• Although mesenchymal stem cells (MSCs) have been shown as a novel approach in tissue regeneration, the therapeutic potential of MSCs mediated by the interaction between MSC-derived paracrine mediators and Mφs remains elusive. (frontiersin.org)
  • This review focused on the elucidation of paracrine crosstalk between MSCs and Mφs during musculoskeletal diseases and injury. (frontiersin.org)
  • In conclusion, MSCs in musculoskeletal system, mediated by the interaction between MSC paracrine and Mφs, have therapeutic potential in musculoskeletal diseases. (frontiersin.org)
  • In the 1980's, Arnold Caplan and his colleagues published an isolation method of fibroblast-like stromal cells from bone marrow and first identified them as mesenchymal stem cells (MSCs) because of their multilineage differentiation potential ( Caplan, 1991 ). (frontiersin.org)
  • Dr. Krishnamurthy and Dr. Zhang hypothesize that exosomes from MSCs are enriched with factors that promote the removal of dead cells by macrophage cells. (bioquicknews.com)
  • The scientists further hypothesize that delivery of exosomes derived from MSCs to the injured heart will enhance removal of dead cells and improve healing of the heart attack wound, thus aiding efficient regeneration and repair of heart tissue and preventing further damage. (bioquicknews.com)
  • We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental autoimmune uveoretinitis (EAU) in rats. (nature.com)
  • Our group recently reported that CD73 on the cell membrane also contributes to the immunomodulatory capacity of MSCs 3 , suggesting that MSCs exert their immunomodulatory properties in a multifactorial manner. (nature.com)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
  • Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (wikipedia.org)
  • While the terms mesenchymal stem cell (MSC) and marrow stromal cell have been used interchangeably for many years, neither term is sufficiently descriptive: Mesenchyme is embryonic connective tissue that is derived from the mesoderm and that differentiates into hematopoietic and connective tissue, whereas MSCs do not differentiate into hematopoietic cells. (wikipedia.org)
  • Mesenchymal stem cells (MSCs), a term first coined by Arnold I. Caplan in 1991, are characterized morphologically by a small cell body with a few cell processes that are long and thin. (wikipedia.org)
  • However, MSCs are found in much higher concentration in the Wharton's jelly compared to cord blood, which is a rich source of hematopoietic stem cells. (wikipedia.org)
  • These cells have several advantages over bone-marrow-derived MSCs. (wikipedia.org)
  • MSCs have been seen to even differentiate into neuron-like cells, but doubt remains about whether the MSC-derived neurons are functional. (wikipedia.org)
  • Mesenchymal stem cells (MSCs) are multipotent cells with regenerative and immunomodulatory properties. (frontiersin.org)
  • Overall, the results presented in this study show a common mechanism of endocytosis for MSC EVs across different cell types and the feasibility to generate functionally enhanced EVs by modifications to parental MSCs. (frontiersin.org)
  • Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials. (stemedix.com)
  • Until recently, when the immunomodulation properties of MSCs were proven to be clinically relevant, the use of these stem cells was met with skepticism and doubt by a large portion of the scientific community. (stemedix.com)
  • However, since that time, MSCs have demonstrated tremendous potential for allogeneic use in a number of applications, including cell replacement, and tissue regeneration, and for use in the therapeutic treatment of immune- and inflammation-mediated diseases. (stemedix.com)
  • Interestingly, nearly half of these trials involve attempts to better understand the use of MSCs in treating immune- and inflammation-mediated diseases - an indication of the recent shift in focus when determining effective therapeutic applications of MSCs. (stemedix.com)
  • Despite the mixed findings for use of MSCs in the treatment of GVHD, trials reviewed for other immune/inflammation-mediated diseases, including MS, inflammatory bowel disease, OA, RA, and inflammatory airway and pulmonary diseases demonstrated positive results pertaining to the safety of MSC therapy when used in this application. (stemedix.com)
  • Mesenchymal stem cells (MSCs), the non-hematopoietic progenitor cells, are multi-potent stem cells from a variety of tissues with the capability of self-renewal, proliferation, differentiation into multi-lineage cell types, as well as anti-inflammatory and immunomodulatory. (thestemcellfoundation.com)
  • These properties make MSCs an ideal source of cell therapy in bone and joint diseases. (thestemcellfoundation.com)
  • Mesenchymal stem cells (MSCs) are under investigation to treat autoimmune and degenerative disorders due to their immunomodulatory and regenerative properties. (biomedcentral.com)
  • Since mesenchymal stem cells (MSCs) and/or cerebrolysin (CBL, a combination of neurotrophic factors and active peptide fragments) have neuroprotective effects in various CNS disorders, we examined nanowired delivery of MSCs and CBL on NPL content and brain pathology in AD using a rat model. (northwestern.edu)
  • Here, we used phenotypically uniform trophoblast stage-derived mesenchymal stem cells (T-MSCs) from embryonic stem cells, which are capable of stable production, and their exosomes (T-MSCs-Exo) to explore the molecular mechanisms involved in dopaminergic (DA) neuron protection in PD models using experimental assays (e.g., western blotting, immunofluorescence and immunohistochemistry staining). (biomedcentral.com)
  • We assessed the levels of DA neuron injury and oxidative stress in MPTP-induced PD mice and MPP + -induced MN9D cells after treating them with T-MSCs or T-MSCs-Exo. (biomedcentral.com)
  • Similarly, intranasal administration of umbilical cord mesenchymal stem cells (UC-MSCs) significantly alleviated the locomotor deficits and rescued DA neurons in MPTP-induced PD mice by cross-talk between the brain and gut [ 12 ]. (biomedcentral.com)
  • The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
  • The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
  • Cell-based approaches, primarily using mesenchymal stromal cells (MSCs), have demonstrated a strong safety profile and possible efficacy in patients with acute respiratory distress syndrome (ARDS), but whether these therapies are effective for treating respiratory virus-induced ARDS is unknown. (nih.gov)
  • Therefore, although there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these need to be investigated in a rationally designed, controlled approach if safety and efficacy are to be demonstrated accurately. (nih.gov)
  • The current study aimed to investigate the effect of mesenchymal stem cells (MSCs) transplantation as a new strategy for treatment of diabetes in Streptozotacin (STZ) induced diabetic male albino rats. (alliedacademies.org)
  • Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
  • Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
  • Mesenchymal Stem Cells (MSCs) are a heterogeneous subset of stromal stem cells that originate from the mesoderm layer of the fetus. (tocris.com)
  • Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation, differentiation, and immune regulation. (techscience.com)
  • Stem cells, specifically mesenchymal stem cells (MSCs,) stem cells found in tissue, have emerged as a major tool for research into the causes of ALS and in the research for new treatments. (cryo-cell.com)
  • Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) are being studied as a potential therapeutic tool to prevent various neurodegenerative diseases including Alzheimer's. (cryo-cell.com)
  • [iii] MSCs derived from umbilical cord blood and umbilical cord tissue are a safe, easily collected, readily available, and noncontroversial source of stem cells. (cryo-cell.com)
  • Mesenchymal stem cells (MSCs) have been studied for their potential benefits in treating acute respiratory distress syndrome (ARDS) and have reported mild effects when trialed within human clinical trials. (lu.se)
  • Human integrin α10β1-selected adipose tissue-derived MSCs (integrin α10β1-MSCs) have shown immunomodulatory and regenerative effects in various disease models. (lu.se)
  • We hypothesized that integrin α10β1 selected-MSCs can be used to treat a sepsis-induced ARDS in a porcine model when administering cells after established injury rather than simultaneously. (lu.se)
  • 6 cells/kg integrin α10β1-selected MSCs and both groups were followed for 12 h. (lu.se)
  • This provides new opportunities to investigate integrin α10β1-selected MSCs as a treatment for a disease which does not yet have any definitive therapeutic options. (lu.se)
  • MSCs have gained significant attention because of their therapeutic potential for many difficult-to-treat diseases. (promocell.com)
  • Mesenchymal stem/stromal cells (MSCs) regulate wound repair processes in the lung, and may contribute to either proresolution or -fibrotic lung responses. (cdc.gov)
  • This study examines the role of mesenchymal stem cells (MSCs) in an experimental sepsis model developed with colistin -resistant Acinetobacter baumannii ( CRAB ). (bvsalud.org)
  • We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
  • The standard test to confirm multipotency is differentiation of the cells into osteoblasts, adipocytes and chondrocytes as well as myocytes. (wikipedia.org)
  • Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
  • Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
  • 2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
  • Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
  • The administration of bone marrow-derived mesenchymal stem cells (BMSCs) is emerging as a promising approach for I/R injury-induced myocardial infarction due to its multiple differentiation potential(7, 8). (researchsquare.com)
  • It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
  • The TGFβ-1 protein triggers chemical signals that regulate various cell activities, including the growth and division (proliferation) of cells, the maturation of cells to carry out specific functions (differentiation), cell movement (motility), and controlled cell death (apoptosis ). (medlineplus.gov)
  • Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. (tocris.com)
  • This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. (tocris.com)
  • Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids. (tocris.com)
  • Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. (tocris.com)
  • Low-level laser therapy has been investigated as a possible stimulus for enhancement of proliferation and differentiation of various cell types, but few reports relate undifferentiated mouse pulp cells (OD-21) response to irradiation in in vitro models. (bvsalud.org)
  • Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
  • Obtaining a better understanding of these capacities has opened new doors in regenerative medicine and demonstrated that these somatic progenitor cells are highly versatile for a wide range of therapeutic applications. (stemedix.com)
  • [ii] They have also recently emerged as a promising source of stem and progenitor cells for use in other novel cell therapies. (cryo-cell.com)
  • The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
  • Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
  • Bone marrow-derived mesenchymal stem cells (MSC) have been promoted for multiple therapeutic applications. (nih.gov)
  • In conclusion, hBMSC-derived Exo with upregulated miR-29a-3p inhibited laryngocarcinoma progression via regulating PTEN, providing a potential diagnostic and therapeutic target in this disease. (hindawi.com)
  • In view of this, it is crucial to develop new therapeutic drugs that have disease-altering properties in order to enhance the quality of life for individuals with PD. (biomedcentral.com)
  • With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)
  • The term encompasses multipotent cells derived from other non-marrow tissues, such as placenta, umbilical cord blood, adipose tissue, adult muscle, corneal stroma, or the dental pulp of deciduous (baby) teeth. (wikipedia.org)
  • Batsali, A.K., Kastrinaki, M.C., Papadaki, H.A. and Pontikoglou, C. (2013) Mesenchymal Stem Cells Derived from Wharton's Jelly of the Umbilical Cord: Biological Properties and Emerging Clinical Applications. (scirp.org)
  • Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
  • Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
  • Not long ago, Cryo-Cell International provided funding to complete an Investigational New Drug Application (IND) for an FDA approved Phase I clinical trial for patients with ALS using umbilical cord blood cells. (cryo-cell.com)
  • The study will involve the administration of U-CORD-CELL®, Saneron's proprietary mononuclear enriched cell fraction of umbilical cord blood to be processed in Cryo-Cell's GMP laboratory. (cryo-cell.com)
  • The transplantation of bone marrow-derived mesenchymal stem cells (BMMSCs) alleviates neuropathology and improves cognitive deficits in animal models with Alzheimer's disease. (biomedcentral.com)
  • Laughlin, M. and Lazarus, H. (2010) Allogeneic Stem Cell Transplantation. (scirp.org)
  • 8 Department of Laboratory Medicine, Karolinska Institutet, Cell Therapy and Allogeneic Stem Cell Transplant, Patient Area Cell Therapies and Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden. (nih.gov)
  • In conclusion: treatment with MSC.s transplantation as a cell-therapy could restore pancreatic β-cell function and improved liver and kidney functions in diabetes as a new strategy for diabetes treatment. (alliedacademies.org)
  • Lung transplantation is the only treatment for patients with severe lung disease, but the organs are not enough, resulting in patients dying while waiting for organs. (lu.se)
  • Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)
  • Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
  • www.cdc.gov/pcd/issues/2022/21_0231.htm Preventing Chronic Disease. (cdc.gov)
  • The drug combo in steroid-eligible patients also "reduces morbidity related to infections, rehospitalizations, and hepatic encephalopathy, reduces infection rates," Sarin said at The Liver Meeting 2022, the annual meeting of the American Association for the Study of Liver Diseases. (medscape.com)
  • Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice. (ca.gov)
  • Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)
  • Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
  • The miR-29a-3p level was decreased, and PTEN level was elevated in laryngocarcinoma tissues and the cancer cell lines. (hindawi.com)
  • Within the limits of this study, Cimicifugae Rhizoma influenced the viability of stem cells derived from the gingiva, and its direct application onto oral tissues may have adverse effects at high concentrations. (spandidos-publications.com)
  • These stem cells mainly function for the replacement of damaged cell and tissues. (medgadget.com)
  • Stem cells have potential as a source of cells and tissues for research and treatment of disease. (tocris.com)
  • In addition to the embryo, stem cells are also found in various organs and tissues of adult individuals, where they take part in tissue homeostasis, generating new cells owing to physiological renewal and opening new perspectives for regenerating and recovering tissues and organs. (bvsalud.org)
  • These cell populations or adult stem cells have been easily identified by their morphology and location in a the of tissues. (bvsalud.org)
  • Cells Tissues Organs. (cancercentrum.se)
  • Can Mesenchymal Stem Cell Exosomes Be Effective Therapy for Heart Disease in Diabetes? (bioquicknews.com)
  • These results suggest that MSC-Exo effectively ameliorate EAU by inhibiting the migration of inflammatory cells, indicating a potential novel therapy of MSC-Exo for uveitis. (nature.com)
  • Mesenchymal stem cell (MSC)-based therapy for the treatment of autoimmune diseases has demonstrated a particular promise after its successful applications in both animal models and patients. (nature.com)
  • focus on this non-traditional clinical use of tissue-specific stem cells and highlight important findings and trends in this exciting area of stem cell therapy. (stemedix.com)
  • In considering this, the authors suggest a focus on better clarifying pathophysiological details and subsets within disease entities to better tailor MSC therapy and standardization of in vitro culture protocols with stringent criteria for testing of functional parameters as two important steps to improve our understanding on the mechanistic properties of MSC immunomodulation. (stemedix.com)
  • Despite these recommendations, the authors conclude that the current results and developments of these clinical trials demonstrate that the tremendous potential of MSC therapy in a wide range of areas, including the treatment of immune/inflammation-mediated diseases, can be expected in the near future to achieve clinical relevance. (stemedix.com)
  • This review describes the advances of animal study and preliminary clinical application in the past few years, related to MSC-based cell therapy in the common bone and joint diseases, including osteoarthritis, rheumatoid arthritis, osteoporosis, osteonecrosis of the femoral head and osteogenesis imperfecta. (thestemcellfoundation.com)
  • For all eight dogs, the owners considered euthanasia but accepted cell therapy as a last possibility. (biomedcentral.com)
  • According to the World Health Organization International Clinical Trials Registry Platform and the National Institutes of Health ClinicalTrials.gov databases, 27 clinical investigations of MSC-based cell therapy approaches have begun in China since the onset of the COVID-19 outbreak, with a growing number of academic and industry trials elsewhere as well. (nih.gov)
  • However, the standardization of the manufacturing process of MSC-based cell therapy medicinal products in compliance with the requirements of the local authorities is obligatory and will allow us to obtain the necessary permits for product administration according to its intended use. (mdpi.com)
  • Bone marrow mesenchymal stem cells (BMSC) have been the choice, thus far, for stem cell therapy for bone regeneration. (oregonstate.edu)
  • Our guide highlights the use of small molecules in stem cell research and cell therapy and lists relevant products. (tocris.com)
  • This funding was made through an additional investment in Cryo-Cell's cell therapy research affiliate, Saneron CCEL Therapeutics, Inc. The hope is that the IND will lead to regenerative therapies using cord blood to treat devastating neurodegenerative diseases such as ALS. (cryo-cell.com)
  • Advances in the field of translational stem cell therapy will continue to gain momentum and we are poised to maximize the potential of cellular therapies to provide much-needed treatments for neurodegenerative diseases. (cryo-cell.com)
  • T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)
  • The aim of this study was to analyze the influence of low-level laser therapy (=660 nm), with three different irradiation times, on the behavior of OD-21 cell line. (bvsalud.org)
  • In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
  • Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
  • Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
  • However, TSEs can develop in the absence of Transmissible spongiform encephalopathies (TSEs detectable PrPTSE and, conversely, PrPTSE might accumulate or prion diseases) are a heterogeneous group of without causing either clinical illness or the neuropathologic fatal neurodegenerative diseases that affect animals and alterations typical of TSEs (i.e., a progressive fatal illness humans. (cdc.gov)
  • Because of the similarities in morphology and prognosis, OSA in dogs represents an effective model for the equivalent disease in humans. (oregonstate.edu)
  • In collaboration with investigators in Taiwan, we implanted one type of autologous OMSCs (periodontal ligament progenitors, PDLPs) to treat an orofacial infectious bone defect disease periodontitis. (ca.gov)
  • This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
  • Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
  • Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
  • found that the most common immune-/inflammation-mediated indications in MSC clinical trials were for graft-versus-host disease (GVHD), osteoarthritis (OA), obstructive airway disease, multiple sclerosis (MS), and solid organ transplant rejection. (stemedix.com)
  • The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
  • Plasma and synovial fluid cell-free DNA concentrations following induction of osteoarthritis in horses. (cabi.org)
  • Equine osteoarthritis: strategies to enhance mesenchymal stromal cell-based acellular therapies. (cabi.org)
  • Osteoarthritis (OA) is a degenerative disease that eventually leads to the complete degradation of articular cartilage. (cabi.org)
  • Implication of cellular senescence in osteoarthritis: a study on equine synovial fluid mesenchymal stromal cells. (cabi.org)
  • Osteoarthritis (OA) is described as a chronic degenerative disease characterized by the loss of articular cartilage. (cabi.org)
  • At the end of 2023, researchers at Lund Stem Cell Center received funding amounting to SEK 77.5 million from the Swedish Research Council, the Swedish Cancer Society, and the Swedish Childhood Cancer Fund. (lu.se)
  • Kim and Park, 2017 ) and make HMSCs attractive cells for regenerative therapies. (frontiersin.org)
  • Although several efficient therapies for this disease including surgical operation, and the combination of radiotherapy and chemotherapy, have been developed in recent years, the prognosis of patients at advanced stage is still poor [ 3 ]. (hindawi.com)
  • The serious consequences of the global coronavirus disease 2019 (COVID-19) pandemic have prompted a rapid global response to develop effective therapies that can lessen disease severity in infected patients. (nih.gov)
  • Good manufacturing practice (GMP) guidelines are particularly important for the media and reagents used in the development and manufacture of cell therapies. (promocell.com)
  • The search for new therapies to restore the structural integrity of the periodontium, destroyed by the progression of periodontal disease, has gained new perspectives with the advance in stem cell research and tissue bioengineering. (bvsalud.org)
  • The project recognizes the limitations of EVLP in treating all damaged lungs and therefore aims to develop new therapies, particularly based on mesenchymal stem cells (MSC). (lu.se)
  • Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
  • Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)
  • The in vitro effects of MSC-Exo on immune cell migration and responder T cell proliferation were examined by chemotactic assays and lymphocyte proliferation assays, respectively. (nature.com)
  • These stem cells are capable of differentiating into chondrocytes, cardiomyocytes, melanocytes, and hepatocyte‐like cells in vitro. (wikipedia.org)
  • MiR-29a-3p was enriched in hBMSC-derived Exo, and the Exo from miR-29a-3p mimics transfected hBMSCs could inhibit laryngocarcinoma cell malignant phenotypes in vitro and prevent tumor progression in vivo . (hindawi.com)
  • 2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)
  • HADSCs were induced to confirm that they can express the characteristics of endothelial cells (ECs) in vitro. (molvis.org)
  • Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
  • Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
  • Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. (springer.com)
  • Currently, many ALF treatment strategies are aimed at simply preventing complications and decelerating disease progression. (springer.com)
  • The long-term goal of this proposal is to develop stem cell-based treatment for major defects in the orofacial regions. (ca.gov)
  • GMSC can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases. (ca.gov)
  • The clinical treatment of Alzheimer's disease remains a challenge since the pathogenesis is not fully understood. (biomedcentral.com)
  • Therefore, the investigation of the underlying mechanisms during laryngocarcinoma progression may be helpful to find novel treatment strategies in this disease. (hindawi.com)
  • The pathogenesis of Parkinson's disease (PD) has not been fully elucidated, and there are no effective disease-modifying drugs for the treatment of PD. (biomedcentral.com)
  • To date, PD treatment including medications (e.g., levodopa) and surgery (e.g., deep brain stimulation) can only improve the clinical symptoms and does not stop disease progression to achieve a cure [ 7 ]. (biomedcentral.com)
  • Cimicifugae Rhizoma has also been suggested to be useful for the treatment of dental diseases, including periodontitis ( 8 ). (spandidos-publications.com)
  • Scientists are majorly focusing on developing new and innovative treatment options for the various chronic diseases like cancer. (medgadget.com)
  • The global mesenchymal stem cells market growth is primarily driven by the increasing demand for these stem cells as an effective treatment alternative for knee replacement in the recent past. (medgadget.com)
  • However, some of the political point of views, and higher cost of treatment by using mesenchymal stem cells might restraint the growth during the forecast period. (medgadget.com)
  • Intra-articular injection of mitochondria is a novel treatment that has the potential to improve cell metabolism and decrease inflammation, but safety of this treatment has yet to be established in the horse. (cabi.org)
  • The successful treatment of diabetes is how to regenerate pancreatic islets β-cells. (alliedacademies.org)
  • During the waves of infections, hospitals can become overwhelmed and even treatment of other disease, beside COVID-19, becomes problematic. (diabetesresearch.org)
  • The efficacy of mesenchymal stem cell treatment and colistin-fosfomycin combination on colistin-resistant Acinetobacter baumannii sepsis model. (bvsalud.org)
  • However, no inhibitory effect of MSC-Exo on IRBP-specific T cell proliferation was observed. (nature.com)
  • We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
  • The morphology of the cells was viewed under an inverted microscope and the analysis of cell proliferation was performed using a Cell Counting kit‑8 (CCK‑8) assay on days 1, 3, 5 and 7. (spandidos-publications.com)
  • These cells contribute to the aggressive behavior of glial tumors by altering the environment favorable for the proliferation of glioma stem cells. (cns.org)
  • Irradiation time of group I influenced positively the proliferation and viability of OD-21 cells in late cell culture period. (bvsalud.org)
  • Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
  • Neprilysin (NPL), the rate-limiting enzyme for amyloid beta peptide (AβP), appears to play a crucial role in the pathogenesis of Alzheimer's disease (AD). (northwestern.edu)
  • In contrast, The conclusion that PrPTSE is central to the pathogenesis animals inoculated with cells exposed to the BSE agent of TSE is based on the temporal and anatomic correlations remained asymptomatic. (cdc.gov)
  • TSEs include scrapie in the molecular basis of TSE infection and the role of PrPTSE sheep and goats, bovine spongiform encephalopathy (BSE) (unquestionably important in pathogenesis of TSEs) are in cattle, chronic wasting disease in cervid ruminants, not yet entirely clear, and both remain key issues in TSE and mink encephalopathy. (cdc.gov)
  • They will test this in murine and porcine models of heart disease. (bioquicknews.com)
  • Immortalized murine pulp cells (OD-21)6 are considered as the major action mechanism of those lasers.11 undifferentiated mesenchymal stem cells derived from fetal Although this mechanism has not been fully clarified, the most molar papillae7. (bvsalud.org)
  • Mitochondrial biology, stress signaling and aging-related degenerative diseases. (upstate.edu)
  • Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
  • These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)
  • In patients with diabetes the increased levels of glucose in the blood, the increased level of inflammation, and the problems at the level of beta cells all facilitate the emergence of symptoms that are more severe. (diabetesresearch.org)
  • Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
  • Agricultur al organic dust exposures trigger harmful airway inflammation, and workers experiencing repetitive dust exposures are at increased risk for lung disease. (cdc.gov)
  • These findings warrant future investigations to assess how organic dusts affect lung-resident mesenchymal stem/stromal cell function and impact airway inflammation, injury, and repair during agricultur al aerosol exposures. (cdc.gov)
  • At Lund Stem Cell Center, researchers are using innovative approaches to advance the field, offering exciting possibilities for the future. (lu.se)
  • We hope that this new method will foster a culture of proactive health management and shift the paradigm towards preventive care, in addition to paving the way for more effective treatments," says Sandra Linstedt, research group leader at Lund Stem Cell Center. (lu.se)
  • Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
  • GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
  • Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
  • In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
  • In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (wikipedia.org)
  • Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
  • [6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • For current information on the number of cases and fatalities, see the Centers for Disease Control and Prevention (CDC): COVID Data Tracker and the WHO Coronavirus (COVID-19) Dashboard . (msdmanuals.com)
  • The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
  • The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
  • After intervention, the treated group showed decreased need for inotropic support, fewer signs of histopathological lung injury including less alveolar wall thickening and reduction of the hypercoagulative disease state. (lu.se)
  • Effects of agricultur al organic dusts on human lung-resident mesenchymal stem (stromal) cell function. (cdc.gov)
  • The project funded by Cancerfonden, will focus on using exhaled breath particles as a non-invasive method for diagnosing and monitoring non-small-cell lung cancer. (lu.se)
  • Mediterranean journal of hematology and infectious diseases 2021 0 0. (cdc.gov)
  • Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
  • Isolation and culture of mesenchymal stem cells was done in DMEM/F12 culture medium containing 10% fetal bovine serum and 1% penicillin/streptomycin. (cns.org)
  • More interestingly, PTEN was identified to be one of the downstream genes of miR-29a-3p and participated in the regulation of this miRNA during human diseases [ 21 , 22 ]. (hindawi.com)
  • Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. (tocris.com)
  • Parkinson's disease (PD) is the prevalent movement disorder globally and ranks as the second most frequent age-related neurodegenerative condition. (biomedcentral.com)
  • Sozzi E, Nilsson F, Kajtez J, Parmar M, Fiorenzano A. Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells . (lu.se)
  • We have successfully established BRONJ minipig and mouse models treated with oncologic doses of zolendronate (Zometa)/Dexamethasone (Dex) developed BRONJ-like pathological lesions with similar clinical, radiographic, and histological features as described in the human disease. (ca.gov)
  • Gimble, J.M., Bunnell, B.A. and Guilak, F. (2012) Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation. (scirp.org)
  • Human Mesenchymal Stem Cells (hMSCs) are the non-hematopoietic, multipotent stem cells with the capacity to differentiate into mesodermal lineages such as osteocytes, adipocytes, and chondrocytes as well ectodermal (neurocytes) and endodermal lineages (hepatocytes). (stemedix.com)
  • In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. (karger.com)
  • The exosomes (Exo) from human bone marrow mesenchymal stem cells (hBMSCs) after the transfection of miR mimics/inhibitor/si-PTEN were isolated and used to stimulate M4E and Hep2 cells. (hindawi.com)
  • Previous studies indicated that exosomal miR-29a-3p derived from human bone mesenchymal stem cells (hBMSCs) could efficiently suppress cell migrative ability and vasculogenic mimicry in glioma [ 15 ]. (hindawi.com)
  • The present study was performed to evaluate the extracts of Cimicifugae Rhizoma on the morphology and viability of human stem cells derived from gingiva. (spandidos-publications.com)
  • The aim of the present study was to evaluate the effects of extracts of Cimicifugae Rhizoma on the morphology and viability of human stem cells derived from gingiva. (spandidos-publications.com)
  • No PrPTSE or vCJD infections have been transmitted by transfusions of infectivity has been detected in any exposed cell line under nonleukoreduced erythrocyte concentrates and by a human- study so far. (cdc.gov)
  • SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas, including insulin producing beta cells (4). (diabetesresearch.org)
  • Find out how our extensive portfolio of cell culture media for a wide variety of human primary cells and cancer cells can help you achieve more accurate, reliable, and reproducible results. (promocell.com)
  • Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)
  • However, extensive bone loss due to disease or trauma requires tissue-engineering applications. (oregonstate.edu)
  • The major diagnostic decision is between infectious and non-infectious diseases. (biomedcentral.com)
  • Department of Infectious Diseases and Clinical Microbiology, Kayseri City Education and Research Hospital, Kayseri, Turkey. (bvsalud.org)
  • MiR-125b participates in the oncogenic role of lncRNA MALAT1 in the phenotypes including cell proliferative and invasive rates in laryngocarcinoma [ 6 ]. (hindawi.com)
  • Furthermore, increasing elderly population across the globe, and rising prevalence of various chronic diseases including cancer, autoimmune diseases, bone and cartilage diseases are factors expected to boost the market growth during the forecast period. (medgadget.com)
  • Saneron's sponsored preclinical studies using U-CORD-CELL® have demonstrated efficacy in various disease models including: ALS, stroke, myocardial infarction, and Alzheimer's disease. (cryo-cell.com)
  • Alzheimer's disease (AD) is characterized by the accumulation of aberrant Aβ peptide plaques and neurofibrillary tau tangles in pathology [ 1 ]. (biomedcentral.com)
  • Nowadays, there is no cure for Alzheimer's disease. (biomedcentral.com)
  • Research shows that professional football players may be at a higher risk of death from diseases that damage the cells in the brain, such as Alzheimer's and ALS compared to the general U.S. population. (cryo-cell.com)
  • Diabetes mellitus (DM) is a chronic disease distinguished with a massive and progressive devastation of pancreatic insulin secretory β-cells which give rise to insulin deficiency (Chhabra et al. (alliedacademies.org)
  • Moreover, it is also known that patients with chronic wound healing diseases have compromised mesenchymal stem cell functionality. (uni-muenchen.de)
  • The acute or fulminant form of the disease (aGvHD) is normally observed within the first 10 to 100 days post-transplant, [9] [10] and is a major challenge to transplants owing to associated morbidity and mortality. (wikipedia.org)
  • This usually results from a spontaneous somatic mutation in the unaffected APC gene of a single cell in a patient with the FAP syndrome. (medscape.com)
  • In FAP syndrome patients, one APC germline gene is already mutated in every cell in the body (barring a rare reverse somatic mutation in some cells), and, therefore, only one new somatic mutation is required in the opposite APC gene for the tumor to develop. (medscape.com)
  • After this past summer's ALS ice-bucket challenge took the world by storm, many more people than ever are aware of this fatal neurodegenerative disease. (cryo-cell.com)
  • Rules, technique, technology and medical research are all coalescing, advancing both safety and treatments for those suffering from neurodegenerative diseases. (cryo-cell.com)
  • [iv] For those former NFL players battling neurodegenerative diseases, for anyone fighting the battle, stem cell research and treatments will continue to advance long after these athletes have hung up their cleats for the last time. (cryo-cell.com)
  • Stem Cell Technology for Neurodegenerative Diseases. (cryo-cell.com)
  • The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
  • However, it has been shown that adipose-derived stem cells (ASC) have similar immunophenotype, morphology, multilineage potential, and transcriptome compared to BMSC. (oregonstate.edu)