AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation Science
Myeloproliferative DisordersPolycythemia VeraJanus Kinase 2Primary MyelofibrosisThrombocythemia, EssentialThrombocytosisLeukemia, Myelomonocytic, ChronicLeukemia, Myelogenous, Chronic, BCR-ABL PositiveSplenomegalyLeukemia, Myelomonocytic, JuvenileHematopoiesis, ExtramedullaryReceptors, ThrombopoietinFusion Proteins, bcr-ablBone MarrowLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeHematopoietic Stem CellsLeukocytosisGenes, ablOncogene Proteins, FusionMutationLeukemia, Neutrophilic, ChronicMyelodysplastic-Myeloproliferative DiseasesSTAT5 Transcription FactorLeukemia, Myeloid, AcuteMyelodysplastic SyndromesBone Marrow TransplantationBone Marrow CellsTranslocation, GeneticBenzamidesMutation, MissenseHematopoiesisLeukemia, Megakaryoblastic, AcuteGene Expression Regulation, LeukemicBipolar DisorderGranulocytesMegakaryocytesReceptor, Fibroblast Growth Factor, Type 1fms-Like Tyrosine Kinase 3Leukemia, MyeloidDown SyndromeCell Transformation, NeoplasticMyeloid CellsLeukemiaPyrimidinesPolycythemiaHypereosinophilic SyndromePiperazinesBone Marrow NeoplasmsMental DisordersHepatomegalyRetroviridaeProtein-Tyrosine KinasesAnxiety DisordersDisease Models, AnimalThrombopoietinReceptors, ErythropoietinMood DisordersSignal TransductionBudd-Chiari SyndromeChromosomes, Human, Pair 8Blast CrisisMice, Inbred C57BLMyelopoiesisProto-Oncogene ProteinsHydroxyureaChromosomes, Human, Pair 20PhenotypeCell ProliferationX Chromosome InactivationPhiladelphia ChromosomeColony-Forming Units AssayChromosomes, Human, Pair 5Mice, KnockoutAnemia, Refractory, with Excess of BlastsChronic DiseasePlatelet CountDiagnostic and Statistical Manual of Mental DisordersJanus KinasesMice, TransgenicDNA Mutational AnalysisSarcoma Viruses, MurineMyeloid Progenitor CellsGATA1 Transcription FactorPoint MutationFlow CytometryTransduction, GeneticHematologic DiseasesBlood Cell CountMice, Inbred BALB CHematologic NeoplasmsHydrops FetalisCells, CulturedAmino Acid SubstitutionMoloney murine sarcoma virusChromosomes, Human, XKaryotypingChromosomes, Human, Pair 13ValineAnemia, RefractoryDepressive Disorder, Major
NeoplasmsNeoplasmLymphomaPolycythemia veraTypes of myeloproliferativeMyelofibrosisHemophiliaCannot be curedMalignanciesMPDsCenters for DiseasInhibitorsLeukemiaBoneSyndromeMalignancyHematopoieticPrimaryHematologicSymptomsHodgkinJAK2V617FCoagulation DisordersDefectsInfectious diseasesBloodTreatmentsAcute Graft-Versus-CryoglobulinemiaSevereTreatmentTherapyThromboticPatientsSecondaryDependSystemicProteinsInhibitionLeukaemia
Neoplasms11
  • Myeloproliferative disorders - sometimes called myeloproliferative neoplasms - are cancer-like diseases in which too many blood cells are produced in the bone marrow. (edu.au)
  • This mutation is found in approximately 95% of patients with PV, as well as in some patients with other kinds of myeloproliferative neoplasms (MPN). (cdc.gov)
  • Myeloproliferative neoplasms, or MPNs - also called myeloproliferative disorders, or MPDs - are a collection of blood disorders that are believed to be caused by mutations in bone marrow stem cells. (ucsfhealth.org)
  • Although myeloproliferative neoplasms usually cannot be cured, there are treatments for all patients with the condition. (ucsfhealth.org)
  • What are Chronic Myeloproliferative Disorders/Myeloproliferative Neoplasms? (massgeneral.org)
  • Chronic Myeloproliferative Disorders, also called Myeloproliferative Neoplasms, are a group of diseases in which the bone marrow makes too many blood cells. (massgeneral.org)
  • The objective of this project is to decipher mechanisms driving transformation of myeloproliferative neoplasms (MPNs) to secondary acute leukemia (sAML). (lls.org)
  • Myeloproliferative neoplasms (MPNs) are chronic blood disorders that that can cause severe symptoms and early death. (lls.org)
  • Secondary erythrocytosis occurs due to arterial hypoxemia in chronic pulmonary disease, smoking, some neoplasms or hemoglobin disorders. (fundacionmapfre.org)
  • Interferon-Alpha in the Treatment of Philadelphia-Negative Chronic Myeloproliferative Neoplasms. (eurekaselect.com)
  • Title : Updated and Expanded Study of Polycythemia Vera and Other Myeloproliferative Neoplasms in the Tri-County Area Personal Author(s) : Buchanich, J. M.;Mertz, K. J.;Washington, T. L.;Logue, J. N.;Marchetto, D.;Roda, P. I.;Irvin-Barnwell, E. (cdc.gov)
Neoplasm1
  • Polycythemia vera is a myeloproliferative neoplasm characterized by increased production of red blood cells and often other blood cell lines. (cdc.gov)
Lymphoma4
  • Higher disease activity, recurrent parotid gland swelling, presence of cryoglobulins, and hypocomplementemia at baseline indicate a higher likelihood of developing lymphoma. (medscape.com)
  • The LLS mission: Cure leukemia, lymphoma, Hodgkin disease and myeloma, and improve the quality of life of patients and their families. (lls.org)
  • Myeloproliferative disorders (MPD) with eosinophilia (or chronic eosinophilic leukemia (CEL) and sporadic cases with acute myeloid leukemia (AML), B-cell acute lymphoblastic leukemia (ALL) or lymphoma. (atlasgeneticsoncology.org)
  • Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
Polycythemia vera7
Types of myeloproliferative2
Myelofibrosis1
  • 2005). In addition, about half of patients with the closely related blood diseases, essential thrombocythemia (ET) and primary myelofibrosis (PMF), also carry the JAK21 m utation (Baxter et al. (cdc.gov)
Hemophilia3
  • Acquired hemophilia is a rare but potentially life-threatening bleeding disorder caused by the development of autoantibodies (inhibitors) directed against plasma coagulation factors, most frequently factor VIII (FVIII). (medscape.com)
  • [ 1 ] Acquired hemophilia can arise in the context of a variety of disorders, including autoimmune diseases and malignancies, or be due to medications, but approximately half of cases are idiopathic. (medscape.com)
  • Patients with blood disorders receive consultation and treatment for a broad range of benign conditions, such as hemoglobinopathies (sickle cell anemia and thalassemia), hemochromatosis, bleeding and thrombotic disorders (von Willebrand's disease and hemophilia), hypercoagulable states, myeloproliferative disorders, myelodysplasia and anemia, and malignancies such as leukemia, lymphoma and myeloma. (bmc.org)
Cannot be cured1
Malignancies5
  • Some of the diseases that rheumatologists treat are associated with malignancies. (medscape.com)
  • Systemic sclerosis is also associated with a risk for malignancy, including lung cancer and hematologic malignancies, especially in those who develop disease at an older age and who test positive for anti-RNA polymerase antibody. (medscape.com)
  • Besides our diseases, our medications have also been associated with malignancies. (medscape.com)
  • Other Malignancies: Pre-malignant and malignant diseases have been reported. (nih.gov)
  • 2015). 5 patients with myeloid malignancies had secondary disorders treated for a previous malignancy (Mecucci et al. (atlasgeneticsoncology.org)
MPDs1
Centers for Diseas2
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
Inhibitors2
  • Specific inhibitors of JAK2 are effective in treating some people with myeloproliferative disorders. (edu.au)
  • We believe BET inhibitors have the potential to become a major new drug class for the treatment of vitiligo and other immuno-inflammatory diseases," said David Domzalski, President and Chief Executive Officer of VYNE. (pipelinereview.com)
Leukemia5
  • The Center for Leukemia at the Mass General Cancer Center provides treatments and clinical trials for all types of acute and chronic leukemia and related blood disorders. (massgeneral.org)
  • Sometimes chronic myeloproliferative disorders become Acute Leukemia, a condition where too many abnormal white blood cells are made and do not work properly. (massgeneral.org)
  • Deletion of 7p as the sole abnormality occurs in disorders with myelodysplastic or myeloproliferative features and acute lymphoblastic leukemia, and may therefore affect early hematopoietic progenitor cells. (atlasgeneticsoncology.org)
  • Myeloproliferative diseases are a heterogeneous group of disorders characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
  • They are also at risk of developing secondary acute leukemia from their underlying disorder, as well as from their treatment. (medscape.com)
Bone7
Syndrome3
Malignancy2
  • we now know that there are disease characteristics, such as NXP2 or TIF1 gamma antibody positivity, that should lead us to consider the possibility of a malignancy. (medscape.com)
  • GRAPHITE (vedolizumab-3035) is a randomized, double-blind, placebo controlled study designed to evaluate the use of vedolizumab as prophylaxis of intestinal aGvHD in participants who receive allo-HSCT as treatment for a hematologic malignancy or myeloproliferative disorder from an unrelated donor. (businesswire.com)
Hematopoietic1
  • Complete or partial loss of chromosome 7 is a recurrent cytogenetic abnormality that may be observed in both de novo and therapy-related hematopoietic disorders. (atlasgeneticsoncology.org)
Primary1
  • In primary Raynaud phenomenon, also termed Raynaud disease, vasospasm is not associated with ischemic injury or an underlying associated disease. (logicalimages.com)
Hematologic1
  • Funding encompasses a broad spectrum of hematologic inquiry, ranging from stem cell biology to medical management of blood diseases and to assuring the adequacy and safety of the nation's blood supply. (hhs.gov)
Symptoms5
  • Many people with these conditions have few, if any, symptoms, but complications can occur, including stroke in patients with poorly controlled disease. (ucsfhealth.org)
  • What are the symptoms of myeloproliferative disorders? (massgeneral.org)
  • The symptoms depend on the type of disorder you have. (massgeneral.org)
  • New treatments have become available that help ameliorate symptoms, but they do not reliably slow or halt disease progression. (lls.org)
  • Patients should be followed closely as Raynaud phenomenon can precede other symptoms of connective tissue disease by years. (logicalimages.com)
Hodgkin1
JAK2V617F1
Coagulation Disorders1
  • Dr. Onyeaso has experience treating conditions like Coagulation Disorders, Adult Failure to Thrive and Hepatitis C among other conditions at varying frequencies. (sharecare.com)
Defects3
  • Revealing how normal blood cell production is controlled, and the defects that lead to myeloproliferative disorders. (edu.au)
  • Secondary gout is related to medications or conditions that cause hyperuricemia, such as myeloproliferative diseases and their treatment, hyperproliferative skin disorders, enzymatic defects, and renal failure. (medscape.com)
  • Stem Cell Defects in Philadelphia Chromosome Negative Chronic Myeloproliferative Disorders: A Phenotypic and Molecular Puzzle? (eurekaselect.com)
Infectious diseases1
  • Baseline immunosuppression can be the main predisposing condition for the development of infectious diseases caused by different pathogens, such as bacteria, 1 , 2 fungi, 3 , 4 or viruses. (lww.com)
Blood5
Treatments5
Acute Graft-Versus-1
  • Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
Cryoglobulinemia1
  • Apheresis is also available for the treatment of a variety of disorders including sickle cell disease, Waldenstrom's macroglobulinemia, and cryoglobulinemia. (bmc.org)
Severe2
  • Myeloproliferative disorders are severe and potentially fatal. (edu.au)
  • In 2015, after he had been feeling intensely tired for several months and had suffered severe weight loss - nearly 20 kilos in just a year - the axe fell: Vazquez disease. (etui.org)
Treatment4
  • Circulatory overload occurs in patients with anemia and with heart disease, where the transfusion causes congestive heart failure requiring specific treatment. (fundacionmapfre.org)
  • It is advisable to take inside the car, in a visible place, a report including the data on the disease, and the treatment, in case road assistance should be required for the occurrence of complications while driving or in the event of an accident. (fundacionmapfre.org)
  • VYN201 is a locally administered, small molecule, pan-bromodomain and extra-terminal domain (BET) inhibitor that is being developed for the treatment of immuno-inflammatory diseases. (pipelinereview.com)
  • For diseases that require treatment over a longer period or in the long-term prophylaxis of diseases, it is desirable to keep the dosing frequency of medicaments as low as possible. (justia.com)
Therapy1
Thrombotic1
  • Early atherosclerotic and thrombotic disease occurring with stroke, myocardial infarction and peripheral vascular disease are characteristic. (fundacionmapfre.org)
Patients4
  • We seek to better understand what drives disease development and leukemic progression in MPNs, so that we can develop better therapies for patients with these diseases. (lls.org)
  • Hypertension is present in up to 75% of gout patients, and chronic kidney disease (stage 3 or greater) is present in many patients with gout. (medscape.com)
  • The initiation of this clinical trial for VYN201, the first of several planned programs for our InhiBET TM BET inhibitor platform, is a major milestone in our mission to improve the lives of patients suffering from immuno-inflammatory diseases. (pipelinereview.com)
  • Patients do not have a history of peripheral vascular disease or ischemic injury. (logicalimages.com)
Secondary1
  • Secondary Raynaud phenomenon is associated with an underlying disease, usually a connective tissue disease of which systemic sclerosis is the most common. (logicalimages.com)
Depend1
  • The ability to drive will depend on the stage of the disease, for the multiple organ involvement frequently occurring. (fundacionmapfre.org)
Systemic1
  • VYN201 is a locally-administered pan-bromodomain BET inhibitor, designed as a "soft" drug to address diseases involving multiple, diverse inflammatory cell signaling pathways while providing low systemic exposure. (pipelinereview.com)
Proteins2
  • Explore our series of high-quality proteins covering comprehensive diagnostic indicators in order to facilitate the in vitro diagnostic research of neurological diseases. (acrobiosystems.com)
  • Pre-formed fibrils are an invaluable preclinical model for exploring pathogenesis of neurological diseases through aggregation of misfolded proteins. (acrobiosystems.com)
Inhibition1
Leukaemia4