• J. Bolanos-Meade, J. Koreth, and R. Reshef, "A multicenter phase II trial randomizing novel approaches for graft-versus-host disease prevention compared to contemporary controls (BMT CTN 1203)," 2015, https://clinicaltrials.gov/ct2/show/NCT02208037 . (hindawi.com)
  • This study aimed to assess the outcome of stem cell transplantation (SCT), including overall survival (OS), failure-free survival (FFS) and graft-versus-host disease (GvHD)-free/failure-free survival (GFFS), and to analyze prognostic factors in children with aplastic anemia (AA). (bvsalud.org)
  • Results from a phase 2 clinical trial, presented by Seattle Children's Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants. (med-chemist.com)
  • Graft-versus-host disease occurs when the donated T cells, white blood cells in the immune system that fight infection, launch a vigorous attack on a patient's organs, including the skin, liver, kidneys, lung, and the gastrointestinal tract. (med-chemist.com)
  • Given the serious threat of graft-versus-host disease, new approaches to make stem cell transplants safer for patients remain a critical unmet need," said Dr. Leslie Kean, the trial's principal investigator and associate director of the Ben Towne Center for Childhood Cancer Research at Seattle Children's. (med-chemist.com)
  • As a transplant physician, it's beyond heartbreaking to witness a patient develop severe acute graft-versus-host disease after having their leukemia cured through bone marrow transplant," said Kean. (med-chemist.com)
  • To have a therapy at our disposal that safely targets just the T cells causing graft-versus-host disease would represent a major step forward in stem cell transplantation. (med-chemist.com)
  • However, there was no significant difference in disease-free survival when nodal volume was used as a predictor ( P = .599). (ajnr.org)
  • 10 These studies imply that tumor vascularity may be an important predictor of local treatment response and disease control in HNSCC because elevated blood flow may permit improved delivery of therapeutic agents to the tumor. (ajnr.org)
  • Follicular Lymphoma: Experimental Vaccine Extends Disease-Fr. (lww.com)
  • Follicular lymphoma is the second most common subtype of the disease-accounting for about 25% of the total number of cases. (lww.com)
  • The primary outcome measure was disease-free survival. (springer.com)
  • The primary outcome, referred to as "disability-free survival," was a composite of all-cause mortality, dementia, or persistent physical disability. (nih.gov)
  • Donor cytomegalovirus status influences the outcome of allogeneic stem cell transplant: a study by the European group for blood and marrow transplantation," Clinical Infectious Diseases , vol. 59, no. 4, pp. 473-481, 2014. (hindawi.com)
  • When we controlled for these other factors to the extent possible, black race was still associated with a worse outcome, but only in HR-positive disease - this was a new and surprising finding," said Sparano. (healthcanal.com)
  • To see a survival advantage like this is quite remarkable, and the difference in outcome between this group and the younger population is unlikely to be a chance finding. (wordpress.com)
  • We aimed to improve the outcome of t(8;21) acute myeloid leukemia (AML) in the first complete remission (CR1) by applying risk-directed therapy based on minimal residual disease (MRD) determined by RUNX1/RUNX1T1 transcript levels. (bloodjournal.org)
  • Shioya A, Guo X, Motono N, Mizuguchi S, Kurose N, Nakada S, Aikawa A, Ikeda Y, Uramoto H, Yamada S. The Combination Of Weak Expression Of PRDX4 And Very High MIB-1 Labelling Index Independently Predicts Shorter Disease-free Survival In Stage I Lung Adenocarcinoma. (medsci.org)
  • Since fT3 in patients with end-stage renal diseases (ESRD) is frequently reduced and is associated with inflammation and cardiovascular damage, we prospectively tested the hypothesis that it predicts death in a cohort of 200 hemodialysis patients. (mendeley.com)
  • Administering targeted trastuzumab therapy to these patients may result in the elimination of HER2 expressing disseminated tumor cells and improved disease free survival. (clinicaltrials.gov)
  • An absence of satellite lesions and an uneventful postoperative course are the two main independent predictors for long-term disease-free survival in HCC patients undergoing hepatic resection. (springer.com)
  • The aim of this study was to examine the association among statins, dementia-free and disability-free survival, and cardiovascular disease (CVD) among healthy older adults using data from the ASPREE (Aspirin in Reducing Events in the Elderly) trial. (nih.gov)
  • OBJECTIVE: To determine the effect of intercessory prayer, a widely practiced complementary therapy, on cardiovascular disease progression after hospital discharge. (isharonline.org)
  • Estimation of cardiovascular disease risk is increasingly used to inform decisions on interventions, such as the use of antihypertensives and statins, or to communicate the risks of smoking. (biomedcentral.com)
  • Crude 10-year cardiovascular disease risk risks may not give a realistic view of the likely impact of an intervention over a lifetime and will underestimate of the risks of smoking. (biomedcentral.com)
  • This study aims to describe the development of such a model for use with people free of cardiovascular disease and evaluates its accuracy against data from a United Kingdom cohort. (biomedcentral.com)
  • A Markov cycle tree evaluated using cohort simulation was developed utilizing Framingham estimates of cardiovascular risk, 1998 United Kingdom mortality data, the relative risk for smoking related non-cardiovascular disease risk and changes in systolic blood pressure and serum total cholesterol total cholesterol with age. (biomedcentral.com)
  • The average gain in life expectancy from the elimination of cardiovascular disease risk as a cause of death was 4.0 years for all the 35 year-old men in the sample (n = 24), and 1.8 years for all the 35 year-old women in the sample (n = 32). (biomedcentral.com)
  • The evaluation of the risk of developing coronary heart disease (CHD) is increasingly used as a basis for making treatment decisions to prevent cardiovascular disease (CVD). (biomedcentral.com)