Disease burden and clinical outcomes. Medical search. Frequent questions

And the incidence and prevalence of the disease is increasing. (medscape.com)
Accurate data are desperately needed regarding the prevalence, ictal- and interictal burden of migraine and MOH in Australia. (brainfoundation.org.au)
This pilot study will assess the feasibility of a questionnaire-based epidemiological study to assess migraine and MOH prevalence, burden, and treatment gaps in a representative sample of the Australian general population in metropolitan and regional Victoria and New South Wales. (brainfoundation.org.au)
2 , 4 The prevalence of primary osteoporosis (i.e., osteoporosis without underlying disease) increases with age and differs by race/ethnicity. (uspreventiveservicestaskforce.org)
1, 2 Because of continuing changes in the incidence and prevalence of digestive diseases, important changes in health care, such as the emphasis on outpatient care whenever possible, and the availability of new statistical resources, the time is right to generate a new report to capture the impact of digestive diseases in the United States. (nih.gov)
The examined patients showed a high prevalence of oral diseases such as dental caries and gingivitis/periodontitis, and therefore a great need for dental treatment. (bvsalud.org)

I joined Sheffield Hallam University in 2022 as Professor of Clinical Epidemiology in the Department of Allied Health Professions and Director of the interdisciplinary Centre for Applied Health & Social Care Research (CARe) whose mission is to produce ideas, evidence and knowledge for future health and social care needs. (shu.ac.uk)
He subsequently did an MSc and PhD in Epidemiology at the London School of Hygiene and Tropical Medicine, exploring potential links between infectious and non-communicable diseases. (kemri-wellcome.org)
The New Zealand influenza surveillance system compiles information from a variety of sources on disease burden, epidemiology, viral aetiology, risk factors, clinical presentation and outcomes, and vaccine effectiveness. (apo.org.au)
Analysis Group's health care experts apply analytical expertise to health economics and outcomes research, clinical research, market access and commercial strategy, and health care policy engagements, as well as drug safety-related engagements in epidemiology. (analysisgroup.com)

Moffitt participates in over 350 clinical trials. (moffitt.org)
Phase I and II clinical trials) for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) based on the underlying mutational drivers of each disease. (moffitt.org)
He has published significantly on this topic including recently in highly regarded journals including Leukemia and Haematologica and these work form the foundation of the clinical trials that he is bringing to patients in order to improve their quality of life and survival. (moffitt.org)
Choosing accurate outcome measures for the evaluation of the management of ankle fractures in clinical trials facilitates better decision-making. (uib.no)
Joshua Brody, MD, Director of the CLL/Lymphoma Immunotherapy Program, Icahn School of Medicine at Mount Sinai, New York, who was not involved in these trials, commented: "CLL is an extremely prevalent disease affecting nearly 200,000 patients in the United States. (ascopost.com)
His work spans a wide range of study designs and settings, including clinic and field based observational studies as well as clinical trials in Kenya and other low and middle income countries. (kemri-wellcome.org)
Espay will present " Long-term Safety and Efficacy of IPX203 in Parkinson's Disease Patients with Motor Fluctuations: A 9-Month Open-label Extension Trial " at 4:30 p.m. April 25 during the Movement Disorders: Trials session, presented in person and online. (uc.edu)
7,8 In fact, epidemiologic studies and clinical trials have consistently demonstrated that a 20% to 25% relative reduction in homocysteine levels is associated with a significant reduction in cardiovascular events. (dsm.com)
In Alzheimer's Disease (AD) clinical trials, cognition is a key outcome that is measured to evaluate the efficacy of potential treatments. (cogstate.com)
This introduces cultural bias to tests limiting their application in studies and clinical settings with culturally and linguistically diverse people, and in global clinical trials. (cogstate.com)
Furthermore, as with other Cogstate tests, the DSST-Meds can be administered in both supervised and unsupervised (remote) settings, make it an option for decentralized clinical trials. (cogstate.com)
The Cogstate Digital DSST-Symbols has been included in 12 clinical trials across Ph 1 and Ph 2 research, supporting indications including Alzheimer's Disease, Narcolepsy, and Safety. (cogstate.com)
The Cogstate DSST-Meds version has been included in 5 clinical trials across Pilot, Ph 1, Ph2, and Ph3 research, supporting indications including Alzheimer's Disease, MCI, Parkinson's Disease, and Safety. (cogstate.com)
Yet it remains unclear how improved efficacy of new antiretrovirals reported in clinical trials has translated to population-level effectiveness in general clinical care. (bl.uk)
Although clinical trials that include cost data can be used to compare the cost-effectiveness of specific interventions, they only deal with outcomes within the time frame of the trial. (eur.nl)
Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error rates are controlled. (psiweb.org)
Common time-to-event efficacy endpoints in randomized clinical trials including leukemia patients after allogeneic stem-cell transplantation (ASCT) are, for instance, overall-survival or the incidence of graft-versus-host-disease (GvHD). (psiweb.org)

Despite evidence for clinical benefits, recommendations in guidelines, and options for electronic data collection, routine assessment of patient-reported outcomes (PROs) is mostly not implemented in clinical practice. (nih.gov)
The most challenging issue was the integration of the results in clinical practice. (nih.gov)
2002). "Health Status and Clinical Practice: When Will They Meet? (wikipedia.org)
Provide recommendations to inform future interventions to improve asthma outcomes in research and practice. (auckland.ac.nz)
This is a critical first step to direct future research, clinical practice, and healthcare policy on headache in Australia. (brainfoundation.org.au)
Intravascular ultrasound (IVUS) is superior to coronary angiography in terms of accurate assessment of lumen area and plaque burden and thus is commonly applied to evaluate intermediate stenotic lesions and guide the decision about revascularization in real-world practice [ 4 , 7 ]. (hindawi.com)
New Zealand conducts both hospital- and general practice (GP) based surveillance, because these systems capture disease presentations at different levels of severity. (apo.org.au)
With health care costs rising, there is a growing need for comprehensive estimates of the economic burden of such chronic and progressive diseases to inform clinical practice and lead to more cost-effective decision making. (analysisgroup.com)
The project is a significant undertaking, with 26 named investigators, most of whom are Indigenous, and all of whom are leaders in Indigenous health education, research and in clinical practice and public health. (otago.ac.nz)
Does the antiamyloid mAb meaningfully improve health outcomes (i.e., slow the decline of cognition and function) for patients in broad community practice? (cms.gov)
BANT practitioners are Registered Nutritional Therapy Practitioners trained and qualified in clinical practice, who habitually support clients with diet, weight management, diabetes prevention and symptoms of diet-induced chronic disease that the NHS is struggling to manage. (politicshome.com)
Anecdotal feedback gathered by BANT from GPs at a series of health industry events hints at widespread frustration at their inability to help their patients, coupled with an interest in and admiration for what nutrition practitioners do in clinical practice. (politicshome.com)
This system has been adopted by the National Comprehensive Cancer Network (NCCN) and is used widely in clinical practice when making decisions regarding treatment and/or active surveillance. (medscape.com)

Routine outcome assessment of individuals with MCCs could facilitate system-based care improvement and clinical effectiveness research. (cdc.gov)
This study aimed to plan, conduct and evaluate the implementation of electronic PRO (e-PRO) assessment in the clinical routine of an inpatient radiation oncology clinic. (nih.gov)
Process evaluation focused on potential clinical benefit (number of documented symptoms and supportive measures), feasibility and acceptance (patient contacts resulting in completion/non-completion of the e-PRO assessment, reasons for non-completion, preconditions, facilitators and barriers of implementation), and required resources (duration of patient contacts to explain/support the completion). (nih.gov)
Analyses of clinical records showed that e-PRO assessment identified more symptoms followed by a higher number of supportive measures compared to records of patients without e-PRO assessment. (nih.gov)
The aim of our study was, to plan, conduct and evaluate the implementation of electronic patient-reported assessment in a radio-oncology inpatient clinic under "real-life" clinical conditions instead of study conditions. (nih.gov)
Starting in 2004, he led the development and implementation of the VA's Clinical Assessment Reporting and Tracking (CART) Program. (wikipedia.org)
The USPSTF found adequate evidence that clinical risk assessment tools are moderately accurate in identifying risk of osteoporosis and osteoporotic fractures. (uspreventiveservicestaskforce.org)
A neurocognitive evaluation and a description of the instruments used to assess cognition and function for the clinical diagnosis of MCI due to AD or mild AD dementia for study enrollment and outcomes assessment. (cms.gov)

CAMBRIDGE, Mass., June 10, 2022 (GLOBE NEWSWIRE) -- Fulcrum Therapeutics, Inc ® FULC , a clinical stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases, today announced clinical proof-of-concept data from the ongoing Phase 1b trial of FTX-6058 for the treatment of sickle cell disease (SCD). (benzinga.com)

The pathogeneses of bacterial and viral exacerbations are significant as clinical symptoms are more severe and there is a marked increase in neutrophilic inflammation and tissue damage. (frontiersin.org)
Recommendations for PRO-based clinical action and self-management advice for patients concerning nine core symptoms were developed. (nih.gov)
this highlights the need for primary care and secondary care health professionals to be familiar with the risk factors for ectopic pregnancy, its clinical symptoms, and the local facilities that provide care for women with early pregnancy problems. (bmj.com)
[ 16 ] A correlation between clinical symptoms and stiffness values has also been suggested by MRI elastography. (medscape.com)
By linking the largest ambulatory EHR for life science research dataset with Komodo's Healthcare Map, Veradigm leverages the strengths of each source to offer researchers opportunities to integrate patient history and behavior, detailed clinical symptoms and outcomes, patterns of drug and health services utilization, along with costs to individuals and payers. (allscripts.com)
The U.S. Preventive Services Task Force (USPSTF) makes recommendations about the effectiveness of specific clinical preventive services for patients without obvious related signs or symptoms. (uspreventiveservicestaskforce.org)
Background: Huntington's disease (HD) is a rare, neurodegenerative disease and its complex motor, cognitive and psychiatric symptoms exert a lifelong clinical burden on both patients and their families. (lu.se)
Disease burden of all individuals alive in Sweden was described during a single calendar year (2018), including the occurrence of key symptoms, treatments and hospitalizations. (lu.se)
abstract = "Background: Huntington{\textquoteright}s disease (HD) is a rare, neurodegenerative disease and its complex motor, cognitive and psychiatric symptoms exert a lifelong clinical burden on both patients and their families. (lu.se)
Several studies have found that combinations of clinical signs and symptoms may have better sensitivity and specificity for detecting dehydration in children than do individual signs or symptoms. (medscape.com)

Indigenous people in Canada, Australia and New Zealand experience a greater burden of chronic diseases such as diabetes, heart disease and mental illness than non-Indigenous people. (otago.ac.nz)
Chronic diseases, such as Type 2 diabetes and metabolic syndrome, pose a significant threat to the future of the NHS, unless change is made and made soon. (politicshome.com)
Standard treatments for chronic diseases often involve long-term medication use as illustrated above. (politicshome.com)
Because type 2 diabetes and other chronic diseases are associated with both rising costs and modifiable lifestyle factors, consumer-directed health care advocates suggest that health systems should encourage greater patient cost-awareness and individual responsibility for health (2,3). (cdc.gov)

This literature review was therefore conducted to describe the burden of epidemic- and pandemic-prone acute respiratory infections (ARI) in the Region which may help in the development of evidence-based disease prevention and control policies. (who.int)
This review provides a descriptive summary of the burden of acute respiratory diseases in the Region, but there still remains a lack of necessary data. (who.int)
Another major consequence of susceptibility to infection is that people with underlying severe disease frequently develop acute exacerbations of COPD (AECOPD). (frontiersin.org)
As an example, Dr. Sallman has focused research and clinical trial efforts on patients who have TP53 mutation (often associated with complex genes/cytogenetics) given their high risk of transformation to acute leukemia and poor survival. (moffitt.org)
In a study reported in the Journal of Clinical Oncology, Elsayed et al developed a risk score based on single nucleotide polymorphisms (SNPs) associated with cytarabine pharmacodynamics or clinical outcomes that identified pediatric patients with acute myeloid leukemia (AML) who could benefit from. (ascopost.com)
Other clinical scenarios requiring IVUS examination (restenosis, acute coronary syndrome, left main disease, and chronic total occlusion) were excluded. (hindawi.com)
Though often considered a benign disease, acute gastroenteritis remains a major cause of pediatric morbidity and mortality around the world, accounting for 1.34 million deaths annually in children younger than 5 years, or roughly 15% of all child deaths. (medscape.com)
The availability of rotavirus vaccines has made norovirus the most common cause of medically attended acute gastroenteritis in American children younger than 5 years, according to a 2013 study from the US Centers for Disease Control and Prevention (CDC). (medscape.com)

On that day, millions of patients and their families around the world share their stories in order to raise awareness about rare diseases and their impact. (cdc.gov)
In the United States, a rare disease is defined as a condition that affects fewer than 200,000 people, and rare diseases as a whole affect about 25 million people in the United States, and about 400 million worldwide. (cdc.gov)
Examples of rare diseases include Huntington disease, fragile X syndrome, Guillain-Barré syndrome, Crohn disease, and Duchenne muscular dystrophy. (cdc.gov)
In addition, the economic impact of rare diseases is substantial not only for affected patients and their families, but for society as a whole. (cdc.gov)
What does genomics have to do with rare diseases? (cdc.gov)
Most rare diseases have a genetic and/or congenital cause. (cdc.gov)
To date, more than 7,000 rare diseases have been described, although the precise genetic causes for many of them remain unknown. (cdc.gov)
Molecular genomic diagnosis of rare diseases can lead to changes in medical care including use of existing medications or development of new ones to help people with specific mutations, as well as discontinuing ineffective therapies. (cdc.gov)
Molecular insights have not led to effective therapies for most rare diseases so far, but they do promise deeper understanding into the biology of these conditions that could lead to better management and improved outcomes in the future. (cdc.gov)
For an increasing number of rare diseases, treatments are becoming readily available, which can ameliorate or reduce the burden of illness and delay death. (cdc.gov)
The economic burden associated with rare diseases is often overlooked by physicians, payers, and regulators," said Myrlene Sanon Aigbogun, Director, Health Economics and Outcomes Research, Otsuka Pharmaceutical Development & Commercialization. (analysisgroup.com)
While the research team's focus was on a rare kidney disease, the article notes that the lifetime economic burdens of rare diseases can be similar to, if not greater than, those of more common diseases, if they translate to a greater cost per patient. (analysisgroup.com)
Rare diseases in general are subject to high unmet needs, in part due to limited knowledge of the diseases and the challenges of conducting intensive research to develop therapeutic options for small patient populations," said Martin Cloutier, a Vice President at Analysis Group. (analysisgroup.com)
This phenomenon is particularly of note in rare diseases, as study sizes need to be feasible. (psiweb.org)

Association Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association. (bvsalud.org)
Along with the rising burden of peripheral artery disease (PAD), mental health concerns are increasingly being recognized as a comorbidity to address in the chronic disease management of symptomatic PAD. (bvsalud.org)
Areas for behavioral health needs and interactions with PAD treatment are discussed, including the use of opioids , depression management, anxiety and stress reduction interventions, the use of benzodiazepines and antidepressants , smoking cessation , rehabilitation trajectories after amputation , and the role of cognitive decline for PAD treatment and outcomes. (bvsalud.org)
A case summary highlights the stigma around mental health and vascular disease and the fragmentation of care. (bvsalud.org)
Although antimicrobial drug stewardship programs have contributed to a decrease in incidence in some countries, such as the United Kingdom and Finland ( 2 , 4 ), CDI is still a major health burden in other countries. (cdc.gov)
At its core, public health is an organized effort by society to keep its members healthy and to prevent disease and disabilities. (cdc.gov)
Public health is no stranger to the world of rare and genetic diseases. (cdc.gov)
Universal health outcome measures for older persons with multiple chronic conditions. (cdc.gov)
Because the persistence and progression of diseases and courses of treatments affect health status in multiple dimensions, well-validated universal outcome measures across diseases are needed for research, clinical care, and administrative purposes. (cdc.gov)
Suitable composite measures include the Medical Outcomes Study 8 (SF-8) and 36 (SF-36) -item Short-Form Survey and the Patient Reported Outcomes Measurement Information System 29-item Health Profile. (cdc.gov)
Diagnostic criteria based on objective clinical, imaging, immunological and epidemiological data have been proposed for different levels of the health care system, but are not generally used in areas endemic for the disease. (who.int)
Objective Determine the long-term health-related quality-of-life (HRQoL), work limitation, physical activity, health/economic cost and disease burden of traumatic ACL and/or meniscal injury. (bmj.com)
Eligibility Studies reporting HRQoL, work limitations, physical activity levels, health/economic costs or disease burden, ≥2 years post-ACL and/or meniscal injury. (bmj.com)
Support the launch, pricing, and post-launch strategies for your product with Health Economics and Outcomes Research (HEOR). (iconplc.com)
7 To aid in shared clinical decision making, quality assurance in health care, and potential stratification for best clinical care pathways, it is reasonable for clinicians to incorporate validated patient-reported outcome measures (PROMs) and/or screening tools (STs). (allenpress.com)
Untreated, COPD may lead to other health complications including respiratory infections, heart disease, lung cancer and depression. (americashealthrankings.org)
During today's presentation when we refer to a public health emergency this can include large scale natural disasters, man-made disasters, and significant infectious disease outbreaks. (cdc.gov)
He was a founding member of the national Cardiovascular Outcomes Research Consortium and the Colorado Cardiovascular Outcomes Research (C-COR) consortium, which includes the University of Colorado Denver Health and Hospitals, VA Eastern Colorado Healthcare System, and Kaiser Colorado. (wikipedia.org)
Rumsfeld's doctoral thesis and early cardiovascular outcomes research work principally focused on the measurement and predictors of patient health status outcomes, including patient symptom burden from disease, mental and physical functional status, and health-related quality of life. (wikipedia.org)
She has an MBA degree with a concentration in Marketing and an MA in Clinical Mental Health Counseling, graduating with a 4.2/4.0 GPA. (legalreader.com)
My specific interests are clinical, epidemiologic, and data-intensive research to understand and improve musculoskeletal health and care, particularly osteoarthritis. (shu.ac.uk)
Before joining SHU I worked in the Arthritis Research UK/Versus Arthritis national Primary Care Centre of Excellence at Keele University, designing and undertaking clinical, epidemiologic, and data-intensive research to understand and improve musculoskeletal health and care. (shu.ac.uk)
There is some evidence that asthma education can improve health outcomes. (auckland.ac.nz)
OBJECTIVE: People with epilepsy (PWE) develop complications and comorbidities often requiring admission to hospital, which adds to the burden on the health system, particularly in low-income countries. (kemri-wellcome.org)
Improved supply of AEDs in the community, early initiation of treatment, and adherence would reduce hospitalization of PWE and thus the burden of epilepsy on the health system. (kemri-wellcome.org)
We all make levodopa, but Parkinson's patients make less of it," said Espay, the James J. and Joan A. Gardner Family Center for Parkinson's Disease Research Endowed Chair in UC's Department of Neurology and Rehabilitation Medicine and a UC Health physician. (uc.edu)
To promote a commitment to and a guide for action to achieve the Government of Samoa's Goals to improve the health of the population through the prevention of non-communicable diseases. (who.int)
Women must prioritise their own health, especially since heart disease is largely preventable. (escardio.org)
The authors said: "If extreme public health measures are not taken to mitigate cardiovascular risk factors, focusing on high-risk groups, heart disease mortality may supersede cancer to become the leading cause of death in young women. (escardio.org)
Calculating the cost-effectiveness of interventions is an important step in accurately assessing the health and financial burdens of a disease. (eur.nl)
Health economic models can synthesize epidemiologic, clinical, economic, and quality-of-life data from many different sources and extrapolate results to a point many years in the future. (eur.nl)
The use of health economic models to assess the economic burden of chronic obstructive pulmonary disease (COPD) and the value of interventions is growing, and will continue to do so as the burden of the disease is better appreciated. (eur.nl)
In support of Veradigm's mission to simplify healthcare with data-driven insights and technology that can help manage cost and improve outcomes, the partnership with Komodo Health will enable Veradigm to develop new and creative real-world evidence solutions for its life science customers. (allscripts.com)
This relationship will enhance our ability to provide a comprehensive understanding of both clinical and economic health outcomes while enabling us to develop new innovative solutions for real world research. (allscripts.com)
Data increasingly must be the backbone of every decision and every product in healthcare - yet stakeholders across the healthcare ecosystem lack access to an accurate view of patient health, provider practices, and outcomes," said Arif Nathoo, MD, CEO and co-founder of Komodo Health. (allscripts.com)
Veradigm is an integrated data systems and services company that combines data-driven clinical insights with actionable tools to help healthcare stakeholders improve the quality, efficiency, and value of healthcare delivery- including biopharma, health plans, healthcare providers, health technology partners, and most importantly, the patients they serve. (allscripts.com)
BOSTON, MA - April 30, 2020 - Analysis Group , Inc., a global leader in health economics and outcomes research (HEOR), announced the publication of the first study of the direct and indirect costs of autosomal dominant polycystic kidney disease (ADPKD) in the US. (analysisgroup.com)
By publishing this study, we hope to increase awareness of the economic burden associated with ADPKD, and show that the costs associated with ADPKD go beyond direct health care costs. (analysisgroup.com)
The study, titled "The societal economic burden of autosomal dominant polycystic kidney disease in the United States," is published in the current issue of BMC Health Services Research . (analysisgroup.com)
Educating for Equity is about how health professional education can reduce disparities in chronic disease care and improve outcomes for indigenous populations. (otago.ac.nz)
Indigenous patients tend to receive poorer quality health care than non-Indigenous people, partly due to 'health professional factors', such as clinical decision-making, communication and engagement with patients and families. (otago.ac.nz)
Currently little is known about how educational approaches influence the health professional factors which contribute to poor outcomes in Indigenous health, or about what approaches work best. (otago.ac.nz)
The Educating for Equity project will help contribute to improving health professionals' knowledge, attitudes and behaviours, plus share experiences and approaches to Indigenous health teaching and learning in the area of chronic disease. (otago.ac.nz)
The World Health Organization characterizes psoriasis as "a chronic, non-communicable, painful, disfiguring and disabling disease for which there is no cure. (skintherapyletter.com)
A new population health study investigated the economic burden of this disease, including the patient's total healthcare utilization, costs, and work productivity, based on self-reported outcomes. (ahdbonline.com)
Lead investigator Kathleen F. Villa, MS, Senior Director, Health Economics and Outcomes Research, Jazz Pharmaceuticals, Inc, and colleagues, used data for this analysis from responses to the 2011-2013 US National Health and Wellness Survey, a health-related survey conducted annually that represents a cross-section population in the United States. (ahdbonline.com)
The principal purpose of the study is to test whether the item or service meaningfully improves health outcomes of affected beneficiaries who are represented by the enrolled subjects. (cms.gov)
Nor is it able to curb the increase in obesity, mental health problems and most long-term diseases. (politicshome.com)
Patients who understand their own health conditions and partner with their clinical teams to adopt the best treatment plan are more satisfied with their care and achieve better outcomes. (primeinc.org)
Continued progress in improving the health welfare of the population of the United States requires a continued investment in digestive disease research, public health initiatives, the health care system, and the education of the general public about how to improve their health. (nih.gov)
In addition, congressional report language accompanying the Fiscal Year 2005 appropriations bills in the House and Senate for Labor-Health and Human Services-Education and Related Agencies called for the creation of an advisory committee, the National Commission on Digestive Diseases, and tasked it with addressing the burden of digestive diseases and developing a long-range research plan. (nih.gov)
As outlined in the report, for any specific disease condition, there are numerous limitations on the types of data that can be obtained in the diverse and decentralized U.S. health care system. (nih.gov)
In addition, the limitations of the report and the statistical data mandate a strong digestive disease research effort aimed at improving health in the United States through pursuit of the many recommendations of the Commission's research plan, improving our ability to capture needed statistical and epidemiological information, and spurring fundamental improvements in the health care system. (nih.gov)
1 and is of great public health concern because of its huge morbidity and mortality burden. (who.int)
The notion of person, taken as a subject of discourses and holder of rights, contrasts with the notion of a biological-behavioral individual of the health psychology tradition that remained active in other paradigms of health-disease processes. (bvsalud.org)
OBJECTIVE: To study differences in pain reports between patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (nr-axSpA), and to assess how pain sensitivity measures associate with disease and health outcomes. (lu.se)
Linear regression models were used to compare pain measures between patients with AS and nr-axSpA, and to assess associations between pain sensitivity measures and disease and health outcomes. (lu.se)
Lower pain tolerance was associated with longer symptom duration, worse Ankylosing Spondylitis Disease Activity Score using C-reactive protein (ASDAS-CRP), Bath Ankylosing Spondylitis Functional Index, and Bath Ankylosing Spondylitis Metrology Index (BASMI), more pain regions, unacceptable pain, worse Maastricht AS Enthesitis Score (MASES), fatigue, anxiety, and health-related quality of life. (lu.se)
Further, higher pain sensitivity is associated with having worse disease and health outcomes. (lu.se)
Impact of Emerging Health Insurance Arrangements on Diabetes Outcomes and Disparities: Rationale and Study Design. (cdc.gov)
Results could be used to design health plan features that promote high-quality care and better outcomes among people who have diabetes. (cdc.gov)
As discussed by Gregg et al in an accompanying article in this issue of Preventing Chronic Disease (1), diabetes is a growing threat to public health. (cdc.gov)
In addition to its detrimental clinical impacts, diabetes creates an economic burden on both people and the health care system. (cdc.gov)

New topical therapeutic options need to offer higher efficacy and better patient acceptability, including easier application, to reduce treatment burden and enhance patient adherence. (skintherapyletter.com)
10 Increasing awareness of the burden of psoriasis and the psychosocial impact of the disease have underscored the clinical need for a topical therapy that is easy to use, cosmetically appealing, rapidly efficacious with short-term use, as well as be able to induce sustained efficacy for long-term maintenance. (skintherapyletter.com)
1) Monoclonal antibodies directed against amyloid that are approved by FDA for the treatment of AD based upon evidence of efficacy from a change in a surrogate endpoint (e.g., amyloid reduction) considered as reasonably likely to predict clinical benefit may be covered in a randomized controlled trial conducted under an investigational new drug (IND) application. (cms.gov)
2) Monoclonal antibodies directed against amyloid that are approved by FDA for the treatment of AD based upon evidence of efficacy from a direct measure of clinical benefit may be covered in CMS approved prospective comparative studies. (cms.gov)

In fact, we have seen a rapid emergence of sequencing in clinical research in the past few years. (cdc.gov)
Obviously, these are the early days of the application of whole genome sequencing in rare disease research and management and many scientific, ethical and societal challenges remain . (cdc.gov)
As part of our commitment to delivering innovative therapies to patients worldwide, Novartis believes in the need to support ethical independent clinical and non-clinical research conducted by qualified third-party investigators. (novartis.com)
He is a member of the American College of Cardiology Board of Trustees, and is the current Chair of the American Heart Association's Quality of Care and Outcomes Research Council. (wikipedia.org)
He served on the National Heart, Lung, and Blood Institute (NHLBI) Cardiovascular Outcomes Research Workgroup. (wikipedia.org)
He has had a long-standing research and clinical interest in the intersection of cardiovascular disease and depression. (wikipedia.org)
In recent years, his research has focussed on the effectiveness and safety of cardiovascular care delivery and therapeutics, building on his work with the ACC NCDR programs and national clinical quality programs in the VA. Dr. Rumsfeld has more than 200 scientific publications, including original research, editorials, and scientific statements. (wikipedia.org)
The University of Cincinnati's Alberto Espay, MD, will present Parkinson's disease research at the American Academy of Neurology's annual meeting, April 22-27, in Boston, Massachusetts, and online. (uc.edu)
Recent research has also highlighted folate's role in improving vascular outcomes via increased NOS (nitric oxide synthase) coupling and NO (nitric oxide) bioavailability. (dsm.com)
The research is published in European Heart Journal - Quality of Care and Clinical Outcomes, a journal of the European Society of Cardiology (ESC). (escardio.org)
2 The Centers for Disease Control and Prevention (CDC) Wide-ranging Online Data for Epidemiologic Research (WONDER) database contains the assigned cause of mortality from all death certificates in the US. (escardio.org)
The vision of the Cardiovascular Clinical Research group is to optimize the outcomes for patients with congenital heart disease, and reduce the burden of such disease on them, their parents and society. (texaschildrens.org)
the research plan can be accessed on the Opportunities & Challenges in Digestive Diseases Research page . (nih.gov)
The NIH sponsored the current report on the burden of digestive diseases to serve not only as a needed statistical reference, but also as a companion volume to inform research goals recommended in the Commission's research plan. (nih.gov)

BD is leveraging its extensive global capabilities to meaningfully engage around 5 key strategies to reduce the burden of drug-resistant infections. (bd.com)

We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. (cdc.gov)
Therefore, we conducted a large territory-wide study to investigate the disease burden and clinical outcomes of CDI in Hong Kong, China. (cdc.gov)
The children in the study had a high burden of disease, as reflected by the duration of EoE as well as histologic, endoscopic, and clinical scores. (medscape.com)
The study included multiple secondary outcomes. (medscape.com)
An IIT may be a clinical study conducted without the participation of Novartis, for which the IIT sponsor requests Novartis to provide either funding, drug product or both. (novartis.com)
In particular, in-vitro and clinical data will be presented which show how the study of the ultrasound spectral features [3] could lead to a quantitative ultrasound method dedicated to the lung. (acoustics.org)
The Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Sweden, has released a study in which deep, repetitive transcranial magnetic stimulation (TMS) showed promise for the treatment of alcohol addiction. (legalreader.com)
He added, "If and when this replicates in the equivalent of a phase 3 study, we will actually have a completely novel treatment available for this difficult to treat and very impactful disease. (legalreader.com)
In this study, we introduce a cardiovascular disease (CVD) policy model which can be used to model remaining life expectancy including a measure of socioeconomic deprivation as an independent risk factor for CVD. (bmj.com)
The Global Burden of Disease Study 1 estimated that in 2010 cardiovascular disease (CVD), including rheumatic heart diseases, hypertensive diseases, ischaemic heart diseases, pulmonary heart disease, other forms of heart disease, cerebrovascular diseases (CBVDs), diseases of arteries and diseases of veins, was the cause of death in approximately 30% of all global deaths. (bmj.com)
The 2016 Global Burden of Disease (GBD) study places migraine/MOH as the second leading cause of years lived with disability worldwide . (brainfoundation.org.au)
The study was wavied by the IRB of the First Affiliated Hospital of Xi'an Jiaotong University due to all the data used in this study were from the Global Burden of Diseases (GBD) 2019 database. (wjgnet.com)
There was no requirement to give informed consent in this study, because all the data used in this study were from the Global Burden of Diseases (GBD) 2019 database. (wjgnet.com)
The aim of this study was to investigate the impact of arterial remodeling of intermediate coronary lesions on long-term clinical outcomes. (hindawi.com)
In the recent study , Williamson and colleagues showed that performance on the Cogstate DSST-Meds and Cogstate DSST-Symbols tests were associated strongly with performance on the WAIS coding test in cognitively unimpaired older adults and in adults with early symptomatic Alzheimer's disease. (cogstate.com)
A nationwide US study has found increasing death rates from heart disease in women under 65. (escardio.org)
1 The study found that while death rates from cancer declined every year between 1999 and 2018, after an initial drop, heart disease death rates have been rising since 2010. (escardio.org)
This study compared heart disease- and cancer-related deaths in women under 65 in the US. (escardio.org)
Across the entire study period, age-adjusted mortality rates decreased for both cancer and heart disease. (escardio.org)
Moreover, this study provides important insights that may help clinicians target their treatment strategies for improving or delaying disease progression that reduce a rare disease's economic burden. (analysisgroup.com)
Study sites with clinical expertise and infrastructure to provide treatments consistent with the safety monitoring outlined in the FDA-approved label. (cms.gov)
This leads to a challenge in the context of the statistical and clinical interpretation of study data (Fleming 2009, DeMets 2012). (psiweb.org)
The study design for a potentially life-saving drug in a rare disease can further enhance the informative censoring phenomenon due to the extent (or lack) of post-treatment follow-up. (psiweb.org)
Conclusions: This study demonstrates the significant and progressive clinical burden in individuals with HD and presents novel insights into the natural history of JoHD. (lu.se)
In this cross-sectional, descriptive study the indexes DMFT and CPI were used to evaluate dental caries and periodontal disease, respectively, from August 2009 through March 2010. (bvsalud.org)
We designed a pre-post, longitudinal, quasi-experimental study to determine the effect of HDHPs on diabetes quality of care, outcomes, and disparities. (cdc.gov)

METHODS: We describe NTS infections reported to the Foodborne Diseases Active Surveillance Network during 2018-2019 that were screened for genetic resistance determinants, including those conferring decreased susceptibility to first line agents (ciprofloxacin, ceftriaxone, or azithromycin). (cdc.gov)

We identified all patients in Hong Kong given a diagnosis of CDI during January 1, 2006-December 31, 2014, from the Clinical Data Analysis and Reporting System (CDARS), which is a computerized database of patient records managed by the Hong Kong Hospital Authority. (cdc.gov)
The diagnosis of cysticercosis of the central nervous system involves the interpretation of non-specific clinical manifestations, such as seizures, often with characteristic findings on computed tomography or magnetic resonance imaging of the brain, and the use of specific serological tests. (who.int)
Cost effective and largely available solutions for the diagnosis and monitoring of lung diseases would be of tremendous help, and this is exactly the role that could be played by ultrasound (US) technologies. (acoustics.org)
A clinical diagnosis of mild cognitive impairment (MCI) due to AD or mild AD dementia, both with confirmed presence of amyloid beta pathology consistent with AD. (cms.gov)
Patients alive with HD in Sweden in 2018 displayed a pattern of increased clinical burden for a number of years since diagnosis. (lu.se)

Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and death world-wide, where chronic inflammation accelerates lung function decline. (frontiersin.org)
Chronic obstructive pulmonary disease (COPD) is an umbrella term encompassing multiple lung pathologies (including emphysema, chronic bronchitis and bronchiolitis) that manifest into persistent and poorly reversible airflow limitation. (frontiersin.org)
2] The clinical and economic burden of chronic obstructive pulmonary disease in the USA, A.J. Guarascio et al. (acoustics.org)
Chronic obstructive pulmonary disease ( COPD ) is a chronic lung disease that slowly damages air sacs in the lungs, decreasing airflow and making it difficult to breathe. (americashealthrankings.org)
RePub, Erasmus University Repository: Economic modeling in chronic obstructive pulmonary disease. (eur.nl)
Reviews have also noted that antibiotic use in smokers without chronic obstructive pulmonary disease is no more effective than use in nonsmokers. (medscape.com)
Studies have focused on healthy individuals (patients with asthma excluded) or patients with chronic obstructive pulmonary disease (COPD). (medscape.com)

Based on responses to items in the initial measure, short follow-on measures should be selectively targeted to symptom burden, depression, anxiety, and daily activities. (cdc.gov)

Komodo Health's AI platform cross-links patient journey data with other medical and healthcare datasets to better understand disease burden, predict disease and optimize patient outcomes. (allscripts.com)

Professor Etyang's studies are providing much needed local data for control of high burden infectious and non-communicable diseases. (kemri-wellcome.org)
The high burden of treatment and the substantial effort required to maintain ongoing therapy leads to treatment fatigue. (skintherapyletter.com)

NCD interventions will take time to show population level outcomes in risk reduction. (who.int)

Recent studies have linked BV to adverse pregnancy and gynecologic outcomes, such as preterm labor and delivery, low birth weight, premature rupture of membranes, post-Cesarean endometritis, and post-abortal and post-hysterectomy infections. (cdc.gov)
IVUS-derived negative remodeling is associated with adverse long-term clinical outcome in stable patients with intermediate coronary artery stenosis. (hindawi.com)
However, most studies have not controlled for member-level selection or examined adverse clinical outcomes. (cdc.gov)

Based on a large body of genetic, clinical, and observational evidence showing the effects of higher levels of HbF in patients with SCD, the induction of HbF by 5-10% over baseline is associated with reduced disease burden and improved clinical outcomes. (benzinga.com)

ABSTRACT There are gaps in the knowledge about the burden of severe respiratory disease in the Eastern Mediterranean Region (EMR). (who.int)
Remaining gaps to be considered for measure development include disease burden, cognitive function, and caregiver burden. (cdc.gov)
and that the current clinical pathways involve substantial treatment gaps that contribute to the burden of disease. (brainfoundation.org.au)

Using our industry-leading, integrated data platform, Integrated Dataverse (IDV®), we combine prescription and claims data with electronic medical records, lab results, and other clinical data, into one cohesive dataset. (iconplc.com)
The aim of the project is to evaluate the effect of asthma education on outcomes using data from this dataset. (auckland.ac.nz)
By analysing a dataset that collects data from all HIV-infected patients in clinical care in the Netherlands it was shown that the use of combination antiretroviral therapy (cART) regimens in the Netherlands closely follows changes in guidelines, to the benefit of patients. (bl.uk)
Using Komodo Health's platform, the collaboration will enable Veradigm to provide a linked dataset containing a complete longitudinal view of nearly 50 million deidentified patients to support life sciences companies as they investigate new ways to reduce disease burden. (allscripts.com)
The linked dataset combines detailed clinical and patient lifestyle information along with cost and utilization data captured across all care settings. (allscripts.com)

In Scotland, although mortality rates have declined steadily for decades (eg, coronary heart disease (CHD) mortality rates for men were 72% lower in 2009 than in 1950), in 2009, Scottish CHD mortality rates for men and women were 39% and 64% higher, respectively, than the average for Western Europe. (bmj.com)
Consecutive patients with stable coronary heart disease who received IVUS examination between January 2011 and January 2014 were retrospectively screened. (hindawi.com)

Chronic Obstructive Pulmonary Diseases (COPD) and lower respiratory infections are respectively the third and fourth leading cause of death in the world, and are responsible for six million deaths per year [1]. (acoustics.org)
As a result of drug resistance, infections become harder to treat, increasing the risk of disease spread, severe illness and death. (bd.com)

It is a major chronic disease that is predicted to become the third leading cause of death world-wide by 2030 ( 1 ) and has a huge economic burden costing $50 billion annually in the USA alone ( 2 ). (frontiersin.org)
The disease burden and economic costs to the patient and society are considerable. (uib.no)
researchers took on the issue of vaccine hesitancy by estimating the disease burden and economic costs associated with declines in the measles-mumps-rubella (MMR) vaccination rate. (scienceblogs.com)

These features place a major burden on healthcare systems. (cdc.gov)
Allscripts (NASDAQ: MDRX) is a leader in healthcare information technology solutions that advance clinical, financial and operational results. (allscripts.com)
Its Healthcare Map links more than 150 payer complete datasets, providing real-time and longitudinal data on more than 320 million patients, representing more than 65 billion clinical encounters with 15 million new encounters added daily. (allscripts.com)
These diseases not only reduce the quality of life for individuals but also place a heavy burden on healthcare resources. (politicshome.com)

Furthermore, previous studies have shown that arterial remodeling assessed by IVUS in vivo affects hemodynamic stress on the lesion site [ 8 - 10 ] and is correlated with clinical presentation [ 11 , 12 ]. (hindawi.com)
See Clinical Presentation for more detail. (medscape.com)

With respect to mechanisms concerning the B-vitamin complex, it has long been established that folate deficiency leads to increased plasma homocysteine (hyperhomocysteinemia), an independent risk factor for coronary artery disease, stroke, peripheral vascular atherosclerosis, and both arterial and venous thromboembolism. (dsm.com)
The critical role of NO bioavailability in vascular biology is well documented, and endothelial dysfunction - the reduced ability of the endothelium to produce NO - is a hallmark of cardiovascular disease. (dsm.com)

The challenge of making the "data actionable" within the clinical workflow and motivating clinical staff to use the results became evident. (nih.gov)
We also examined the predictors of prolonged hospital stay and death using data from linked clinical and demographic surveillance system. (kemri-wellcome.org)
To find out, researchers used vaccine data from the Centers for Disease Control and Prevention to simulate county-level MMR vaccine coverage for children ages 2 to 11. (scienceblogs.com)
However, data regarding the long-term clinical outcomes of IVUS-guided deferral of coronary revascularization are limited. (hindawi.com)
According to published data, approximately 75% of patients 3 with psoriasis vulgaris (plaque psoriasis), regardless of severity, manage their disease with topical therapies, which may lead to quicker treatment fatigue as the daily treatment regimen can be cumbersome and time consuming. (skintherapyletter.com)
There is general awareness of the risks of informative censoring, e.g. when data from patients without follow up beyond end of treatment is not independent of the underlying disease process, therefore introducing bias. (psiweb.org)

Centers for Disease Control and Prevention. (cdc.gov)
In addition, over the past 4 years, the NIH funded Centers for Mendelian Genomics have conducted sequencing and analysis of protein-coding portions of more than 20,000 human genomes and have identified over 740 genes that likely cause genetic diseases. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
Cognizant of this, the Centers for Disease Control and Prevention recently collaborated with numerous medical societies to publish a series of articles on the judicious use of antibiotics for several common conditions, including bronchitis, and have recommended against routine antibiotic use in uncomplicated bronchitis. (medscape.com)

People with sickle cell disease have a tremendous need for therapeutic options that can reduce morbidity and mortality and improve their quality of life,' said Julie Kanter, M.D., associate professor of Hematology and Oncology and director of the Adult Sickle Cell Program at the University of Alabama at Birmingham. (benzinga.com)
Over 17 million patients die annually of cardiovascular disease (CVD), representing 31% of all deaths and making CVD the leading cause of global morbidity and mortality by a significant margin. (dsm.com)
During the 19-year period, the age-adjusted mortality rates for cancer and heart disease were 52.6 and 24.0 per 100,000, respectively. (escardio.org)
As a result, the absolute mortality gap between cancer and heart disease significantly decreased from 32.7 to 23.0 per 100,000/year. (escardio.org)
A comparative analysis of premature heart disease- and cancer-related mortality in women in the USA, 1999-2018. (escardio.org)

Well we know that for some infectious diseases there's a disproportionate burden among pregnant women. (cdc.gov)

But while cancer death rates consistently declined throughout the 19 years, heart disease death rates fell initially and then increased between 2010 and 2018. (escardio.org)

Univariate analyses were presented in In sub-Saharan Africa, the burden of stroke appears the form of frequencies, percentages, means, 4 to be on the increase. (who.int)

each uses a consistent definition of COPD severity that is based on FEV(1)% predicted, but the models differ in the allowed transitions, disease progression estimates, utility weights, and costs. (eur.nl)

This will result in an increased burden of co-morbidity, polypharmacy and an increasing proportion of patients who will experience potential complications with their HIV-treatment. (bl.uk)

However, adherence to topical treatment remains a challenge, as the daily application creates a significant treatment burden. (skintherapyletter.com)
As with any chronic disease, patient adherence to topical psoriasis therapy is low. (skintherapyletter.com)
5-7 Factors influencing adherence include patient specific characteristics, disease-related characteristics, treatment satisfaction, cosmetic acceptability and complexity of treatment protocols. (skintherapyletter.com)

An important paradox in COPD is that despite the accumulation of leukocytes in the airways with increasing disease severity, there is still a major failure to adequately control and eradicate respiratory pathogens. (frontiersin.org)
Chronic lower respiratory diseases, mainly COPD, are the sixth-leading cause of death in the United States. (americashealthrankings.org)
The most common cause of heart disease death was ischaemic heart disease (56%) while respiratory tract/lung cancer (23%) was the leading cause of cancer death. (escardio.org)

Administering time-limitedcombination regimens of venetoclax plus obinutuzumab or venetoclax plus obinutuzumab and ibrutinib was superior to chemoimmunotherapy in achieving undetectable measurable residual disease (MRD) in the peripheral blood at month 15 in fit patients with chronic lymphocytic. (ascopost.com)
Exposition found that fixed-duration treatment with ibrutinib and venetoclax achieved deep and sustained undetectable measurable residual disease (MRD) status when used as first-line therapy for. (ascopost.com)
This will facilitate ongoing monitoring of policy progress, enable timely corrective actions, and produce measurable outcomes. (amcham.gr)

To describe the clinical use of patient-reported outcome measures (PROMs) and screening tools (STs) for low back pain (LBP) in clinics of chiropractic teaching institutions in the United States. (allenpress.com)
Objective: To describe the clinical burden and natural history of HD. (lu.se)

This technology has provided success in identifying new causal mutations for rare suspected genetic diseases of previously unknown cause, with diagnostic rates of 25%-50% in recent studies . (cdc.gov)
Dr. Sallman studies the genetic drivers of myeloid diseases in order to improve prognostication for patients and also to allow for more personalized treatment. (moffitt.org)
To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients. (uni-muenchen.de)

Understand the behavioral, emotional, and clinical drivers of a patient population across the treatment journey. (iconplc.com)
In addition, as announced today, we are excited to partner with Simcere Pharmaceutical to advance rademikibart as a potential new treatment option for patients with AD and potentially other disease indications in Greater China. (myfox8.com)
The team noted, "Alcohol addiction is associated with a high disease burden, and treatment options are limited. (legalreader.com)
1 Although death after ectopic pregnancy is rare, the burden of disease is high owing to the cost of diagnostic tests and expensive treatment. (bmj.com)
Integrating a smoking cessation programme or changing HIV-treatment guidelines to recommend prescribing a polypill for CVD to all HIV-patients aged 45 or 55 years and over could improve the burden of CVD, improve patient outcome and be cost saving in the long-term. (bl.uk)
Hence, by addressing the several crucial unmet clinical needs in patients with mild-to-moderate psoriasis, this optimized foam formulation is poised to improve treatment follow-through. (skintherapyletter.com)

Eosinophilic esophagitis is a chronic, aggressive, type 2 inflammatory disease that has a substantial impact on quality of life," said Mirna Chehade, MD, MPH, of the Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai in New York City. (medscape.com)

The results indicate that patients with AS and nr-axSpA, in line with most clinical characteristics, have a similar pain burden, and they highlight large unmet needs regarding individualized pain management, regardless of axSpA subgroup. (lu.se)

The database contains laboratory and clinical information, including patient demographics, disease diagnoses, investigations, procedures, and drug prescription records in the public hospital system. (cdc.gov)
What is the burden of disease for a given patient population? (iconplc.com)
This systematic review assesses the evidence for the measurement properties of patient-reported outcome measures (PROMs) used in the evaluation of adult patients with ankle fractures. (uib.no)
Background To assess the effect of baricitinib on patient-reported outcomes (PROs) in patients with active rheumatoid arthritis and an inadequate response to methotrexate (MTX). (bmj.com)
Globally, clinical outcomes vary considerably according to dietary standards, vitamin and mineral fortification and a variety of patient-specific risk factors and comorbidities. (dsm.com)
The incorporation of nutritional therapy into NHS primary care could revolutionise patient care and outcomes. (politicshome.com)

Most people with mild-to-moderate psoriasis manage their disease with topical therapies. (skintherapyletter.com)

Cardiovascular disease (CVD) in particular will become a major burden of co-morbid disease. (bl.uk)

Anatomy1

Organisms3

Diseases36

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment92

Psychiatry and Psychology7

Phenomena and Processes12

Disciplines and Occupations13

Anthropology, Education, Sociology and Social Phenomena16

Humanities1

Information Science14

Named Groups7

Health Care115

Geographicals30

Prevalence6

Epidemiology4

Trials17

Practice13

Assessment8

20221

Symptoms10

Chronic diseases4

Acute8

Rare diseases14

Health63

Efficacy4

Research14

Reduce the burden1

Study26

Methods1

Diagnosis5

Pulmonary Disease7

Symptom1

Optimize1

High burden2

Interventions1

Adverse3

Observational1

Gaps3

Dataset5

Coronary heart d2

Infections2

Economic3

Healthcare4

Presentation2

Vascular2

Data6

Centers4

Mortality5

Infectious diseases1

20181

Analyses1

Progression1

Morbidity1

Adherence3

Respiratory3

Measurable3

Describe the clinical2

Genetic3

Treatment6

Inflammatory disease1

Unmet needs1

Patient6

Therapies1

Major burden1