• Coats disease is characterized by the presence of vascular dilatations (retinal telangiectasia), including ectatic arterioles, microaneurysms, venous dilations (phlebectasias), and fusiform capillary dilatations, which are frequently associated with exudative retinal detachment. (aao.org)
  • The clinical findings vary widely, ranging from mild retinal vascular abnormalities and minimal exudation to extensive areas of retinal telangiectasia associated with massive leakage and exudative retinal detachment. (aao.org)
  • Neovascularization in the posterior eye can lead to vitreous hemorrhage and retinal detachment. (medscape.com)
  • Reattachment of the retina (for retinal detachment, a complication of diabetic retinopathy). (cdc.gov)
  • If this series of events does not stabilize or reverse with recanalization of the occluded retinal vessels, the subsequent end-stage results may be retinal infarction and/or detachment. (medscape.com)
  • Since vitreous hemorrhage and retinal detachment account for most visual loss in hemoglobinopathies, the primary goal in treating proliferative sickle retinopathy is to minimize or eliminate neovascularization. (medscape.com)
  • Follow-up care is usually within 1 week after laser surgery to rule out retinal detachment from contracture of the neovascular membrane after laser treatment. (medscape.com)
  • Most patients experience PVD after age 60, once in each eye, and the condition is usually non-sight-threatening but occasionally affects vision more permanently in the event of complication, such as retinal detachment or epiretinal membrane . (asrs.org)
  • If PVD is complicated by vitreous hemorrhage , retinal detachment , epiretinal membrane , or macular hole , the flashes and floaters may be accompanied by decreased or distorted vision. (asrs.org)
  • These conditions can lead to further complications, such as retinal detachment or epiretinal membrane, which can result in permanent vision loss. (asrs.org)
  • That said, complications of PVD are rare but can be serious and require urgent treatment, such as laser for a retinal tear or surgery for a retinal detachment . (asrs.org)
  • More severely affected dogs may also have abnormalities close to where the optic nerve enters the eye, and some will have detachment of the retina. (merckvetmanual.com)
  • Vision is not noticeably affected unless detachment of the retina is present. (merckvetmanual.com)
  • OSCULLO-YEPEZ, Jasson J. y OSCULLO-YEPEZ, Grace J. . Stickler syndrome: when retinal detachment becomes heritable. (isciii.es)
  • After poor clinical course, retinal detachment appears, accompanied with sensorineural hearing loss. (isciii.es)
  • Organized fibroglial bands with traction retinal detachment and vitreous hemorrhage may occur, along with potential complications such as glaucoma or permanent vision loss. (medscape.com)
  • A former employee of the company requested the evaluation in response to three cases of retinal detachment among the welders. (cdc.gov)
  • Retinal vein occlusion (RVO) is a common vascular disorder of the retina and one of the most common causes of vision loss worldwide. (medscape.com)
  • Occlusion of the central retinal vein at the level of the optic nerve is referred to as central retinal vein occlusion (CRVO). (medscape.com)
  • Occlusion at the primary superior branch or primary inferior branch involving approximately half of the retina is referred to as hemiretinal vein occlusion (HRVO). (medscape.com)
  • Obstruction at any more distal branch of the retinal vein is referred to as branch retinal vein occlusion (BRVO). (medscape.com)
  • Prognostic Tests at 1 Month Foretell Macular Edema Outcome In macular edema secondary to branch retinal vein occlusion, assessment a month after the first anti-VEGF treatment predicts long-term outcome better than baseline testing, a case series shows. (medscape.com)
  • The rigid sickled erythrocytes lead to vascular occlusion, which results in retinal hypoxia, ischemia, and neovascularization. (medscape.com)
  • 13 Roche also continues to explore areas where faricimab has the potential to deliver additional benefits to patients, including retinal vein occlusion. (ophthalmologytimes.com)
  • ABSTRACT To investigate the possible relationship between hyperhomocysteinaemia and retinal vascular occlusion, we measured plasma homocysteine levels in 25 patients with a history of retinal vascular occlu- sion in the previous 2 years and in a control group of 24. (who.int)
  • Most of the patients had branch retinal vein occlusion associated with recent onset of occlusion. (who.int)
  • Factors such as emotional status and associated systemic disease may play a role in predisposition of retinal vascular occlusion, so more-precise studies are needed to determine the possible risk factors of hyperhomocysteinaemia in retinal vascular occlusion. (who.int)
  • Although retinal vascular occlusion, glaucoma, uvei- the relationship between hyperhomocys- tis or intraocular surgery/trauma. (who.int)
  • BRVO (macular or main branch) or central and central retinal vein occlusion (CRVO) retinal artery occlusion. (who.int)
  • Considering the various uncertainties plasma samples were packed in an icebox regarding the many possible risk factors and sent to the Pars Laboratory, Tehran to for retinal vascular occlusion, this study measure plasma homocysteine levels. (who.int)
  • AMD), occlusion of retinal vessels (ORV), etc. (who.int)
  • For milder cases of lipid exudation, additional considerations are diabetic retinopathy, BRVO, juxtafoveal retinal telangiectasia, and radiation retinopathy. (aao.org)
  • Specifically, it is the second most common cause of blindness from retinal vascular disease after diabetic retinopathy . (medscape.com)
  • Retinal cysts and a diagnosis of retinal vascular disease such as diabetic macular edema were less likely to be associated with significant errors. (nih.gov)
  • In both English and Spanish TV and radio spots, America's retina specialists urge the public to learn the symptoms of two common adult retinal conditions, age-related macular degeneration (AMD) and diabetic retinopathy, and seek care from a retina specialist promptly to safeguard vision. (asrs.org)
  • Eye diseases that can affect people with diabetes include diabetic retinopathy, macular edema (which usually develops along with diabetic retinopathy), cataracts, and glaucoma. (cdc.gov)
  • Diabetic retinopathy is caused when high blood sugar damages blood vessels in the retina (a light-sensitive layer of cells in the back of the eye). (cdc.gov)
  • I would say all of them are diabetic, but most of them have kidney disease, and on top of that they have diabetes, and they receive combined kidney and pancreas transplant. (upstate.edu)
  • Prediction of Diabetic Retinopathy Severity Using a Combination of Retinal Neurodegeneration and Capillary Nonperfusion on OCT Angiography. (mdfoundation.com.au)
  • To generate a prediction model of diabetic retinopathy (DR) severity stages based on retinal neurodegeneration and capillary nonperfusion area (NPA) detected using optical coherence tomography (OCT) and OCT angiography (OCTA). (mdfoundation.com.au)
  • For the treatment of retinal diseases such as diabetic retinopathy, your doctor may recommend the use of a retina laser. (od-os.com)
  • Pain and accuracy of focal laser treatment for diabetic macular edema using a retinal navigated laser (Navilas). (od-os.com)
  • Robert (Bob) Vitti and Alyson Berliner sit down to discuss their motivations for studying diabetic retinopathy (DR) and how their job was to shift the mindset around the disease. (regeneron.com)
  • So, when we set out to design a clinical trial to explore a different approach, we were really setting out to potentially shift the paradigm of the disease: we hypothesized that earlier and consistent treatment could make an impact and prevent some diabetic-related blindness. (regeneron.com)
  • The group leads a large Sino-Dutch screening project, 'RetinaCheck' for early detection of diabetic retinopathy and other eye diseases in North-East China. (tue.nl)
  • Patients were classified into 3 clusion is a major cause of retinal vascular major categories of retinal vascular occlu- disease, second only to diabetic retinopathy sion based on their first episode: CRVO, [ 3 ]. (who.int)
  • On each of the line scans, graders evaluated the position of the automated retinal boundary lines (inner retinal surface and retinal pigment epithelium band) used by the OCT machine for thickness calculations and graded the positioning on a 6-point subjective, categorical error scale to generate an error score. (nih.gov)
  • Autofluorescence allows doctors to monitor the retinal pigment epithelium, which is the deepest layer of the retina. (medicalnewstoday.com)
  • Although intravitreal administration of therapeutics increases concentration in the area of diseased tissue (i.e. retina, choroid, retinal pigment epithelium), while reducing systemic side effects, other drug delivery options reviewed in this manuscript offer promise for posterior segment conditions. (medscape.com)
  • EURETINA Retina Specialists Seek to Stem Myopia Epidemic In an effort to slow the explosive increase in myopia and its subsequent progression, retina specialists are recommending early intervention. (medscape.com)
  • Feeder vessel photocoagulation frequently is complicated by the following: vitreous hemorrhage, retinal detachments, choroidal ischemia, choroidal neovascularization, subretinal hemorrhage and/or fibrosis, or macular pucker and hole formation. (medscape.com)
  • Flashes and floaters are typically more obvious when PVD is complicated by a retinal tear or vitreous hemorrhage. (asrs.org)
  • It may occur with vascular disease, retinal dystrophy, uveitis, and usage of certain medications. (aao.org)
  • In this report, we describe using NGS to identify multiple disease-causing mutations that contribute concurrently or independently to retinal dystrophy in three relatively small families. (molvis.org)
  • 1 n.p.) identified three retinal dystrophy genes ( PRPH2 , PRPF8 , and USH2A ) with disease-causing mutations in varying combinations among the affected family members. (molvis.org)
  • Multiple genes contributing to the retinal dystrophy genotypes within a family were discovered using retinal gene-targeted NGS. (molvis.org)
  • Although PROM1-macular dystrophy (Stargardt disease 4) can exhibit phenotypic overlap with recessive Stargardt disease, significantly increased SW-AF levels were not detected. (mdfoundation.com.au)
  • IMI's Learning Retinal Implant System replaces the signal-processing functions of a healthy retina and provides input to the retinal nerve cells (the ganglion cells) that, in turn, provide input to the optic nerve and the brain. (medgadget.com)
  • During this test, a doctor uses special eye drops to dilate the pupils, allowing them to examine the retina for disease and see any optic nerve damage. (medicalnewstoday.com)
  • But we believe retinal ganglion cells are placed under immense metabolic stress during normal development, when they form the incredibly long optic nerve. (sciencedaily.com)
  • Nowadays, more advanced segmentation algorithms and higher resolution imaging enable the automated and precise identification of additional retinal layers including the outer retina as well as novel and more precise peripapillary retinal nerve fiber layer (pRNFL) parameters such as Bruch's membrane opening-minimum rim width (BMO-MRW) around the optic disk 13 . (nature.com)
  • Later in the disease when patients have lost considerable numbers of retinal ganglion cells and optic nerve axons, and have thereby lost considerable vision, stem cells may be useful to replace lost ganglion cells and restore the connections from the eye to the brain. (newswise.com)
  • Clinical picture of the retina, showing a pair of dilated and tortuous feeder vessels coursing on the surface of the retina from the optic nerve head toward the angioma (which is not seen in this image because it is in the extreme periphery). (medscape.com)
  • Note that the retinal vessels appeared to be emanating from below, within a circular, lighter area known as the optic disc. (cdc.gov)
  • This was the point where the retinal arterioles, and optic nerve, entered the rear of the eyeball. (cdc.gov)
  • The eye's retina is made up of photoreceptor (light-sensitive) cells and nerve cells in the optic nerve (which connects the eye to the brain). (medlineplus.gov)
  • Moreover, fukutin may be involved in synaptic functions of retinal neurons through the glycosylation of α-DG. (intechopen.com)
  • This negative plasticity is not passive in the face of photoreceptor degeneration, with a phased revision of retinal structure and function found at the molecular, synaptic, cell, and tissue levels involving all cell classes in the retina, including neurons and glia. (nih.gov)
  • However, there are a number of potential opportunities for intervention that are revealed through the study of retinal remodeling, including therapies that are designed to slow down photoreceptor loss, interventions that are designed to limit or arrest remodeling events, and optogenetic approaches that target appropriate classes of neurons in the remnant neural retina. (nih.gov)
  • Researchers have identified a gene necessary for the survival of retinal ganglion cells -- a class of neurons located in the retina that are critical for vision. (sciencedaily.com)
  • Seeking to uncover the reason behind this retinal defect, Prof Masai's unit labelled the three different types of neurons that connect in the inner plexiform layer -- retinal ganglion cells, amacrine cells and bipolar cells -- to see how they developed when strip1 was mutated. (sciencedaily.com)
  • First, we and others have discovered molecular pathways that can be used to coax stem cells to turn into neurons that look and act like real retinal ganglion cells. (newswise.com)
  • Tiny zebrafish can also regrow parts of the eye, including neurons in the eye's retina (the light-sensitive tissue at the back of the eyeball). (medlineplus.gov)
  • Although angiography demonstrates the presence of retinal capillary nonperfusion, posterior segment neovascularization is unusual. (aao.org)
  • The widely accepted pathogenesis for sickle cell retinopathy is vasoocclusion that leads to retinal hypoxia, ischemia, infarction, neovascularization, and fibrovascularization. (medscape.com)
  • In retinal images of a patient with sickle cell disease, PSR is characterized by a retinal lesion known as a sea fan neovascularization complex. (jhu.edu)
  • By independently blocking both pathways involving Ang-2 and VEGF-A, faricimab is designed to stabilize blood vessels and thereby reduce inflammation, leakage and abnormal vessel growth (neovascularization) more than inhibition of VEGF-A alone.7 This sustained blood vessel stabilization may improve disease control, vision and anatomical outcomes for longer. (ophthalmologytimes.com)
  • ASRS has released its first-ever national television and radio public service announcements (PSAs) to educate the public about protecting their vision from preventable blindness and vision loss due to retinal disease and the importance of expert retina specialist care. (asrs.org)
  • This common eye disease is the leading cause of blindness in working-age adults. (cdc.gov)
  • Then we'll learn about a disease that causes blindness in dogs and humans. (upstate.edu)
  • Inherited retinal degenerations, collectively termed retinitis pigmentosa (RP), constitute one of the leading causes of blindness in the developed world. (lu.se)
  • For early-stage treatment of these degenerative retinal diseases, the rationale is to stop or delay the death of the retinal cells, which is challenging, with many patients ultimately progressing to severe visual impairment and eventually complete blindness. (lu.se)
  • The Navilas® Laser System is the only retina laser system to date that uses advanced eye-tracking technology, making the highly modern treatment of retinal diseases possible with extreme precision and safety, less pain and fewer subsequent treatments. (od-os.com)
  • Early clinical sequelae of Ebola virus disease in Sierra Leone: a cross-sectional study. (cdc.gov)
  • Clinical studies, particularly those pertaining to subretinal diseases, should consider these errors when incorporating OCT imaging in the study design. (nih.gov)
  • In clinical practice, once all this has been formulated and codified, it is possible that we could have these fairly inexpensive retinal cameras available through[out] the medical world so that patients can be screened by them as part of their routine medical care," Smith told MedPage Today . (medpagetoday.com)
  • The main outcome measures were frequency of clinically observable ocular inflammatory attacks, background retinal and disc vascular leakage as assessed by fluorescein angiography during periods of clinical quiescence, visual acuity and adverse effects. (bmj.com)
  • Actively involved in retinal clinical research, Dr. Kaiser is study chairman of 4 major, multi-center, international clinical trials and is a principal investigator in multiple other trials. (clevelandclinic.org)
  • To determine the 12-month compliance with and retention of home monitoring (HM) with Melbourne Rapid Fields (MRFh) for patients with intermediate age-related macular degeneration (iAMD) and compare visual acuity (VA) and retinal sensitivity (RS) results to clinical measures. (mdfoundation.com.au)
  • This indicates that easily accessible retinal SD-OCT assessments may serve as biomarkers for clinical monitoring of neurodegenerative diseases and merit further research. (nature.com)
  • Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)
  • Because VHL disease is a multiple-organ disease that widely varies in clinical presentation, various manifestations may lead to diagnosis. (medscape.com)
  • As the incidence of cone degenerative diseases such as age-related macular degeneration is expected to rise in the future, the understanding of cone physiology and pathophysiology is urgently needed to develop therapeutic approaches for the preservation of cone-mediated vision in patients. (nature.com)
  • The acute model of light-induced retinal degeneration uses short exposure to bright white light to study photoreceptor cell death leading to loss of vision. (nature.com)
  • NEW YORK CITY -- Subretinal drusenoid deposits (SDD) had a significant association with underlying cardiovascular disease (CVD), adding a missing link between age-related macular degeneration (AMD) and CVD, a prospective study showed. (medpagetoday.com)
  • Scientists plan to test an implanted chip with four times the resolution of the previous version in people blinded by retinal degeneration. (technologyreview.com)
  • However, if the forces of separation are strong or concentrated in a particular part of the retina, or if there is an abnormal adhesion (sticking together) between the vitreous gel and the retina (such as lattice degeneration ), the PVD can tear the retina or a retinal blood vessel. (asrs.org)
  • Retinal photoreceptor degeneration takes many forms. (nih.gov)
  • Age-related macular degeneration (AMD) is an eye disease that causes the macula to lose its normal structure (called degeneration). (msdmanuals.com)
  • RVO is further subdivided into nonischemic and ischemic types, according to the amount of retinal capillary ischemia seen by the ophthalmologist on fluorescein angiography. (medscape.com)
  • Macular ischemia occurs when these capillaries, which supply oxygen to the retina, manifest leakage and nonperfusion. (medscape.com)
  • There are too few retina specialists, ophthalmologists, and optometrists in the world to see the billions of patients who need to be seen, therefore, Artificial Intelligence (AI) is needed. (appengine.ai)
  • The data make a compelling case to evaluate patients with SDD for undiagnosed high-risk CVD, he stated in a presentation at the American Society of Retina Specialists meeting. (medpagetoday.com)
  • This resource is made possible in part through generous support from the Foundation of the American Society of Retina Specialists, Allergan, Genentech, Novartis, and Regeneron Pharmaceuticals. (asrs.org)
  • Dr. Kaiser has been recognized by the American Academy of Ophthalmology and American Society of Retina Specialists with Achievement and Senior Achievement Awards, and is listed in the "Best Doctors in America" list. (clevelandclinic.org)
  • American Society of Retina Specialists (ASRS) Web site. (regeneron.com)
  • In an eye with Coats disease, the abnormal vessels are compromised, resulting in the leakage of serum and other blood components, which accumulate in and under the retina. (aao.org)
  • A, Ultra-wide-field fundus photograph of a patient with Coats disease showing dilated vessels with aneurysmal changes in the inferior temporal periphery as well as moderate to severe accumulation of exudate in the macula. (aao.org)
  • B, Corresponding fluorescein angiography image shows nonperfusion in the peripheral retina and around the abnormal blood vessels. (aao.org)
  • Advanced stage (proliferative): In this stage, the retina begins to grow new blood vessels. (cdc.gov)
  • These new vessels are fragile and often bleed into the vitreous (the clear gel between the lens and retina). (cdc.gov)
  • Your doctor will also look at the retina and inside of your eyes and may use a dye to reveal leaky blood vessels. (cdc.gov)
  • Obliterating feeder vessels by retinal photocoagulation has been used to cause infarction of peripheral neovascular beds. (medscape.com)
  • Doctors have recognised that changes to the tiny blood vessels in the retina are indicators of broader vascular disease, including problems with the heart. (leeds.ac.uk)
  • Retinal capillary hemangiomas, usually supplied by large dilated feeder vessels, may occur in any part of the retina. (medscape.com)
  • Serum leakage from these vessels and hemangiomas leads to retinal exudates. (medscape.com)
  • Also note, the presence of fibrous deposition within the retinal tissues adjacent to these occluded vessels, as well as the tortuosity of the retinal arterioles. (cdc.gov)
  • The inciting factor in BRVO is often compression of the adjacent vein by atherosclerotic retinal arteries at the site of AV crossing, leading to turbulent flow and venous stasis. (medscape.com)
  • In both ischemic and nonischemic CRVO, blockage of the retinal vein occurs, but the nonischemic type is able to maintain better relative blood flow to the retina through collaterals. (medscape.com)
  • Genetic factors are im- oedema along obstructed retinal vein). (who.int)
  • Retinal vein oc- measured. (who.int)
  • The most widely used therapeutic modalities include laser retinal photocoagulation, retinal cryotherapy, and vitrectomy/membranectomy. (medscape.com)
  • Recently, we generated R91W;Nrl −/− double-mutant mice, which display a well-ordered all-cone retina with normal retinal vasculature and a strong photopic function that generates useful vision. (nature.com)
  • Macular scarring is formation of the fibrous tissue in place of the normal retinal tissue on the macular area of the retina which provides the sharpest vision in the eyes. (wikipedia.org)
  • Similarly, vascular leakage was abundant in the inner and outer retina in R91W;Nrl −/− mice, whereas it was mild and restricted to the subretinal space in wt mice. (nature.com)
  • Conclusion Infliximab over the first year of treatment appeared effective in reducing ocular inflammatory attacks, as well as background retinal and disc vascular leakage, in patients with refractory uveoretinitis associated with Behçet's disease. (bmj.com)
  • Localized scatter photocoagulation is effective in treating early proliferative changes, especially neovascular lesions that lie flat against the retina. (medscape.com)
  • The major observation considered to be involved in the pathogenesis of retinal lesions is abnormalities in the internal limiting membrane formed by Müller cells, which is corresponding to the glia limitans formed by astrocytes in the brain. (intechopen.com)
  • In this chapter, ocular lesions of fetal and child FCMD patients are presented, especially focusing on pathological findings of the retina, and functions of fukutin are discussed. (intechopen.com)
  • The macula is a small area of the retina that has a high concentration of light-sensitive cells. (msdmanuals.com)
  • we use AI to look at the RETINA and understand the status of one's HEALTH. (appengine.ai)
  • When you look at the retina under a microscope, you can see that it has this beautifully organized structure. (sciencedaily.com)
  • Prof. Masai, along with his PhD student, Mai Ahmed, first became interested in the strip1 gene due to its role in correctly forming inner retinal layers. (sciencedaily.com)
  • von Hippel-Lindau (VHL) disease, or von Hippel-Lindau syndrome, is a rare genetic disorder characterized by visceral cysts and benign tumors in multiple organ systems that have subsequent potential for malignant change. (medscape.com)
  • Prevalence of retinal scar lesion types in a case-control study of ocular signs in Ebola virus disease survivors, Sierra Leone, 2016. (cdc.gov)
  • Expanding the spectrum of Ebola-associated eye disease: a summary of ocular findings in a large cohort of Ebola survivors. (cdc.gov)
  • In 1930, ocular changes associated with sickle cell disease were noted. (medscape.com)
  • In 1966, Welch and Goldberg introduced and described much of the modern terminology associated with sickle cell disease with respect to ocular changes. (medscape.com)
  • Diseases of the ocular fundus may occur on their own or as a part of generalized diseases. (merckvetmanual.com)
  • The authors conclude that no definite causal relationship between the cases of detached retina and exposures to gold, platinum, and ocular radiation could be established. (cdc.gov)
  • According to the press release (.pdf) , the Learning Retinal Implant System is by far the most complex retinal implant tested in humans (the reference and comparison is made against a 16-electrode array from US-based Second Sight . (medgadget.com)
  • In humans, our immune response causes scar tissue to form, which can stop parts of the retina from responding to light. (medlineplus.gov)
  • CME arises from the accumulation of fluid within the retina when there is disruption of the normal blood-retinal barrier and abnormal permeability of the perifoveal retinal capillaries. (aao.org)
  • Abnormal results may be due to diseases or central nervous system (CNS) disorders, such as tumors that damage or press on (compress) the parts of the brain that deal with vision. (ucsfhealth.org)
  • An abnormal development of the retina called retinal dysplasia is present at birth and may arise from trauma, genetic defect, or damage occurring while in the womb. (merckvetmanual.com)
  • To report the frequency and severity of optical coherence tomography (OCT) retinal thickness measurement errors and to describe parameters that predict these errors. (nih.gov)
  • Areas of granular deposition in SW-AF and NIR-AF corresponded to intermittent loss of the ellipsoid zone, whereas discrete regions of hypoautofluorescence corresponded with a loss of outer retinal layers in spectral-domain optical coherence tomography scans. (mdfoundation.com.au)
  • The patient displayed a pathologic phenomenon that was associated sickle cell disease (SCD), and included posterior retinal and macular vascular occlusions. (cdc.gov)
  • Purpose of review Emerging developments and research for drug delivery to the posterior segment offer a promising future for the treatment of vitreoretinal disease. (medscape.com)
  • Currently available, intravitreal, corticosteroid-release devices offer surgical and in-office management of retinal vascular disease and posterior uveitis. (medscape.com)
  • Intravitreal delivery of pharmacologic agents is the key method of drug delivery for posterior segment disease including retinal vascular disorders and posterior uveitis. (medscape.com)
  • August 24, 2023 - The OPTIMUM study aims to improve the care of people with low-grade glioma by learning more about the biology of the disease and engaging participants in research. (nih.gov)
  • Inherited abnormalities may be present at birth or appear later, and are important in the development of diseases of the retina in dogs. (merckvetmanual.com)
  • Viral infections of the mother (for example, herpesvirus in dogs), especially during early fetal development, can result in many eye abnormalities with retinal dysplasia in puppies. (merckvetmanual.com)
  • All participants completed a checklist certain, it is of increasing interest that less consisting of questions covering demo- severe abnormalities of methionine metabo- graphic data, current disease, disease histo- lism may predispose to the development of ry, eye trauma and consumption of drugs. (who.int)
  • Capillary nonperfusion seems to initially occurs in midperipheral retina with macular neurodegeneration and progress posteriorly. (mdfoundation.com.au)
  • Collectively, our data suggest that exposure of R91W;Nrl −/− mice to blue light not only induces cone cell death but also disrupts the inner blood-retinal barrier. (nature.com)
  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. (frontiersin.org)
  • Sickle cell disease, the most common inherited blood disorder, can affect every organ system, including the eyes. (jhu.edu)
  • Treatment of Coats disease generally consists of ablation with photocoagulation or cryotherapy, and, in severe cases, retinal reattachment surgery. (aao.org)
  • Although many hemoglobinopathies exist, those resulting in proliferative retinopathy are limited to sickle cell disease. (medscape.com)
  • Homozygous sickle cell disease (SS disease), sickle cell C disease (SC disease), and sickle cell-thalassemia disease (S-Thal disease) are common hemoglobinopathies that can present with mild-to-severe proliferative retinal findings. (medscape.com)
  • The $50,000 grant, co-sponsored by the International Retina Research Foundation (IRRF), will support the project, "Automated Detection of Proliferative Sickle Cell Retinopathy in Ultra-Widefield Fundus Images. (jhu.edu)
  • To measure the retinal /choroidal thicknesses in the macular area of asymptomatic pediatric patients with sickle cell disease (SCD). (bvsalud.org)
  • The AI system identified associations between pathology in the retina and changes in the patient's heart. (leeds.ac.uk)
  • Retinal and choroidal thickness in pediatric patients with sickle cell disease: a cross-sectional cohort study. (bvsalud.org)
  • In 1959, Lieb and coworkers associated angioid streaks with sickle cell disease. (medscape.com)
  • Errors of retinal boundary detection and thickness measurement were observed in 92% of eyes, but were severe in only 13.5% of eyes. (nih.gov)
  • Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disease leading to severe cognitive loss and eventual death. (frontiersin.org)
  • These images are typically acquired for severe eye diseases like sickle cell retinopathy at their early stages," said Craig Jones, an assistant research professor of computer science. (jhu.edu)
  • Dr. Kaiser received his medical degree magna cum laude from Harvard Medical School in Boston, Mass. He completed an internship in internal medicine at Massachusetts General Hospital, an ophthalmology residency at the Massachusetts Eye and Ear Infirmary in Boston and a retinal fellowship at Bascom Palmer Eye Institute in Miami, Florida. (clevelandclinic.org)
  • Characteristic to the disease is the profound atrophy of the brain accompanied by amyloid-beta (Aβ) plaques and the presence of tau neurofibrillary tangles (NFTs). (frontiersin.org)
  • Retinal assessments have been discussed as biomarkers for brain atrophy. (nature.com)
  • Retinal implants can take over for these lost cells, converting light into neural signals that are then interpreted by the brain. (technologyreview.com)
  • When implanted in the retina, the electrodes transmit electrical signals from the chip to neural cells in the eye, which then send the message to the brain. (technologyreview.com)
  • Retinal remodeling is a universal finding subsequent to retinal degenerative disease that results in deafferentation of the neural retina from photoreceptor input as downstream neuronal elements respond to loss of input with negative plasticity. (nih.gov)
  • Retinal remodeling has direct implications for the rescue of vision loss through bionic or biological approaches, as circuit revision in the retina corrupts any potential surrogate photoreceptor input to a remnant neural retina. (nih.gov)
  • The neurosensory retina and the brain derive from the same neural tissue, share morphologic and physiologic similarities and maintain direct synaptic connections over the whole life span 1 . (nature.com)
  • To date, researchers have not identified an associated gene or chromosome or any hereditary pattern, and no association between Coats disease and systemic disease has been found. (aao.org)
  • Uveitis and systemic inflammatory markers in convalescent phase of Ebola virus disease. (cdc.gov)
  • The research program of the Retinal Image Analysis group is aimed at the development and exploitation of computer-aided diagnosis (CAD) algorithms for early detection of multiple systemic diseases from optical imaging of the retina. (tue.nl)
  • Investigators hypothesized that high-risk CVD -- including myocardial infarction (MI), valvular disease, and internal carotid artery stenosis (ICA) -- are strongly associated with SDDs but not drusen. (medpagetoday.com)
  • Writing in the journal Nature Machine Intelligence, the researchers report in their paper - ' Predicting Infarction through your retinal scans and minimal personal Information ' - that the AI system had an accuracy of between 70% and 80% and could be used as a second referral mechanism for in-depth cardiovascular examination. (leeds.ac.uk)