• Already doing an hour and a quarter (11 minutes/day) of exercise could reduce the risk of early death, cardiovascular disease, stroke, and cancer. (wikipedia.org)
  • Platelet activation: There is scientific evidence that marijuana can activate platelets and therefore potentially increase the risk of myocardial infarction (MI) and stroke. (thrombosis.org)
  • Over a mean follow-up period of 8.44 years, 268 subjects developed a major cardiovascular event (composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and heart failure requiring hospitalization) and 220 subjects died. (limkinase-signal.com)
  • The major causes of death in stroke-related moralities are a consequence of neurological damage and/or cardiovascular complications. (justia.com)
  • Post-stroke neurological deficits increase the risk of cardiovascular diseases roughly by three times, and the ischemic brain transmits indirect cell death signals to the heart. (justia.com)
  • Necropsy analyses of patients who suffered a fatal cerebral stroke indicate a high prevalence of coronary atherosclerosis and myocardial infarction. (justia.com)
  • Patients can develop myocardial injuries after stroke even when patients do not have pre-existing cardiac diseases. (justia.com)
  • However, it is unclear how cerebral ischemic stroke regulates cardiac function, what are the direct effects of stroke on cardiac function, and what are the underlying molecular mechanisms. (justia.com)
  • To date, there have been few effective modalities in the treatment of cardiovascular disease and/or disorder subsequent to stroke, including in subjects with a glucose metabolism disorder. (justia.com)
  • The present disclosure provides experimental support regarding the treatment of cardiovascular disease or disorder subsequent to stroke, using a novel composition. (justia.com)
  • Using Framingham risk scoring system, the probability of myocardial infarction or stroke events was calculated for a representative sample population, ages 35 to 69 years, of people at high risk for cardiovascular disease, with a history of coronary heart disease. (ahdbonline.com)
  • Reductions in cardiovascular and stroke events reported in clinical trials with aggressive statin therapy were applied to these cohorts. (ahdbonline.com)
  • 1 Hypercholesterolemia, particularly elevated lowdensity lipoprotein cholesterol (LDL-C), is strongly associated with an increased risk of CVD, including coronary heart disease (CHD) events (ie, myocardial infarction [MI], angina, coronary revascularization) and stroke. (ahdbonline.com)
  • NSAIDs 1 may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction (MI), and stroke, which can be fatal. (nih.gov)
  • The Framingham risk score was predictive of stroke, myocardial infarction, and angina among a nationally representative sample of adults in South Korea. (cdc.gov)
  • For example, anxiety affects more than 25% of the population and is associated with increased development of unstable angina, myocardial infarction, ventricular arrhythmia, cardiovascular mortality, heart failure and stroke. (acc.org)
  • This free application calculates the possible 10-year risk of myocardial infarction, stroke or cardiovascular death. (paho.org)
  • Exposure to air pollution, especially fine particulate matter, is a leading risk factor for noncommunicable diseases, in particular: ischaemia, myocardial infarction, stroke, chronic obstructive pulmonary disease and cancers. (who.int)
  • Main outcome measures Primary outcome measures, identified from registry data, were time to death from all causes (n=11 944) and cause specific cardiovascular disease (n=3862), ischaemic heart disease (n=1932), and stroke (n=1100). (bmj.com)
  • Compared with intakes between 600 and 1000 mg/day, intakes above 1400 mg/day were associated with higher death rates from all causes (hazard ratio 1.40, 95% confidence interval 1.17 to 1.67), cardiovascular disease (1 49, 1.09 to 2.02), and ischaemic heart disease (2.14, 1.48 to 3.09) but not from stroke (0.73, 0.33 to 1.65). (bmj.com)
  • Conclusion High intakes of calcium in women are associated with higher death rates from all causes and cardiovascular disease but not from stroke. (bmj.com)
  • Familial hypercholesterolemia (FH) and multifactorial dyslipidemia are 2 conditions that cause abnormally high lipid levels in children, which can lead to premature cardiovascular events (eg, myocardial infarction and stroke) and death in adulthood. (cdc.gov)
  • Approximately two-thirds of patients sustaining a myocardial infarction do not make a complete recovery and often are left with debilitating congestive heart failure. (ca.gov)
  • Despite the advances in medical treatment and interventional procedures to reduce mortality in patients with CAD, the number of patients with refractory myocardial ischemia and congestive heart failure is rapidly increasing. (ca.gov)
  • Little is known about the relationship between food security status and predicted 10-year cardiovascular disease risk. (cdc.gov)
  • The objective of this study was to examine the associations between food security status and cardiovascular disease risk factors and predicted 10-year risk in a national sample of US adults. (cdc.gov)
  • Adults aged 30 to 59 years with very low food security showed evidence of increased predicted 10-year cardiovascular disease risk. (cdc.gov)
  • Little is known about the associations between food security and predicted cardiovascular disease risk, but some research has addressed associations between food security and several cardiovascular disease risk factors. (cdc.gov)
  • Diets of food-insecure adults may be of low quality ( 12 ), which in turn could affect cardiometabolic risk factors for cardiovascular disease. (cdc.gov)
  • Consequently, these considerations suggest that food insecurity could be associated with increased cardiovascular disease risk. (cdc.gov)
  • Therefore, the objective of this study was to examine the cross-sectional associations between cardiovascular disease risk factors, cardiovascular disease risk, and food security among US adults. (cdc.gov)
  • The authors add it can take decades to progress to a clinically detectable degree, and thus further follow-up of our cohort is necessary to determine whether a substantial absolute increase in morbidity and mortality from therapy-related cardiovascular disease will emerge. (natap.org)
  • This finding is plausible because combination antiretroviral therapy can cause adverse metabolic changes that are known risk factors for cardiovascular disease. (natap.org)
  • The topic of our conversation will be on marijuana use in patients with cardiovascular disease (CVD). (thrombosis.org)
  • And we go on to estimate that probably more than 2 million persons in the United States with underlying cardiovascular disease have also reported either current or prior marijuana use. (thrombosis.org)
  • There are plenty of data suggesting that prediabetes places patients on a trajectory toward cardiovascular disease. (healthytruck.org)
  • Early detection and prevention will prevent diabetes and, by extension, cardiovascular disease, but her data suggest that control of prediabetes with lower cardiovascular risk by a more direct route. (healthytruck.org)
  • Despite mounting evidence, many clinicians are unaware that prediabetes is also a major risk factor for atherosclerotic cardiovascular disease ," said Thota, an internal medicine resident at Saint Peter's University Hospital, New Brunswick, N.J. (healthytruck.org)
  • Notably, we identify multiple risk factors for cardiovascular disease, including red blood cell distribution width. (nature.com)
  • In the US, it is estimated that cardiovascular disease affects 60 million patients costing the healthcare system approximately $186 billion annually. (ca.gov)
  • The present disclosure provides a method for the treatment or prevention of a cardiovascular disorder or disease in a subject who has suffered cerebrovascular injury, the method comprising administering a therapeutically effective amount of a miR-126 containing agent or an agent that induces expression of miR-126 to the subject in need thereof. (justia.com)
  • The target population consists of working-age people who are considered high-risk for cardiovascular disease events because of a history of coronary heart disease. (ahdbonline.com)
  • Aggressive low-density lipoprotein cholesterol-lowering therapy for working-age people at high risk for cardiovascular events and with a history of heart disease appears to have a significant potential to reduce the rate of clinical events and is cost-neutral for payers. (ahdbonline.com)
  • Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. (ahdbonline.com)
  • Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS). (nih.gov)
  • In patients with cardiovascular disease, diltiazem hydrochloride administered intravenously in single bolus doses, followed in some cases by a continuous infusion, reduced blood pressure, systemic vascular resistance, the rate-pressure product, and coronary vascular resistance and increased coronary blood flow. (nih.gov)
  • Dr. Courtman is trained incellular and molecular pathology and biophysics with extensive expertise in the development of novel therapies for cardiovascular disease. (oirm.ca)
  • He has also participated in the development of a number of cellular based gene therapies for the treatment of cardio-pulmonary disorders taking them from initial concept, through appropriate animal disease models, and into first-in-human clinical trials. (oirm.ca)
  • Elevated levels of the transaminases can indicate myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. (cdc.gov)
  • The Framingham risk score is a robust algorithm to predict cardiovascular disease (CVD) risk based on demographic and clinical factors among European Americans. (cdc.gov)
  • consequently, thousands of hospitals will have Medicare payments deducted by up to 3% in 2015 if patients with certain conditions (eg, myocardial infarction, heart failure, chronic obstructive pulmonary disease) return to hospital within 30 days of discharge. (bmj.com)
  • 4 Dietary intervention has become increasingly more impactful in primary and secondary prevention of cardiovascular disease. (acc.org)
  • Clinicians should also emphasize to their patients the mind-body connection as a crucial component of preventing and managing cardiovascular disease. (acc.org)
  • This also results in elevated cortisol levels, causing insulin resistance, impaired glucose tolerance, dyslipidemia and ultimately cardiovascular disease. (acc.org)
  • 7,8 Objective measures of cardiovascular disease, such as ischemic changes on stress testing, were observed in a study of individuals with a diagnosis of post-traumatic stress disorder without any other risk factors for coronary disease. (acc.org)
  • It's important to note that there is evidence that even a negative outlook, or lack of sense of purpose, is associated with an increased risk of cardiovascular disease and all-cause mortality. (acc.org)
  • A study a few years ago discovered stents "did not reduce the risk of death, myocardial infarction, or other major cardiovascular events" for patients with stable coronary artery disease. (atlas.md)
  • Objective To investigate the association between long term intake of dietary and supplemental calcium and death from all causes and cardiovascular disease. (bmj.com)
  • Peripheral cardiac sympathetic hyperactivity in cardiovascular disease: role of neuropeptides. (ox.ac.uk)
  • Coronary atherosclerotic disease is a leading cause of mortality and morbidity due to major cardiovascular events in the United States and abroad. (bvsalud.org)
  • Randomized controlled trials have shown that lowering blood pressure significantly reduces cardiovascular disease (2). (cdc.gov)
  • According to the model, a cue to action triggers cognitive deliberations about the perceived threat of a disease and about barriers to and benefits of the recommended behavior, which influence a person's likelihood of taking a particular action. (cdc.gov)
  • The researchers developed and validated three machine learning models to predict in-hospital mortality based on comorbidities, medical history, presentation characteristics and initial laboratory values. (acc.org)
  • According to the researchers, "improvements in risk prediction for in-hospital mortality with machine learning models were small and likely do not meet the threshold to be relevant for clinical practice. (acc.org)
  • Myocardial infarction (MI) is the primary cause of cardiovascular mortality, and therapeutic strategies to prevent or mitigate the consequences of MI are a high priority. (elsevierpure.com)
  • IHD mortality data for men and women of any age were gathered from national vital registration, and age, sex, country, year-specific IHD mortality rates were estimated in an ensemble model. (bmj.com)
  • Clinical question: Is there an improved 30-day mortality rate if patients receive blood transfusion at higher hematocrit values after postoperative myocardial infarction (MI)? (the-hospitalist.org)
  • Clinical question: Does taking a perioperative beta-blocker increase the risk of major adverse cardiovascular events (MACEs) and all-cause mortality in low-risk patients with essential hypertension (HTN)? (the-hospitalist.org)
  • We hypothesised that long term intake of low or high calcium increases the risk of cardiovascular mortality. (bmj.com)
  • We investigated associations between long term dietary and supplemental intake of calcium with all cause mortality as well as with cardiovascular mortality in a large population based prospective study of Swedish women. (bmj.com)
  • In 2019, Discovery Health published a risk adjustment model to determine standardised mortality rates across South African private hospital systems, with the aim of contributing towards quality improvement in the private healthcare sector. (who.int)
  • Cardiac fibrosis is a pathological manifestation of myocardial remodeling, which is characterized by increased fibroblast-to-myofibroblast conversion and excessive extracellular matrix (ECM) deposition within the myocardial interstitium, leading to myocardial stiffness, ventricular dilation, arrhythmias, and heart failure [ 1 , 2 ]. (hindawi.com)
  • In addition, In vitro cell culture models will be studied to address the underlying cellular mechanisms by utilizing: 1) Adult mouse cardiac fibroblasts (F2KO and WT) and 2) Neonatal rat ventricular cardiomyocytes. (centerforpediatricresearch.org)
  • Stimulation of the cardiac vagus reduces heart rate, lowers myocardial oxygen demand, improves coronary blood flow, and independently raises ventricular fibrillation threshold. (ox.ac.uk)
  • We found that miR-409-3p was consistently increased in three fibrotic models, including heart tissues of postmyocardial infarction (MI) mice and neonatal rat cardiac fibroblasts treated with angiotensin II (Ang II) or transforming growth factor- β (TGF- β ). (hindawi.com)
  • Subsequent studies with hESC-derived endothelial progenitor cells decreased MI size and improved LV function in a mouse model of myocardial ischemia. (ca.gov)
  • MiR-126 facilitates vascular re-modeling, decreases fibrosis in multiple organs, and has been reported to be beneficial in the treatment of atherosclerosis and re-stenosis. (justia.com)
  • An association between periodontal pathogens, such as Porphyromonas gingivalis, and atherosclerosis has been suggested because of the pathogen's possible direct effect on atheroma formation. (medscape.com)
  • Vasopressin, on the other hand, increases coronary blood flow and myocardial oxygen availability. (medscape.com)
  • The second is a tax model applied to estimate the economic benefit and health outcomes in different price increase scenarios in 10 years. (whiterose.ac.uk)
  • ACC's NCDR suite of registries are a robust source of data for researchers, and a critical component in continuing to help hospitals, practices and clinicians advance the quality of cardiovascular care and improve patient outcomes. (acc.org)
  • Methods: A decision model was developed to estimate the healthcare costs in Canadian dollars and the clinical outcomes among patients who have suffered an MI and are treated with colchicine. (bvsalud.org)
  • Outcomes were projected over patient lifetimes using the IQVIA CORE Diabetes Model. (springer.com)
  • Biomarkers of microvascular health could then represent possible markers for the early detection of poor cardiovascular outcomes. (frontiersin.org)
  • To model the financial and health outcomes impact of intensive statin therapy compared with usual care in a high-risk working-age population (actively employed, commercially insured health plan members and their adult dependents). (ahdbonline.com)
  • The association between psychological health and cardiovascular outcomes is highlighted in a scientific statement encouraging a more holistic model for patient care from the American Heart Association. (acc.org)
  • Before joining the Center for Cardiovascular Health Services Research, Ms. Daudelin was Director of Outcomes Analysis and Quality Improvement at Tufts-NEMC, where she developed and implemented operational QI and patient safety programs, co-developed QI and Resource Utilization software, and worked with clinicians to evaluate incidences and causes of medical errors. (tuftsmedicalcenter.org)
  • Currently, she directs a research project developing mathematical models to predict the outcomes of knee replacement surgery with an emphasis on patient and stakeholder involvement in research and shared decision making. (tuftsmedicalcenter.org)
  • Sveréus S, Larsson K, Rehnberg C. Clinic continuity of care, clinical outcomes and direct costs for COPD in Sweden: a population based cohort study. (janusinfo.se)
  • The prognosis value of apelin-12 in predicting short-term (during hospitalisation) and long-term (2.5 years) major adverse cardiovascular events, respectively, was analysed among patients with estimated glomerular filtration rate exceeding and below 90 mL/min×1.73m 2 . (bmj.com)
  • These specific conditions in the oral cavity may create foci of infection that can affect many other vital systems, such as the cardiovascular and renal systems. (medscape.com)
  • Background: Colchicine is an anti-inflammatory therapy with a low associated cost that has been shown in 2 large studies to reduce cardiovascular (CV) events, but its use is associated with side effects. (bvsalud.org)
  • Other known risk factors for myocardial infarction probably contributed to the occurrence of these events. (natap.org)
  • predictor of cardiovascular events, whereas an excessive BP surge did not portend an increased risk of events. (limkinase-signal.com)
  • Our analysis models the cost impact of aggressive statin therapy for a commercially insured cohort of members at high risk for secondary events from CVD as a result of a history of CHD. (ahdbonline.com)
  • This provides an excellent opportunity to intervene in order to reduce the number and severity of cardiovascular events. (medscape.com)
  • Preventive Lessons from Hypertension and Myocardial Infarction: Treating Asymptomatic Individuals to Lower the Risk for Subsequent Cardiovascular Events -- Part III. (nshealth.ca)
  • Value of Brachial and Central Blood Pressure for Predicting Cardiovascular Events -- 21. (nshealth.ca)
  • Predictive Value of Arterial Stiffness for Cardiovascular Events -- 22. (nshealth.ca)
  • Potential adverse events associated with ablation procedures include, but are not limited to, cardiovascular related complications, such as hematoma, effusion and infection. (modernhealthcare.com)
  • Risk stratification and early preventive measures can reduce major cardiovascular events given the long latent asymptomatic period. (bvsalud.org)
  • They add that "for many clinical prediction tasks, the simpler approach - the generalized linear model - may be all that we need. (acc.org)
  • To derive the greatest clinical value from the research outlined above, it is important to understand the relative role of insulin resistance in CAD compared with other well-known cardiovascular risk factors that may exist independently of insulin resistance. (diabetesjournals.org)
  • Clinical question: Is the Caprini risk assessment model (RAM) a valid tool to predict venous thromboembolism (VTE) risk in critically ill surgical patients? (the-hospitalist.org)
  • The addition of key condition-specific clinical data points at the time of hospital admission will dramatical y improve model performance. (who.int)
  • Two models were developed: the first is a mathematical model based on a probabilistic microsimulation of thousands of individuals using hypothetical cohorts that considered the natural history, costs, and quality of life of these individuals. (whiterose.ac.uk)
  • RESEARCH DESIGN AND METHODS -The Archimedes model was used to estimate the proportion of myocardial infarctions that would be prevented by maintaining insulin resistance and other risk factors at healthy levels. (diabetesjournals.org)
  • Methods A 2-group effectiveness study was completed comparing patients who received the 'Ottawa Model' for Smoking Cessation intervention (n=726) to usual care controls (n=641). (bmj.com)
  • A better understanding of the variations in total cost of care for PCI, when evaluated against related quality of care measures in ACC's CathPCI Registry , may help facilities improve the value of care delivery, according to an abstract presented as part of ACC's Cardiovascular Summit Virtual. (acc.org)
  • The total cost was BRL 56.9 billion (USD 14.7 billion), with 70% corresponding to the direct cost associated with healthcare and the rest to indirect cost due to lost productivity from premature death and disability. (whiterose.ac.uk)
  • In addition, the XGBoost model reclassified 32,393 (27%) individuals and the meta-classifier model reclassified 30,836 (25%) individuals considered to be at moderate or high risk of death in logistic regression as low risk. (acc.org)
  • 1 Poor mental health can have an unseen impact on the cardiovascular system - even beyond stress-induced, or takotsubo, cardiomyopathy - leading to an increase in cardiovascular risk and comorbidities downstream. (acc.org)
  • Conversely, significant contributions from diabetes, hypertension, and lipodystrophy were not identified…… we found no evidence to suggest that the duration of HIV-1 infection, the level of prior immunodeficiency, or the degree of HIV-1 RNA replication affected the association between exposure to therapy and the risk of myocardial infarction. (natap.org)
  • Hypertension: Evaluation of Cardiovascular Risk and Organ Damage -- 20. (nshealth.ca)
  • By 2025, HEARTS will be the model for cardiovascular risk management, including hypertension, diabetes, and dyslipidemia, in primary health care (PHC) in the Americas. (paho.org)
  • This has been studied in depth using the spontaneously hypertensive rat, an animal model of genetic essential hypertension, where larger neuronal calcium transients, increased release and impaired reuptake of norepinephrine in neurons of the stellate ganglia lead to a significant tachycardia even before hypertension has developed. (ox.ac.uk)
  • Antagonists of the NPY receptors Y1 and Y2 may be therapeutically beneficial both acutely during myocardial infarction and also during chronic heart failure and hypertension. (ox.ac.uk)
  • Prediabetes is not only a predictor of diabetes and the cardiovascular complications that ensue, but it is also a risk factor by itself for myocardial infarction(MI) (ie, heart attack) , according to data drawn from almost 1.8 million patients hospitalized for MI. (healthytruck.org)
  • We explore the cellular mechanisms of glucose metabolism dysfunction in an in vitro model of cultured cardiomyocytes, with the aim of transposing our in vitro results to an animal model of diabetic cardiomyopathy. (unige.ch)
  • In addition to its role in metabolic regulation, nesfatin-1 also plays a principal role in other physiological activities such as adipose tissue differentiation, gastrointestinal motility, gluconeogenesis and insulin sensitivity, reproduction and, more importantly, cardiovascular function, as it is expressed in heart cells [ 2 ]. (biomedcentral.com)
  • Thus, the project is directed at the regulation of cardiovascular function from compensation to failure. (centerforpediatricresearch.org)
  • He has a long-standing interest in the development of novel cardiovascular biomaterialsand the regulation of biological responses within the unique spatially oriented matricellular environment of blood vessels. (oirm.ca)
  • This review aims to synthesize the current literature to gauge whether assessing the microvasculature can better estimate the cardiovascular impact of wildland fires. (frontiersin.org)
  • Accumulating studies have revealed that miRNAs that participate in the myocardial fibrotic program, such as miR-18a-5p, attenuate cardiac fibrosis via regulating the Notch2 pathway [ 13 ], and miR-24-3p alleviates myocardial fibrosis through PHB2 [ 14 ]. (hindawi.com)
  • Screening tools like the Generalized Anxiety Disorder-7 and the PHQ-2, used for anxiety and depression respectively, can be used routinely in the outpatient and inpatient settings to help identify patients who would benefit from treatment, which would also lead to improving their cardiovascular health. (acc.org)
  • Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. (nih.gov)
  • They conclude that "compared with logistic regression, the models offered improved resolution of risk for high-risk individuals. (acc.org)
  • This large international study in 20,000 individuals finds the annual rate for myocardial infarction was low 0.6% but that combination therapy increased the risk 26% per year. (natap.org)
  • We found no direct evidence on the benefits or harms of pediatric lipid screening was identified. (cdc.gov)
  • Connexins form gap junctions, clusters of intercellular channels synchronizing responses in multi-cellular organisms through the direct exchange of ions, small metabolites and second messengers between adjacent cells. (unige.ch)
  • These data have an important message, but they are not surprising, according to Deepak L. Bhatt, MD, executive director, interventional cardiovascular programs, Brigham and Women's Hospital Heart & Vascular Center, Boston. (healthytruck.org)
  • 6 For example, depression has been found to directly increase oxidative stress through the increased production of reactive oxidative species and has been shown in numerous studies to increase the risk of myocardial infarction and re-infarction. (acc.org)