Disease as congenital hepatic fibrosis. Medical search. Frequent questions

We report the case of a 27-year-old Iranian woman with congenital hepatic fibrosis leading to cirrhosis and subsequently hepatocellular carcinoma. (biomedcentral.com)
Liver disease in psoriasis patients can range from simple steatosis (NAFLD) and nonalcoholic steatohepatitis (NASH), through to fibrosis and cirrhosis. (audience.pics)
The study also found that as the body surface area affected by psoriasis increased, so did the prevalence of liver disease and cirrhosis. (audience.pics)
PFIC is a progressive disease and will progress to cirrhosis and death. (hkjpaed.org)
He was suffering from posthepatitic cirrhosis caused by hepatitis B with a history of 6 years, having ascites as the initial presentation in 2003, but constantly without prior recurrent episodes of hepatic encephalopathy. (openventio.org)
It is caused most often by cirrhosis (in North America), schistosomiasis (in endemic areas), or hepatic vascular abnormalities. (msdmanuals.com)
Cirrhosis Cirrhosis is a late stage of hepatic fibrosis that has resulted in widespread distortion of normal hepatic architecture. (msdmanuals.com)
Using a cut-off HA concentration of 135.94 ng/ml, the sensitivity and specificity for diagnosis for advanced liver fibrosis/cirrhosis was 100% (95% CI, 50.6-100) and 90.8% (95% CI, 81.6-95.7), respectively. (researcher.life)
These findings suggest that serum HA concentration is a potential non-invasive biomarker for advanced liver fibrosis and/or cirrhosis in dogs. (researcher.life)
It is usually caused by an increase in resistance in the portal-hepatic vascular bed due to obstruction to flow, which in the vast majority of patients is related to cirrhosis. (gastrotraining.com)
Most infants have the sickle cell disease, graft-versus-host disease, acute valvular incompetence, and hiv serology ebv antibody titers are higher in patients with pulmonary venous congestion from congestive heart failure, cirrhosis, or treatment that takes place over sev-eral hours thereafter. (elastizell.com)
Intrahepatic causes of portal hypertension include cirrhosis and hepatic fibrosis or scarring. (hdkino.org)
Methotrexate causes hepatotoxicity, fibrosis and cirrhosis, but generally only after prolonged use. (nih.gov)
Patients with chronic liver disease, including hepatitis B, hepatitis C, chronic alcoholic hepatitis, and cirrhosis may also be at risk for developing bile duct cancer. (brainandnervecenter.com)

Abstract We describe a case of Caroli syndrome (Caroli's disease and congenital hepatic fibrosis) in a 10-year-old boy with bilobar involvement and numerous renal cysts. (zib.de)
Imaging findings in Caroli's disease. (qxmd.com)
The disease now most often referred to as Caroli's disease is a rare condition characterized by nonobstructive saccular or fusiform dilatation of the intrahepatic bile ducts. (qxmd.com)
Caroli's disease usually is manifested in childhood and is thought to be congenital and probably inherited. (qxmd.com)
This pictorial essay illustrates the broad spectrum of imaging findings in Caroli's disease. (qxmd.com)
Approximately 20% of choledochal cysts are classified as type 5 cysts, which are also referred to as Caroli's disease. (healthcaretip.com)
There are rare congenital diseases that increase the risk of bile duct cancer, including Lynch II syndrome (hereditary nonpolyposis colorectal cancer associated with biliary tree and other cancers) and Caroli's syndrome (portal hypertension, hepatic fibrosis, and biliary tree cysts). (brainandnervecenter.com)

Congenital hepatic fibrosis is a ductal plate malformation of the small interlobular bile ducts, whereas Caroli disease involves the large intrahepatic bile ducts. (medscape.com)
Caroli disease is multifocal segmental dilatation of the large intrahepatic bile ducts that connect to the main duct. (raredis.org)
There are two types of Caroli: the first type is the simple type, Caroli disease, which includes only cystic dilatation of the intrahepatic bile ducts. (raredis.org)

Congenital hepatic fibrosis is one of the fibropolycystic diseases, which also include Caroli disease , autosomal dominant polycystic kidney disease (ADPKD), and autosomal recessive polycystic kidney disease (ARPKD). (medscape.com)
Congenital hepatic fibrosis is associated with an impairment of renal functions, usually caused by an ARPKD, which is a severe form of polycystic kidney disease . (medscape.com)
The classic renal lesion associated with congenital hepatic fibrosis is ARPKD, which results in an impairment of renal functions. (medscape.com)
The relationship of ARPKD to congenital hepatic fibrosis remains a controversial issue. (medscape.com)
[ 9 ] Most cases of ARPKD and congenital hepatic fibrosis are genetically homogeneous. (medscape.com)
Autosomal Recessive Polycystic Kidney Disease (ARPKD) affects approximately 1/20,000 children and has two main features, polycystic kidneys and the liver disease, congenital hepatic fibrosis (CHF). (pkdcure.org)
Although kidney disease is common in many ARPKD patients early in life, CHF may not be evident until later in childhood or adulthood. (pkdcure.org)
Our collaborative research team (Drs. Dell & Flask) has been studying novel MRI methods to assess ARPKD kidney and liver disease progression for over a decade. (pkdcure.org)
To address this important limitation, our group has applied and optimized a novel technique, MR-Fingerprinting (MRF), to study both ARPKD kidney and liver disease. (pkdcure.org)
With supplemental funding, we obtained initial liver MRF images, showing that mean T1 values are significantly higher in ARPKD patients with advanced CHF vs. both healthy volunteers and ARPKD patients with milder disease. (pkdcure.org)
The Specific Aims are to evaluate T1-MRF across a spectrum of ARPKD liver disease and compare T1-MRF with US measures of liver scarring. (pkdcure.org)
Her clinical and translational research program has focused on identifying novel MRI biomarkers of ARPKD kidney and liver disease progression. (pkdcure.org)
Analysis of missense variants in the PKHD1-gene in patients with autosomal recessive polycystic kidney disease (ARPKD). (medscape.com)
Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis (ARPKD/CHF). (medscape.com)
abstract： OBJECTIVES:Congenital hepatic fibrosis (CHF) is an important cause of morbidity and mortality in patients with autosomal recessive polycystic kidney disease (ARPKD). (shengsci.com)
The autosomal recessive polycystic kidney disease (ARPKD) is characterized by a variable combination of multiple cysts in both kidneys and congenital hepatic fibrosis. (revistamedica.com)
The autosomal recessive form of polycystic kidney disease (ARPKD) is rarer but affects the pediatric population. (basicmedicalkey.com)
Topology of autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) proteins polycystin-1, polycystin-2, and fibrocystin/polyductin (FPC) are shown. (basicmedicalkey.com)

CONCLUSIONS: Although congenital smooth muscle hamartomas of the conjunctiva have been rarely reported in the literature, this is the first described case of a smooth muscle hamartoma presenting in adolescence in the bulbar conjunctiva. (bvsalud.org)
These disorders include congenital hepatic fibrosis, biliary hamartomas, autosomal dominant polycystic liver disease, choledochal cysts and Caroli disease. (kansascity.edu)

Congenital hepatic fibrosis results from a malformation of the ductal plate (the embryological precursor of the biliary system), secondary biliary strictures, and periportal fibrosis. (medscape.com)
Embryogenically, congenital hepatic fibrosis is due to malformation of the duct plate, a round structure appearing in the eighth week of gestation that is formed by primitive hepatocytes, which differentiate into cholangiocytes. (wikipedia.org)
Congenital malformation of the collecting tubules. (mhmedical.com)
Type 1 choledochal cysts are thought to be caused by a congenital impairment or malformation of the bile duct wall, while the exact reason is unknown. (healthcaretip.com)

Congenital hepatic fibrosis is characterized by the intrahepatic form of portal hypertension, which is caused by the intrahepatic obstruction that affects the blood supply to the liver and subsequently leads to the development of cavernous transformations of the portal vein with a rise in portal venous pressure. (medscape.com)
2,3 The list of differential diagnosis included: Progressive Familial Intrahepatic Cholestasis (PFIC), Benign Recurrent Intrahepatic Cholestasis (BRIC), bile acid synthetic disorders, portal vein obstruction, and congenital hepatic fibrosis. (hkjpaed.org)
Fibrosis develops even more rapidly in mechanical biliary obstruction. (msdmanuals.com)
This obstruction can be intrahepatic (intra=within +hepatic=liver), pre-hepatic (pre=before) or post- hepatic (post=after). (hdkino.org)

The hepatic disease progresses to develop portal hypertension associated with splenomegaly and esophageal varices. (medscape.com)
The second is called Caroli syndrome, which consists of Caroli disease and congenital hepatic fibrosis and might lead to portal hypertension leading to esophageal varices and splenomegaly. (raredis.org)

Both theories imply the presence of congenital structural anomalies that are likely to reflect a failure in the hepatobiliary-pancreatic development during embryonic stages. (biomedcentral.com)
Methotrexate has been reported to cause fetal death and/or congenital anomalies. (nih.gov)
Cranioectodermal dysplasia (CED) is a rare developmental disorder characterized by congenital skeletal and ectodermal defects associated with dysmorphic features nephronophthisis hepatic fibrosis and ocular anomalies (mainly retinitis pigmentosa). (globalgenes.org)

Congenital hepatic fibrosis is an inherited fibrocystic liver disease associated with proliferation of interlobular bile ducts within the portal areas and fibrosis that do not alter hepatic lobular architecture. (wikipedia.org)
Since 1988, the American Liver Foundation Marathon Team has made a dramatic impact on the American Liver Foundation's mission to promote education, advocacy, support services and research for the prevention, treatment, and cure of liver disease. (liverfoundation.org)
There are approximately 100 million people in the U.S. affected by liver disease, that's nearly 1 in every 3 Americans. (liverfoundation.org)
Over the last 34 years, ALF's partnership with the Boston Athletic Association has raised more than $40 million in crucial funds for the fight against liver disease. (liverfoundation.org)
The American Liver Foundation team is made up of novice to experienced runners, most of whom have a connection to liver disease . (liverfoundation.org)
We run in honor of our dad, who has Primary Sclerosing Cholangitis (PSC), a rare autoimmune liver disease that currently has no cure and will soon require a liver transplant ," said sisters Emily and Sarah Tully who are the American Liver Foundation 2022 National LIVEr Champions. (liverfoundation.org)
Both times in honor of her father who died of liver disease in 2017. (liverfoundation.org)
She also runs for one of her closest friends, Tracy Broyles, who was diagnosed with liver disease and later passed away at age 32. (liverfoundation.org)
Morrissey, a liver patient was diagnosed with Non-alcoholic Fatty Liver disease, NAFLD. (liverfoundation.org)
Psoriasis and liver disease often go hand and hand. (audience.pics)
Many psoriasis patients develop liver disease. (audience.pics)
Patients with moderate or severe psoriasis have a high prevalence of chronic liver disease. (audience.pics)
Psoriasis patients are at a higher risk of developing liver disease due to various reasons. (audience.pics)
Fibropolycystic Liver Disease in Children" by Myka Call Veigel, Julia Prescott-Focht et al. (kansascity.edu)
We present a discussion and illustrations of the embryology, genetics, anatomy, pathology, imaging approach and key imaging features that distinguish fibropolycystic liver disease in children. (kansascity.edu)
In rare cases, liver cysts may indicate a serious, underlying condition such as polycystic liver disease (an inherited disorder associated with multiple cysts of varying size), echinococcosis (parasitic infection), or liver cancer. (mygoodgut.com)
Patients with Chronic Liver Disease (CLD) frequently experience neurologic sequel, usually associated with extensive portosystemic shunt of blood, a liver bypass either by portosystemic anastomosis or as a result of the development of an extensive portosystemic collateral circulation. (openventio.org)
Whether you are a patient, a caregiver, a friend or a loved one of someone with a liver disease we believe your story is important. (livercoalition.org)
Laura's Story: Fatty Liver Disease Steatohepatitis In 2009 I went to the doctor's office for a routine physical exam. (livercoalition.org)
That is when I received the diagnosis of a fatty liver disease medically known as Steatohepatitis. (livercoalition.org)
The aim of the study was to assess serum hyaluronic acid (HA) and transforming growth factor beta 1 (TGF-β1) concentrations: 1) to differentiate hepatic fibrosis from other forms of liver disease, and 2) for the non-invasive staging of canine liver fibrosis. (researcher.life)
It is the onset of symptoms associated with liver disease that might cause the health care professional to look for the presence of portal hypertension . (hdkino.org)
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. (bvsalud.org)
The unique nature of inherited and acquired liver diseases in infants and children are now recognized, thanks in part to greater insight into hepatobiliary physiology and the development of more precise approaches to the diagnosis and management of liver disease in infants and children, including both liver transplantation and nontransplant treatment options. (medscape.com)
NAFLD is now the most common liver disease in adults in the United States, affecting 20%-40% of the population. (medscape.com)

Associated conditions include renal cystic disease, choledochal cysts, and cholangiocarcinoma. (qxmd.com)
The Caroli syndrome is characterized by both type V choledochal cysts and congenital hepatic fibrosis. (healthcaretip.com)
Congenital dilatation of the bile ducts (choledochal cyst/CDD) result in bile retention, with cholangitis, pancreatitis and malignancies as associated complications. (biomedcentral.com)

We excluded congenital hypertrophy of the retinal pigment epithelium (CHRPE) from our differential diagnosis, as solitary CHRPE is a flat well-demarcated lesion at the level of retinal pigment epithelium (RPE). (bvsalud.org)
Our final diagnosis was simple congenital hamartoma of RPE. (bvsalud.org)
Inflammatory bowel disease in children and adolescents: recommendations for diagnosis--the Porto criteria. (shengsci.com)
Autosomal recessive polycystic kidney disease, bilateral renal cysts, prenatal diagnosis of multicystic disease. (revistamedica.com)
In many areas, enteritis due to s aureus focal infection, such as the world and are favored in severe combined immunodeficiency diseases scid that encompass congenital diseases caused by klebsiella granulomatis, a gram-negative bacillus that produces highly detailed pancreatic images, the posterior pharyngeal wall confirms the diagnosis. (elastizell.com)
It is a slow-growing cancer that invades local structures and for that reason, the diagnosis is often made late in the disease process when the bile ducts become blocked. (brainandnervecenter.com)

Congenital hepatic fibrosis is included in the group of congenital diseases of fibropolycystic disorders. (biomedcentral.com)
Fibropolycystic liver diseases are a group of associated congenital disorders that present most often in childhood. (kansascity.edu)
The polycystic kidney diseases are a group of genetically heterogeneous disorders and a leading cause of kidney failure. (basicmedicalkey.com)
Congenital disorders of glycosylation. (lookformedical.com)

This protein complex has also been implicated in regulating a number of signaling pathways, including Wnt, mammalian target of rapamycin (mTOR), STAT3, cMET, phosphoinositide 3-kinase (PI3K)/AKT, G protein-coupled receptor (GPCR), and epidermal growth factor receptor (EGFR), as well as in the localization and activity of cystic fibrosis transmembrane conductance (CFTR). (basicmedicalkey.com)
Cystic fibrosis (CF) is a disease of exocrine gland function that involves multiple organ systems but chiefly results in chronic respiratory infections, pancreatic enzyme insufficiency, and associated complications in untreated patients. (medscape.com)
Chest radiograph of a patient with advanced cystic fibrosis. (medscape.com)

A new neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys, is decribed. (hum-molgen.org)

Lipschitz B, Berdon WE, Defelice AR, Levy J. Association of congenital hepatic fibrosis with autosomal dominant polycystic kidney disease. (medscape.com)
The autosomal dominant form of polycystic kidney disease (ADPKD) is the most common life-threatening monogenic disease, affecting 12 million people worldwide. (basicmedicalkey.com)

The patient was already diagnosed with Caroli disease and polydactyly (six fingers on each limb) when she was born. (raredis.org)
Type V or Caroli disease, refers to a congenital polycystic dilatation only affecting intra hepatic biliary ducts. (biomedcentral.com)

It is the most common genetically determined childhood cystic disease of the kidneys. (mhmedical.com)
Our data supports a strong genetic basis for CDD and show that CDD is not only genetically heterogeneous but also non-monogenic, requiring mutations in more than one genes for the disease to develop. (biomedcentral.com)

It may dispose patients with coronary artery disease to cardiac ischemia. (medscape.com)
Conclusion Late hepatic dysfunction and cirrhotic change were often seen in Fontan patients. (bmj.com)
Ulcerative colitis and Crohn disease may present before the age of 20 years in 25% to 30% of all patients with inflammatory bowel disease. (shengsci.com)
1 The serum GGT levels in patients with PFIC-3, Multidrug Resistance Gene 3 (MDR3)-deficient disease, are high. (hkjpaed.org)
We also evaluated the association between serum HA concentration and the size of the shunt vessel as an indirect marker of decreased liver clearance in patients with single congenital vascular anomaly. (researcher.life)
Two patients developed liver fibrosis in their first year of life. (nature.com)
Two patients with truncating mutations had liver fibrosis that in one patient resolved on treatment with the Src kinase inhibitor dasatinib. (nature.com)

Coronary artery disease is a notable undesirable effect. (medscape.com)
Once in the liver, the portal vein and hepatic artery (which accounts for 25% of the liver's blood supply) come together to form sinusoids, spaces where the blood is filtered. (hdkino.org)

The most characteristic ultrasound findings are bilateral nephromegaly, symmetrical findings, small multiple cysts, loss of medullary cortical differentiation, lack of bladder filling, hepatomegaly, dilation of bile ducts and peritoneal fibrosis. (revistamedica.com)
Other diseases can sometimes look like liver cysts, so it is necessary to seek medical attention in order to rule out more problematic diseases. (mygoodgut.com)
Kidney cysts are often seen in a wide range of syndromic diseases. (basicmedicalkey.com)

Additionally, prevents increases in portal pressure (hepatic venous pressure gradient) during physical exertion. (medscape.com)
Chapter the respiratory system in infants is self-limited, but may depend on the surface area bp = systemic blood pressure associ-ated with malignancy, prior venous thromboembolic disease, and diabetes mellitus and the incidence of preterm pda. (elastizell.com)
Portal hypertension is defined by a hepatic venous pressure gradient (HVPG) greater than 5 mmHg. (gastrotraining.com)

However, the exact pathogenesis of association between congenital hepatic fibrosis and ADPKD still requires further research and study. (medscape.com)
Repurposing drugs that target inflammatory cytokines has confirmed the prominent roles of pro-inflammatory cytokines, including IL-1, Type-I IFN, and TNF in the disease pathogenesis of autoinflammatory diseases, and identified the inflammasome and viral sensors as novel targets for drug development 2 . (nature.com)

Enfermedad hepática en la que hay destrucción, de magnitud variable, de la microcirculación, la anatomía vascular macroscópica y de la arquitectura hepática normales que resultan alteradas por septos fibrosos que rodean nódulos parenquimatosos regenerativos o en regeneración. (bvsalud.org)

The association of liver diseases, polydactyly, and congenital heart diseases is extremely rare and is only documented few times in the literature. (raredis.org)

citation needed] Management includes control of esophageal bleeding/varices and treatment of associated renal disease if present. (wikipedia.org)
Type V is considered as a distinct entity as, unlike the other types, is usually associated with both cystic renal disease and liver fibrosis (Caroli syndrome). (biomedcentral.com)

Increased expression of transforming growth factor-beta1 and thrombospondin-1 in congenital hepatic fibrosis: possible role of the hepatic stellate cell. (medscape.com)
Activation of the hepatic perivascular stellate cells (Ito cells, which store fat) initiates fibrosis. (msdmanuals.com)

Commonly, fibrosis progresses, disrupting hepatic architecture and eventually function, as regenerating hepatocytes attempt to replace and repair damaged tissue. (msdmanuals.com)
even when fulminant, does not necessarily distort the scaffolding architecture and hence does not cause advanced fibrosis, despite loss of hepatocytes. (msdmanuals.com)
Fibrous tracts join branches of afferent portal veins and efferent hepatic veins, bypassing the hepatocytes and limiting their blood supply. (msdmanuals.com)
5% of hepatocytes displaying steatosis in the absence of significant ethanol intake and metabolic disease or toxic injury. (medscape.com)

During admission, she developed abdominal pain, worsening abdominal distention and hepatic encephalopathy. (biomedcentral.com)
The most common and widely recognized is the reversible syndrome of Hepatic Encephalopathy (HE). (openventio.org)
Tom's Story: Hepatic Encephalopathy Congenital Hepatic Fibrosis. (livercoalition.org)

In 1958 Jacques Caroli described communicating cavernous ectasia of the biliary tree as an uncommon cause of chronic, often life-threatening hepatobiliary disease. (qxmd.com)
After months or years of chronic or repeated injury, fibrosis becomes permanent. (msdmanuals.com)
Liver fibrosis is characterized by excessive accumulation of extracellular matrix (ECM) which results from both increased synthesis and decreased degradation of ECM and is observed in most types of chronic liver diseases (Liu et al 2012). (researcher.life)
Methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis, is a potentially dangerous lesion, which may occur acutely at any time during therapy and has been reported at low doses. (nih.gov)
Diseases that can cause this type of chronic inflammation include primary sclerosing cholangitis and chronic parasite infections. (brainandnervecenter.com)

Because of the variable clinical presentations, congenital hepatic fibrosis is believed to represent a broad spectrum of hepatic and renal lesions rather than a single clinical entity. (medscape.com)
Skeletal muscle hypertonicity may be associated with PYRAMIDAL TRACT lesions or BASAL GANGLIA DISEASES. (lookformedical.com)

The different phenotypic expressions of this disease are due to multiple mutations of this gene 3. (revistamedica.com)

Did you know that Downs' syndrome is a condition or a syndrome, not a disease? (cram.com)

These include a broad spectrum of clinical diseases which are usually accompanied by hepatic involvement. (biomedcentral.com)
Objective To identify the prevalence, clinical characteristics, risk factors of hepatic complications after a Fontan operation. (bmj.com)
For a list of clinical trials in this disease area, please click here . (globalgenes.org)

The family of fibropolycystic diseases are characterized by varying degrees of persistent bile duct structures, fibrosis, and duct dilatation. (medscape.com)

Congenital hepatic fibrosis is an uncommon cause of portal hypertension. (biomedcentral.com)

citation needed] The condition is usually congenital, but sporadic cases have also been reported. (wikipedia.org)
Congenital dilatation of the bile-duct (CDD) is a rare, mostly sporadic, disorder that results in bile retention with severe associated complications. (biomedcentral.com)

Pathologically, it is defined by its variable degree of periportal fibrosis and irregularly shaped proliferating bile ducts. (medscape.com)
Gradual disappearance of bile duct profiles associated with increased periportal fibrosis results from a progressive destructive cholangiopathy that involves the immature bile duct structures. (medscape.com)
In biopsy there is diffuse periportal and perilobular fibrosis in broad bands, containing distorted duct like structure or microcyst formation. (wikipedia.org)

Investigations biochemical studies on congenital hepatic fibrosis, see table. (albionfoundation.org)

The fibrosis would affect resistance in portal veins leading to portal hypertension. (wikipedia.org)

Autosomal recessive PKD is a neonatal disease that has been associated to a gene map locus at 6p21.1-p12. (mhmedical.com)

It is considered a rare disease with an incidence rate of 1 in 1,000,000 births. (raredis.org)

It may be associated with other congenital defects, commonly with autosomal recessive polycystic kidney disease, the most severe form of PKD. (wikipedia.org)
Defects in the primary cilia are linked to a wide spectrum of human diseases, collectively termed ciliopathies. (basicmedicalkey.com)

Anatomy6

Organisms2

Diseases17

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Cirrhosis14

Caroli's7

Intrahepatic bile3

ARPKD18

Hamartomas2

Malformation4

Obstruction4

Esophageal varices2

Anomalies3

Liver disease25

Choledochal3

Diagnosis6

Disorders4

Cystic fibrosis3

Polycystic kidneys1

Autosomal dominant2

Caroli Disease2

Genetically2

Patients7

Artery2

Cysts3

Venous3

Pathogenesis2

Vascular1

Polydactyly1

Renal disease2

Stellate2

Hepatocytes4

Encephalopathy3

Chronic5

Lesions2

Mutations1

Syndrome1

Clinical3

Fibropolycystic1

Uncommon cause1

Sporadic2

Periportal3

Biochemical1

Portal veins1

Neonatal1

Incidence1

Defects2