Disease Models, AnimalMutationDNA Repeat ExpansionAmyotrophic Lateral SclerosisPhenotypeDiseaseInduced Pluripotent Stem CellsGenetic Predisposition to DiseaseMutation, MissenseNeurodegenerative DiseasesTrinucleotide Repeat ExpansionRetinitis PigmentosaNeuronal Ceroid-LipofuscinosesMice, TransgenicGenome-Wide Association StudyEye ProteinsAlzheimer DiseaseGene Expression ProfilingFrameshift MutationRetinal DegenerationGene Expression RegulationMotor NeuronsPolymorphism, Single NucleotideGene Regulatory NetworksNerve DegenerationPedigreeBiological MarkersMolecular Sequence DataParkinson DiseaseAnimals, Genetically ModifiedHuntington DiseaseHomozygoteSignal TransductionBrainGenotypeProteomicsDisease ProgressionMembrane ProteinsOligonucleotide Array Sequence AnalysisSuperoxide DismutaseAge of OnsetComputational BiologyCells, CulturedNeuronsExonsAutoimmune DiseasesProtein FoldingCell Culture TechniquesAmino Acid SequenceHaplotypesInflammationModels, BiologicalAllelesBlotting, WesternProtein Structure, TertiaryPoint MutationCell DifferentiationMice, Inbred C57BLRNA, MessengerCase-Control StudiesCell LineReverse Transcriptase Polymerase Chain ReactionBase SequenceGene ExpressionMass SpectrometryNerve Tissue ProteinsMice, KnockoutReproducibility of ResultsModels, GeneticFibroblastsImmunohistochemistryProtein BindingSequence Analysis, DNAProteinsTranscription FactorsNeoplasmsRisk FactorsTransfection