• Clinical research may also be conducted to learn other things about medical treatments or procedures, such as how to make an earlier diagnosis or how the treatment interacts with other drugs. (wikipedia.org)
  • The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health today issued the first clinical guidelines in the United States for the diagnosis and management of von Willebrand Disease (VWD), the most common inherited bleeding disorder. (nih.gov)
  • The guidelines include recommendations on screening, diagnosis, disease management, and directions for future research. (nih.gov)
  • Other skin findings include vitiligo, which most often is seen in association with hyperpigmentation in idiopathic autoimmune Addison disease. (medscape.com)
  • An important focus is on studies that effectively test the comparative efficacy and safety of new and existing therapies (drugs, biologics, devices), address comorbidities and patient-important outcome measures relating to disease damage, symptoms (e.g., pain) and functional impairment by utilizing creative approaches to trial design and implementation in both common and rare autoimmune diseases of interest to the NIAMS. (nih.gov)
  • Some of that unfulfilled promise has carried over to True North, which is producing antibody therapies against rare autoimmune and inflammatory diseases. (xconomy.com)
  • Of interest, said Stagliano, are autoimmune hemolytic anemias, a group of rare diseases in which a patient's antibodies turn against her own red blood cells and essentially blow them up. (xconomy.com)
  • True North has already done tests with blood samples from patients with cold agglutinin disease , one of the autoimmune hemolytic anemias that seems to be triggered by lower body temperature. (xconomy.com)
  • Celiac disease (CD) is an autoimmune disorder which occurs in genetically predisposed individuals. (medpace.com)
  • PD study designs require special thought, especially for therapies that have the potential to modify the course of the disease, since clinical outcomes can be confounded by the symptomatic effect of treatment. (iconplc.com)
  • Recent studies have raised questions about the possible persistence of WNV infection and subsequent renal disease. (cdc.gov)
  • For example, researchers trying to identify causes of PD may conduct an observational study to examine genetic or environmental factors that may have triggered the disease in an individual. (wikipedia.org)
  • Researchers are also investigating vaccines for Parkinson's disease that produce cells that change the way the body's immune system responds to the loss of dopamine. (wikipedia.org)
  • This treatment has shown success in reversing Parkinson's in mice, and researchers are investigating the viability of clinical studies in people. (wikipedia.org)
  • As a full service , global CRO with an integrated central lab , Medpace has the scientific, operational and regulatory expertise to manage your celiac disease clinical trial. (medpace.com)
  • Patient recruitment is a challenge because participation in a clinical trial adds an extra level of burden to individuals whose quality of life is already being negatively affected by the condition. (worldwide.com)
  • If you're a healthy volunteer interested in participating in a clinical trial click here . (worldwide.com)
  • When you participate in a clinical trial, you can receive some of the latest treatments and devices before they're widely available. (stelizabeth.com)
  • Talk to your doctor and discuss whether a clinical trial is right for you. (stelizabeth.com)
  • A slow heart rate made even the simplest daily tasks difficult for Marianne, but a next-generation pacemaker available through a clinical trial got her back on her feet. (stelizabeth.com)
  • With our years of clinical trial experience in PD, we can help you implement specific study design features. (iconplc.com)
  • True North hasn't yet chosen a specific disease to tackle, says CEO Nancy Stagliano (pictured above), who was CEO at iPierian from 2011 until its purchase this year, but the Series A cash should allow the firm to get into a Phase 1 clinical program to look at several disorders. (xconomy.com)
  • A low imperforate anus with a perineal orifice may have a similar presentation to that of a patient with Hirschsprung disease. (medscape.com)
  • These studies are intended to test hypotheses and translate early evidence into clinically meaningful, valid information to improve adherence to, and the quality of routine patient care by aiming to treat, cure or prevent these rheumatic diseases. (nih.gov)
  • Research on Parkinson's disease has investigated the link between quality of life and axial rigidity, personality traits, and patient education. (wikipedia.org)
  • West Nile virus (WNV) disease should be considered in any person with a febrile or acute neurologic illness who has had recent exposure to mosquitoes, blood transfusion, or organ transplantation, especially during the summer months in areas where virus activity has been reported. (cdc.gov)
  • Less than 1% of infected persons develop neuroinvasive disease, which typically manifests as meningitis, encephalitis, or acute flaccid paralysis. (cdc.gov)
  • This conference provides a firm platform for scientists, engineers, directors of various companies, industrial professionals and students in the field of microbiology, virology, infectious diseases and other related fields to share their knowledge. (vaccineconferences.com)
  • Heanue TA, Pachnis V. Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies. (medscape.com)
  • Despite encouraging advances in the clinical, vendor and policy realms, vast swaths of America's healthcare infrastructure and connected devices remain vulnerable to attack and disruption. (rsaconference.com)
  • You can provide doctors with important information that can lead to better treatment for heart disease in the future. (stelizabeth.com)
  • WNV encephalitis is a more severe clinical syndrome that usually manifests with fever and altered mental status, seizures, focal neurologic deficits, or movement disorders such as tremor or parkinsonism. (cdc.gov)
  • Signs of the disease appear earlier and are more severe in affected males than in females. (centerwatch.com)
  • Type 2 Diabetes with Severe Chronic Kidney Disease with inadequate glycemic control. (centerwatch.com)
  • Medpace offers four celiac disease marker testing that are primarily used in serologic screening and therapeutic monitoring in children and adults. (medpace.com)
  • Crohn's disease is a debilitating condition characterized by inflammation of the digestive tract. (worldwide.com)
  • Hyperpigmentation is usually generalized but most often prominent on the sun-exposed areas of the skin, extensor surfaces, knuckles, elbows, knees, and scars formed after the onset of disease. (medscape.com)
  • Scars formed before the onset of disease (before the ACTH is elevated) usually are not affected. (medscape.com)
  • Despite significant constipation and abdominal distension, children with Hirschsprung disease rarely develop encopresis. (medscape.com)
  • BET bromodomain inhibition is an epigenetic mechanism that can regulate disease-causing genes. (newswire.ca)
  • Effectively implementing the guideline will enhance the quality, appropriateness, timeliness, and cost effectiveness of care delivered to veterans with ischemic heart disease. (clinicaltrials.gov)
  • In consultation with the American Society of Hematology, the NHLBI convened an expert panel on VWD whose members were selected for their scientific and clinical knowledge and experience, including specialists in hematology as well as family medicine, obstetrics and gynecology, pediatrics, internal medicine, and laboratory sciences. (nih.gov)
  • The portfolio will also encompass biomarker validation protocols, especially those that will enhance the ability to personalize treatment decisions, particularly at early stages of disease. (nih.gov)
  • Currently, a strict gluten free diet is the only available treatment for the disease. (medpace.com)