• Physicians must understand both the natural history of multiple myeloma (MM) and the limitations of current therapy in the treatment of the disease. (medscape.com)
  • A new drug, GSK2857916, was granted a breakthrough therapy designation by the FDA to treat patients who have relapsed or refractory multiple myeloma, according to GlaxoSmithKline (GSK), the manufacturer of the agent. (curetoday.com)
  • GSK also noted in a press release that the European Medicines Agency (EMA) granted PRIME designation to GSK2857916 in October for the treatment of patients with relapsed and refractory multiple myeloma whose prior therapy included a proteasome inhibitor, an immunomodulatory agent and an anti-CD38 antibody. (curetoday.com)
  • The breakthrough designation is based on results from a phase 1 open-label, dose escalation and expansion study in patients with relapsed/refractory multiple myeloma, irrespective of BCMA expression. (curetoday.com)
  • The primary objective of the study is to determine the safety and tolerability of I-131-CLR1404, with and without concurrent weekly dexamethasone, in patients with relapsed or refractory multiple myeloma who have previously been treated with, or are intolerant of, an immunomodulator and a proteasome inhibitor. (mayo.edu)
  • We aimed to report our CP experience in Sars-Cov-2 infection in our relapsed / refractory Multiple myeloma (MM) patient. (annalsmedres.org)
  • Study C1071017 is a single-arm, open-label study in patient with relapsed /refractory multiple myeloma. (clinicaltrials.gov)
  • Acute Graft Versus Host Disease (GVHD) is a serious medical condition that is a common development after Bone Marrow Transplant (BMT). (clinicaltrialsgps.com)
  • No patients experienced immune effector cell-associated neurotoxicity syndrome, graft versus host disease, or hemophagocytic lymphohistiocytosis. (medpagetoday.com)
  • Background Despite the increasing performance of allogeneic hematopoietic cell transplantation over the last decades, graft-versus-host disease (GVHD) remains the main cause of morbidity and mortality. (istinye.edu.tr)
  • The diagnosis and management of refractory celiac disease remains challenging, but ongoing studies can provide the proper diagnostic criteria and identify the optimal management strategies, according to a new American Gastroenterological Association expert review published in Gastroenterology. (medscape.com)
  • Celiac disease (CD) is a gluten-sensitive enteropathy with a broad spectrum of clinical manifestations. (medscape.com)
  • Celimmune LLC, a clinical development-stage immunotherapy company focused on treating and preventing autoimmune diseases, announced today that it has licensed a Phase 2-stage, anti-IL-15 monoclonal antibody (AMG 714) from Amgen. (news-medical.net)
  • Diagnosis of the disease is made primarily from the clinical features presented during the illness. (scirp.org)
  • Patient fulfilling these criteria are diagnosed with complete Kawasaki disease and those not fulfilling these criteria but having 2 or 3 criteria and a strong clinical suspicion of KD [5] can further be evaluated with the help of laboratory and echocardiographic evaluation and if further criteria fulfilled then those are diagnosed as incomplete Kawasaki disease. (scirp.org)
  • Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease. (nih.gov)
  • Combination tofacitinib and a biologic was effective in achieving clinical and endoscopic improvement in some patients with severe, refractory CD, although a larger sample size is needed to further assess the efficacy and long-term safety of this treatment strategy. (unboundmedicine.com)
  • We present here the clinical and detail electrophysiological features of the largest series of 7 patients and further characterise and hence rename the syndrome as progressive cortical hyperexcitability with ataxia and refractory coeliac disease. (bmj.com)
  • Clinical manifestations are heterogeneous and may vary from mild cases (abdominal pain, changes in bowel habit and weight loss) to serious complications such as acute abdomen, perineal sepsis, fistulizing disease and colorectal cancer. (scielo.br)
  • Henriksen M, Jahnsen J, Lygren I, Aadland E, Schulz T, Vatn MH, Moum B. Clinical course in Crohn's disease: results of a five-year population-based follow-up study (the IBSEN study). (scielo.br)
  • 6 The Canadian Thoracic Society recently released a clinical practice guideline 7 that recommends the use of opioids for refractory dyspnea in patients with advanced COPD. (cmaj.ca)
  • These refractory symptoms, which are frequently encountered in clinical practice, may stem from GERD as well as non-GERD etiologies. (duke.edu)
  • Given the interferon signature, which is well described in JDM, and previous use of JAK inhibitors in Mendelian interferonopathies, we studied the use of baricitinib (a JAK inhibitor) in refractory JDM, demonstrating proof of concept in pharmacodynamic studies as well as clinical efficacy (PMID 32843325 ). (nih.gov)
  • In clinical trials, patients with treatment-refractory MAC lung disease had improved culture conversion with ALIS+GBT versus GBT [ 4 , 5 ]. (ersjournals.com)
  • These post hoc analyses of ALIS clinical trial data aimed to assess the NNTs and NNHs for ALIS+GBT compared with GBT in patients with treatment-refractory MAC lung disease. (ersjournals.com)
  • We studied results from adults with confirmed MAC lung disease diagnoses [ 7 ] and persistently positive sputum cultures despite ≥6 months of GBT who were enrolled in clinical trials evaluating the efficacy and safety of adding ALIS (or placebo) to continued GBT [ 5 ]. (ersjournals.com)
  • Topics of discussion will include refractory SE, post SE neuropathology, current clinical trials, gaps in the research for follow-on treatments and barriers to transitioning therapies to the clinic. (nih.gov)
  • To educate in the area of refractory, atypical and nonresponsive psychosis, particularly the clinical psychopharmacologic management. (pni.org)
  • In single-arm studies that were performed when diagnostic criteria for PAN were not well defined, vascular imaging, in tandem with clinical signs and pathology, helped validate the diagnosis (8) and determine disease severity (9). (vasculitisfoundation.org)
  • The timing of follow-up imaging is dependent, in part, on clinical factors, such as the extent and severity of vascular abnormalities, overall disease course, and response to therapy. (vasculitisfoundation.org)
  • Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in metabolite and protein levels, provide functional evidence to map disease associations and translate them into clinical applications. (nature.com)
  • Patients should be assessed annually to determine whether they are at increased risk of developing chronic kidney disease based on clinical and sociodemographic factors. (aafp.org)
  • About a quarter of the patients that develop acute GVHD may not respond to steroid and have steroid refractory GVHD (SR-aGVHD). (clinicaltrialsgps.com)
  • There is no consensus to the definition of steroid refractory (SR) aGvHD, but generally aGvHD is considered to be SR, when there is progression of GvHD after 3 days or no response after 7 days of treatment with 2mg/kg/day of methyl prednisolone. (clinicaltrialsgps.com)
  • It has been used as monotherapy for steroid refractory aGvHD with promising results. (clinicaltrialsgps.com)
  • Procedure This study aimed to evaluate the efficacy of ruxolitinib in 29 children with steroid-refractory acute or chronic GVHD. (istinye.edu.tr)
  • Conclusion Steroid-refractory acute and chronic pediatric GVHD patients treated with ruxolitinib had a high overall response rate, with the additional benefit of steroid sparing. (istinye.edu.tr)
  • For patients who do not promptly achieve return of spontaneous circulation (ROSC) with these measures and in whom cardiac arrest becomes refractory, brain and end‐organ dysfunction progresses and survival with good neurological outcomes becomes extremely uncommon. (mja.com.au)
  • However, effective treatments that improve neuropathic outcomes after SE becomes refractory to benzodiazepines is a common unmet need for both epilepsy and nerve agent researchers. (nih.gov)
  • GSK2857916, a B-cell maturation antigen (BCMA) antibody-drug conjugate, is indicated for patients who have failed at least three prior lines of therapy, including an anti-CD38 antibody, and who are also refractory to a proteasome inhibitor and an immunomodulatory agent. (curetoday.com)
  • This expanded access protocol will provide access to elranatamab until it becomes commercially available to patients who are refractory to at least one proteasome inhibitor, one immunomodulatory drug and one anti-CD38 antibody and have no access to other comparable/alternative therapy and for whom elranatamab could be a possible treatment option. (clinicaltrials.gov)
  • Refractory to at least one IMiD, one PI, and one anti-CD38 antibody. (clinicaltrials.gov)
  • One of the 2 patients with type 2 refractory enteropathy died 13 years later from metastatic enteropathy-associated lymphoma. (bmj.com)
  • We tested the feasibility and toxicity of high activities Rhenium-186 hydroxyethylidene diphosphonate, with peripheral blood stem cell rescue in patients with progressive hormone refractory prostate cancer metastatic to bone. (nih.gov)
  • Administered activities of 5000 MBq of Rhenium-186 hydroxyethylidene diphosphonate are feasible using autologous peripheral blood peripheral blood stem cell rescue in patients with progressive hormone refractory prostate cancer metastatic to bone. (nih.gov)
  • In stage IV metastatic disease the paradigm has completely shifted in the frontline setting. (ajmc.com)
  • Metastatic, hormone refractory prostate cancer (HRPCa) is the end stage, lethal form of the disease. (aacrjournals.org)
  • To our knowledge, this durable CR is the first to be achieved with allogeneic CAR T-cell therapy in patients with relapsed and refractory solid tumors," said Sumanta Pal, MD, of the City of Hope Comprehensive Cancer Center in Duarte, California, who reported the results at the Society for Immunotherapy of Cancer (SITC) annual meeting in Boston. (medpagetoday.com)
  • These individuals continue to have symptoms and histologic abnormalities or have symptomatic relapse despite treatment with gluten-free diet and ultimately develop a potentially life-threatening disease known as refractory sprue. (medscape.com)
  • Even with first dose of IVIG up to 10% - 20% of patients develop refractory Kawasaki Disease, i.e., remain unresponsive to initial IVIG treatment. (scirp.org)
  • Second dose of IVIG is recommended treatment for refractory Kawasaki Disease but other alternative treatments are also being considered to lower the risk of complications. (scirp.org)
  • We will review general treatment approach in refractory Kawasaki disease. (scirp.org)
  • Treatment regimen is determined by disease histological subtype and stage, along with patient performance status and comorbidities, including CD4 cell count, HIV viral load, and prior history of AIDS-related complications. (medscape.com)
  • Macroscopic observation of endobronchial Microascus cirrosus lesion in patient in France with refractory microascus bronchopulmonary infection before (A) and after (B) olorofim treatment. (cdc.gov)
  • Treatment of long-standing Lyme disease with ceftriaxone. (nih.gov)
  • The diagnosis and treatment of Lyme disease: a report of six cases]. (nih.gov)
  • We evaluated ustekinumab in adults with moderate-to-severe Crohn's disease that was resistant to anti-tumor necrosis factor (TNF) treatment. (nih.gov)
  • Some studies have shown benefits of hyperbaric oxygen therapy (HBOT) especially in the treatment of complex perineal wounds, pyoderma gangrenosum (PG) and fistulizing disease 4 4. (scielo.br)
  • Weisz G, Lavy A, Adir Y, Melamed Y, Rubin D, Eidelman S, Pollack S. Modification of in vivo and in vitro TNF-alpha, IL-1, and IL-6 secretion by circulating monocytes during hyperbaric oxygen treatment in patients with perianal Crohn's disease. (scielo.br)
  • Jennifer R. Brown, MD, PhD , of Dana-Farber Cancer Institute, discusses phase III findings of the ALPINE study, which showed that zanubrutinib is more efficacious and better tolerated than ibrutinib as a treatment for patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). (ascopost.com)
  • It is described as "iron-refractory" because the condition is totally resistant (refractory) to treatment with iron given orally and partially resistant to iron given in other ways, such as intravenously (by IV). (medlineplus.gov)
  • This phase I trial studies the side effects and best dose of palbociclib when given alone and in combination with sorafenib, decitabine, or dexamethasone in treating patients with leukemia that has come back (recurrent) or that does not respond to previous treatment (refractory). (mdanderson.org)
  • Follow-up may include blood tests to check levels of certain antibodies , which are higher in untreated celiac disease but typically return to normal after treatment. (nih.gov)
  • Corey S. Cutler, MD, MPH, FRCPC, provides insight on the case of a 49-year-old man with chronic GVHD and reviews current and emerging treatment options for disease management. (targetedonc.com)
  • A recent national practice guideline recommends the use of opioids for the treatment of refractory dyspnea in patients with advanced chronic obstructive pulmonary disease (COPD). (cmaj.ca)
  • Bridging this gap will require initiatives to improve the uptake of practice guidelines and to increase confidence in prescribing opioids for dyspnea refractory to conventional treatment. (cmaj.ca)
  • We performed a retrospective cohort of all patients in a Toronto clinic who began treatment for either M. avium or M. xenopi pulmonary disease during 2009-2012 (early period) or 2015-2018 (late period), studying their relative proportions and sputum culture conversion. (cdc.gov)
  • To be eligible for the study, patients were required to meet the American Thoracic Society/Infectious Diseases Society of America criteria for Mav-PD or Mx-PD ( 15 ) and to have begun treatment for NTM-PD during January 1, 2009-December 31, 2012, or January 1, 2015-December 31, 2018. (cdc.gov)
  • CARY, N.C., March 12, 2021 - Biologics by McKesson , an independent specialty pharmacy specializing in oncology and rare disease areas, was selected by AVEO Oncology as a specialty pharmacy provider for FOTIVDA ® (tivozanib) for the treatment of adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) who have received two or more prior systemic therapies. (mckesson.com)
  • FOTIVDA addresses an unmet need in patients with advanced RCC who otherwise lack a vital treatment option that targets their disease while improving quality of life," said Ela Lourido, vice president of Biopharma Services at Biologics. (mckesson.com)
  • Overall, the care of patients with MM is complex and should focus on treatment of the disease process and any associated complications. (medscape.com)
  • In up to half of patients with symptoms suspected to stem from gastroesophageal reflux disease (GERD), these symptoms persist despite treatment with daily proton pump inhibitor (PPI) therapy. (duke.edu)
  • After introducing the initial evaluation of patients with suspected GERD symptoms, this article discusses approaches to the esophageal diagnostic workup of patients with refractory symptoms in the setting of proven GERD, focusing on EGD, high-resolution manometry (HRM), and pH-impedance monitoring during treatment with PPI therapy. (duke.edu)
  • pH-impedance monitoring during treatment with PPI therapy can help distinguish between PPI-refractory GERD-as evidenced by pathologic acid exposure despite PPI therapy and/or excess burden of reflux events regardless of acidity-and PPI-controlled GERD. (duke.edu)
  • Fourteen patients discontinued treatment due to disease progression. (curetoday.com)
  • History and physical examination may give direction as to the diagnosis, but commonly it takes many visits with the patient complaining of recurrent abdominal pain , nonspecific joint aches, or demonstrating chronic anemia that does not respond to iron treatment, to raise the suspicion that celiac disease is a possibility. (medicinenet.com)
  • In a prospective trial comparing 2mg/kg/day with 10mg/kg/day of methylprednisolone in 94 patients with grade II-IV aGvHD, response rates, progression to grade III-IV disease, non- relapse mortality (NRM) and overall survival were similar in both treatment groups. (clinicaltrialsgps.com)
  • Our collaborative group studies are focused on better understanding the etiology and mechanisms of disease in juvenile myositis in order to optimize management and treatment. (nih.gov)
  • Elucidating the immunopathogenesis of the disease and potential predictors of treatment response by the discovery of novel biomarkers through transcriptomic, proteomic, and/or immunophenotyping analyses. (nih.gov)
  • Based on these data, the U.S. Food and Drug Administration (FDA) has accepted the supplemental Biologics License Application (sBLA) and granted Priority Review designation for Tecartus for the treatment of adult patients with relapsed or refractory B-cell precursor ALL, with a target action date under the Prescription Drug User Fee Act (PDUFA) of October 1, 2021. (gilead.com)
  • Tecartus is currently approved for the treatment of relapsed or refractory mantle cell lymphoma, as the first and only CAR T-cell therapy to receive accelerated approval from the FDA in this indication. (gilead.com)
  • The treatment of resistant or relapsed patients with multifocal disease remains challenging. (muni.cz)
  • Patients with MAC lung disease have substantial disease burden and limited treatment options [ 1 ]. (ersjournals.com)
  • For patients with treatment-refractory MAC lung disease (persistent MAC-positive sputum despite ≥6 months of guideline-based therapy (GBT)), international guidelines recommend the addition of amikacin liposome inhalation suspension (ALIS) to GBT regimens [ 3 ]. (ersjournals.com)
  • Follow-up imaging permits assessment of disease control and treatment response. (vasculitisfoundation.org)
  • The heat map derived signature readily distinguishes between prostate cancer specimens from men who were treatment naïve vs. hormone refractory cancers with 5 different expression patterns. (aacrjournals.org)
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
  • Clinically, the disease can be asymptomatic, and patients may have typical malabsorptive symptoms along with diarrhea, weight loss, and nutritional deficiencies. (medscape.com)
  • The presenting symptoms may be diarrhea, weight loss, abdominal pain, and refractory iron-deficiency anemia, or other nutritional deficiencies. (medscape.com)
  • The symptoms of iron-refractory iron deficiency anemia can include tiredness (fatigue), weakness, pale skin, and other complications. (medlineplus.gov)
  • Researchers suspect that iron-refractory iron deficiency anemia is underdiagnosed because affected individuals with very mild symptoms may never come to medical attention. (medlineplus.gov)
  • Celiac disease is present in about 1% of the U.S. population and can cause various symptoms, wrote Peter H. R. Green, MD, director of the Celiac Disease Center at Columbia University, New York, and colleagues. (medscape.com)
  • However, recurrent symptoms and elevated celiac antibodies can persist in some patients after a year of trying a gluten-free diet, a condition called nonresponsive celiac disease. (medscape.com)
  • First, in patients who have persistent or recurring symptoms, an initial celiac disease diagnosis should be confirmed through review of prior diagnostic testing, including serologies, endoscopies, and histologic findings. (medscape.com)
  • Next, in those with confirmed but nonresponsive celiac disease, ongoing gluten ingestion should be excluded as a cause of symptoms with serologic testing, dietitian review, and potentially detection of immunogenic peptides in stool or urine samples. (medscape.com)
  • After excluding gluten, clinicians should perform a systematic evaluation for other potential causes of symptoms, including functional bowel disorders, lactose or fructose intolerance, microscopic colitis , pancreatic insufficiency, inflammatory bowel disease , and small intestinal bacterial growth. (medscape.com)
  • Symptoms greatly improve for most people with celiac disease who stick to a gluten-free diet. (nih.gov)
  • A gluten-free diet will treat or prevent many of the symptoms and complications of celiac disease. (nih.gov)
  • Your doctor may recommend regular follow-up visits to make sure symptoms and health problems related to celiac disease are improving on a gluten-free diet. (nih.gov)
  • If you continue to have celiac disease symptoms while you are following a gluten-free diet, talk with your doctor or a registered dietitian, who can help you find the cause. (nih.gov)
  • In about 20 percent of people with celiac disease, symptoms continue or come back even while they are following a gluten-free diet. (nih.gov)
  • [ 32 ] This study evaluated 638 consecutive untreated subjects with MM. Of these subjects, 95 were asymptomatic and were not treated until their M protein value rose to greater than 5 g/dL or they developed new lytic bone lesions or symptoms of bone disease. (medscape.com)
  • This article also discusses potential approaches for patients with symptoms stemming from refractory GERD, encompassing lifestyle, pharmacologic, endoscopic, and surgical management options. (duke.edu)
  • What are the signs and symptoms of celiac disease? (medicinenet.com)
  • Symptoms of celiac disease can vary from mild to severe. (medicinenet.com)
  • Diarrhea and weight loss because of malabsorption are the classic symptoms of celiac disease, but they occur in less than one-half of people with the disease. (medicinenet.com)
  • The diagnosis of celiac disease is often delayed and it may take several months or years for the patient and the doctor to think of it as the cause of its many nonspecific symptoms. (medicinenet.com)
  • Below, we explore the symptoms of celiac disease in detail, as well as the diagnostic process, the risk factors, and gluten-free diets. (medicalnewstoday.com)
  • The only way for someone with celiac disease to avoid symptoms is to keep gluten out of their diet. (medicalnewstoday.com)
  • Health issues such as surgery, pregnancy, infections, or severe stress can sometimes trigger celiac disease symptoms. (medicalnewstoday.com)
  • As time goes by, children may experience spontaneous remission and remain free from symptoms of celiac disease until later in life. (medicalnewstoday.com)
  • Iron-refractory iron deficiency anemia results from an inadequate amount (deficiency) of iron in the bloodstream. (medlineplus.gov)
  • Although iron deficiency anemia is relatively common, the prevalence of the iron-refractory form of the disease is unknown. (medlineplus.gov)
  • Mutations in the TMPRSS6 gene cause iron-refractory iron deficiency anemia. (medlineplus.gov)
  • People with celiac disease may develop nutrient deficiencies as damage to the gut gradually limits the absorption of nutrients such as vitamins B12, D, and K. For the same reason, a person may also develop iron deficiency anemia . (medicalnewstoday.com)
  • Therefore, the addition of rituximab is generally recommended for CD20+ disease in patients whose CD4 count is above 50/μL. (medscape.com)
  • To report our experience using rituximab as therapy for refractory antisynthetase syndrome (ASS)-associated interstitial lung disease. (nih.gov)
  • Our findings suggest that rituximab may be a helpful therapy for refractory interstitial lung disease in patients with ASS. (nih.gov)
  • In this interview, we discuss the results of the phase III MURANO trial, which tested the combination of venetoclax with rituximab in relapsed/refractory CLL. (cancernetwork.com)
  • Dr. Seymour is the lead author on a paper of the results of the phase III MURANO trial, which studied venetoclax in combination with rituximab in patients with relapsed/refractory chronic lymphocytic leukemia (CLL). (cancernetwork.com)
  • However, in many other parts of the world, chemoimmunotherapy remains the standard in the relapsed/refractory setting, particularly with bendamustine and rituximab, given that ibrutinib is not universally available or reimbursed for that indication. (cancernetwork.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • This was a single-center, single- arm trial, prospective study of 88 patients with proton pump inhibitor (PPI)-refractory GERD who underwent ARMS between June 2012 and June 2017. (bvsalud.org)
  • Giving palbociclib alone and in combination with sorafenib, decitabine, or dexamethasone may work better in treating patients with recurrent or refractory leukemia. (mdanderson.org)
  • Formalin fixed paraffin embedded tumor samples from 14 cases (8 primary, chemotherapy-naïve and 6 locally recurrent, hormonal therapy-refractory carcinomas) were analyzed for the whole genome RNA (29,285 transcripts) microarray analysis using Illumina cDNA-mediated annealing, selection, extension and ligation (DASL) process with the HumanHT-12 v4 beadChip (Illumina Inc., San Diego, CA). Additionally, a select number of chemotherapy-predictive (theranostic) biomarkers were analyzed using immunohistochemical methods. (aacrjournals.org)
  • Coronary artery aneurysm (CAA) is the main complication of this disease which can be prevented largely by the early diagnosis and administration of IVIG (Intravenous Immunoglobulin). (scirp.org)
  • Scholars@Duke publication: Diagnosis and Management of Refractory Gastroesophageal Reflux Disease. (duke.edu)
  • Recommendation: For patients with suspected PAN, we conditionally recommend using abdominal vascular imaging to aid in establishing a diagnosis and determining the extent of disease. (vasculitisfoundation.org)
  • After the diagnosis of chronic kidney disease is made, staging based on estimated glomerular filtration rate determines prognosis, evaluation, and management. (aafp.org)
  • We have already seen the impact of Tecartus for patients with relapsed or refractory mantle cell lymphoma, and these new data are a significant next step in our continued commitment in developing our therapies for patients with leukemias and lymphomas. (gilead.com)
  • The true prevalence of this disease entity is unknown. (medscape.com)
  • The prevalence of chronic obstructive pulmonary disease (COPD) in Canada is high and rising. (cmaj.ca)
  • In patients with Crohn's disease, the efficacy of ustekinumab, a human monoclonal antibody against interleukin-12 and interleukin-23, is unknown. (nih.gov)
  • Long-term efficacy of antireflux mucosectomy in patients with refractory gastroesophageal reflux disease. (bvsalud.org)
  • Better markers to help monitor and predict the disease course and guide therapy are needed, as well as more targeted therapy options with better efficacy and fewer side effects. (nih.gov)
  • A small percentage of patients diagnosed with celiac disease fail to have a long-term favorable response to a strict gluten-free diet. (medscape.com)
  • When you are diagnosed with celiac disease, your doctor may test you for low levels of certain vitamins and minerals and may recommend or prescribe supplements if you need them. (nih.gov)
  • When you are diagnosed with celiac disease, your doctor may recommend additional testing if you are at risk for certain complications. (nih.gov)
  • Since it is often familial, once one person in the family is diagnosed with celiac disease, it is reasonable to have other close family members screened. (medicinenet.com)
  • We identified 19 patients treated with tofacitinib and a biologic for refractory CD between 2017 and 2019. (unboundmedicine.com)
  • however, this allele is known to be associated with many autoimmune diseases. (medscape.com)
  • The immune system is supposed to protect us from threats like bacteria and viruses, but in autoimmune diseases, it also attacks our own cells. (nih.gov)
  • The majority of patients with Crohn's disease (CD) will not achieve endoscopic remission on current therapy. (unboundmedicine.com)
  • Adjunctive Hyperbaric Oxygen Therapy promotes successful healing in patients with refractory Crohn's disease 1 1 Research performed at the Division of Coloproctology, Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo. (scielo.br)
  • To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn's disease. (scielo.br)
  • A total of 29 subjects with refractory Crohn's disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. (scielo.br)
  • The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn's disease. (scielo.br)
  • Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn's disease. (scielo.br)
  • Crohn's disease (CD) is a chronic inflammatory condition resulting from aberrant immune system activation. (scielo.br)
  • Management of Crohn's disease in adults. (scielo.br)
  • 7. Fraser GM, Niv Y. Six patients whose perianal and ileocolic Crohn's disease improved in the Dead Sea environment. (scielo.br)
  • Ae triseriatus, Culex quinquefasciatus partially refractory and Anopheles quadrimaculatus resistant. (cdc.gov)
  • refractory (heat-resistant applications). (cdc.gov)
  • Refractory uses of chromium include magnesite-chrome firebrick for metallurgical furnace linings and granular chromite for various other heat-resistant applications. (cdc.gov)
  • Kawasaki disease is an acute, self-resolving systemic vasculitis [1] , that is commonly seen in children under the age of five years. (scirp.org)
  • SANTA MONICA, Calif.--(BUSINESS WIRE)-- Kite, a Gilead Company (Nasdaq: GILD), announced today results from the primary analysis of ZUMA-3, a global, multicenter, single-arm, open-label Phase 1/2 study evaluating its chimeric antigen receptor (CAR) T-cell therapy Tecartus ® (brexucabtagene autoleucel) in adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). (gilead.com)
  • Celiac disease is thought to be an autoimmune disorder and may have a familial or genetic component. (medicinenet.com)
  • There seems to be a genetic predisposition to developing celiac disease, however, not all people with a family history of celiac disease develop the condition. (medicinenet.com)
  • A doctor can often diagnose celiac disease by considering the medical histories of the person and their family and ordering tests such as blood tests, genetic tests, and biopsies. (medicalnewstoday.com)
  • Our associations overlap with 57 genetic risk loci for 42 unique disease end points. (nature.com)
  • Mycobacterium avium complex (MAC) is the leading cause of nontuberculous mycobacterial lung disease, which can be associated with progressive lung damage and increased mortality [ 1 ]. (ersjournals.com)
  • Based on data reported in recent studies, the majority of patients with refractory sprue have abnormal intraepithelial lymphocytes and a poor prognosis. (medscape.com)
  • The first, called RCD1, is characterized by villous atrophy but has intraepithelial lymphocytes similar to conventional celiac disease. (medscape.com)
  • Table 1 presents definitions of selected terms used in the recommendations, including the definition of severe and nonsevere disease, as well as dosing ranges for glucocorticoids. (vasculitisfoundation.org)
  • The disease occurs nearly equally in men and women but tends to be more severe in men, typically beginning during their 20s. (msdmanuals.com)
  • This image shows a severe ulcer on the scrotum resulting from Beçhet disease. (msdmanuals.com)
  • Whilst coeliac disease (gluten sensitive enteropathy) remains one of the best characterised GRD, neurological dysfunction is one of the commonest extraintestinal manifestations with a range of presentations such as cerebellar ataxia, neuropathy, sensory ganglionopathy and encephalopathy (headaches and white matter abnormalities). (bmj.com)
  • All patients adhered to a strict gluten-free diet with elimination of gluten-related antibodies, despite which there was still evidence of enteropathy in keeping with refractory celiac disease (type 1 in 5 and type 2 in 2). (bmj.com)
  • Celiac disease is also known by other names including celiac sprue , non-tropical sprue, and gluten enteropathy. (medicinenet.com)
  • The mean age was 41.2 years (28-62), mean disease was duration 16.9 years (6-36), and prior exposure to biologics was a median of 4 (1-6). (unboundmedicine.com)
  • The population was an all-comer relapsed/refractory population with a median of one prior therapy, which was chemoimmunotherapy by and large. (ascopost.com)
  • The median time for disease progression was 10 months in the high-risk group, 25 months in the intermediate-risk group, and 61 months in the low-risk group. (medscape.com)
  • 97% of those responders had deep molecular remission, with undetectable minimal residual disease (MRD), and median overall survival (OS) among all responders was not reached. (gilead.com)
  • Minimally invasive treatments have been applied for gastroesophageal reflux disease ( GERD ), but the long-term results are controversial. (bvsalud.org)
  • The authors noted that persistent gluten ingestion, whether intentional or inadvertent, accounts for 40%-50% of patients with nonresponsive celiac disease. (medscape.com)
  • Patients with malabsorption and histologic findings consistent with CD who are unable to achieve long-term remission on a gluten-free diet, and in whom other causes of flat mucosa have been excluded, are considered to suffer from unclassified or refractory sprue (RS). (medscape.com)
  • An investigational new drug offers hope of relief for celiac disease patients who are inadvertently exposed to gluten while on a gluten-free diet. (news-medical.net)
  • Hyperexcitable brain and refractory coeliac disease: a new syndrome Gluten related disorders (GRD) is the newly proposed term to encompass a spectrum of immune mediated diseases triggered by gluten ingestion. (bmj.com)
  • Doctors treat celiac disease by helping people to follow a gluten-free diet . (nih.gov)
  • In people who have celiac disease, consuming gluten triggers an abnormal immune system reaction that damages the small intestine . (nih.gov)
  • Your doctor will explain the gluten-free diet and may refer you to a registered dietitian who specializes in treating people who have celiac disease. (nih.gov)
  • Celiac disease is a digestive disorder that occurs in reaction to gluten, a protein found in rye, barley, wheat, and hundreds of foods made with these grains. (medicinenet.com)
  • In people with celiac disease , inflammation occurs in the small intestinal mucosa when it is exposed to gluten in the diet . (medicinenet.com)
  • People with celiac disease experience inflammation and pain in the gut when they consume gluten. (medicalnewstoday.com)
  • In a person with celiac disease, exposure to gluten causes inflammation in the gut. (medicalnewstoday.com)
  • Celiac disease is an autoimmune disorder in which the immune system responds negatively to the gluten found in wheat and other grains. (medicalnewstoday.com)
  • High-dose chemotherapy and autologous stem-cell transplant (HDT-ASCT) is standard second-line consolidation therapy in relapsed or refractory large B-cell lymphoma (R/R LBCL). (ispor.org)
  • Presence or history of cardiovascular disease, radiotherapy to the mediastinal/pericardial area, previous therapy with other anthracyclines or anthracenediones, or use of other cardiotoxic drugs may increase this risk. (nih.gov)
  • We are so pleased to distribute this meaningful therapy to patients whose disease has relapsed or become refractory to multiple lines of therapy. (mckesson.com)
  • These studies have highlighted how we have looked at particular pathways and utilized Mendelian disease to better understand pathogenesis and guide the selection of targeted therapy. (nih.gov)
  • If approved, Tecartus would become the first and only CAR T-cell therapy approved for adults (≥18 years old) with relapsed or refractory ALL. (gilead.com)
  • In 2016, Tecartus received Breakthrough Therapy Designation in recognition of the unmet medical need in adult patients with relapsed or refractory B-cell precursor ALL. (gilead.com)
  • So this has changed our options for salvage because generally, if you've progressed on a triplet or a quadruplet regimen, I don't think that your disease will be well controlled with a monotherapy checkpoint inhibitor. (ajmc.com)
  • Aging and the Psychological Refractory Period: Task-Coordination Strategies in Young and Old Adults. (millisecond.com)
  • Chronic kidney disease affects an estimated 27 million adults in the United States, and is associated with significantly increased risk of cardiovascular disease and stroke. (aafp.org)
  • Chronic kidney disease (CKD) affects an estimated 27 million adults in the United States and is associated with increased mortality, morbidity, and health care costs. (aafp.org)
  • Adults with cardiovascular disease should be screened for CKD. (aafp.org)
  • Cardiovascular disease, a family history of CKD, and ethnic or racial minority status do not significantly increase the risk of CKD in adults older than 60 who have diabetes and hypertension. (aafp.org)
  • So in summary, the Alpine study demonstrated that zanubrutinib has a superior progression-free survival to ibrutinib in relapsed/refractory CLL patients and is also better tolerated with a particularly better cardiac profile, which is one of our key points we worry about with BTK inhibitors. (ascopost.com)
  • An important study by Dimopoulos and associates evaluated the risk of disease progression in asymptomatic subjects with MM. (medscape.com)
  • The generalized progression of the disease was observed later. (muni.cz)
  • Each patient will receive study intervention until disease progression, unacceptable toxicity, withdrawal of consent, study termination or until elranatamab becomes commercially available. (clinicaltrials.gov)
  • Unlike some other relapsed/refractory studies in which the patients could have had an unlimited number of prior treatments, this one was capped at three, although, they did need to have at least one prior chemotherapy-containing regimen. (cancernetwork.com)
  • What treatments and diets are available for celiac disease? (medicinenet.com)
  • Medical records research - uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best. (mayo.edu)
  • Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. (mayo.edu)
  • In this study, we investigated the differentially expressed genes in primary prostate tumor vs. hormone refractory prostate tumor in order to identify potentially important therapeutic targets. (aacrjournals.org)
  • We identify 539 independent, single-nucleotide polymorphism (SNP)-protein associations, which include novel inter-chromosomal ( trans ) links related to autoimmune disorders, Alzheimer's disease, cardiovascular disease, cancer and many other disease end points. (nature.com)
  • Other risk factors include cardiovascular disease, family history of chronic kidney disease, and ethnic and racial minority status. (aafp.org)
  • Patients should be assessed for risk factors leading to the further loss of kidney function and cardiovascular disease. (aafp.org)
  • 1 , 2 CKD is also associated with significantly increased risks of cardiovascular disease 3 and stroke. (aafp.org)
  • Annual CKD screening is recommended by the American Diabetes Association, 10 by the National Kidney Foundation for patients at risk, 9 , 11 by the Joint National Committee on Hypertension 12 for patients with diabetes and hypertension, and by the American Heart Association for patients with cardiovascular disease. (aafp.org)
  • Its deficiency in the body has been associated with diabetes, infertility, and cardiovascular disease. (cdc.gov)
  • Before the term Kawasaki disease (KD), it was reported as syndrome of mucocutaneous lymph node with infantile polyarteritis nodosa which was common among younger Asian population. (scirp.org)
  • This syndrome whilst rare, appears to be the commonest neurological manifestation of refractory CD. (bmj.com)
  • Refractory cytopenia with multilineage dysplasia is a form of myelodysplastic syndrome. (wikipedia.org)
  • Abstract B92: Differences in gene expression between primary chemotherapy-naive prostate carcinomas and hormone-refractory prostate carcinomas. (aacrjournals.org)
  • Pulmonary infection with nontuberculous mycobacteria (NTM) is a chronic, often progressive, debilitating disease. (cdc.gov)
  • Celiac disease can overlap with other gastrointestinal conditions, and some pathologic findings aren't specific to celiac disease. (medscape.com)
  • We supplemented this approach with quantitative measures to further describe participants and maximize comprehensiveness, 10 an approach consistent with current calls for mixed-methods approaches to evaluate dyspnea in advanced disease 11 - 13 and the benefit of palliative care interventions. (cmaj.ca)
  • This disease primarily affects medium sized arteries which complicate into acquired childhood cardiac disease. (scirp.org)
  • Extracorporeal cardiopulmonary resuscitation (ECPR) in patients with prolonged or refractory out‐of‐hospital cardiac arrest (OHCA) is likely to be beneficial when used as part of a well developed emergency service system. (mja.com.au)
  • Preliminary results from a multinational project to study the impact of early childhood nutrition on celiac disease will be among the highlights of this month's 15th International Celiac Disease Symposium, hosted by the University of Chicago Medicine Celiac Disease Center. (news-medical.net)
  • However, indefinite routine vascular imaging should be avoided if the abdominal vascular disease is shown to be quiescent. (vasculitisfoundation.org)