Disease progression association diabetic angiopathies. Medical search. Frequent questions

In particular, his studies of diabetic retinopathy, in collaboration with ophthalmological colleagues at UWMS, defined the progression of changes that eventuate in retinal hemorrhages, plaques, exudates, and other lesions producing visual compromise. (wikipedia.org)
Diabetes mellitus (DM) is associated with macrovascular and microvascular complications (coronary artery disease, ischemic stroke, peripheral arterial disease, nephropathy, and retinopathy) [ 1 , 2 ]. (hindawi.com)
Diabetic retinopathy (DR), one of the leading causes of blindness and vision impairment, is suggested to exhibit functional and structural changes in retinal neurons as the earliest manifestation, which could be used to predict the progression of related angiopathy. (biomedcentral.com)
A large body of evidence now implicates increased leukocyte-endothelial cell adhesion as a key early event in the development of diabetic retinopathy. (diabetesjournals.org)
Levels of enzyme activity in plasma-treated U937 cells were closely dependent on the severity of diabetic retinopathy, with the highest values observed upon treatment with plasma of patients affected by proliferative retinopathy. (diabetesjournals.org)
Based on the prominent role of TNF-α in the development of diabetic retinopathy, these observations further validate the significance of core 2 GlcNAc-T in the pathogenesis of capillary occlusion, thereby enhancing the therapeutic potential of specific enzyme inhibitors. (diabetesjournals.org)
Diabetic retinopathy is a progressive vision-threatening complication of diabetes, characterized by capillary occlusion, formation of microvascular lesions, and retinal neovascularization adjacent to ischemic areas of the retina ( 1 - 2 ). (diabetesjournals.org)
The IGF system has been associated with development and progression of diabetic retinopathy. (diabetesjournals.org)
We examined whether a simple measurement of the IGF system (serum total IGF-I) correlated with progression of diabetic retinopathy in pregnancy in type 1 diabetes. (diabetesjournals.org)
Serum IGF-I increased with increasing progression of retinopathy. (diabetesjournals.org)
Pregnancy is a prominent risk factor for the development and progression of retinopathy in women with type 1 diabetes. (diabetesjournals.org)
Progression of retinopathy has been reported to be associated with suboptimal regulation of blood glucose and blood pressure, albuminuria, and adverse perinatal outcomes. (diabetesjournals.org)
However, after it was shown that pituitary ablation could halt the progression of proliferative diabetic retinopathy, increased focus has been put on the hormonal changes with growth-stimulating potential that accompanies pregnancy ( 1 ). (diabetesjournals.org)
Although some regression of nonproliferative retinopathy occurs after delivery, new cases with progression of retinopathy during pregnancy have been reported with a prevalence ranging between 20 and 85% ( 3 - 5 ). (diabetesjournals.org)
The aim of the present study was to examine the correlation between serum IGF-I and progression of retinopathy in diabetic pregnancy in 103 pregnant women with type 1 diabetes. (diabetesjournals.org)
Changes in serum IGF-I and progression of retinopathy, as well as their time course during and after pregnancy, were studied in a cross-sectional manner. (diabetesjournals.org)
The women were scheduled for ophthalmologic examination, including visual acuity testing and fundus photography, before pregnancy, once in each trimester, and 4 months after birth, according to the principles defined in the Early Treatment for Diabetic Retinopathy Study ( 6 ). (diabetesjournals.org)
This publication is dedicated to the application of a complex of peptide bioregulators being highly effective in treatment of different retinal diseases (diabetic retinopathy, pigment retinitis, age-related macular degeneration etc. (antiaging-peptides.com)
Among the most frequent retinal diseases there are age-related macular degeneration, hereditary retinal degenerations (including retinitis pigmentosa), complicated myopia, diabetic retinopathy. (antiaging-peptides.com)
Patients with diabetic retinopathy (DR) comprised 68% of the group with CIMT ≥1.0 mm, while they were 28% of the group without CIMT thickening ( P =0.003). (e-enm.org)
Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)

The occurrence of diabetic foot is closely related to micro-angiopathy, micro-thrombosis in the lower limb, which may predate the presentation of diabetic foot. (biomedcentral.com)
However, very little data are available on IS of circulating cells of MetS patients although clinical data show that inhibited mTOR, with specific inhibitors such as Serolimus or Everolimus after kidney transplantation, significantly increase the presence of de novo thrombotic micro-angiopathy with artery lesion characterized by intimal cell proliferation, necrosis and narrowed lumen. (biomedcentral.com)

Diabetic nephropathy (DN) is one of the most serious complications of DM. (biomedcentral.com)
Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. (e-dmj.org)
We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. (e-dmj.org)
CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (e-dmj.org)
Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)

Recent studies have shown that diabetic microangiopathies are associated with macroangiopathies and suggest that microangiopathies may have a prominent role in the pathogenesis of microangiopathy development [ 2 ]. (e-enm.org)
Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. (e-dmj.org)

In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications. (e-dmj.org)
CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study. (e-dmj.org)

Research suggests that fibrinogen (Fib) concentrations are used to assess the occurrence and severity of diabetic foot (DF) and to monitor the progression of diabetic foot in patients. (biomedcentral.com)

Platelets have a "key role" in atherogenesis and its thrombotic complications in subjects with DM [ 3 ], and the concomitant presence of multiple "classical" cardiovascular risk factors (arterial hypertension, cigarette smoking, and hyperlipidemia) in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
But, if a diabetic patient takes Ayurvedic treatment of diabetes, the chances of complications are less and the condition can be reversed naturally. (deepayurveda.com)
Cardiac autonomic neuropathy (CAN) is one of the most common complications of diabetes, and represents a significant cause of morbidity and mortality in diabetic patients. (e-enm.org)
Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)

It is not unusual for patients with type 1 diabetes to present with diabetic ketoacidosis (DKA). (medscape.com)
He was admitted to the surgical intensive care unit of the CHRU La Cavale Blanche of Brest on 12 September, 2015 for decompensated diabetic ketoacidosis, acute renal failure and hemolytic anemia. (scirp.org)

A large clinical study found that peripheral vascular disease (PAD) in patients with T2DM is a serious complication. (biomedcentral.com)
The role of chronic administration of antiplatelet drugs in primary prevention of arterial vascular events is known to be less clear than in secondary prevention, and, also in diabetic patients, the decision to give primary prophylaxis should be taken on an individual-patient basis, after a careful evaluation of the balance between the expected benefits and the risk of major bleedings. (hindawi.com)
Although, currently, treatment has proven useful in reducing vascular events, diabetic patients continue to have a higher risk of adverse cardiovascular events compared with those in nondiabetic patients. (hindawi.com)
This paper reviews the role of currently available antiplatelet drugs in primary and secondary prevention of vascular events in diabetic patients and the limitations of these drugs, and it discusses the role of novel and more potent antiplatelets and of new agents currently under clinical development. (hindawi.com)
Despite the recent advancements in treatment (in particular anti-vascular endothelial growth factor agents) and efforts in early detection of the disease, DR was still ranked in the top five leading causes of blindness and vision impairment, together with uncorrected refractive error, cataracts, glaucoma, and age-related macular degeneration, in adults aged 50 years and older in 2020. (biomedcentral.com)
This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
Systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. (scirp.org)
ABSTRACT Chronic diseases such as diabetes and vascular disease are a major public health problem in Lebanon, where primary care is not well developed. (who.int)
The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments. (gov.gy)
Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment. (gov.gy)
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the responsible agent for the coronavirus disease 2019 (Covid-19), has its entry point through interaction with angiotensin converting enzyme 2 (ACE2) receptors, highly expressed in lung type II alveolar cells and other tissues, like heart, pancreas, brain, and vascular endothelium. (nutrition-evidence.com)

Diabetes mellitus and cardiovascular disease increase the overall risk of acute and chronic osteomyelitis. (medscape.com)
Diabetes mellitus (referred to as diabetes below) is a chronic progressive disease characterized by uncontrolled hyperglycemia and a series of metabolic disorders. (biomedcentral.com)
Diabetes mellitus (DM) is a common disease in the modern society. (biomedcentral.com)
Retina is as a rule damaged in case of the following diseases: hypertension, diabetes mellitus, renal insufficiency etc. (antiaging-peptides.com)
The leading cause of death in type 2 diabetes mellitus (T2DM) is cardiovascular disease (CVD) [ 1 ]. (e-enm.org)

First reliable positive results of retinal diseases treatment were achieved in the middle 1980ies in Leningrad (Saint Petersburg). (antiaging-peptides.com)

Alzheimer's summit 2018 conference creates a platform for expert's interaction simultaneously with networking opportunities and also provides an opportunity to explore the innovative ideas of the other communities, companies and associations. (global-summit.com)
Let us unite to expand the knowledge on Alzheimer's disease , Dementia Care Research and its Awareness on Aug 31 - September 01 2018, Boston, Massachusetts, USA. (global-summit.com)
As you are aware , Neurodegenerative disorders like Alzheimer's disease and dementia is an emergent condition in USA and European countries like France, Germany and Poland over the last decade. (global-summit.com)

A better mechanistic understanding of how bacteria invade, survive within, and trigger pathologic remodeling of bone could lead to new therapies aimed at prevention or treatment of osteomyelitis, as well as amelioration of disease morbidity. (medscape.com)
Cardiovascular (CV) diseases are the leading cause of morbidity and mortality in diabetic patients. (hindawi.com)
Diabetes is a methabolic disease characterized by hyperglycemia, with high morbidity and mortility worldwide. (scialert.net)
Clinical data to date with an associated six-month follow-up, suggests the combination therapy may prevent the progression of the disease from mild to moderate to severe, as well as prevent/treat many of the aspects of 'Long COVID,' thereby cost effectively reducing both morbidity and mortality. (nutrition-evidence.com)

A large clinical study found that the prevalence of PAD in patients with T2DM was 23.5% [ 2 ], and diabetic patients with combined PAD are more likely to develop ulceration and gangrene of the limb, significantly increasing the risk of amputation. (biomedcentral.com)

A thoughtfully curated programme will support the exploration of how leading experts, in cardiology, nephrology, and diabetology, are treating the interrelated diseases. (espacecrm2023.org)

Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)

The exact pathogenic mechanism by which capillary nonperfusion, as demonstrated by fluorescein angiography, occurs is still unclear, but recent experimental animal studies ( 3 - 5 ) demonstrate that increased leukocyte entrapment in retinal capillaries of diabetic rats is an early event associated with areas of capillary nonperfusion and the development of endothelial cell damage. (diabetesjournals.org)

1] Pussinen PJ, Paju S, Mäntylä P, Sorsa T. Serum microbial- and host-derived markers of periodontal diseases: a review. (edu.pl)
We plan to examine corneal structures of diabetic patients and compare IVCCM with conventional tools and analyze their serum and tear NGF levels. (e-dmj.org)
METHODS: IVCCM, nerve conduction velocity (NCV), and serum, urine, and tear samplings were done to 42 diabetic patients. (e-dmj.org)

The purpose of this study is to determine if pioglitazone is effective in preventing future strokes or heart attacks among non-diabetic persons who have had a recent ischemic stroke. (stanford.edu)

In the present study, we demonstrate that following exposure to plasma from diabetic patients, the human promonocytic cell line U937 exhibits a significant elevation in core 2 GlcNAc-T activity and increased adherence to cultured retinal capillary endothelial cells. (diabetesjournals.org)

For his contributions to the field of endocrinology, Bloodworth received the prestigious Eli Lilly Research Award on behalf of the American Diabetes Association in 1963. (wikipedia.org)
The Trail Making Test in prodromal Huntington disease: contributions of disease progression to test performance. (gov.gy)

This study primarily aimed to investigate mitochondrial functional changes in a diabetic rodent model. (biomedcentral.com)

B cell acute lymphoblastic leukemia (B-ALL) remains a hard-to-treat disease with a poor prognosis in adults. (bvsalud.org)

Angle α, k-value and fibrinogen have clinical significance on the risk of occurrence and development of diabetic foot, which can contribute to early diagnosis and early clinical intervention in DF. (biomedcentral.com)
Therefore, finding indicators that predict the risk of occurrence and progression of diabetic foot and early intervention can help improve the quality of life. (biomedcentral.com)
There is a lack of uniform quantitative standards for biomarkers that predict the risk of diabetic foot occurrence and progression. (biomedcentral.com)

Many people with hypertension are either diabetic or pre-diabetic and have elevated insulin levels due to insulin resistance. (thediabeticpharmacist.com)

Plain film radiography should be performed as initial imaging, but sensitivity is low in early stages of the disease. (medscape.com)

The International Working Group on the Diabetic Foot has developed guidelines for the diagnosis of the diabetic foot. (biomedcentral.com)
Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans. (dovepress.com)

Association of cerebral amyloid-beta aggregation with cognitive functioning in persons without dementia. (edu.pl)

We assume that there might be an association between DM and YKL-40 since YKL-40 is a new inflammatory marker. (biomedcentral.com)
Increased pro-inflammatory cytokines associated with cardiovascular disease. (thediabeticpharmacist.com)

Follow-up results will be featured in an oral presentation (Abstract #OA14.03) and have been selected for the official press program at the IASLC 2023 World Conference on Lung Cancer (#WCLC23) hosted by the International Association for the Study of Lung Cancer on September 11, 2023, from 2:32 a.m. to 2:42 a.m. (advfn.com)

Ayurvedic Treatment of Diabetes - Diabetes disease is described as a severe and chronic metabolic disorder characterized by elevated levels of blood glucose or blood sugar, which leads over time to serious damage to the blood vessels, eyes, heart, kidneys , and nerves . (deepayurveda.com)
In the clinical 2 practice this preparation turned out to be highly effective in the treatment of the aftereffects of retinal veins thrombosis, glaucoma, haemorrhagic retinopathies, retinal sun and laser burns and many other diseases. (antiaging-peptides.com)
While many non-metastatic NSCLC patients are cured by surgery, 30% to 55% develop recurrence and die of their disease despite resection, contributing to a need for treatment options administered before surgery (neoadjuvant) and/or after surgery (adjuvant) to improve long-term outcomes. (santaclara.com)
Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts treatment type 2 diabetes order flexeril 15mg with visa. (gov.gy)
Until recently, the majority of the research investigating vitamin K's potential for the prevention and treatment of age-associated diseases has been conducted using pharmacological doses of supplemental K1 or MK-4. (vitamindwiki.com)
BCG is approved by the FDA (Food & Drug Administration) for the treatment of CIS and is the preferred initial intravesical treatment for CIS according to the AUA (American Urological Association) Guideline for the Management of Nonmuscle Invasive Bladder Cancer . (blogspot.com)

It has been shown that MPV is significantly higher in diabetic populations [ 5 ]. (hindawi.com)

Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. (e-dmj.org)

Detailed neuropsychiatric evaluations were performed and disease entities classified according to the Diagnostic and Statistical Manual of Mental Disorders (DSM IV) criteria when applicable. (bvsalud.org)
In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. (e-dmj.org)

However, even non-invasive high-grade cancers can progress to invasive disease and therefore have the potential to be fatal. (blogspot.com)

rare hereditary diseases, hazardous environmental conditions, unusual toxic exposures, or unsafe consumer products may only be suspected or identified after a complete, detailed and through autopsy rules out more likely causes. (medscape.com)

Although the precise underlying mechanisms linking the diabetic microangiopathies and macroangiopathies are unclear, some evidence suggests that the effects of microangiopathies may be linked to subclinical atherosclerosis [ 3 - 5 ]. (e-enm.org)

Antiplatelet agents are effective in primary and secondary prevention of arterial thrombosis (cardiovascular events, ischaemic stroke, and peripheral arterial occlusive disease). (hindawi.com)

Moreover, the concomitant presence of multiple "classical" cardiovascular risk factors in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
however patients with T1 disease and concomitant CIS have a 55% risk of upstaging. (blogspot.com)

Cognitive and psychiatric aspects of Huntington disease contribute to functional capacity. (gov.gy)
Cognitive decline in prodromal Huntington Disease: implications for clinical trials. (gov.gy)

Optimal diabetic control requires frequent self-monitoring of blood glucose levels, which allows rational adjustments in insulin doses. (medscape.com)

6] Mahanonda R, Pichyangkul S. Toll-like receptors and their role in periodontal health and disease. (edu.pl)

C57BLKsJ-db/db (db/db) mice (a type 2 diabetic mouse model) were used with their normoglycemic heterozygous littermates (db/+) serving as controls. (biomedcentral.com)
An international expert committee appointed by the ADA, the European Association for the Study of Diabetes, and the International Diabetes Association recommended the HbA 1c assay for diagnosing type 1 diabetes only when the condition is suspected but the classic symptoms are absent. (medscape.com)
Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. (e-dmj.org)

The role of novel and more potent antiplatelet strategies, currently under clinical development, seems attractive in diabetic patients. (hindawi.com)
Obesity and sedentary lifestyle, related to economic development and urbanization, have been found to be major risk factors of this disease [ 1 ]. (biomedcentral.com)
Understanding the mutations in APOE, their structural properties, and their isoforms is important to determine its role in various diseases and to advance the development of therapeutic strategies. (dovepress.com)

In the present case, the management of this disease required a high dose of corticosteroid therapy and extra-renal purification. (scirp.org)

Numerous studies were conducted in collaboration with the leading medical organizations, such as: S.M. Kirov Military Medical Academy, the Helmholtz Moscow Research Institute of Eye Diseases, State Research Institute of Eye Diseases of the Russian Academy of Medical Sciences, Main Military Clinical Hospital named after N.N. Burdenko of the Ministry of Defence of the Russian Federation etc. (antiaging-peptides.com)

Bloodworth was an active member of several professional societies, including the American Society for Experimental Pathology, the Endocrine Society, the American Diabetes Association, the Society for Experimental Biology and Medicine, and the American Society of Clinical Endocrinology. (wikipedia.org)

However, most of the relevant studies have focused on the analysis of risk factors associated with the diabetic foot and comprehensive management. (biomedcentral.com)
Surgical bony debridement is often needed, and further surgical intervention may be warranted for high-risk patients or for those with extensive disease. (medscape.com)
However, although the currently available treatments have proven to be useful in reducing ischemic events, diabetic patients continue to have a higher risk of adverse events compared with those in non-diabetic patients. (hindawi.com)
Patients with metabolic syndrome (MetS) have an increased risk of cardiovascular disease. (biomedcentral.com)
Furthermore, the precise pathophysiological characteristics underlying the association of different cardiovascular risk factors in MetS remain elusive [ 5 ]. (biomedcentral.com)
Even when a death is unequivocally due to a natural disease process, careful attention should be paid to an individual's risk factors for that particular disease. (medscape.com)

Onset most often occurs in childhood, but the disease can also develop in adults in their late 30s and early 40s. (medscape.com)
Growth hormone (GH) exerts many of its effects via the synthesis and release of IGF-I. IGF-I has been variably associated with diabetic microvascular disease, and a transient rise in IGF-I has been reported in the early phase of neovascularization of the retina ( 2 ). (diabetesjournals.org)
Carotid atherosclerosis as estimated by carotid intima-media thickness (CIMT) and plaques is considered to reflect an early stage of atherosclerotic disease and is therefore used as a surrogate marker for diabetic macroangiopathies [ 6 - 8 ]. (e-enm.org)

Usually a prognosis for a disease in these patients is unfavorable (gradual and progressive decrease in the visual functions up to blindness). (antiaging-peptides.com)

Anatomy19

Organisms15

Diseases69

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment66

Psychiatry and Psychology3

Phenomena and Processes42

Disciplines and Occupations1

Information Science5

Named Groups1

Health Care29

Retinopathy21

Micro-angiopathy2

Nephropathy5

Pathogenesis3

Microvascular complications2

Severity of diabetic1

Complications4

Ketoacidosis2

Vascular12

Diabetes mellitus5

Retinal diseases1

Alzheimer's3

Morbidity4

T2DM1

Diabetology1

20011

Rats1

Serum3

Ischemic stroke1

Endothelial1

Contributions2

Mitochondrial1

Acute1

Occurrence3

Hypertension1

Sensitivity1

Diagnosis2

Amyloid beta1

Inflammatory2

Abstract1

Treatment6

Significantly1

Nerves1

Diagnostic2

Cancers1

Hereditary1

Suggests1

Peripheral1

Concomitant2

Huntington Disease2

Insulin1

Health and dis1

Type3

Development3

Renal1

Collaboration1

Pathology1

Risk6

Early3

Blindness1