardiovascular disease. (ohsu.edu)
  • When patients have increased blood pressure in the lungs or diseases of the left side of the heart, the right ventricle is exposed to higher pressure that can lead to heart failure. (dal.ca)
  • 1745 patients with idiopathic PAH (IPAH), drug-induced PAH (DPAH), heritable PAH (HPAH) (collectively "(I/D/H)PAH"), or connective tissue disease-associated PAH (CTD-PAH), who had completed emPHasis-10 questionnaires at one of six UK referral centres between 2014 and 2017, were identified. (ersjournals.com)
  • Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. (researchandmarkets.com)
  • In his New York State supported stem cell program (N09G-302), he is examining embryonic stem (ES) cells to model and replace diseased human retinal cells. (researchandmarkets.com)
  • She anticipates that this work will help future efforts to restore light sensitivity following the death of rods and cones that occurs as a consequence of inherited retinal degeneration diseases. (dal.ca)
  • Anti-RNP antibodies can precede overt clinical manifestations of MCTD, but overt disease generally develops within 1 year of anti-RNP antibody induction. (medscape.com)
  • Tissue specimens also were evaluated by various immunohistochemical assays using antibodies that are specifically reactive with S. pneumoniae , Streptococcus pyogenes , Staphylococcus aureus, or Haemophilus influenzae . (cdc.gov)
  • An Enzyme-Linked Immunosorbant Assay (ELISA) for the semi-quantitative detection of IgA antibodies to tissue transglutaminase (endomysium) in human serum. (cdc.gov)
  • Endomysial antibodies of the IgA subclass present in the serum bind to the reticulin component of the endomysium of the smooth muscle in monkey esophagus tissue and can be detected by indirect immunofluorescence. (cdc.gov)
  • The 'Mesobank UK' tissue bank recently launched at Papworth Hospital in Cambridge (a part of Cambridge University Health Partners) will provide vital tissue samples and anonymous, detailed clinical information which can be used to conduct research studies. (survivingmesothelioma.com)
  • We report presence of M. leprae in armadillo tissue samples from endemic and nonendemic areas of the Americas, suggesting that public health policy should contemplate zoonotic leprosy transmission routes carefully. (cdc.gov)
  • They are contracted mainly in Peru and Brazil, although the disease is endemic and can be contracted in any country from Mexico to Argentina, except Uruguay and Chile. (aafp.org)
  • West Nile Virus, a mosquito-borne flavivirus, was detected in North America in 1999 and has since become endemic to the United States, where it causes annual seasonal outbreaks. (cdc.gov)
  • Mixed connective-tissue disease (MCTD) was first recognized by Sharp and colleagues (1972) in a group of patients with overlapping clinical features of systemic lupus erythematosus (SLE), scleroderma , and myositis, with the presence of a distinctive antibody against what now is known to be U1-ribonucleoprotein (RNP). (medscape.com)
  • Nevertheless, whether MCTD is a distinct disease entity has been in question since shortly after its original description. (medscape.com)
  • The overall goals of therapy for MCTD are to control symptoms, to maintain function, and to reduce the risk of future disease consequences. (medscape.com)
  • Scar tissue forms because of injury or long-term disease. (medlineplus.gov)
  • Scar tissue cannot do what healthy liver tissue does - make protein, help fight infections, clean the blood, help digest food and store energy. (medlineplus.gov)
  • Nothing will make the scar tissue disappear, but treating the cause can keep it from getting worse. (medlineplus.gov)
  • If too much scar tissue forms, you may need to consider a liver transplant . (medlineplus.gov)
  • When extensive scar tissue replaces healthy tissue, the liver stops functioning. (healthline.com)
  • In this condition, hard scar tissue has replaced much of the healthy liver tissue, leading to a significant loss of liver function. (healthline.com)
  • Serum PCB analysis is less invasive than tissue biopsy, and it can be performed by most commercial reference laboratories. (cdc.gov)
  • Abstract Background Accurately prioritizing candidate disease genes is an important and challenging problem. (elsevierpure.com)
  • Various network-based methods have been developed to predict potential disease genes by utilizing the disease similarity network and molecular networks such as protein interaction or gene co-expression networks. (elsevierpure.com)
  • Although successful, a common limitation of the existing methods is that they assume all diseases share the same molecular network and a single generic molecular network is used to predict candidate genes for all diseases. (elsevierpure.com)
  • As part of a broad effort to develop preclinical models of Parkinson's disease (PD), MJFF sponsored the generation and initial characterization of knockout pre-clinical models for the Parkin, DJ-1, PINK1 and LRRK2 genes because mutations in these genes are causally linked to inherited forms of PD. (michaeljfox.org)
  • The objective of this project is to analyze some of these frozen pre-clinical model brain tissue samples to determine whether mutations causally linked to inherited forms of PD cause biochemical or neurochemical abnormalities in the brains of models bearing mutations in the same genes. (michaeljfox.org)
  • We analyzed frozen brain tissue from pre-clinical models with deletion mutations in the PD-linked genes Parkin, DJ-1, PINK1 and LRRK2 as well as wild-type (non-mutant) controls. (michaeljfox.org)
  • Because mitochondrial dysfunction has been implicated in Parkinson's disease and because several of these genes are believed to affect mitochondrial function, we analyzed the function of mitochondria in frozen brain tissue samples from the same wild-type and mutant pre-clinical models at age 8 months. (michaeljfox.org)
  • However, the authors redefine mixed connective tissue disease as "a core of minor symptoms (ie, Raynaud phenomenon, puffy fingers, mild myositis, and arthritis) associated significantly with anti-U1-68kD antibody, defining an undifferentiated connective tissue (UCTD) disease that may ultimately overlap with features of major connective tissue disease. (medscape.com)
  • Early in the 2009 influenza A (H1N1) virus pandemic, CDC provided guidelines for submission of tissue specimens for evaluation of influenza virus infections. (cdc.gov)
  • V. vulnificus wound infections have a short incubation period and are characterized by necrotizing skin and soft tissue infection , with or without hemorrhagic bullae. (cdc.gov)
  • In the United States, V. vulnificus infections have been most commonly reported by Gulf Coast states. (cdc.gov)
  • However, V. vulnificus infections in the Eastern United States increased eightfold from 1988-2018, and the northern geographic range of infections has increased 48 km per year [4]. (cdc.gov)
  • During the same period, several East Coast states, including Connecticut , New York , and North Carolina , have reported severe and fatal V. vulnificus infections. (cdc.gov)
  • Many of these infections were acquired after an open wound was exposed to coastal waters in those states. (cdc.gov)
  • As with other parasitic diseases, roundworm infections are more common in warm climates than in cooler, temperate areas of the world. (medhelp.org)
  • In the United States, it is the most common of all parasitic roundworm infections, affecting up to 32 percent of the country's children. (medhelp.org)
  • Overall health issues and problem solving techniques for domesticated ungulates, including a review of indicators for disease or parasitic infections. (uaf.edu)
  • Infiltrative diseases such as sarcoidosis or amyloidosis, and rare genetic diseases such as Wilson disease, primary hemochromatosis, and alpha-1-antitrypsin deficiency, must be excluded. (cdc.gov)
  • This infection may be the In the United Arab Emirates (UAE), the first clinical manifestation of disease and national neonatal screening programme carries a case fatality rate as high as 30% started by screening for phenylketonuria in [ 1 ]. (who.int)
  • Needle aspiration of tissue fluid from the margin of a lesion can yield fluid for culture to isolate the organism and identify the species. (aafp.org)
  • Previously undiagnosed family members with this organism is greater in the first 3 with the trait or disease can also be identi- years of life and can occur as early as 4 fied [ 5 ]. (who.int)
  • However, by investigating the ratio S-T3/S-T4 in selected clinical states we can depict the ability of the organism to protect its normal S-T3 level in situations with divergent S-T4 concentrations, even if details about the mechanisms cannot be explained. (lu.se)
  • We examined armadillos from museum collections in the United States using molecular assays to detect leprosy-causing bacilli. (cdc.gov)
  • CDC receives tissue specimens routinely from patients with confirmed or suspected infectious diseases and provides histopathologic, immunohistochemical, and molecular evaluations. (cdc.gov)
  • However, different diseases tend to manifest in different tissues, and the molecular networks in different tissues are usually different. (elsevierpure.com)
  • An ideal method should be able to incorporate tissue-specific molecular networks for different diseases. (elsevierpure.com)
  • Results In this paper, we develop a robust and flexible method to integrate tissue-specific molecular networks for disease gene prioritization. (elsevierpure.com)
  • This validates the importance to integrate tissue-specific molecular networks for studying disease gene prioritization and show the superiority of our network models and ranking algorithms toward this purpose. (elsevierpure.com)
  • Understanding transitions from one cell type or state to another is in the focus of modern molecular biology. (nature.com)
  • Endometriosis (en-doe-me-tree-O-sis) is an often painful disorder in which tissue that normally lines the inside of your uterus - the endometrium - grows outside your uterus. (who.int)
  • After surgeons removed as much of the visible mesothelioma tumor and surrounding tissue as possible, patients received 50Gy of radiation to the effected side of their chest, delivered in 25 fractions. (survivingmesothelioma.com)
  • A Yale study, published online in May in the New England Journal of Medicine , demonstrated that removing more tissue all the way around the tumor site during the initial surgery - known as cavity shave margins (CSM) - could cut the need for a second surgery in half. (yale.edu)
  • Although confusing, perhaps the best way to consider mixed connective tissue disease is as an undifferentiated connective tissue disease represented mostly by Raynaud phenomenon and anti-RNP antibody. (medscape.com)
  • Parasitic diseases are much more widespread than many people realize. (medhelp.org)
  • Many roundworm parasitic diseases result from human carelessness and a lack of appropriate personal hygiene and sanitation measures. (medhelp.org)
  • Cutaneous leishmaniasis is a parasitic disease occurring throughout the Americas from Texas to Argentina, and in the Old World, particularly the Middle East and North Africa. (aafp.org)
  • Estimate the prevalence of celiac disease in the United States population. (cdc.gov)
  • Advances in diagnostic testing now allow accurate disease prevalence estimates using two step serological testing. (cdc.gov)
  • Infectious hepatitis includes disease caused by viruses such as A, B, C, and other possible agents of non-A, non-B hepatitis. (cdc.gov)
  • In the United States, the most common causes are chronic alcoholism and hepatitis . (medlineplus.gov)
  • others classify the disorder as an undifferentiated connective tissue disease or overlap syndrome, which may have features of lupus, progressive systemic sclerosis, rheumatoid arthritis, and myositis but should not have its own separate name. (medscape.com)
  • This decrease is evidenced by lower PCB levels reported in human adipose tissue, blood serum, and breast milk [Anderson et al. (cdc.gov)
  • Some researchers believe that PCB levels in the serum and tissue provide a reliable measurement of long-term exposure. (cdc.gov)
  • PCB levels in the serum and tissue can be measured by many laboratories although analyses results may not be consistent with health effects. (cdc.gov)
  • Alzheimer disease (AD) is the most common progressive degenerative form of dementia, strongly associated with advancing age. (medscape.com)
  • However, only frontal cortex tissue was available for analysis and it is possible that significant mitochondrial dysfunction occurs in the mutant pre-clinical models in the brains regions most affected in Parkinson's disease (the substantia nigra and the caudate/putamen). (michaeljfox.org)
  • Coronary artery disease is an inflammatory process involving the walls, and subsequent function, of the coronary arteries, and it is at this tissue level where the interaction of these inflammatory mediators results in CAD. (bmj.com)
  • The one remaining antibody that can successfully be used against the beta receptor, however, can find no trace of the receptor in cancerous or healthy breast tissue, the study states. (sciencedaily.com)
  • They also searched large databases of gene expression, including The Cancer Genome Atlas, The Genotype-Tissue Expression, and the Human Protein Atlas, and pin-pointed a universal lack of estrogen receptor beta messenger RNA in breast tissue. (sciencedaily.com)
  • The Mesobank will offer 20 new mesothelioma cell lines for study and will accept tissue and blood samples from a collaborative group of doctors and scientists across the UK. (survivingmesothelioma.com)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • It controls transportation of molecules between blood and tissue. (ohsu.edu)
  • Field necropsy techniques and blood and tissue collection procedures. (uaf.edu)
  • Results of blood cultures and serological tests for autoantibodies were negative, indicating that the clinical manifestations were not due to infection or a specific collagen disease. (bvsalud.org)
  • Punch biopsies with tissue-impression smears also can be diagnostic. (aafp.org)
  • Stony coral tissue loss disease (SCTLD) is a particularly destructive disease of unknown etiology, capable of transmitting through the water column and killing entire colonies within a matter of weeks. (usgs.gov)