• It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
  • HIV-1-infected podocytes showed markedly elevated cyclin D 1 mRNA and cyclin D 1 protein, the latter of which did not down-regulate during cell-cell contact or differentiation, suggesting post-transcriptional stabilization of cyclin D 1 protein levels by HIV-1. (biomedcentral.com)
  • Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. (affbiotech.cn)
  • p15INK4B is a member of your INK4 family members of CDK inhibitors, which binds to CDK4 and CDK6 subunits, inactivates their catalytic ac tivity and prevents cyclin D CDK4 six complex formation. (mirnaarray.com)
  • It indicates that the mature let-7 miRNAs may be regulated in a post-transcriptional manner. (wikipedia.org)
  • As a group, miRNAs are small (17-27 nucleotides) noncoding RNAs that govern gene expression in a post-transcriptional manner by binding directly to the 3′UTRs of target mRNAs, thereby repressing their translation or inducing their degradation [ 6 ]. (biomedcentral.com)
  • AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22 α (SM22 α ) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. (hindawi.com)
  • miR-128-5p directly targeted the 3′UTR-binding sequences of the p21 gene, negatively regulated p21 expression, and supported the proliferation of VSMCs. (hindawi.com)
  • Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis. (hindawi.com)
  • Several studies have shown that miRNAs play multiple roles in the phenotypic transformation, migration, and proliferation of VSMCs by inhibiting ERK1/2 activation [ 11 , 12 ], partly by regulating the tissue inhibitor of metalloproteinases (TIMPs)-MMPs and p21-cyclins interactions [ 13 - 18 ]. (hindawi.com)
  • This study aimed to explore adipogenic transcriptional dynamics before (proliferation) and after (differentiation) initial preadipocyte differentiation in ducks. (biomedcentral.com)
  • At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
  • Previous researches completed by our team have also demonstrated that resveratrol inhibits the proliferation, invasion, and metastasis of colorectal cancer cells [ 5 ]. (hindawi.com)
  • TGF B as a tumor promoter TGF B acts as tumor suppressor in normal epithelium, it inhibits cell proliferation and induces apoptosis. (mirnaarray.com)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
  • According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
  • They are important post-transcriptional regulators of gene expression in plants, metazoans, and mammals, and are predicted to control the activity of 30% of all protein-coding genes [ 2 ]. (biomedcentral.com)
  • Also, since BCL6 interacts with several co-repressor complexes to inhibit transcription, and its gene is frequently trans-located and hyper-mutated in diffuse large B cell lymphoma (DLBCL), miR-155 acts to enhance transcription and contribute to the pathogenesis of DLBCL. (biomedcentral.com)
  • In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
  • However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)
  • Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. (abcam.cn)
  • known as RelA) and can directly influence chromatin accessibility at transcriptional memory genes by regulating H2B deposition through Ser32 phosphorylation. (bix02188.com)
  • The control of nuclear localization via phosphorylation and dephosphorylation serves as the primary regulatory mechanism for MiT family proteins, and several kinases and phosphatases have been identified to directly determine the transcriptional activities of MiT proteins. (molcells.org)
  • Recently, we reported that the nucleus-mitochondria positive feedback loop formed by p90 ribosomal S6 kinase (p90RSK) and phosphorylation of S496 on ERK5 (a unique member of the mitogen-activated protein kinase family that is not only a kinase but also a transcriptional co-activator) were vital signaling events that played crucial roles in linking mitochondrial dysfunction, nuclear telomere dysfunction, persistent SASP induction, and atherosclerosis. (oaepublish.com)
  • M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. (beds.ac.uk)
  • These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. (molcells.org)
  • For the other hand, down regulation of Id proteins in epithelial cells is because of activated SMAD3 that induces activating transcription factor expression then together with ATF directly represses the Id promoter. (mirnaarray.com)
  • When lncHERG is highly expressed, cell multiplication, invasion and migration are inhibited in GBM ( 16 ). (spandidos-publications.com)
  • Furthermore, di-GA inhibited the generation of lymphendothelial gaps by cancer cell spheroid-secreted lipoxygenase metabolites. (nature.com)
  • DIM also improved diabetic nephropathy by inhibiting the expression of PKC-α, the marker of albuminuria, and TGF-β1, an indicator of renal hypertrophy, in diabetic mice. (researchgate.net)
  • Indeed, the American Cancer Society estimates that 25% of all deaths in the United States can be directly attributed to cancer, which is anticipated to account for nearly 600,000 deaths and 1.7 million new invasive cancer cases in 2014. (biomedcentral.com)
  • To read the full-text of this research, you can request a copy directly from the authors. (researchgate.net)
  • LIN28 selectively binds the primary and precursor forms of let-7, and inhibits the processing of pri-let-7 to form the hairpin precursor. (wikipedia.org)
  • These forms scavenge reactive nitrogen species, inhibit cyclooxygenase- and 5-lipoxygenase-catalyzed eicosanoids and suppress proinflammatory signalling, such as NF-κB and STAT. The animal and human studies show tocotrienols may be useful against inflammation-associated diseases. (biomedcentral.com)
  • The levels of let-7 have been reported to decrease in models of MYC-mediated tumorigenesis, and to increase when MYC is inhibited by chemicals. (wikipedia.org)
  • The miR-34 family also affected tumorsphere ultra-structure and inhibited the xenografted tumor growth as well as lung metastasis of SC-M1 cells through YY1. (oncotarget.com)
  • Meanwhile, miR-340 inhibited the tumor growth in an orthotopic MDA-MB-231 breast cancer mouse model. (jcancer.org)
  • Depletion of NEAT1 markedly inhibited tumor growth in mice, while PGK1 could reverse this effect. (biomedcentral.com)
  • HDGF knockdown in NAP1L1-overexpressing glioma cells significantly inhibited cell proliferation. (omicsdi.org)
  • Upregulated miR-340 levels by mimics transfection significantly inhibited the MDA-MB-231 and MDA-MB-468 breast cancer cells proliferation, invasion and migration, and induced more cell apoptosis. (jcancer.org)
  • Moreover, CCND1 did not regulate the cell cycle alone, but rather, functioned together with CDK6. (omicsdi.org)
  • It can regulate gene expression at the post transcriptional level by binding to the 3′ untranslated region (UTR) of target mRNAs, Which leads to cleavage of the target mRNA by the Ago2 ribonuclease in the RNA induced silencing complex (RISC) or inhibition of translation [ 6 ]. (jcancer.org)
  • Finally, alcohol use regulates an epigenetic mechanism involving small molecules called miRNAs that control transcriptional events and the expression of genes important to ALD. (nih.gov)
  • Shi Z, Li Y, Qian X, Hu Y, Liu J, Zhang S, Zhang J. MiR-340 Inhibits Triple-Negative Breast Cancer Progression by Reversing EZH2 Mediated miRNAs Dysregulated Expressions. (jcancer.org)
  • 2. Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling. (nih.gov)
  • Testosterone and other androgens have been directly linked to PCa progression since 1941. (ijbs.com)
  • The results of rescue experiments further confirmed that miR-340 inhibited triple-negative breast cancer progression through targeting EZH2. (jcancer.org)
  • Through biochemical and molecular modeling studies we showed that salicylic acid directly binds to CDK2. (sdstate.edu)
  • For example, they all form a complex with RBP-Jκ, a major Notch signaling modulator and a sequence-specific DNA-binding transcription factor that specifically upregulates EBNA-2-mediated transcriptional activation of several viral ( LMP-1/-2 ) or cellular ( CD23 ) genes. (medscape.com)
  • The levels of let-7 have been reported to decrease in models of MYC-mediated tumorigenesis, and to increase when MYC is inhibited by chemicals. (wikipedia.org)
  • The results showed that p27, CDK6, and CCND1 played different roles in tumorigenesis and development, which are in accordance with CDK6 and CCND1 in affecting the cell cycle and cell proliferation. (omicsdi.org)
  • Furthermore, HDGF could interact with c-Jun, an oncogenic transcription factor, which eventually induced the expressions of cell cycle promoters, CCND1/CDK4/CDK6. (omicsdi.org)
  • [ 19 ] EBNA-3 proteins possess a number of similar structural motifs, which include a binding site for a Notch signaling mediator and a highly potent transcriptional regulator RBP-Jκ, a leucine zipper motif, an acidic domain, proline- and glutamine-rich repeats and several arginine and lysine residues known to be important for nuclear localization. (medscape.com)
  • We generated stable SELENBP1-overexpression and their corresponding control cell lines to determine its potential effect on cell cycle and transcriptional activity of p21 by using flow cytometry and luciferase reporter assay, respectively. (biomedcentral.com)
  • The effects of p27, CDK6, and CCND1 on the proliferation of lung cancer cells were examined by the MTT assay, and flow cytometry was used to investigate the mechanism by which p27 affected cell proliferation. (omicsdi.org)
  • 1. SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy. (nih.gov)
  • Some download Flower can be recognizing tRNAs that well mediate upregulated target( NF-kB), whereas bacterial phosphatidylinositols take inhibiting by sensitive synergises. (evakoch.com)
  • LIN28 selectively binds the primary and precursor forms of let-7, and inhibits the processing of pri-let-7 to form the hairpin precursor. (wikipedia.org)
  • Conversion of Cdc2 from "prestart" form to a "poststart" form ( asterisk ) is inhibited by Rum1. (comprehensivephysiology.com)
  • 10. Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer. (nih.gov)
  • However, the underlying mechanisms of miR-340 inhibited cell growth and invasion in triple-negative breast cancer (TNBC) have not been well elucidated. (jcancer.org)
  • In human skeletal muscle, FGF21 can directly increase glucose uptake [ 17 ]. (hindawi.com)
  • Therefore, HCC in these patients is not directly caused by alcohol consumption (Donato et al. (nih.gov)
  • Taking into consideration of possible correlation of bacterial infection to OSCC, it is proposed that capability of Manu A to directly suppress some prevalent bacteria ( 18 ) has also anticancer effect on OSCC. (spandidos-publications.com)