• APOE encodes a secreted apolipoprotein involved in lipid metabolism. (alzforum.org)
  • Every person has an APOE genotype determined by pairs of these alleles: APOE3/E3 (the most common), APOE3/E4, APOE3/E2, APOE2/E4, APOE4/E4, or APOE2/E2. (alzforum.org)
  • Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
  • This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
  • Understanding the mutations in APOE, their structural properties, and their isoforms is important to determine its role in various diseases and to advance the development of therapeutic strategies. (dovepress.com)
  • Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans. (dovepress.com)
  • The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
  • Several major APOE isoforms can be distinguished: E2, E3, and E4. (dovepress.com)
  • 3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
  • The so-called human apolipoprotein E (APOE) gene encodes instructions for creating the homonymous protein. (medicalnewstoday.com)
  • The variant E4 of the APOE gene significantly raises a person's risk of developing Alzheimer's disease . (medicalnewstoday.com)
  • In the new study, the scientists used mouse models of Alzheimer's disease with an activated version of the E4 or E3 variant of the APOE gene. (medicalnewstoday.com)
  • This test determines a person's genetic risk for heart disease associated with the commonly studied gene called apoE, which is involved in the metabolism of cholesterol and triglycerides (fats in the blood). (news-medical.net)
  • Six possible apoE genotypes exist: e2/e2, e2/e3, e2/e4, e3/e3, e3/e4 and e4/e4. (news-medical.net)
  • The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (medlineplus.gov)
  • The e4 version of the APOE gene increases an individual's risk for developing late-onset Alzheimer's disease. (medlineplus.gov)
  • The APOE e4 allele may also be associated with an earlier onset of memory loss and other symptoms compared to individuals with Alzheimer's disease who do not have this allele. (medlineplus.gov)
  • It is not known how the APOE e4 allele is related to the risk of Alzheimer's disease. (medlineplus.gov)
  • It is important to note that people with the APOE e4 allele inherit an increased risk of developing Alzheimer's disease, not the disease itself. (medlineplus.gov)
  • Not all people with Alzheimer's disease have the APOE e4 allele, and not all people who have this allele will develop the disease. (medlineplus.gov)
  • It is thought that the apolipoprotein E produced from the e4 allele of the APOE gene may disrupt the transport of a protein called alpha-synuclein into and out of cells. (medlineplus.gov)
  • It is unclear why some people with the APOE e4 allele develop Alzheimer's disease while others develop dementia with Lewy bodies. (medlineplus.gov)
  • For example, APOE alleles have been shown to influence the risk of cardiovascular diseases. (medlineplus.gov)
  • SNPing away at complex diseases : analysis of single-nucleotide polymorphisms around APOE in Alzheimer's disease. (medecinesciences.org)
  • The APOE gene encodes the Apolipoprotein E protein, which is a major component of chylomicrons and VLDLs (Very Low-Density Lipoproteins). (dnaaccesslab.com)
  • Genetic variations in the APOE gene can influence an individual's predisposition for developing high LDL cholesterol, Type III Hyperlipoproteinemia type III and cardiovascular disease. (dnaaccesslab.com)
  • APOE e2 , APOE e3 and APOE e4 , which differ at two locations in the sequence. (dnaaccesslab.com)
  • Determine whether you carry the APOE genetic variant linked to cardiovascular disease. (dnaaccesslab.com)
  • Homozygous APOE e2 alleles are associated with lower LDL cholesterol levels, and lower incidence of coronary heart disease. (dnaaccesslab.com)
  • The APOE e3 allele is the most commonly observed allele, and is not associated with elevated LDL cholesterol or hyperlipoproteinemia type III. (dnaaccesslab.com)
  • The APOE e4 allele is associated with elevated LDL cholesterol levels, which can lead to increased risk of developing atherosclerosis and cardiovascular disease. (dnaaccesslab.com)
  • The apolipoproteinE (APOE) gene provides instructions for the production of the apolipoprotein E (apoE) protein. (randox.com)
  • Apolipoprotein E (apoE) is a multifunctional glycoprotein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. (randox.com)
  • APOE test can diagnose the presence of the APOE4 variant causing enhanced risk of Alzheimer's disease. (redcliffelabs.com)
  • Certain variants of the APOE gene are associated with an increased risk of developing certain diseases, such as Alzheimer's and cardiovascular disease. (redcliffelabs.com)
  • How is the Apolipoprotein-E (APOE) test performed? (redcliffelabs.com)
  • Twenty patients with Alzheimer's disease (AD) with defined apolipoprotein E (APOE), α 1 -antichymotrypsin (ACT) and presenilin-1 (PS-1) intronic genotypes were examined to quantify the regional cerebral metabolic rate of glucose (rCMRglc) by using positron emission tomography (PET) and 18 F-2-fluoro-2-deoxy-D-glucose (FDG). (elsevierpure.com)
  • abstract = "Twenty patients with Alzheimer's disease (AD) with defined apolipoprotein E (APOE), α1-antichymotrypsin (ACT) and presenilin-1 (PS-1) intronic genotypes were examined to quantify the regional cerebral metabolic rate of glucose (rCMRglc) by using positron emission tomography (PET) and 18F-2-fluoro-2-deoxy-D-glucose (FDG). (elsevierpure.com)
  • Apolipoprotein E (ApoE) is involved on cholesterol and triglycerides metabolism regulation. (biomedcentral.com)
  • The characteristic components of the syndrome are mostly determined by apolipoprotein E (ApoE) modulation of atherogenic plasma Apo-B containing lipoproteins. (biomedcentral.com)
  • Like other apolipoproteins, APOE is involved in lipid binding, and it is the predominant cholesterol transporter in the brain. (j-alz.com)
  • Earlier studies were associated with Apolipoprotein E ( ApoE ) in variable diseases. (edu.pl)
  • The current study aims to investigate the genetic association between FH disease and ApoE gene (rs429358 and rs7412) in the Saudi population. (edu.pl)
  • ApoE gene polymorphism and its relationship with coronary artery disease in ethnic Kashmiri population. (edu.pl)
  • The APOE gene encodes Apolipoprotein E, a protein involved in injury repair and transporting fats between brain cells. (dnaaccesslab.com)
  • There are three forms or alleles of APOE - e2, e3 and e4 . (dnaaccesslab.com)
  • Apolipoprotein E (ApoE) is the strongest genetic risk factor for Alzheimer's disease and has been implicated in the risk for other neurological disorders. (wustl.edu)
  • The three common ApoE isoforms (ApoE2, E3, and E4) each differ by a single amino acid, with ApoE4 increasing and ApoE2 decreasing the risk of Alzheimer's disease (AD). (wustl.edu)
  • Therefore, quantifying ApoE isoform production and clearance rates may advance our understanding of the role of ApoE in health and disease. (wustl.edu)
  • Variants in the apolipoprotein E gene ( APOE ) are the strongest known genetic factors for Alzheimer's disease. (biomedcentral.com)
  • Extensive studies have demonstrated that APOE has three forms: e2 - a rare allele in the general population and is associated with the protection against developing the disease, e3 - the most common form in the population has a neutral effect on disease risk, and e4 - a moderately common allele that increases risk for by more than 5-fold per copy. (biomedcentral.com)
  • Apolipoprotein E (ApoE) a protein component of bloodstream lipid particles has an important function in lipid transportation. (careersfromscience.org)
  • Of the common HhAntag ApoE alleles in the overall Qatari populace E3 dominated with E4 becoming more common than E2 (Table 1). (careersfromscience.org)
  • Triglycerides (TGs) are proatherogenic lipoproteins involving the risk of coronary heart disease (CHD), while apolipoprotein A5 (APOA5) and apolipoprotein C3 (APOC3) are main lipoproteins composing TG-rich lipoproteins. (biomedcentral.com)
  • Coronary heart disease (CHD), also known as coronary atherosclerotic heart disease is a kind of thrombotic arterial disease, caused by hypoxia and myocardial ischemia owing to coronary atherosclerotic mediated vascular obstruction as well as coronary functional change [ 1 , 2 ]. (biomedcentral.com)
  • The impact of common variants in the apolipoprotein gene cluster (APOC3-A4-A5) on prospective coronary heart disease (CHD) risk was examined in healthy UK men. (nih.gov)
  • The case fatality rate for coronary heart disease and other CVDs is higher in India than in the developed countries. (hindawi.com)
  • Next generation sequencing to identify novel genetic variants causative of autosomal dominant familial hypercholesterolemia associated with increased risk of coronary heart disease. (edu.pl)
  • Some previous data do not support the liter- process in the determination of morbidity ature suggesting adverse effects of omega-3 and mortality from coronary heart disease fatty acids on lipid peroxidation [ 2,21,35 ]. (who.int)
  • Moreover, apolipoprotein genotype analysis revealed that AD subjects with the E3/E4 alleles had the highest content of mitochondrial APP. (jneurosci.org)
  • It is best known for its three major alleles-APOE2, APOE3, and APOE4 -with APOE4 increasing the risk for Alzheimer's disease and APOE2 reducing it. (alzforum.org)
  • The major alleles are called e2, e3, and e4. (medlineplus.gov)
  • Both apoE2 and apoE4 alleles are associated with cardiovascular disease (CVD). (randox.com)
  • The Apo-E gene comes in three different forms, known as alleles: E2, E3, and E4. (redcliffelabs.com)
  • Various combinations of these alleles can affect a person's risk of developing heart disease or Alzheimer's disease. (redcliffelabs.com)
  • Apo E has three different alleles (E2, E3 and E4) determining different and complex associations with clinical phenotype expressions. (biomedcentral.com)
  • From the 1012 Caucasians nothing had the R145C polymorphism on the normal E2 E4 or E3 alleles. (careersfromscience.org)
  • Apolipoprotein E4 (apoE4), the major genetic risk factor of Alzheimer's disease (AD), is associated with enhanced brain inflammation. (nih.gov)
  • This study aimed to describe and characterize the published literature on disparities between racial and ethnic groups among individuals with Alzheimer's disease and related dementias. (hhs.gov)
  • The literature shows consistent and adverse disparities among blacks and Hispanics compared to non-Hispanic whites in the prevalence and incidence of Alzheimer's disease, mortality, participation in clinical trials, use of medications and other interventions, use of long-term services and supports, health care expenditures, quality of care, and caregiving. (hhs.gov)
  • Although these disparities are well known, little is known about the effectiveness of various strategies, such as cultural competence training, to address these differences within the context of Alzheimer's disease, with almost no studies available that evaluate possible interventions. (hhs.gov)
  • Existing evidence for Alzheimer's disease and related dementias suggests that there are significant differences in prevalence, incidence, treatment, and mortality of Alzheimer's disease across racial and ethnic groups. (hhs.gov)
  • Reelin may also play a role in Alzheimer's disease, temporal lobe epilepsy and autism. (wikipedia.org)
  • citation needed] There followed a series of speculative reports linking reelin's genetic variation and interactions to schizophrenia, Alzheimer's disease, autism and other highly complex dysfunctions. (wikipedia.org)
  • In this review, we provide information about the associations of physical activity (PA) with major age-related neurodegenerative diseases and syndromes, including Alzheimer's disease, vascular dementia, and mild cognitive impairment. (mdpi.com)
  • [5] Alzheimer's disease is considered the most common cause of dementia ( see "Diagnosing Dementia" shaded box below ), but according to most dementia experts, "the vast majority of dementia cases, especially those occurring late in life, tend to involve a mixture of Alzheimer's disease, vascular disease, and other degenerative factors. (citizen.org)
  • Our studies indicate that Alzheimer's disease can arise from a combination of genetics, poor diet, and environmental stress, under conditions where no single one of these factors would induce the disease. (uml.edu)
  • Mitochondrial dysfunction is one of the major intracellular lesions of Alzheimer's disease (AD). (jneurosci.org)
  • This database is a repository of variants in genes implicated in Alzheimer's disease (AD). (alzforum.org)
  • Mutations in APP are associated with familial forms of early onset Alzheimer's disease as well as with Cerebral Amyloid Angiopathy (CAA). (alzforum.org)
  • MAPT encodes the microtubule associated protein tau, a protein central to Alzheimer's disease neuropathology. (alzforum.org)
  • More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most common cause of early onset Alzheimer's disease. (alzforum.org)
  • Missense mutations in PSEN2 are a rare cause of early onset Alzheimer's disease. (alzforum.org)
  • Multiple studies have associated rare, putative loss-of-function variants in SORL1 with an increased risk of Alzheimer's disease. (alzforum.org)
  • TREM2 variants cause Nasu-Hakola disease (NHD), a rare autosomal recessive early-onset dementia, and may modify the risk of developing Alzheimer's disease (AD), frontotemporal dementia (FTD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). (alzforum.org)
  • Partners in the initiative include experts at Weill Cornell's Helen and Robert Appel Alzheimer's Disease Research Institute, Washington University in St. Louis, The Feinstein Institute for Medical Research, and the University of British Columbia. (genengnews.com)
  • Alzheimer's disease can affects a person's mood, thinking, and behavior, as well as their overall personality , disposition, and sense of self. (psychologytoday.com)
  • According to the DSM-5 , Alzheimer's disease can be classified as either a major or mild neurocognitive disorder, based on the severity of cognitive decline that is observed. (psychologytoday.com)
  • We Americans seem to have an abundance of things to worry about.There is the threat of another attack from crazed, fanatical terrorists looming in our collective psyches, as is the current downward trend in the economy.But there is another threat even more imminent that is facing many of those in the baby boomer generation.That threat is Alzheimer's disease (AD). (ironmanmagazine.com)
  • Alzheimer's disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. (medlineplus.gov)
  • A buildup of amyloid plaques may lead to the death of nerve cells (neurons) and the progressive signs and symptoms of Alzheimer's disease. (medlineplus.gov)
  • Journal of Alzheimer's disease : JAD. (lu.se)
  • Susceptibility locus for Alzheimer's disease on chromosome 10. (medecinesciences.org)
  • Apolipoprotein E and Alzheimer's disease. (medecinesciences.org)
  • ApoE4 is the major genetic risk factor, or causative gene, for Alzheimer's disease (AD) and other neurological disorders, including poor clinical outcomes following traumatic brain injury, stroke, frontotemporal dementia, Down syndrome, certain patients with Parkinson's disease, and Lewy body disease 3 . (randox.com)
  • The Apo-E blood test is usually recommended to help evaluate a person's risk of developing heart disease or certain types of Alzheimer's disease. (redcliffelabs.com)
  • Alzheimer's disease (AD) is the most common form of dementia with symptoms that are severe enough to cause serious health deterioration. (hkmj.org)
  • Apolipoprotein E gene allele 4 (APOE4) is a major genetic risk factor for late-onset Alzheimer's disease (AD). (j-alz.com)
  • Association of apolipoprotein E genetic variation in Alzheimer's disease in Indian population: a meta-analysis. (edu.pl)
  • What are the risk factors for late-onset Alzheimer's disease? (dnaaccesslab.com)
  • The presence of the e4 allele is linked to an increased risk of Alzheimer's disease, whereas the e2 allele has a protective affect. (dnaaccesslab.com)
  • The purpose of this study was to evaluate cholesterol esterification and HDL subclasses in plasma and cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients. (biomedcentral.com)
  • The metabolic derangement that leads to type 2 diabetes also helps foster and promote heart disease, cancer, and Alzheimer's disease. (sameerbajaj.com)
  • In the last decade several genetic risk factors for Alzheimer's disease have been found by comparing cases with normal controls. (biomedcentral.com)
  • Now, in a research article published in Genome Medicine , researchers have taken the opposite approach by examining elderly people with a high risk of for Alzheimer's disease who remain cognitively healthy. (biomedcentral.com)
  • It is known that genetics plays an important role in risk for Alzheimer's disease, and having a parent or sibling with the disease increases your risk by about 3-fold. (biomedcentral.com)
  • Nearly half of the genetic risk for Alzheimer's disease remains unexplained. (biomedcentral.com)
  • To date these variants have not led to effective therapies and nearly half of the genetic risk for Alzheimer's disease remains unexplained. (biomedcentral.com)
  • In a recent study, a team of researchers are tackling the problem from a different angle, asking why some elderly people that are very high risk for Alzheimer's disease remain cognitively healthy. (biomedcentral.com)
  • The Cache County Study, which includes over 5,000 subjects over the age of 65 who have 15 years of longitudinal cognitive assessment, was used to identify individuals who exhibit Alzheimer's disease resilience. (biomedcentral.com)
  • The goal was to find families with above-average rates of Alzheimer's disease that also had at least four people who were resilient to the disease and several relatives who died from Alzheimer's disease. (biomedcentral.com)
  • The key question was simple, "Do these resilient people have something unique in their DNA that is protecting them from Alzheimer's disease? (biomedcentral.com)
  • The team then found areas of the DNA that were shared among resilient members of the family and absent in those who had Alzheimer's disease. (biomedcentral.com)
  • To compare the general clinical conditions and oral alterations, and also evaluate the prosthesis, in subjects diagnosed with Alzheimer's disease (AD) or Parkinson's disease (PD), attended at two geriatric centers in the city of Fortaleza - Ceará. (bvsalud.org)
  • The most common cause of dementia is Alzheimer's Disease (AD) accounting for 60% to 70% of cases, followed by vascular dementia, dementia with Lewy bodies, and frontotemporal dementia 1-2 . (bvsalud.org)
  • The most common allele is e3, which is found in more than half of the general population. (medlineplus.gov)
  • Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type. (medecinesciences.org)
  • The e3 allele is the most of the three and may be considered an ancestral allele. (randox.com)
  • When genotypic distribution was analyzed, E3/3 genotype and E3 allele frequencies were more prevalent. (biomedcentral.com)
  • In fact, epidemiological studies suggested that E4 allele carriers were particularly predisposed to develop higher cholesterol levels and higher coronary artery disease (CAD) mortality, meanwhile others studies concluded E3 and E4 alellles presences were associated with higher risk in men. (biomedcentral.com)
  • Most had been over the E3 allele (E3?E4). (careersfromscience.org)
  • A recent alarming rise of neurodegenerative diseases in the developed world is one of the major medical issues affecting older adults. (mdpi.com)
  • In my laboratory researchers are examining the roles played by axonal cytoskeletal proteins in nervous system development, and in the etiology of Alzheimer's and other related neurodegenerative diseases. (uml.edu)
  • The neurodegenerative diseases candidates acquired from Link Medicine are designed to target famesyltransferase, and so modulate autophagy, a process that could have applications against Parkinson and Alzheimer diseases, which are characterized by the build up of neurotoxic aggregates of incorrectly folded proteins. (genengnews.com)
  • Link is focused on the development of disease-modifying drugs that prevent or reduce protein aggregates involved in specific neurodegenerative diseases. (genengnews.com)
  • Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses. (uwo.ca)
  • Alzheimer disease (AD) is a neurodegenerative disorder marked by cognitive and behavioral impairment that significantly interferes with social and occupational functioning. (medscape.com)
  • The odds are overwhelming that you will die as a result of one of the chronic diseases of aging that I call the Four Horsemen: heart disease, cancer, neurodegenerative disease, or type 2 diabetes and related metabolic dysfunction. (sameerbajaj.com)
  • Elderly patients with AD and PD have poor oral health, as well as those without neurodegenerative diseases. (bvsalud.org)
  • citation needed] The Reelin receptors, apolipoprotein E receptor 2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR), were discovered by Trommsdorff, Herz and colleagues, who initially found that the cytosolic adaptor protein Dab1 interacts with the cytoplasmic domain of LDL receptor family members. (wikipedia.org)
  • These genes encode apolipoprotein (apo) C-II and A-V, lipase maturation factor 1 (LMF1), and glycosylphosphatidylinositol-anchored high-density lipoprotein (HDL)-binding protein 1 (GPIHBP1). (ptcbio.com)
  • Apolipoprotein-E is a protein responsible for producing lipoproteins, which carry cholesterol and other fats through the bloodstream. (redcliffelabs.com)
  • Both variants are rare and both genes ( RAB10 and SAR1A) interact with amyloid precursor protein, which is thought to be key in the development of the disease. (biomedcentral.com)
  • Proteins enriched in HDL from patients with ESRD (ESRD-HDL) included surfactant protein B (SP-B), apolipoprotein C-II, serum amyloid A (SAA), and α-1-microglobulin/bikunin precursor. (lww.com)
  • Variants of apolipoprotein E have been studied extensively as risk factors for many different conditions. (medlineplus.gov)
  • Variants in the apolipoprotein A1 ( APOA1 ) gene play an important role in the regulation of lipids. (biomedcentral.com)
  • They find that rare variants in the RAB10 gene may provide protection from the disease. (biomedcentral.com)
  • AstraZeneca's recently established Neuroscience Innovative Medicines Unit (iMed) has expanded its R&D capabilities through the acquisition of a portfolio of preclinical and clinical small molecule candidates from Link Medicine, and the separate establishment of an Alzheimer disease research consortium with four academic research laboratories. (genengnews.com)
  • AstraZeneca's new Alzheimer disease research consortium, dubbed the A5 alliance, will focus on investigating the relationship between apolipoprotein E and Alzheimer disease, and ultimately aims to identify and validate drug targets. (genengnews.com)
  • We are convinced that ApolE represents a major piece of the Alzheimer disease puzzle and that each member of the A5 alliance brings a critical piece of that puzzle to the table. (genengnews.com)
  • The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease. (medecinesciences.org)
  • Linkage studies in familial Alzheimer disease : evidence for chromosome 19 linkage. (medecinesciences.org)
  • Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. (medecinesciences.org)
  • Coronal T1-weighted magnetic resonance imaging (MRI) scan in a patient with moderate Alzheimer disease. (medscape.com)
  • Alzheimer disease (AD) is an acquired disorder of cognitive and behavioral impairment that markedly interferes with social and occupational functioning. (medscape.com)
  • Foram analisados 70 pacientes (entre 57 à 91 anos) com Doença Alzheimer e Doença Parkinson, por meio de avaliação de prontuários neurológicos e exame clinico oral. (bvsalud.org)
  • The literature suggests numerous underlying causes, including factors related to measurement of the disease, genetics, socioeconomic factors, cultural differences, lack of culturally competent providers, and discrimination. (hhs.gov)
  • Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management? (mdpi.com)
  • Apolipoprotein A5 gene polymorphism (rs662799) and cardiovascular disease in end-stage kidney disease patients. (cdc.gov)
  • ABSTRACT Hyperhomocysteinaemia is considered as an important independent risk factor for atherosclerosis and thrombotic disease. (who.int)
  • Bilingualism in Parkinson's disease: Relationship to cognition and quality of life. (uwo.ca)
  • Senthinathan A, Adams S, Page AD, Jog M. Speech Intensity Response to Altered Intensity Feedback in Individuals With Parkinson's Disease. (uwo.ca)
  • Kulshreshtha D, Pieterman M, Gilmore G, Jog M. Optimizing the selection of Parkinson's disease patients for neuromodulation using the levodopa challenge test. (uwo.ca)
  • Knowles T, Adams SG, Jog M. Variation in Speech Intelligibility Ratings as a Function of Speech Rate Modification in Parkinson's Disease. (uwo.ca)
  • Bernardinis M, Atashzar SF, Patel RV, Jog MS. Abnormal Vision-Based Displacement Perception in Parkinson's Disease. (uwo.ca)
  • and movement problems characteristic of Parkinson's disease such as rigidity of limbs, tremors, and impaired balance and coordination. (medlineplus.gov)
  • Today, dementia is increasingly recognized - as most chronic diseases are - as a result of multiple factors. (citizen.org)
  • There is considerable evidence for a pro- fatty acids in the diet as food additives or tective effect of dietary omega-3 fatty acids as therapeutic substances, it is important in the prevention of heart disease [ 12-15 ], to determine the extent of any effects, and especially in a high-risk population [ 16,17 ]. (who.int)
  • Reelin has been suggested to be implicated in pathogenesis of several brain diseases. (wikipedia.org)
  • BACKGROUND: Although there have been significant advances for clarifying the pathogenesis of psoriasis, exact pathogenic mechanism of the disease is still unknown. (bvsalud.org)
  • Todos os indivíduos participantes foram submetidos à avaliação de rigidez e distensibilidade arterial por mensuração da velocidade de onda de pulso (VOP) carótido-femoral e echo-tracking da artéria carótida comum direita. (usp.br)
  • Animais foram expostos à fumaça de cigarro e suplementados trans-resveratrol (6,0 mg kg-1) durante dois meses. (bvsalud.org)
  • Apolipoprotein A1 (apoA1) is the major apolipoprotein constituent of the high-density lipoprotein (HDL) and is involved in reverse cholesterol transport [ 15 ]. (biomedcentral.com)
  • Maintaining normal levels of cholesterol is essential for the prevention of disorders that affect the heart and blood vessels (cardiovascular diseases), including heart attack and stroke. (medlineplus.gov)
  • The control group was composed of age and sex matched healthy subjects who had undergone a coronary angiography in the same recruitment period as the CAD patients, with normal ECG, negative stress test, without family history of CAD or other cardiovascular diseases or angiographic evidence of CAD. (biomedcentral.com)
  • However, APOE2 carriers could develop type III hyperlipoproteinemia and exhibit increased risk of cerebrovascular diseases and neurological disorders. (j-alz.com)
  • Cardiovascular disease (CVD) is the leading cause of death in India, accounting for 28% of mortality. (hindawi.com)
  • Despite the rapid progress in diagnosis and treatment of cardiovascular disease (CVD), this disease remains a major cause of mortality and morbidity. (mdpi.com)
  • Coronary artery disease (CAD) is the leading cause of mortality and morbidity in the world [ 1 ]. (biomedcentral.com)
  • This graph shows how little real mortality rates have improved since 1900, once you remove the top eight contagious/infectious diseases, which were largely controlled by the advent of antibiotics in the early twentieth century. (sameerbajaj.com)
  • 1 , 2 Mortality remains above 20% per year in the United States with the use of dialysis, with more than one-half of the deaths related to cardiovascular disease. (lww.com)
  • They noted that having the apolipoprotein A4 gene increases your likelihood of acquiring AD, although it doesn't mean that the disease is inevitable. (ironmanmagazine.com)
  • A high-fat and high-cholesterol diet induces overt and latent oxidative damage in hippocampus of mice lacking apolipoprotein E. Open Neuro 12 , 12-18. (uml.edu)
  • Hypertriglyceridemia is indicative of insulin resistance when present with low high-density lipoprotein (HDL) and elevated low-density lipoprotein (LDL), while elevated triglyceride is a clinical risk factor for coronary artery disease (CAD), especially when low HDL is present. (medscape.com)
  • A study by Aberra et al indicated that the average value of triglyceride measurements over time is more accurate than a single triglyceride value in predicting the risk of cardiovascular disease (CVD). (medscape.com)
  • High cholesterol level, the major modifiable risk factor for heart disease, has both an environmental as well as a genetic component. (hindawi.com)
  • Maintaining normal levels of cholesterol is essential for the prevention of cardiovascular disease. (dnaaccesslab.com)
  • Taken together our data indicate that cholesterol esterification is hampered in plasma and CSF of AD patients and that plasma cholesterol esterification biomarkers (unesterified cholesterol and unesterified/total cholesterol ratio) are significantly associated to disease biomarkers (i.e. (biomedcentral.com)
  • 10 , 11 Dyslipidemia in ESRD patients is characterized by a dysregulation of the synthesis and activity of HDL, leading to decreased plasma levels of HDL cholesterol (HDL-C). 10 Many epidemiologic studies have documented an inverse relationship between HDL-C levels and the progression of atherosclerosis and increased risk of cardiovascular disease in the general population. (lww.com)
  • Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B levels compared with subjects with 12 normohomocysteinaemia. (who.int)
  • Hcy levels correlated with total cholesterol ( r = 0.09), apolipoprotein A ( r = 0.012), and B ( r = 0.013) levels and total/HDL cholesterol ratio ( r = -0.085). (who.int)
  • The E3 variant, for instance, is widespread, with half of the population carrying it. (medicalnewstoday.com)
  • If you have two copies of the e4 variant, you are at a higher risk for heart disease, stroke, and Alzheimer's. (redcliffelabs.com)
  • Chronic Kidney Disease: Interaction of Adiponectin Gene Polymorphisms and Diabetes. (cdc.gov)
  • Arora and Trehan [ 7 ] investigated 3020 cases of Indians having Coronary Artery Bypass Graft (CABG) for three or more vessel disease in comparison with those having two or less vessel disease. (hindawi.com)
  • Objective: Inflammatory responses to vascular injury are key events in vein graft disease and accelerated atherosclerosis, which may result in bypass failure. (tno.nl)
  • A murine model for vein graft disease was used to study the. (tno.nl)
  • Unusually low levels of triglycerides can be present in disease states, producing syndromes of malabsorption in addition to patients who carry genes for familial hypobetalipoproteinemia . (medscape.com)
  • Effective immediately, SpectraCell Laboratories now offers apolipoprotein E genotyping. (news-medical.net)
  • Pangenome graphs in infectious disease: A comprehensive genetic variation analysis of Neisseria meningitidis leveraging Oxford Nanopore long reads. (otago.ac.nz)
  • CHD is a complex multifactorial disorder and both non-genetic and genetic factors can contribute to the development and progression of this disease [ 5 ]. (biomedcentral.com)
  • In this study, we aimed to examine the possible associations between the both PON1 L55M and PON1 Q192R polymorphisms and psoriasis susceptibility and disease progression in Turkish population. (bvsalud.org)
  • CONCLUSIONS: This is the first report simultaneously investigating the possible associations between the PON1 L55M and PON1 Q192R polymorphisms and psoriasis susceptibility and disease progression in Turkish population. (bvsalud.org)
  • 2011). Larger quantities of free radicals (reactive disease, diabetes, chronic respiratory diseases, and oxygen species [ROS]) present in the cigarette cancer (WHO, 2012). (bvsalud.org)
  • Association of Vitamin D Receptor Genetic Polymorphisms With Nephrolithiasis and End-Stage Renal Disease: A Meta-Analysis. (cdc.gov)
  • Cigarette smoking and positive family history of CAD was observed more frequently in those with early onset of the disease, whereas hypertension and diabetes mellitus occurred more frequently in those with late onset of disease. (hindawi.com)
  • Its clinical presentation clearly differs from other forms of GSD, because it is caused by the deficiency of the lysosomal enzyme, alpha-1,4-glucosidase, leading to the pathologic accumulation of normally structured glycogen within the lysosomes of most tissues, differs Three forms of the disease exist: infantile-onset, late-onset juvenile and adult onset. (medscape.com)
  • All 4 experienced type 2 diabetes all were obese 1 experienced cataracts 2 experienced cardiovascular disease and another experienced kidney disease (Supplemental Table 4). (careersfromscience.org)