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  • tyrosine
  • In addition, we discuss the role of the tyrosine kinases, FAK, Pyk2, and Src, which are critical for the function of the different adhesion structures. (hindawi.com)
  • We also will highlight several important tyrosine kinases and other signaling proteins that are known to control the formation and function of these adhesion structures, and we will discuss their role in pathophysiology. (hindawi.com)
  • Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. (abcam.com)
  • structures
  • Here we highlight recent findings on the molecular mechanisms by which actin assembly is regulated in adhesion structures and the molecular basis of the mechanosensitivity of focal adhesions. (hindawi.com)
  • In this cycle, proteins from adhesion structures connect the ECM to the actin cytoskeleton (Figure 1 ), allowing the growing actin network to push the plasma membrane forward and the contractile stress fibers to pull the cell body and retract the tail. (hindawi.com)
  • Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia. (hindawi.com)
  • invadopodia
  • In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells. (hindawi.com)
  • In this review, we will discuss our current understanding of the similarities and differences between focal adhesions, podosomes, and invadopodia. (hindawi.com)
  • Although focal adhesions, podosomes, and invadopodia share common signaling proteins, they are distinct in cellular architecture and function (summarized in Table 1 ). (hindawi.com)
  • Common and unique features of focal adhesions, podosomes, and invadopodia. (hindawi.com)
  • contraction
  • In addition, immunofluorescence and immunoblots assay showed that the cells experienced an expansion-contraction-reexpansion process, accompanied by partial focal adhesion (FA) disassembly during contraction. (ijbs.com)
  • organization
  • Case LB, Baird MA, Shtengel G, Campbell SL, Hess HF, Davidson MW, Waterman CM (2015) Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions. (springer.com)
  • adequate
  • Finally, a simplified numerical model was established to reveal that adequate disassembly of FAs reduced the forces transmitting throughout the cell. (ijbs.com)