• While the real emphasis of their review is on using optogenetics for behavioral research and they only mention vision in passing with a couple of nods to two of Busskamp's papers, the article really does a good job of summarizing the general approach to using optogenetics toolboxes to deal with neurodegenerative diseases or investigate neural science. (utah.edu)
  • Because neurodegenerative diseases like HD progress over a lifetime, a rodent's short life span excludes the possibility of studying long-term changes. (medindia.net)
  • Large animal models, such as domesticated farm animals, offer some distinct advantages over rodent models, including a larger brain that is amenable to imaging and intracerebral therapy, longer lifespan, and a more human-like neuro-architecture. (medindia.net)
  • Translating preclinical results for gene-based therapies from rodent models to larger-brained models of HD is an important step along the path toward clinical testing. (medindia.net)
  • While numerous studies have now demonstrated that advanced liver fibrosis in patients and in experimental rodent models is reversible, there is currently no effective therapy for patients," said principal investigator David A. Brenner, MD, vice chancellor for Health Sciences and dean of the School of Medicine at the University of California, San Diego. (ucsd.edu)
  • Here we used MRI to make a dataset of ex vivo brains from two different rodent models of Huntington's disease (HD), the R6/2 line and the YAC 128 mouse. (cam.ac.uk)
  • In particular, knockout and transgenic mouse models for atherosclerosis have been instrumental in understanding the molecular and cellular mechanisms involved in atherogenesis, and in evaluating the effectiveness of new and existing atherosclerotic drugs [ 4 ]. (hindawi.com)
  • Design Using a recently developed AD-like pathology with amyloid and neurofibrillary tangles (ADLP APT ) transgenic mouse model of AD, which shows amyloid plaques, neurofibrillary tangles and reactive gliosis in their brains along with memory deficits, we examined the impact of the gut microbiota on AD pathogenesis. (bmj.com)
  • Mouse models have proved to be useful to study development and progression of atherosclerotic lesion, and several reviews have extensively discussed the different available models [ 1 - 3 ]. (hindawi.com)
  • They found that, just as in cell cultures, CLR01 prevented α-synuclein aggregation and neuronal death, thus stopping the progression of the disorder in the living animal model. (scienceblog.com)
  • The initial idea that stem cell transplants work in vivo via the replacement of endogenous cells lost or damaged owing to disease has been challenged by accumulating evidence of their therapeutic plasticity. (wingsforlife.com)
  • This appears to be the best solution that enables researches to better integrate their investigative efforts, and should be applied to the new rat models that are beginning to become widespread.Rheumatoid arthritisOverviewRheumatoid arthritis (RA) is a common (prevalence = approximately 1%) (Lawrence et al. (brightkite.com)
  • Comprehensive study of these models has yielded vital evidence for the concept that autoimmunity to joint-specific antigens can lead to arthritis.The. (brightkite.com)
  • Cathepsin B cleaves the wild-type β-secretase site sequence in AβPP to produce Aβ, and cathepsin B inhibitors administered to animal models expressing AβPP containing the wild-type β-secretase site sequence reduce brain Aβ in a manner consistent with β-secretase inhibition. (nih.gov)
  • These data indicate that TRPC5 activity drives disease and that TRPC5 inhibitors may be valuable for the treatment of progressive kidney diseases. (broadinstitute.org)
  • As wild-type mice are resistant to lesion development, the current mouse models for atherosclerosis are based on genetic modifications of lipoprotein metabolism with additional dietary changes. (hindawi.com)
  • They assessed the effectiveness of treatment with GKT137831 - a NOX1/4 inhibitor developed by Genkyotex SA of Geneva, Switzerland - in mouse models, and found that treatment with this NOX inhibitor suppressed ROS production, as well as NOX and fibrotic gene expression. (ucsd.edu)
  • A timeline of the generation of mouse models of GD. (biologists.org)
  • As an example of how the library might provide insights in mouse models of HD, we calculated whole brain grey matter volumes across different age groups with different CAG repeat lengths. (cam.ac.uk)
  • For instance, injections of the newer versions were more efficient at reducing normal, human SOD1 mRNA levels in rats and mice and they helped rats, genetically modified to carry a disease-causing mutation in SOD1, live much longer than previous versions of the drug. (eurekalert.org)
  • NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. (eurekalert.org)
  • Further understanding of the pathogenicity of autoreactive CD4 + T cells may lead to disease-specific treatments. (wiley.com)
  • The development of animal models of cardiovascular disease (CVD), including cardiac and atherothrombotic diseases, has provided us today with important insights into the pathophysiology, and they were found to be essential tools to evaluate new therapeutic strategies to predict and to prevent these complications. (hindawi.com)
  • The Disease BioPortal is operated and maintained by the Center for Animal Disease Modeling and Surveillance (CADMS) at the University of California, Davis and is supported through a consortium of national and international institutions, agencies, and organizations. (ucdavis.edu)
  • African swine fever, lumpy skin disease and avian influenza) and to report or assess surveillance data (i.e. (europa.eu)
  • For this purpose, EFSA has over the last years carried out several data collections and gathered specific information on outbreaks, surveillance activities and concerned animal populations (i.e. poultry, domestic pigs, cattle and wildlife such as wild boar). (europa.eu)
  • Significant advances have been made in the creation and characterization of HD models in nonhuman primates (NHP). (medindia.net)
  • Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS. (broadinstitute.org)
  • Most chronic liver diseases are associated with progressive fibrosis, which is triggered by the loss of liver cells and the activation of inadequate wound healing pathways. (ucsd.edu)
  • Kay M. Tye and Karl Deisseroth have published a really nice review paper in Nature Reviews on using optogenetics toolkits to study neural systems for brain disease. (utah.edu)
  • Importantly, the brains of large animals can be studied using sensitive measures that should be highly translatable to the human condition, including MRI and PET imaging, EEG, and electrophysiology, as well as behavioral tests looking at motor and cognitive function," says Professor Jenny Morton, PhD, of the Department of Physiology, Development and Neuroscience at the University of Cambridge. (medindia.net)
  • The position is part of the project "Neurodevelopmental disorders and the synapse" funded by the Lundbeckfonden call "What Causes Brain Disease? (dsfn.dk)
  • Highlighted by Tessa Sinnige , a recent preprint from Carmen Nussbaum-Krammer and co-workers shows that Hsp110 activity protects against amorphous protein aggregation but promotes amyloid aggregation and toxicity in C. elegans models. (biologists.org)
  • This new study provides important validation of the role of NOX in liver fibrosis, and suggests that a NOX inhibitor could provide an effective treatment for this devastating disease. (ucsd.edu)
  • These data highlight the excellent pharmacological properties of GKT137831 and the broad potential for its use in fibrotic diseases,'' said Patrick Page, chief development officer at Genkyotex and contributor to the study. (ucsd.edu)
  • This study used an established spatial analysis method to determine likely high-risk areas for contracting Lyme disease from ticks ( Ixodes scapularis ) near West Point, NY. (health.mil)
  • Some animal species show typical intranuclear inclusion bodies (Joest-Degen inclusions) , which are composed of specific antigen and are located in ganglion cells of the Ammon`s hom, the piriform lobe and the retina. (scialert.net)
  • The great adaptability of the virus to different animal species and its affinity for neurons allow to investigate clinical alterations involving the CNS and to quantitate the virological and immunological interactions of the agent with nerve cells in the brain and the eye. (scialert.net)
  • Emerging infections provide clues about how pathogens might evolve when farm animals are protected from infection. (the-scientist.com)
  • Experimentally, the infection is possible via different routes, but the age of the animal is also decisive. (scialert.net)
  • Spread through the bite of an infected blacklegged tick, infection with the bacterial cause of Lyme disease can have lasting effects that may lead to medical discharge from the military. (health.mil)
  • The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies. (hindawi.com)
  • Stem cell technology is a promising branch of regenerative medicine that is aimed at developing new approaches for the treatment of severely debilitating human diseases, including those affecting the central nervous system (CNS). (wingsforlife.com)
  • UCLA professor of neurology Jeff Bronstein and UCLA associate professor of neurology Gal Bitan, along with their colleagues, report the development of a novel compound known as a "molecular tweezer," which in a living animal model blocked α-synuclein aggregates from forming, stopped the aggregates' toxicity and, further, reversed aggregates in the brain that had already formed. (scienceblog.com)
  • Here, we will summarize the most common models of cardiovascular diseases, including those implemented in both large and small animals, designed for helping to cover with more precision and to better understand every single aspect related to these human pathologies. (hindawi.com)
  • The protein, which has been found to be common to all patients with Parkinson's, is thought to be a pathway to the disease when it binds together in "clumps," or aggregates, and becomes toxic, killing the brain's neurons. (scienceblog.com)
  • Understanding the body's functions requires scientific discoveries from animal research, and because humans and animals share more than 250 common illnesses, testing on animals is extremely beneficial to humans. (brightkite.com)
  • It is important to highlight that the SIGMA - Animal Disease Data Model (r-ADM) focuses on data which are known to be already collected by several Member States under different legal frameworks and for different purposes. (europa.eu)
  • This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, skin injury, stroke and spinal cord injury. (wikipedia.org)
  • Strategies directed against the huntingtin gene in the brain are an important part of CHDI's therapeutic portfolio", says David Howland, PhD, Director of Model Systems at CHDI. (medindia.net)
  • The results, published in the Journal of Clinical Investigation , suggest the newer version of the drug may be effective at treating an inherited form of the disease caused by mutations in SOD1. (eurekalert.org)