Disease chronic neutrophilic leukemia. Medical search. Frequent questions

Neutrophilic eccrine hidradenitis (NEH) was initially described in acute myelogenous leukemia (AML) patients undergoing chemotherapy. (medscape.com)
Also see the Medscape articles Acute Myelogenous Leukemia and Chronic Myelogenous Leukemia . (medscape.com)
Bone marrow fibrosis is also detected in the spent phase of chronic myelogenous leukemia and polycythemia vera. (medscape.com)
Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
The classic myeloproliferative neoplasms, including chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are a phenotypically diverse category of malignancies that are derived from stem cells in the myeloid lineage. (mhmedical.com)
the former constitutes the topic of this chapter and includes chronic myelogenous leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (mhmedical.com)
Chronic myelogenous leukemia is a disease in which too many white blood cells are made in the bone marrow . (cancerhealth.com)
See the PDQ summary on Chronic Myelogenous Leukemia Treatment for information on diagnosis , staging , and treatment. (cancerhealth.com)
2 Associated malignancies include acute and chronic myelogenous leukemia and IgA monoclonal gammopathy. (contemporaryobgyn.net)
The diagnosis of LR is based on the exclusion of chronic myelogenous leukemia (CML) and chronic neutrophilic leukemia (CNL). (medicinembbs.org)

Acute febrile neutrophilic dermatosis, also termed Sweet syndrome, is a reactive process characterized by the abrupt onset of tender, red-to-purple papules, and nodules that coalesce to form plaques. (medscape.com)
Acute febrile neutrophilic dermatosis (Sweet syndrome) is a reactive process (a hypersensitivity reaction) that occurs in response to systemic factors, such as hematologic disease, infection, inflammation, vaccination, or drug exposure. (medscape.com)
Acute febrile neutrophilic dermatosis (Sweet syndrome) is uncommon but not rare. (medscape.com)
Robert Douglas Sweet first described acute febrile neutrophilic dermatosis in 1964, leading to the eponym Sweet syndrome (SS). (medscape.com)

Introduction: The results of a 2001-2005 polycythemia vera (PV) investigation in Eastern Pennsylvania revealed a disease cluster plus underreporting and false reporting to the Pennsylvania Cancer Registry (PCR). (cdc.gov)
The term myeloproliferative disease (MPD) embraces the conditions chronic myeloid leukemia, polycythemia vera (PV), idiopathic myelofibrosis (IMF), essential thombocythemia (ET) and in the revised World Health Organization (WHO) classification also includes rarer entities such as chronic neutrophilic leukemia. (ashpublications.org)
Polycythemia vera is a disease in which too many red blood cells are made in the bone marrow. (cancerhealth.com)
The most common (classic) MPNs are chronic myeloid leukemia ( CML ), essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF). (amboss.com)
See also " Polycythemia vera " and " Chronic myeloid leukemia " for further detail on these conditions. (amboss.com)
INTRODUCTION - An overview of the four classic myeloproliferative neoplasms (MPN): polycythemia vera, essential thrombocythemia, primary myelofibrosis, and chronic myeloid leukemia will be presented here. (medilib.ir)
MPNs include polycythemia vera, essential thrombocythemia, chronic myeloid leukemia (CML), primary myelofibrosis, chronic neutrophilic leukemia, and other less well defined entities such as chronic eosinophilic leukemia, not otherwise categorized. (medilib.ir)
Bullous PG lesions are more superficial and are associated with leukemia or polycythemia vera. (contemporaryobgyn.net)
The World Health Organization (WHO) provides diagnostic criteria for BCR-ABL negative MPNs, including polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia (CNL), and myeloproliferative neoplasms, unclassifiable (MPN-U) (1). (iranpath.org)
Primary myelofibrosis, also known as idiopathic myelofibrosis and agnogenic myeloid metaplasia, is a malignant disease, one of the chronic myeloproliferative neoplasms, along with polycythemia vera and essential thrombocythemia, amongst others (see table 1). (fcarreras.org)

MPNs are subdivided in polycytemia vera (PV), essential thrombocytemia (ET), primary myelofibrosis (PMF) and less common conditions like chronic neutrophilic leukemia (CNL), chronic eosinophilic leukemia (CEL), hypereosinophilic syndrome (HES) and mastocytosis. (mrcholland.com)
Less common MPNs, which are not associated with the driver mutations, include chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia , and myeloproliferative neoplasm , unclassifiable. (amboss.com)

ALL - Acute lymphoblastic leukemia, AML - Acute myeloid leukemia, APL - Acute promyelocytic leukemia, CLL - Chronic lymphocytic leukemia, CML - Chronic myeloid leukemia, and childhood leukemia are all types of Leukemia. (mediflam.com)
In November 2007, a 76-year-old man with diabetes mellitus, chronic lymphocytic leukemia, and chronic obstructive pulmonary disease, who was being treated with prolonged corticosteroid therapy, received a diagnosis of invasive pulmonary aspergillosis. (cdc.gov)

[ 14 ] suggest that the condition is in the spectrum of other neutrophilic dermatoses that have been observed in patients with cancer: erythema elevatum diutinum, intraepidermal immunoglobulin A (IgA) pustulosis, pyoderma gangrenosum, subcorneal pustular dermatosis, Sweet syndrome (and it localized variant, neutrophilic dermatosis/pustular vasculitis of the dorsal hand), and vasculitis. (medscape.com)
Characteristics that distinguish the lesions of Sweet syndrome from other neutrophilic dermatosis are healing of the lesions without scarring and an absence of vasculitis. (medscape.com)
Cavitating pulmonary infiltrate in an adolescent with pyoderma gangrenosum: a rarely recognized extracutaneous manifestation of a neutrophilic dermatosis. (medscape.com)

The 2008 World Health Organization (WHO) classification system considers five broad categories of myeloid malignancies: acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPNs), MDS/MPN overlap, and molecularly characterized MPN with eosinophilia 1 ( Table 78-1 ). (mhmedical.com)
Since then, there has been an accepted association of eosinophilia with hematologic malignancies such as lymphoma and leukemia. (biomedcentral.com)

A skin biopsy specimen demonstrating characteristic pathologic changes of the eccrine glands is required to confirm a diagnosis of neutrophilic eccrine hidradenitis. (medscape.com)
This will improve clarity for the diagnosis of these diseases, provide a strategy for risk stratification, and guide risk-adapted therapy. (elsevierpure.com)
See "Clinical manifestations and diagnosis of chronic myeloid leukemia" . (medilib.ir)
Although there are no validated criteria for diagnosis of PG, wound biopsy to assess for a neutrophilic response and rule out other conditions is recommended. (contemporaryobgyn.net)
thus infection, erythema nodosum, leukemia cutis, and other entities presenting with neutrophilic panniculitis should be considered in the differential diagnosis. (juniperpublishers.com)
1,3 Associated delays in obtaining results can postpone diagnosis and treatment, negatively impact disease management, and be stressful for patients. (oncomine.com)
Cytogenetic and molecular studies are also required, being important for diagnosis, and also in order to estimate the course of the disease. (fcarreras.org)
Similarly, no specific cytogenetic abnormality is associated with the disease, and the absence of a cytogenetic marker does not exclude the diagnosis. (basicmedicalkey.com)

Characteristics that distinguish the lesions of Sweet syndrome from other neutrophilic dermatoses are healing of the lesions without scarring and an absence of vasculitis on histopathological examination. (medscape.com)
Pyoderma gangrenosum and other bowel and arthritis associated neutrophilic dermatoses. (medscape.com)

A rare myeloproliferative disorder that is characterized by a sustained, mature neutrophilic leukocytosis. (bvsalud.org)

Children may develop a palmoplantar variant of neutrophilic eccrine hidradenitis unassociated with underlying disease. (medscape.com)
The mechanism(s) of neutrophilic eccrine hidradenitis (NEH) is unknown, although neutrophilic eccrine hidradenitis pathologic changes observed with intradermal bleomycin injections support a direct toxic effect of chemotherapy. (medscape.com)
More than 70% of oncology patients who develop neutrophilic eccrine hidradenitis do so after their first course of chemotherapy. (medscape.com)
Neutrophilic eccrine hidradenitis in young children may be triggered by thermal damage of eccrine glands. (medscape.com)
The cause of neutrophilic eccrine hidradenitis (NEH) is unknown. (medscape.com)
A direct toxic effect of chemotherapy and a paraneoplastic mechanism have both been proposed to explain neutrophilic eccrine hidradenitis in the context of malignancy. (medscape.com)
Cases of neutrophilic eccrine hidradenitis resolving after withdrawal of chemotherapy and recurring upon reinstitution of the same regimen favor the former. (medscape.com)
Also supporting a direct toxic drug response is a study showing that the intradermal injection of bleomycin can yield local neutrophilic eccrine hidradenitis changes. (medscape.com)
Other reactive neutrophilic disorders, such as neutrophilic eccrine hidradenitis, are closely related and may represent a spectrum with related pathogenesis. (medscape.com)

Autoimmune diseases (AID) have been associated with a variety of lymphoproliferative disorders. (bvsalud.org)
Myeloproliferative diseases are a heterogenous group of disorders characterized by cellular proliferation of 1 or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
Certain diseases or disorders may be diagnosed or ruled out based on the chromosomal changes. (cancerhealth.com)
bone marrow or peripheral blood blasts of 20 percent or more) and the chronic myeloid disorders (bone marrow or peripheral blood blasts less than 20 percent). (medilib.ir)
The chronic myeloid disorders - The chronic myeloid disorders encompass several clinicopathologic entities. (medilib.ir)
Clonal studies in the chronic myeloid disorders - Genetic and enzyme studies based upon X-chromosome inactivation patterns have revealed a multipotent progenitor cell origin for the neoplastic clone in both MDS [ 8 ] and MPN [ 9 ]. (medilib.ir)
This course presents the disease processes leading to abnormal white and red cell morphology, and white blood cell disorders, including both benign and malignant states. (iowacentral.edu)
Recent evidence suggests that PTSD may be a risk factor for the development of subsequent neurodegenerative disorders, including Alzheimer's dementia and Parkinson's disease. (preprints.org)
This review of the literature shows that a number of disorders and diseases of the skin and mucous membranes are related to tobacco use. (medscape.com)

Given the role that LSD1 plays in the function of malignant blood cells, targeting LSD1 for the treatment of blood cancers offers a new mechanism for the treatment of diseases associated with high morbidity and mortality. (merck.com)
All the cancers that arise in the bone marrow are known as Leukemia. (mediflam.com)
Overview of Leukemia Leukemias are cancers of white blood cells or of cells that develop into white blood cells. (msdmanuals.com)

Mutational landscape of patients with acute myeloid leukemia or myelodysplastic syndromes in the context of RUNX1 mutation. (cdc.gov)

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm that features a persistent neutrophilia in peripheral blood, myeloid hyperplasia in bone marrow, hepatosplenomegaly, and the absence of the Philadelphia chromosome or a BCR/ABL fusion gene. (wikipedia.org)

CSF3R mutations, the ORR was 54%, whereas patients with CSF3R wild type disease had an ORR of 8% ( P = .030). (targetedonc.com)
Investigators tracked changes in disease from baseline to the end of treatment cycle 6 out of a possible 24 cycles, and changes were broken down by disease type and the presence of CSF3R mutations. (targetedonc.com)
In the efficacy analysis of patients with CSF3R wild type and CSF3R- mutant myeloid neoplasms, all changes in disease characteristics decreased after 6 cycles of ruxolitinib treatment except platelet counts and spleen reduction. (targetedonc.com)
10 9 /L ( 214.0 to 260.0) in patients with CSF3R- mutant disease ( P = .216). (targetedonc.com)
The number of study participants with CSF3R wild type disease who did not experience spleen reduction ≥35% was 5 (71.4%) versus 3 (21.4%) in patients with CSF3R mutations. (targetedonc.com)
CSF3R T618I, SETBP1 G870S, SRSF2 P95H, and ASXL1 Q780* tetramutation co-contribute to myeloblast transformation in a chronic neutrophilic leukemia. (cdc.gov)

The Department of Hematology, Oncology, Adult and Pediatric Rheumatology at the University Hospital Heidelberg offers the full range of modern diagnostics and treatment of malignant diseases, rheumatic pathologies, including particularly complex clinical cases in these fields. (bookinghealth.com)
Associate hematology test results with appropriate disease states or conditions and recognize potential discrepancies between a test result and patient symptoms. (iowacentral.edu)

Leukemia and Lymphoma. (elsevierpure.com)
In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)

[ 9 ] Plantar neutrophilic hidradenitis is associated with Pseudomonas overgrowth in sweaty or wet sneakers and has also been dubbed Pseudomonas hotfoot. (medscape.com)
PG disproportionately affects women aged 20 to 50 years, and approximately half of patients have an associated proinflammatory disease such as inflammatory bowel disease (IBD), hidradenitis suppurativa, or rheumatoid arthritis. (contemporaryobgyn.net)

Imago is a clinical stage biopharmaceutical company developing new medicines for the treatment of myeloproliferative neoplasms (MPNs) and other bone marrow diseases. (merck.com)
The results of this evalu- ized by bone marrow proliferation and peripheral blood ation indicated that inaccurate reporting of PV to the PCR erythrocytosis, thrombocytosis, or granulocytoses.1 In addi- led to PV risk estimates that were inflated over true values tion to PV, the MPNs include chronic myeloid leukemia by 13% to 62%2. (cdc.gov)
Discovery of a frequent JAK2 mutation (9p24.1), common to classic MPNs (PV, ET and PMF), has linked these diseases on a molecular level. (mrcholland.com)

Treatment for Leukemia includes radiation therapy, Chemotherapy, Immunotherapy, Bone marrow transplant, etc. the treatment cost of Leukemia in India depends on the type and growth of leukemia in the body. (mediflam.com)
Treatment with systemic corticosteroids along with systemic chemotherapy for the underlying leukemia resulted in rapid clinical response with no relapse at last follow-up. (juniperpublishers.com)
Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)

To date, correlations with the presence of this mutation and significantly longer duration of disease, a higher rate of complications (fibrosis, hemorrhage, and thrombosis), and treatment with cytoreductive therapy have only been identified by one group. (ashpublications.org)
Characterized by excessive, abnormal white blood cell (granulocyte) production and the presence of the Philadelphia chromosome/BCR-ABL mutation, chronic myeloid leukemia (CML) is a slow-growing cancer of the blood-forming tissue (bone marrow). (oncomine.com)
In this respect, two thirds of patients have a mutation in the JAK2 (50-60%), CALR (20-30%) or MPL (5-10%) genes that is present in the blood cells and which constitutes a marker for the disease. (fcarreras.org)

The first genetic alteration recognized as a cause of myeloproliferative disease was the translocation that creates the BCR-ABL gene fusion. (mhmedical.com)
We summarized recent genetic data that may guide future efforts towards implementing risk-adapted therapy based on mutational profile and improving disease control and survival of affected patients. (elsevierpure.com)
Recent Findings: Recent genetic data in CNL and aCML prompted modifications to the World Health Organization (WHO) diagnostic criteria, which have improved our understanding of how CNL and aCML are different diseases despite sharing common findings of peripheral granulocytosis and marrow myeloid hyperplasia. (elsevierpure.com)
In these diseases the stem cells in the bone marrow, responsible for producing all the blood cells, have acquired a genetic defect which makes them produce one of the myeloid lineage blood cells in an uncontrolled manner. (fcarreras.org)

Histopathologic analysis revealed predominantly lobular neutrophilic panniculitis without dermal or epidermal involvement. (juniperpublishers.com)
Histological examination from the left medial thigh punch biopsy revealed predominantly lobular neutrophilic panniculitis without dermal infiltrate, papillary dermal edema, or vasculitis. (juniperpublishers.com)

Pyoderma gangrenosum (PG) is a rare, chronic, recurrent cutaneous ulcerative disease with an incidence of 3 to 10 per million in the general population. (contemporaryobgyn.net)

Clinical analysis of 12 cases of acute myeloid leukemia complicated with synchronous primary solid tumor]. (cdc.gov)
The primary criterion for assessing data quality and validity was the demonstration of a causal relationship between tobacco use and skin/mucous membrane disease. (medscape.com)

Described in 1964 by Robert Sweet, the entity currently recognized as Sweet syndrome ranges from classic Sweet disease, which occurs in young women after a mild respiratory illness, to a more aggressive neutrophilic process, which may be associated with other inflammatory diseases or malignancy. (medscape.com)

The main clinical focuses of Prof. Müller-Tidow cover the treatment of acute leukemia, myelodysplastic syndrome, lymphomas, multiple myeloma. (bookinghealth.com)

2 , 3 , 4 Patients with the e19a2 transcript, which encodes P230, often present with prominent neutrophilic maturation or thrombocytosis, whereas patients with the e1a2 transcript, which encodes P190, often present with monocytosis, absence of basophilia and a tendency to progress to lymphoid blast phase (BP). (cmleukemia.com)
Neither phlebotomy nor iron deficiency increases the platelet count relative to the effect of the disease itself, and thrombocytosis is not correlated with thrombosis in PV, in contrast to the strong correlation between erythrocytosis and thrombosis in this disease. (basicmedicalkey.com)

Purpose of Review: We reviewed recent diagnostic and therapeutic progress in chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML). (elsevierpure.com)
The 19 patients with CNL had higher percentages of decreased disease characteristics in the study than patients with aCML, with the exception of hemoglobin levels. (targetedonc.com)
The incidence of some disease characteristic was significantly higher in patients with CNL in contrast to aCML, and in some instances, changes showed a decrease in patients with aCML while increasing in the CNL. (targetedonc.com)

Myelofibrosis appears to be part of the natural history of the disease but is a reactive, reversible process that does not itself impede hematopoiesis and by itself has no prognostic significance. (basicmedicalkey.com)

Bone marrow aspirate and biopsy studies revealed acute myeloid leukemia with 64% blasts. (juniperpublishers.com)
A biopsy sample of the neck showed severe, acute, multifocal, neutrophilic vasculitis with numerous fibrin thrombi and moderate to severe, superficial to deep, perivascular to periadnexal, suppurative lymphohistiocytic dermatitis. (cdc.gov)

With the absence of a standard of care for chronic neutrophilic leukemia and atypical chronic myeloid leukemia, 2 rare BCR-ABL1-negative myeloid neoplasms, ruxolitinib may be a viable treatment option after a phase II study showed potential for response in this patient population. (targetedonc.com)
Chronic myeloid leukemia (CML) is characterized by the presence of BCR-ABL1 fusion gene. (cmleukemia.com)
1 Different subtypes of BCR-ABL1 transcripts encode fusion proteins with different sizes that may lead to different disease phenotypes. (cmleukemia.com)
The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia. (cmleukemia.com)

Myeloproliferative neoplasms are a group of diseases of the bone marrow characterized by excessive production of red blood cells, platelets, or certain white blood cells. (merck.com)
AML is defined by the presence of either 20 percent or more bone marrow/peripheral blood myeloblasts (or promyelocytes in case of acute promyelocytic leukemia) or AML-specific cytogenetic abnormalities such as t(8;21)(q22;q22), t(15;17)(q22;q12) and inv(16)(p13q22). (mhmedical.com)
Myeloproliferative neoplasms are a group of diseases in which the bone marrow makes too many red blood cells, white blood cells, or platelets. (cancerhealth.com)
Tests that examine the blood and bone marrow are used to detect (find) and diagnose chronic myeloproliferative neoplasms. (cancerhealth.com)
in turn, each of these categories is classified as either acute or chronic, depending on the proportion of morphologically and immunophenotypically immature precursors (blasts) in the bone marrow or peripheral blood. (medilib.ir)
An aggressive disease (rapid onset and progression) that occurs primarily in adulthood and is marked by an abnormal increase and accumulation of myeloblasts (immature myeloid cells) in the bone marrow and blood, which leads to impaired hematopoiesis and bone marrow failure. (oncomine.com)

Dasatinib (Sprycel): Indicated for the treatment of adult patients with chronic myeloid leukemia in chronic, accelerated, or myeloid or lymphoid blast phase who are resistant or intolerant to prior therapy including imatinib. (medscape.com)

Because approximately 50% of patients with PG have Crohn disease or ulcerative colitis, a thorough gastrointestinal review of systems and a screening fecal calprotectin serologic test should be performed. (contemporaryobgyn.net)
[ 8 ] either ulcerative colitis or regional enteritis/ Crohn's disease , and a polyarthritis that is usually symmetrical and may be either seronegative or seropositive. (medscape.com)

Mr. Baldry joined X4 in November 2022 as Chief Commercial Officer, bringing more than 30 years of international life science commercial experience to the role, with particular expertise in building high- performing commercial teams, developing effective global strategies, and launching new therapeutics into both specialty and rare disease markets. (x4pharma.com)

it presents with elevated cribriform ulcerations and is not linked to systemic disease. (contemporaryobgyn.net)
We herein report a case of acute myeloid leukemia related subcutaneous sweet syndrome that responded to systemic steroids. (juniperpublishers.com)
A complete history should be taken with special focus on the organ systems discussed below to determine any underlying systemic disease. (medscape.com)

White blood cells that fight infection and disease. (cancerhealth.com)
Peptic ulcer disease can also be due to Helicobacter pylori infection, the incidence of which is increased in PV, while the pruritus associated with this disorder may be a consequence of mast cell activation by JAK2 V617F. (basicmedicalkey.com)

Neutrophilic panniculitis denotes inflammation of the subcutaneous fat involving primarily neutrophils [1]. (juniperpublishers.com)
Subcutaneous Sweet Syndrome is diagnosed according to pertinent clinical and histologic results and after ruling out other major causes of neutrophilic panniculitis such as leukemia cutis, erythema nodosum and infectious panniculitis. (juniperpublishers.com)

Clinical applications of our research involves wound healing, cardiac tissue regeneration, ocular disease, and cancer imaging and therapy. (stanford.edu)
Ongoing preclinical and clinical studies will help to further inform the therapeutic approach to these diseases. (elsevierpure.com)
Monitoring of clonal evolution of acute myeloid leukemia identifies the leukemia subtype, clinical outcome and potential new drug targets for post-remission strategies or relapse. (cdc.gov)
Myelofibrosis is a very heterogeneous disease at the clinical level and it requires individualised treatment that is adjusted to risk. (fcarreras.org)

There was no previous personal or family history of skin diseases. (juniperpublishers.com)
Although the association between tobacco and cardiovascular disease, pulmonary disease, and cancer is well known to health care professionals, the many skin diseases caused by tobacco use may be less recognizable. (medscape.com)

Myelogenous Leukemia10

Acute febrile ne4

Polycythemia10

Eosinophilic leukemia2

Lymphocytic2

Dermatosis3

Malignancies2

Diagnosis8

Dermatoses2

Mature neutrophilic1

Eccrine hidradenitis9

Disorders9

Cancers3

Myelodysplastic syndromes1

Neoplasm1

CSF3R6

Hematology2

Lymphoma3

Hidradenitis2

MPNs3

Chemotherapy4

Mutation3

Genetic4

Lobular2

Cutaneous1

Primary2

Malignancy1

Myeloma1

Thrombocytosis2

ACML3

Reactive1

Biopsy2

ABL14

Bone6

Lymphoid1

Ulcerative colitis2

20221

Systemic3

Infection2

Panniculitis2

Clinical4

Skin Diseases2