Monozygotic twin pairsPhenotypesConcordantAutismGenetically identical twinFraternal twinsSymptomsDifferencesConcordanceDementiaCohortInfluencesFindingsGeneticPairs of identical2019Transfusion SyndromeStudyCohortsDonorGeneticsDizygoticSiblingsPretermChronicEpigeneticPregnant With TwinsGenesExamineInduceStudiesStudy'sDependentCalgaryMultiplesDiseaseRegistryTTTSUniqueLifePairResultsHealthMETHODSCellsResearchPhysicalShareComplicationsMaleModel
Monozygotic twin pairs5
- In this podcast we talk to Dr. Lynnea Myer s about her JCPP Advances paper on Behavioural and Biological Divergence in Monozygotic Twin Pairs Discordant for Autism Phenotypes ( https://doi.org/10.1111/jcv2.12017 ). (acamh.org)
- Hello and welcome to the In Conversation podcast series for the Association for Child and Adolescent to Mental Health, ACAMH, where we will look at the paper ' Behavioral and biological divergence in monozygotic twin pairs discordant for autism phenotypes: A systematic review ' recently published in JCPP Advances . (acamh.org)
- As mentioned in the intro, you have co-authored the paper, 'Behavioral and biological divergence in monozygotic twin pairs discordant for autism phenotypes: A systematic review' published in JCPP Advances . (acamh.org)
- Moreover, review of previous reports of monozygotic twin pairs concordant or discordant for Alzheimer's disease, with adequate family history data, suggest a pattern indicating interactions among age at dementia onset, sex, and familiality. (jamanetwork.com)
- Analysis of monozygotic twin pairs from the National Longitudinal Study of Adolescent Health (Add Health) revealed that between-twin differences in IQ have little effect on the majority of the examined outcome measures. (bvsalud.org)
Phenotypes2
- In identical twin rats with discordant phenotypes (e.g., one obese and one lean, despite identical genetics), the gut bacteria also seems to control their metabolism. (selfdecode.com)
- 11) Emphasizing inherited components by studying concordant or discordant patient pairs with extreme phenotypes, we were able to detect associations of residual chloride conductance and of modifier genes with the CF phenotype. (english-dictionary.help)
Concordant6
- However, even identical twins with SLE are concordant for disease in only 25% of cases and are therefore discordant (ie, one twin has SLE and one does not) in about 75% of cases. (medscape.com)
- 12) That is, identical twins are somewhat more concordant than fraternal twins. (english-dictionary.help)
- 15) Identical twins are not 100% concordant , indicating that there are nongenetic factors involved. (english-dictionary.help)
- Nongenetic pathologic developments of brain-wave patterns in monozygotic twins discordant and concordant for schizophrenia. (uni-heidelberg.de)
- Yet our investigations into mz twins discordant and concordant for schizophrenia yielded a significantly reduced within-pair EEG concordance for both, the pairs discordant for schizophrenia and the pairs concordant for schizophrenia (with concordance for schizophrenia assessed through a syndrome-oriented approach). (uni-heidelberg.de)
- Consequently, EEG anomalies associated with schizophrenia and manifested differently in the mz co-twins concordant for schizophrenia are likely the effect of nongenetic, pathologic processes that evolved independently in the co-twins' genetically identical brains once the illness began to progress. (uni-heidelberg.de)
Autism3
- We had quite a few when we initially pulled the articles on this kind of topic, but we determined studies to be eligible if they used this co-twin control design, and that's where you have a pair of twins participate in a study, and for our review, we were specifically looking at twins that were discordant for autism, clinical symptoms, or traits. (acamh.org)
- Scientists from King's College London have identified patterns of epigenetic changes involved in autism spectrum disorder (ASD) by studying genetically identical twins who differ in autism traits. (kcl.ac.uk)
- 34 pairs who differed for ASD or autism related behaviour traits, 5 pairs where both twins have ASD, and 11 healthy twin pairs. (kcl.ac.uk)
Genetically identical twin2
- The fact that it can strike one genetically identical twin to the exclusion of the other means that there are more than just genes involved. (scienceblog.com)
- His PhD thesis focused on physical activity, eating behaviors, and sleep in genetically identical twin pairs who became discordant for body weight during young adulthood. (easo.org)
Fraternal twins3
- However, a 1975 found that identical twins were 28% discordant, while 31% of non-identical twins were discordant, and concluded that identical twins were no more likely than fraternal twins to both have the same phenotype for tongue rolling. (wikipedia.org)
- This type of pregnancy results in fraternal twins (or more). (themasterpiecemom.com)
- Fraternal twins are more common than identical twins. (themasterpiecemom.com)
Symptoms2
- The first describes the findings of a study involving a group of resilient older people aged 90 or more, while the second examines a case of severe Covid-19 in identical twins, only one of whom had long-term symptoms of the disease. (indiatimes.com)
- A recent study published in the journal Scientific Reports showed that identical twin pairs with more physically active siblings showed fewer symptoms of metabolic disease as indicated by waist size and body mass index. (emedinexus.com)
Differences4
- Despite extraordinary differences between identical twin siblings in occupational and leisure-time physical loading conditions throughout adulthood, surprisingly little effect on disc degeneration was observed. (sciencedaily.com)
- The analysis of the cells in the discordant twins′ cheek swabs by Skinner′s lab revealed epigenetic differences too. (emedinexus.com)
- The aim was to evaluate differences of salivary protein expression in the CFS patient in respect to his healthy twin. (biomedcentral.com)
- In MZ pairs discordant for IWL, co-twins with at least one IWL were 0.4 kg m −2 ( P =0.041) heavier at 25 years than their non-dieting co-twins (no differences in baseline BMIs). (nature.com)
Concordance2
- Among numerous causes, premature ovarian failure (POF) frequently has a genetic aetiology and normal menopausal age is strongly heritable judging by the greater concordance between monozygotic (MZ) than dizygotic twins (Snieder et al. (infertile.com)
- In particular, the within-pair EEG concordance of monozygotic (mz) twins was found to be typically as high as r = 0.81 across channels and frequency bands, thus being comparable to that between repeated assessments on the same individual with typically r = 0.83. (uni-heidelberg.de)
Dementia8
- To this end, we studied a pair of monozygotic female twins appearing discordant for dementia of the Alzheimer type (DAT). (jamanetwork.com)
- Study participants received follow-up assessments for dementia either as part of the OCTO-TWIN study, which began in 1991, or as part of the pilot phase of the Study for Dementia in Swedish Twins, which began between 1987 and 1991. (alzgene.org)
- In the OCTO-TWIN study, individuals could have received up to four dementia assessments over the study follow-up period (1991-1999). (alzgene.org)
- In the pilot phase of the Study of Dementia in Swedish Twins, individuals received one dementia assessment. (alzgene.org)
- Of these 16,824 people, 640 were evaluated for dementia in OCTO-TWIN, while 1496 were assessed for dementia, in the pilot phase of the Study of Dementia in Swedish Twins. (alzgene.org)
- Case ascertainment for the Study of Dementia in Swedish Twins used a two-step process: an initial screening and then a comprehensive clinical evaluation that resulted in a consensus diagnosis. (alzgene.org)
- Subsequently, dementia suspects (i.e., those who scored below preestablished norms for cognitive impairment on MMSE or the telephone screening protocol) and their twin partners were evaluated for dementia by an assessment team that consisted of a nurse, a psychologist, and a physician. (alzgene.org)
- There are lots of papers that have remarked on the apparent association between head injury and subsequent dementia or cognitive decline, but to my knowledge, this is one of the first, if not the first, to use a twin study design, which has the unique advantage of having better control over early life and genetic factors than would ever typically be possible in a dataset of unrelated adults," said Elser. (medscape.com)
Cohort5
- Drawing on information from 600 participants in the population-based Finnish Twin Cohort--147 pairs of identical and 153 pairs of fraternal male twins--the Twin Spine Study has turned the dominant "injury model" approach to disc degeneration on its head. (sciencedaily.com)
- Coding of occupation for the "young cohort" of the Danish twin register. (lu.se)
- Participants enrolled as part of the "old cohort" of the Swedish Twin Registry were sent a questionnaire in 1967 assessing their participation in leisure activities prior to age 40. (alzgene.org)
- Of this cohort, there were 589 pairs of monozygotic twins who were discordant (one twin had TBI and the other had not). (medscape.com)
- Among the monozygotic twin cohort, a history of any TBI and being older than age 24 at the time of TBI, was associated with lower TICS-m scores. (medscape.com)
Influences2
- These cases highlight the potential for environmental influences for discordant presentations in genetically identical siblings. (latitudes.org)
- Twins can provide unique opportunities to study causal influences on variation in human behaviors, development, and diseases. (cambridge.org)
Findings5
- findings from identical twins discordant for combat exposure. (psychiatrist.com)
- The findings of the Twin Spine Study, an ongoing research program started in 1991, have led to a dramatic paradigm shift in the way disc degeneration is understood. (sciencedaily.com)
- During the course of the exposure-discordant twin studies, said Crites-Battié, the observation that struck anyone who viewed the twin sibling images side-by-side was the strong resemblance in disc degeneration, not only in the degree of degeneration, but also in the types of findings and spinal levels involved. (sciencedaily.com)
- There is a dearth of studies examining monozygotic ASD discordant twins, and Lynnea explains why this group is so important for inclusion in research to advance the science into non-shared environmental effects, and explains the implications of the findings for professionals working in child and adolescent mental health. (acamh.org)
- The Cuban Twin Registry: initial findings and perspectives ( Twin Res Hum Genet. (lu.se)
Genetic6
- The Australian Twin Registry as a resource for genetic studies into ophthalmic traits (Twin Res Hum Genet. (lu.se)
- Chinese National Twin Registry as a resource for genetic epidemiologic studies of common and complex diseases in China ( Twin Res. (lu.se)
- His research currently focuses on the genetic risk of obesity, lifestyle behaviors, and long-term (36 y) BMI trajectories in genetically identical and non-identical twin pairs. (easo.org)
- Evidence from twin studies shows there is a strong genetic component to ASD and previous studies suggest that genes that direct brain development may be involved in the disorder. (kcl.ac.uk)
- Because identical twins share the same genetic code, this suggests non-genetic, or epigenetic, factors may be involved. (kcl.ac.uk)
- The results from the MZ pairs discordant for IWLs suggest that dieting itself may induce a small subsequent weight gain, independent of genetic factors. (nature.com)
Pairs of identical1
- A 1952 study involving 33 pairs of identical twins found that 21% of them were discordant - that is, one of the twins had the ability and the other did not. (wikipedia.org)
20191
- The series is based on the twins' 2019 memoir by the same name and will be an Amazon original available only on Amazon Prime which can be accessed by a free 30-day trial . (talesfromthecollection.com)
Transfusion Syndrome2
- TAPS can occur spontaneously or as a result of having had laser surgery for Twin to Twin Transfusion Syndrome (TTTS). (about-twins.com)
- One problem that can occur in monochorionic-diamniotic babies is twin-twin transfusion syndrome (TTTS). (themasterpiecemom.com)
Study17
- Harvard/VA PTSD Twin Study Investigators. (psychiatrist.com)
- A series of monozygotic (MZ) twin pairs discordant for premature ovarian failure presented an unusual opportunity to study ovarian transplantation . (infertile.com)
- Genetically identical siblings were enrolled in the study. (latitudes.org)
- If you are the international team of researchers behind the Twin Spine Study, you find compelling proof that back pain problems may be more a matter of genetics than physical strain. (sciencedaily.com)
- A Korean study * explores how twins diagnosed with Twin Anemia Polycythemia Sequence (TAPS) are doing after they've been born. (about-twins.com)
- Documentary: In Defense of Food, https://www.pbs.org/video/2365635287/ 1:25:00 talks about study in twins where one is malnurished and one isn't. (humanmicrobiome.info)
- The twins were selected from the Twins Early Development Study (TEDS) which is funded by the MRC with additional support from the US National Institutes of Health. (kcl.ac.uk)
- The study of monozgotic twins can elucidate possible environmental causes for a disease in genetically identical subjects. (jamanetwork.com)
- The researchers collected cheek swabs from 70 sets of identical twins who also participated in an exercise study. (emedinexus.com)
- In the present study, we used a proteomic approach to evaluate the global changes in the salivary profile in a couple of monozygotic twins who were discordant for CFS. (biomedcentral.com)
- This study shows the presence of differentially expressed proteins in the saliva of the couple of monozygotic twins discordant for CFS, probably related to the disease. (biomedcentral.com)
- Traumatic brain injury (TBI) that occurs in early adulthood is associated with cognitive decline in later life, results from a study of identical twins who served in World War II show. (medscape.com)
- Being able to study the impact of TBI in monozygotic twins gives this study a unique strength, she noted. (medscape.com)
- For the study, the investigators assessed 8662 participants born between 1917 and 1927 who were part of the National Academy of Sciences National Research Council's Twin Registry. (medscape.com)
- Subjects included 4129 individual twins from the population-based FinnTwin16 study (90% of twins born in Finland 1975-1979). (nature.com)
- The current study addresses this gap in the literature by making use of a monozygotic twin difference scores approach to explore the association between IQ and a variety of outcome measures, including general health, substance use, relationships, sexual behaviors, educational attainment, economic well-being, and criminal justice contacts. (bvsalud.org)
- El análisis de parejas de gemelos monocigóticos del National Longitudinal Study of Adolescent Health ( Add Health ) reveló que, entre gemelos, las diferencias de CI tienen poco efecto en la mayoría de los resultados examinados. (bvsalud.org)
Cohorts2
- The Danish Twin Registry: 127 birth cohorts of twins ( Twin Res. (lu.se)
- In this special issue, we invited papers on twin registries and cohorts from 28 countries representing five continents. (cambridge.org)
Donor1
- The donor twin has too little blood, and the recipient twin has too much blood. (themasterpiecemom.com)
Genetics2
- Despite identical genetics, presentations showed marked variation across siblings (from a full PANDAS presentation to asymptomatic). (latitudes.org)
- The important thing about this is that they are monozygotic twins, and we know they shared a lot of early life exposure, and almost 100% genetics," Chanti-Ketterl said. (medscape.com)
Dizygotic1
- In Canada, the risk for a dizygotic twin of someone with MS is almost twice that for a full non-twin sibling. (bmj.com)
Siblings2
- This report provides phenotypic descriptions of three youth with PANDAS as well as their genetically identical siblings (in two cases of twins and one case of triplets). (latitudes.org)
- Classic studies of twins, adoptees, half siblings, and families 1 - 4 have led to a widely accepted notion that multiple sclerosis (MS) is a complex trait in which susceptibility is determined by the interplay of genes and environmental factors. (bmj.com)
Preterm2
- They were compared with a control group of monochorionic twins who were also born preterm. (about-twins.com)
- More than one half of all twins are born preterm. (themasterpiecemom.com)
Chronic1
- The Qingdao Twin Registry: a focus on chronic disease research ( Twin Res Hum Genet. (lu.se)
Epigenetic2
- When compared to the other twin in the discordant pair, the one engaged in more than 150 minutes of physical activity each week had epigenetic changes in DNA methylation regions, which were associated with a lower body mass index and smaller waist circumference. (emedinexus.com)
- The twins with greater levels of physical activity exhibited epigenetic markers associated with decreased metabolic syndrome, a condition that can result in heart disease, stroke, and type 2 diabetes. (emedinexus.com)
Pregnant With Twins1
- For example, if you are pregnant with twins, you need an extra 600 calories a day. (themasterpiecemom.com)
Genes1
- But genes are only part of the equation, even identical twins are high discordant when it comes to life expectancy. (starvingneuron.com)
Examine3
- They examine identical twins an examine how early adult exercise habits impact long term health outcomes. (healthcare-economist.com)
- The researchers wanted to examine how twins diagnosed with spontaneous TAPS were doing after they were born. (about-twins.com)
- Here we examine genome-wide DNA methylation, first in 50 identical twins discordant for heat pain sensitivity and then in 50 further unrelated individuals. (ox.ac.uk)
Induce1
- The use of fertility drugs to induce ovulation often causes more than one egg to be released from the ovaries and can result in twins, triplets, or more. (themasterpiecemom.com)
Studies6
- Several twin studies on the issue have been conducted. (wikipedia.org)
- Brazilian Twin Registry: A Bright Future for Twin Studies/Twin Research (Twin Res Hum Genet. (lu.se)
- Although DAT was confirmed clinically in only one twin, neuropsychological and brain imaging studies suggested that the unaffected twin may be developing the prodrome of DAT. (jamanetwork.com)
- Subjects covered include how to establish and maintain twin registries, accurately assess zygosity, collect biospecimens, and other important issues related to twin studies. (cambridge.org)
- This special issue shows that over 1.5 million twins and their families are participating in twin studies worldwide. (cambridge.org)
- 8 The role of environment is seen in twin studies, which report a 70-90% discordance in identical twins. (bmj.com)
Study's2
- Last month a paper presenting an overview of the Twin Spine Study's multidisciplinary investigation into the root causes of disc degeneration received a Kappa Delta Award from the American Academy of Orthopaedic Surgeons. (sciencedaily.com)
- Holly Elser, MD, PhD, MPH, an epidemiologist and resident physician in neurology at the University of Pennsylvania, Philadelphia, and co-author of an accompanying editorial , told Medscape Medical News that the study's twin design was a definite strength. (medscape.com)
Dependent2
- Exercise electrocardiography and aortic Doppler velocimetry in asymptomatic identical twins discordant for type 1 (insulin dependent) diabetes. (bmj.com)
- Anti‐DNA antibody synthesis in response to DNA was T‐dependent, and the experiments with reconstituted lymphocytes from identical twins discordant for SLE showed that B cells and T cells from SLE patients must cooperate to synthesize anti‐DNA antibody. (elsevierpure.com)
Calgary2
- High School is the revelatory and unique coming-of-age story of the identical twins from Calgary, Alberta. (timessquaregossip.com)
- High School is the revelatory and unique coming-of-age story of Sara and Tegan Quin, identical twins from Calgary, Alberta, growing up in the height of grunge and rave culture in the 90s, well before they became the celebrated musicians and celebrated LGBTQ icons we know today. (mpmgarts.com)
Multiples2
- The Western Australian Twin Register: a population-based register of adult and child multiples (Twin Res Hum Genet. (lu.se)
- Identical multiples also may result if the fertilized egg splits after transfer. (themasterpiecemom.com)
Disease2
- The Chinese National Twin Registry: A Unique Data Source for Systems Epidemiology of Complex Disease ( Twin Res hum Genet. (lu.se)
- The twins' varied life histories suggest that environmental risk factors may contribute to apparent discordance for DAT and possible delay in disease onset for the currently nondemented twin. (jamanetwork.com)
Registry20
- Australian Twin Registry: 30 years of progress (Twin Res Hum Genet. (lu.se)
- The introduction of the Australian twin registry (in Chinese) ( Zhonghua Liu Xing Bing Xue Za Zhi. (lu.se)
- Australian Twin Registry: a nationally funded resource for medical and scientific research, incorporating match and WATCH (Twin Res Hum Genet. (lu.se)
- The Australian Twin Registry (Twin Res. (lu.se)
- Australian NHMRC Twin Registry: a resource for pediatric research (Pediatr Cardiol. (lu.se)
- Australian N.H. & M.R.C. Twin Registry (Aust N Z J Med. (lu.se)
- Australian NHMRC twin registry (Med J Aust. (lu.se)
- The Brazilian Twin Registry (Twin Res Hum Genet. (lu.se)
- Chilean school-age children twin registry: planning, sampling and implications ( Twin Res Hum Genet. (lu.se)
- The Chinese National Twin Registry: a 'gold mine' for scientific research ( J Intern Med. (lu.se)
- The Chinese National Twin Registry: an update ( Twin Res hum Genet. (lu.se)
- Current status of the Chinese National Twin Registry ( Twin Res Hum Genet. (lu.se)
- The Qingdao Twin Registry: a status update ( Twin Res hum Genet. (lu.se)
- The Danish Twin Registry: An Updated Overview ( Twin Res Hum Genet. (lu.se)
- The Danish Twin Registry: linking surveys, national registers, and biological information ( Twin Res Hum Genet. (lu.se)
- The Danish Twin Registry (Scand J Public Health. (lu.se)
- The Danish Twin Registry in the new millennium ( Twin Res Hum Genet. (lu.se)
- The danish twin registry: past and present ( Twin Res. (lu.se)
- The early history of the Danish twin registry (in Danish) ( Dan Medicinhist Arbog. (lu.se)
- report that 16,824 (81%) of the 20,770 Swedish Twin Registry members who were sent the questionnaire in 1967 responded to the leisure activity items. (alzgene.org)
TTTS1
- In TTTS, the blood flow between the twins becomes unbalanced. (themasterpiecemom.com)
Unique1
- Are twins representative of the general population or are they unique in terms of their risk factors? (medscape.com)
Life1
- Additionally, the twins responded to survey questions regarding their areas and way of life. (emedinexus.com)
Pair2
- It was remarkable, therefore, to identify a MZ twin pair in which one sister had undergone menopause for unexplained reasons at age 14 years, whereas the other, aged 24, was still fertile with three naturally conceived children, as well as normal ovulatory cycles and ovarian reserve (Silber et al. (infertile.com)
- An 81-year-old female monozygotic twin pair. (jamanetwork.com)
Results2
- When a single fertilized egg splits, it results in multiple identical embryos. (themasterpiecemom.com)
- This type of pregnancy results in identical twins (or more). (themasterpiecemom.com)
Health1
- monozygotic (MZ) twin pairs discordant for health habits provide an interesting natural experiment. (healthcare-economist.com)
METHODS1
- METHODS: Ten MZ twin pairs requested ovarian transplantation and eight have undergone transplantation with cryopreservation of spare tissue. (infertile.com)
Cells2
- An imbalance of red blood cells between the twins develop. (about-twins.com)
- Germ-free mice (with no gut bacteria) populated with the obese twin had increased fat cells and reduced gut bacteria diversity compared to mice that were populated with the lean twin's fecal matter [ 10 ]. (selfdecode.com)
Research2
- Twin Research. (wikipedia.org)
- The research, which included almost 9000 individuals, showed that twins who had experienced a TBI were more likely to have lower cognitive function at age 70 versus their twin who did not experience a TBI, especially if they had lost consciousness or were older than age 24 at the time of injury. (medscape.com)
Physical1
- for example, one of the twins had a sedentary job while the other had heavy occupational physical demands, or one routinely engaged in occupational driving while the other did not. (sciencedaily.com)
Share5
- TAPS is the name of a rare condition that can only affect identical twins who share a placenta (monochorionic twins). (about-twins.com)
- They typically do not share a placenta and can be fraternal or identical. (themasterpiecemom.com)
- Monochorionic-diamniotic-Twins who share a chorion but have separate amniotic sacs. (themasterpiecemom.com)
- They share a placenta and are identical. (themasterpiecemom.com)
- Monochorionic-monoamniotic-Twins who share one chorion and one amniotic sac. (themasterpiecemom.com)
Complications2
- About-twins.com encourages expectant mothers to get regular check-up's and be monitored for complications in relation to monochorionic pregnancies. (about-twins.com)
- Monochorionic twins have a higher risk of complications than those with separate placentas. (themasterpiecemom.com)
Male2
- 1(p1324) This conclusion was based on a comparison between combat-exposed Vietnam veterans and identical male twins who were not exposed to combat trauma. (psychiatrist.com)
- This was a population of White male twins born between 1917 and 1927," she noted. (medscape.com)
Model1
- Marjan van de Merbel , (Medicine/LUMC), Implementatie van een drie-dimensionaal co-cultuur model van prostaatkanker met immuuncellen voor bepalen van anti-tumor werking door oncolytische virussen en immunotherapie. (luf.nl)