Disease cartilage oligomeric matrix protein. Medical search. Frequent questions

Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. (wikipedia.org)
COMP is a marker of cartilage turnover. (wikipedia.org)
Serum cartilage oligomeric matrix protein (COMP) concentration is elevated in patients with early osteoarthritis and early rheumatoid arthritis, and may be a biomarker of cartilage turnover. (researchgate.net)
One such potential biological marker of arthritis is cartilage oligomeric matrix protein (COMP). (escholarship.org)
In various studies, COMP has shown promise as a diagnostic and prognostic indicator and as a marker of the disease severity and the effect of treatment. (escholarship.org)
Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. (biomedcentral.com)
Finally, COMP-deficient and wild-type mice responded similarly to collagen antibody-induced arthritis, indicating no difference in how collagen II antibodies interact with COMP-deficient cartilage during the initial stages of arthritis. (biomedcentral.com)
These findings accentuate the importance of COMP in cartilage stability. (biomedcentral.com)
In fact, the immunization with other cartilage proteins in some cases will cause a disease similar in type to CIA, which has been shown to be immunized with COMP [ 7 ]. (biomedcentral.com)
COMP is a 524-kDa homopentameric extracellular matrix glycoprotein and a member of the thrombospondin (TSP) family [ 8 ]. (biomedcentral.com)
Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen organization. (lu.se)
In vitro experiments confirmed that COMP-expressing cells had a more invasive phenotype, which could in part be attributed to an upregulation of matrix metalloprotease-9. (lu.se)
This observation was confirmed in vitro as COMP-expressing cells showed better survival as well as a higher rate of protein synthesis when treated with brefeldin A, compared with control cells. (lu.se)
In conclusion, COMP is a novel biomarker in breast cancer, which contributes to the severity of the disease by metabolic switching and increasing invasiveness and tumor cell viability, leading to reduced survival in animal models and human patients. (lu.se)
COMP and MATN3 are thought to bridge extracellular matrix proteins. (medscape.com)
Objective -To assay concentrations of cartilage oligomeric matrix protein (COMP) in canine sera and synovial fluid (SF), to compare COMP concentrations in clinically normal dogs and dogs with joint disease, and to analyze changes in COMP concentrations in dogs with experimentally induced acute synovitis. (avma.org)
The COMP concentrations were determined by use of an inhibition ELISA that had canine cartilage COMP and monoclonal antibody against human COMP. (avma.org)
Conclusions and Clinical Relevance -These results supported the hypothesis that COMP concentration in serum and SF of dogs may be altered after cartilage degradation or synovitis. (avma.org)
This study represents a novel approach to detect an altered activity of the disease process detected as increasing serum-COMP levels over a short time and whether this would correlate with joint damage progression over the first 5 years of disease. (biomedcentral.com)
The group of patients with increasing COMP levels had higher ESR at inclusion but there were no baseline differences between the groups for age, gender, disease duration, disease activity (DAS28), function (HAQ), CRP, nor presence of rheumatoid factor or anti-CCP. (biomedcentral.com)
Cartilage oligomeric protein (COMP)-degrading ADAMTS-7 and ADAMTS-12). (nih.gov)
We found already that fibromodulin and cartilage oligomeric matrix protein (COMP) are potent activators of complement. (lu.se)
Here, three studies were complete to further assess the occupational relevance/utility of three selected biomarkers: Cartilage Oligomeric Matrix Protein (COMP), Interleukin-6 (IL6), and Creatine Kinase (CK). (cdc.gov)
we found that the expression of cartilage protein COMP is associated with metastases and a poor prognosis for patients with various types of solid cancers. (lu.se)

Altered enchondral ossification may be associated with changes in the articular cartilage. (medscape.com)
The resultant articular cartilage is deficient in underlying osseous support and fails to withstand normal cyclical loading. (medscape.com)
Mesenchymal stem cells (MSCs) play a key role in articular cartilage repair. (hindawi.com)
Native and concentrated BMA have been intensively studied in the context of articular cartilage repair. (hindawi.com)
Such enhanced techniques of marrow stimulation have been shown to improve articular cartilage repair in both animal models and patients. (hindawi.com)

Further analysis showed that levels of cartilage oligomeric matrix protein, resistin, monocyte chemoattractant protein-1, and nerve growth factor were significantly different between patients with psoriatic arthritis and those with osteoarthritis. (mdedge.com)

Osteoarthritis and Cartilage. (wikipedia.org)
A panel of four biomarkers of cartilage metabolism, metabolic syndrome, and inflammation could help physicians to distinguish between osteoarthritis and psoriatic arthritis, new research suggests. (mdedge.com)
Dr. Chandran was first author on a study published online in Annals of the Rheumatic Diseases that analyzed serum samples from the University of Toronto Psoriatic Arthritis Program and University Health Network Arthritis Program for differences in certain biomarkers from 201 individuals with osteoarthritis, 77 with psoriatic arthritis, and 76 healthy controls. (mdedge.com)
The authors noted that previous research has observed high expression of monocyte chemoattractant protein-1 and resistin in patients with psoriatic arthritis when compared with those with osteoarthritis. (mdedge.com)
Nerve growth factor has been seen at elevated levels in the synovial fluid of individuals with osteoarthritis and is known to play a role in the chronic pain associated with that disease. (mdedge.com)
Similarly, higher cartilage oligomeric matrix protein levels are associated with a higher risk of knee osteoarthritis. (mdedge.com)
Mild forms of the disease may remain undiagnosed, or they may be misdiagnosed as bilateral Perthes disease or early-onset osteoarthritis. (medscape.com)
TNF-α, and improve the histopathological features in rabbit knee cartilage with osteoarthritis. (unpad.ac.id)
Data are also lacking on their distinguishing abilities from other cartilage-damaging diseases, such as osteoarthritis (OA) and their usefulness as a monitoring tool in patients with RA. (biomedcentral.com)
Matrix metalloproteinases (MMPs) and 'aggrecanase' a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potential targets for development of OA therapies. (nih.gov)
Introduction: Biomarkers to identify osteoarthritis (OA) patients at risk for disease progression are needed. (harvard.edu)
Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. (nordicbioscience.com)
This article was prepared following a working meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis convened to discuss the value of biochemical markers of matrix metabolism in drug development in osteoarthritis. (nordicbioscience.com)
Biomarkers in osteoarthritis can be categorised using the burden of disease, investigative, prognostic, efficacy of intervention, diagnostic and safety classification. (nordicbioscience.com)
There are a number of promising candidates, notably urinary C-terminal telopeptide of collagen type II and serum cartilage oligomeric protein, although none is sufficiently discriminating to differentiate between individual patients and controls (diagnostic) or between patients with different disease severities (burden of disease), predict prognosis in individuals with or without osteoarthritis (prognostic) or perform so consistently that it could function as a surrogate outcome in clinical trials (efficacy of intervention). (nordicbioscience.com)

Cartilage and bone metabolism in rheumatoid arthritis. (wikipedia.org)
Many currently investigated biomarkers are associated with collagen metabolism in cartilage or bone, or aggrecan metabolism in cartilage. (nordicbioscience.com)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

Rheumatoid arthritis (RA) is a human autoimmune disease that affects the synovial membranes of the peripheral joints. (biomedcentral.com)
OBJECTIVE To compare four different inception cohorts of patients with early rheumatoid arthritis (RA) with respect to treatment strategies, disease activity, and outcome during a five year follow up period. (bmj.com)
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a variable and capricious course, ranging from episodes with a mild non-destructive polyarthritis, alternated by spontaneous remissions, to a rapidly progressive disabling arthritis, sometimes with widespread systemic features. (bmj.com)
This study aimed to provide an overview of ultrasonographic cartilage evaluation in patients with rheumatoid arthritis (RA) and identify research gaps in the utilization of cartilage evaluation. (biomedcentral.com)
A systematic literature search of the PubMed, Embase, and Cochrane Library databases was conducted for articles published up to July 2022 using the search term variations of "cartilage," "ultrasonography," and "rheumatoid arthritis. (biomedcentral.com)
Rheumatoid arthritis (RA) is a systemic autoimmune disease that predominantly involves the peripheral joints. (biomedcentral.com)
The search terms included were variations of "cartilage," "ultrasonography," and "rheumatoid arthritis. (biomedcentral.com)
Currently available biomarkers for the early tissue process leading to joint damage in rheumatoid arthritis are insufficient and lack prognostic accuracy, possibly a result of variable activity of the disease over time. (biomedcentral.com)
Rheumatoid arthritis (RA) is a heterogeneous disease with a markedly variable course in different patients. (biomedcentral.com)
Misguided or excessive complement activation is involved in many common diseases such as rheumatoid arthritis, systemic lupus erythematosus, vasculitis and age-related macula degeneration. (lu.se)
Joint inflammation in rheumatoid arthritis (RA), a common chronic inflammatory disease that causes long-term suffering and disability in 1% of our population, is a complex process also involving complement activation. (lu.se)

Binding to other ECM proteins such as collagen appears to depend on divalent cations. (wikipedia.org)
The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. (biomedcentral.com)
In the CIA model, an immunization against one specific cartilage protein, collagen II (CII), starts an autoimmune reaction leading to arthritis. (biomedcentral.com)
Collagen IX is important for the adhesive properties of cartilage. (medscape.com)
The term systemic sclerosis is used to describe a systemic autoimmune disease of unknown origin characterized by excessive deposition of collagen and other connective tissue macromolecules in skin and multiple internal organs, prominent and often severe fibroproliferative alterations in the microvasculature, and numerous humoral and cellular immunologic abnormalities. (medscape.com)
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. (lookformedical.com)
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. (lookformedical.com)
A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. (lookformedical.com)
This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (lookformedical.com)
A fibrillar collagen found primarily in interstitial CARTILAGE. (lookformedical.com)
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. (lookformedical.com)
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. (lookformedical.com)

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. (wikipedia.org)
Extracellular matrix structure. (lu.se)
During cartilage injury, large quantities of complement factors are exposed to components of extracellular matrix, which are liberated from cartilage by proteases. (lu.se)
Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. (embl.de)
Integrins are transmembrane receptors that mediate cell adhesion by forming links between the extracellular matrix and cytoskeleton. (biologists.com)

The best candidates are generally molecules or molecular fragments present in cartilage, bone or synovium and may be specific to one type of joint tissue or common to them all. (nordicbioscience.com)

Subsequently plasma samples from the baseline visit of 173 subjects in an observational OA cohort were tested by SRM for peptides from nine of these proteins: afamin, clusterin, cartilage oligomeric matrix protein, hepatocyte growth factor, kallistatin, insulin-like growth factor binding protein, acid labile subunit, lubricin, lumican, and pigment epithelium-derived factor. (harvard.edu)

Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). (biomedcentral.com)
Many types of cardiovascular diseases (CVDs) are associated with complex immune responses that can significantly contribute to their progression and remission. (biomedcentral.com)

A valuable approach to monitor arthritis would be by measuring biological markers of cartilage degradation and repair to reflect variations in joint remodeling. (escholarship.org)
TNF-α activates fibroblasts and synovial macrophages to secrete degradation enzymes and supress cartilage proteoglycan synthesis, leading to histopathological changes in cartilages. (unpad.ac.id)
Studies aimed at elucidating the pathophysiological roles of these enzymes in cartilage will contribute to our understanding of OA pathogenesis and enable design of targeted inhibitors that effectively target metalloproteinase-mediated cartilage degradation while sparing cartilage repair pathways. (nih.gov)

Existing work has identified biomarkers of cartilage and muscle damage, and demonstrated responsiveness to various forms of physical activity and biomechanical loading. (cdc.gov)

Utilize Nordic Bioscience's proprietary biomarker technology to measure specific protein fragments. (nordicbioscience.com)

Persistent synovitis causes bone and cartilage damage, leading to joint destruction and deformity. (biomedcentral.com)
However, radiographic outcome may be considered a key variable since it reflects a cumulative effect of inflammation, the tissue destroying process in bone and cartilage and accounts for a great deal of the disability in RA [ 2 - 4 ]. (biomedcentral.com)

Furthermore, we discuss how p53 tumor suppressor proteins holds promise being a medication target for latest and future book remedies in these illnesses. (gasyblog.com)
RITA was considered to bind with amino terminal website of p53, inducing a conformational switch from the proteins and raising its half existence and its build up in tumor cells. (gasyblog.com)

In dementia news, a variant of the RELN gene has been discovered which appears to offer protection from a form of early onset "autosomal dominant Alzheimer's disease" (ADAD). (genewhisperer.com)

The causes and treatment of these conditions are very different and vary from food intolerance, chronic inflammation conditions to autoimmune diseases. (biovendor.group)
PGRN has been introduced among the secreted growth factors as one related to wound healing, inflammation, and human embryonic development, as well as a wide variety of autoimmune diseases. (biomedcentral.com)
The clinical rationale for this project is based on the observation that cartilage contains molecules that initiate/enhance joint damage and inflammation in arthritis. (lu.se)
Indeed, when the cartilage is removed surgically, a dramatic decrease in inflammation and disease symptoms is observed. (lu.se)
Other biomarkers are related to non-collagenous proteins, inflammation and/or fibrosis. (nordicbioscience.com)
Rutin caused attenuation of streptozotocin-induced inflammation by decreasing the activity of the glial fibrillary acidic protein, interleukin-8, cyclooxygenase-2, inducible nitric oxide synthase and nuclear factor-kB and thereby prevented gross anatomical changes in rat hippocampus. (fuqna.com)

Further we aim to study handling of apoptotic cells and DNA from various sources by complement, in relation to autoimmune diseases . (lu.se)
Systemic lupus erythematosus (SLE) is a relatively common autoimmune disease involving skin, joints and kidneys and is characterized by autoantibodies against self-antigens including DNA and histones. (lu.se)
Exposure to other viral and ambient antigens are known causal factors in chronic autoimmune diseases of the airways including asthma. (danielsolis.cz)

This study aimed to use mass spectrometry assays to identify representative peptides from several proteins in synovial fluid and peripheral blood, and assess their levels as biomarkers of OA progression. (harvard.edu)
Methods: Multiplexed high throughput selected reaction monitoring (SRM) assays were developed to measure tryptic peptides representative of 23 proteins in matched serum and synovial fluid samples from late OA subjects at the time of joint replacement. (harvard.edu)
A high correlation between different peptides from individual proteins was observed, indicating our assays correctly measured their target proteins. (harvard.edu)

The CIA model shares some important features with RA, namely major histocompatibility complex (MHC) association and the fact that peripheral joints primarily are affected and that the disease can be divided into an acute and a chronic stage. (biomedcentral.com)
therefore, it is considered useful for cartilage evaluation, including small joints. (biomedcentral.com)

As part of a proteomic analysis of knee synovial fluid from normal and OA patients, differentially expressed proteins were identified that could represent potential biomarkers for OA. (harvard.edu)
Results: In the matched cohort, 17 proteins could be identified in synovial fluid and 16 proteins were detected in serum. (harvard.edu)

Arthritis is a chronic disease with a significant impact on the population. (escholarship.org)
Current methods for diagnosis of and monitoring the disease are only able to detect clinical manifestations of arthritis late in the process. (escholarship.org)
Reduction of TNF-α level and histopathological improvement are found in rabbit knee cartilage with arthritis when fractionated Papuan ant nest is given. (unpad.ac.id)

This paper aims to provide a comprehensive review of the expression and potential roles of other, lesser-known ADAMTSs and related adamalysins (or a disintegrin and metalloproteinases (ADAMs)) in cartilage, with a view to identifying potentially protective or homeostatic metalloproteinases in the joint and informing consequent selective inhibitor design. (nih.gov)
In addition to the well-characterised MMPs, ADAMTS-4 and ADAMTS-5, many other ADAMTSs and ADAMs are expressed in cartilage and several show significantly altered expression in OA. (nih.gov)
A constitutive expression of both mRNAs and proteins was detected in undifferentiated U-937 cells. (shengsci.com)
Depending on the cultivation technique we found significant differences in both gen and protein expression. (biomedcentral.com)
We found very high levels of expression of the central complement protein, C3, and complement inhibitor CD59 in human pancreatic islets. (lu.se)

Inhibition and enhancement of odorant-induced cAMP accumulation in rat olfactory cilia by antibodies directed against G alpha S/olf- and G alpha i-protein subunits. (shengsci.com)
The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)

In collaboration with clinicians we are studying molecular mechanisms of complement involvement in these diseases. (lu.se)
Therefore, we are investigating the possible modulatory effects that cartilage proteins may have on complement. (lu.se)
A certain level of complement activation is a prerequisite for efficient and 'silent' disposal of dying cell debris, since complement proteins function as strong opsonins, but a tight balance must be maintained to prevent full-blown activation against self-antigens. (lu.se)
Unlocking the Mysteries of the Immune System: new Roles of complement proteins in Diabetes and Cancer. (lu.se)

These include enzymes likely to play roles in cartilage matrix anabolism (e.g., the procollagen N-proteinases ADAMTS-2, ADAMTS-3 and ADAMTS-14), chondrocyte differentiation and proliferation (e.g. (nih.gov)

Animals -69 control dogs without joint disease, 23 dogs with naturally occurring aseptic arthropathy, and 6 dogs with experimentally induced synovitis. (avma.org)

Diagnosis is based on clinical manifestations, but tests and procedures may be used initiallly to exclude alternative diagnoses, and later for assessment of organ involvement and monitoring of disease progression (see Presentation and Workup ). (medscape.com)
Systemic sclerosis is a complex and heterogeneous disease with clinical forms ranging from limited skin involvement (limited cutaneous systemic sclerosis) to forms with diffuse skin sclerosis and severe and often progressive internal organ involvement (diffuse cutaneous systemic sclerosis), and occasionally a fulminant course (fulminant systemic sclerosis). (medscape.com)
Rather than NAFLD, Metabolic-Associated Fatty Liver Disease (MAFLD), defined as increased liver fat with presence of adverse cardio-metabolic measures, might have more clinical relevance in children. (bvsalud.org)
Therefore, the usefulness of cartilage evaluation by US in RA has not been fully clarified, which is one of the reasons why it is not used in daily clinical practice. (biomedcentral.com)
The purpose of this review is to bridge the gap in our understanding between the basic science knowledge on MSCs and BMA and the clinical and technical aspects of marrow stimulation-based cartilage repair by examining available data on the role and mechanisms of MSCs and BMA in osteochondral repair. (hindawi.com)
This Akt activity may be related to the clinical characteristics of our subjects (who tended to have less severe disease), the low to moderate intensity of the exercise, and the relatively short period of exercise training. (tyrosinekinases.com)
All patients were categorized into two groups: group I (n=68), those who had confirmed moderate or severe COVID-19 disease and group II (n=112), those without any history of clinical manifestations of the new coronavirus infection (including those with potentially asymptomatic disease). (almclinmed.ru)

This is especially critical in the early phases of disease so that these treatments can be started as soon as possible to slow down progression of the disease. (escholarship.org)
CONCLUSION This observational study of cohorts of patients with early RA confirms that early aggressive treatment results not only in a more rapid reduction of disease activity but also in less radiographic progression in the long term. (bmj.com)
Biomarkers are being developed to quantify joint remodelling and disease progression. (nordicbioscience.com)

Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)

Progress in Heritable Soft Connective Tissue Diseases. (wikipedia.org)

On the other hand, with reliable prognostic indicators patients who have a potentially mild disease could be spared therapy associated with risks of side effects. (biomedcentral.com)

Learn more about how our metabolic dysregulation biomarkers can make a difference in diseases affected by multiple organ failure. (nordicbioscience.com)

Validity of screening tests for Sjögren's syndrome in ambulatory patients with chronic diseases. (jrheum.org)
Studies that included patients with RA who underwent cartilage evaluation by ultrasonography were selected. (biomedcentral.com)
This review highlights the need for further research and validation of ultrasonographic cartilage assessment in patients with RA. (biomedcentral.com)
2001 Kraetsch HG, Antoni C, Kalden JR, Manger B. Successful treatment of a small cohort of patients with adult onset of Still's disease with infliximab: first experiences. (arztpraxis-schwanstetten.de)
In view of new developments in pharmacotherapy, it would be optimal to early identify those patients who are likely to develop a severe disease and enroll them for early aggressive treatment. (biomedcentral.com)
The patients were adaptively randomized into two groups of similar gender distribution, age, and disease duration. (almclinmed.ru)

The study showed that the reduction in transport of large amino acids by the encoded SLC7A5 protein leads to neurons switching from metabolizing lipids instead of amino acids and higher levels of neuronal cell death. (genewhisperer.com)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
The MARV matrix layer confers the virion filamentous shape and stability but how host lipids modulate mVP40 oligomerization is mostly unknown. (uci.edu)

The effect of dexamethasone on mRNA and protein synthesis of lipocortins (LCT) 1, 2 and 5 has been investigated in U-937 cells. (shengsci.com)

RA in humans is a heterogenous disease, and the environmental and genetic factors involved in its manifestation and perpetuation may vary from individual to individual. (biomedcentral.com)

By participating in our research projects, you will gain valuable experience in cutting-edge research techniques, broaden your understanding of cellular mechanisms in physiology and disease, and contribute to our mission to advance knowledge in the field of immunology. (lu.se)

In the chronic stage of the disease, when the erosion of the cartilage is taking place, it is possible that immune reactions to other cartilage proteins are initiated and contribute to the disease course. (biomedcentral.com)

The following genes that previously had placeholder symbols have recently been shown to encode proteins that are found in the lumen of microtubules. (genewhisperer.com)

Therefore, early diagnosis and monitoring of therapeutic targets using modern therapeutic strategies, such as biological disease-modifying antirheumatic drugs, may not be sufficient. (biomedcentral.com)

Mapping of the genes encoding human protein matches to pathways point to targets that could explain the observed presentation of symptoms in COVID-19 disease. (danielsolis.cz)

Chronic active Epstein-Barr virus (EBV) infection is a severe systemic disease associated with high rates of mortality and morbidity. (researchgate.net)

It was found in the thrombospondin protein where it is repeated 3 times. (embl.de)

Learn how our biomarkers can be utilized in a wide range of chronic diseases. (nordicbioscience.com)

Compound 20 showed outstanding biological data, inhibiting tau protein and Aβ40 aggregation with IC50 = 1.8 and 1.3 μM, respectively. (ibecbarcelona.eu)

Grape seed extract is typically extracted from the seeds of red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins. (isotonix.com)

RESULTS Despite similar inclusion criteria, significant differences in demographic factors and baseline disease activity were found between the different cohorts. (bmj.com)

A set of twenty-five thioxanthene-9-one and xanthene-9-one derivatives, that were previously shown to inhibit cholinesterases (ChEs) and amyloid β (Aβ40) aggregation, were evaluated for the inhibition of tau protein aggregation. (ibecbarcelona.eu)

Generally, alkaline phosphatase (ALP), COL1A1, BSP, RUNX2, transforming growth factor-beta 1 (TGFB1), osteonectin (ON), and bone morphogenetic protein-2 (BMP2) are known to be early markers of osteoblastic differentiation, whereas OC and osteopontin (OPN) are expressed later in the differentiation process [ 20 ]. (biomedcentral.com)

Anatomy12

Organisms3

Diseases9

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes6

Disciplines and Occupations1

Information Science3

COMP24

Articular5

Levels of cartilage oligome1

Osteoarthritis15

Metabolism3

Rheumatoid11

Collagen12

Extracellular Matrix5

Present in cartilage1

Hepatocyte growth1

Cardiovascular Diseases2

Degradation3

Biomarkers of cartilage1

Biomarker1

Bone and cartilage2

Tumor2

Early onset1

Inflammation6

Autoimmune3

Peptides3

Joints2

Synovial fluid2

Arthritis3

Expression5

Subunits2

Complement4

Enzymes1

Synovitis1

Clinical7

Progression3

Centers for Diseas2

Connective Tissue D1

Prognostic1

Metabolic1

Patients6

Lipids3

Synthesis1

Humans1

Physiology1

Erosion1

Encode1

Therapeutic1

Pathways1

Systemic disease1

Thrombospondin1

Chronic diseases1

Biological1

Compounds1

Found1

Inhibition1

Differentiation1