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Cyclin D1Cyclin-Dependent KinasesCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 5Cyclin-Dependent Kinase 2Cyclin D2Cyclin DCyclinsCDC2-CDC28 KinasesCyclin D3Cyclin-Dependent Kinase 6CDC2 Protein KinaseCell CycleCyclin-Dependent Kinase 9Genes, bcl-1Cell Cycle ProteinsG1 PhaseChromosomes, Human, Pair 11Gene AmplificationCyclin ECyclin-Dependent Kinase Inhibitor p27PhosphorylationProtein-Serine-Threonine KinasesLymphoma, Mantle-CellKinetinCyclin-Dependent Kinase 8Diagnostic Techniques, RadioisotopeS PhaseCell Line, TumorOncogene ProteinsIn Situ Hybridization, FluorescenceCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Proto-Oncogene ProteinsPurinesCyclin HGene Expression Regulation, NeoplasticCell ProliferationCyclin BTumor Suppressor ProteinsMitosisCyclin-Dependent Kinase Inhibitor p18Translocation, GeneticCyclin-Dependent Kinase 3Genes, mycCyclin TFibroblast Growth Factor 3Cyclin CCyclin B1cdc25 PhosphatasesChromosomes, Human, Pair 14Gene Expression ProfilingRNA, MessengerBreast NeoplasmsCell Cycle CheckpointsCortactinProto-Oncogene Proteins c-mycMicrotubule-Associated ProteinsGenes, cdcCyclin-Dependent Kinase Inhibitor ProteinsDown-RegulationReverse Transcriptase Polymerase Chain ReactionMutationOligonucleotide Array Sequence AnalysisNuclear ProteinsSignal TransductionProtein BindingCell DivisionApoptosisCell LineMolecular Sequence DataG2 PhaseEnzyme InhibitorsRNA InterferenceGene DosageRNA, Small InterferingDNA, NeoplasmCarcinoma, Squamous CellGenes, erbB-2Positive Transcriptional Elongation Factor BPolymorphism, GeneticCell NucleusHeLa CellsGene Expression RegulationComparative Genomic HybridizationProlactinomaDNA PrimersCells, CulturedTechnetium CompoundsTumor Cells, CulturedGenes, p16Enzyme ActivationSOXC Transcription FactorsThreonineTransfectionTranscription, GeneticGenotypeTranscription FactorsCell Transformation, NeoplasticTumor Suppressor Protein p53
CellCDK4CyclinCell cycle arrestComplex
Cell1
  • Direct comparison of the cell types were made to primary tissues using gene expression atlases and fetal human brain single-cell gene expression data, and this established that the cell types resembled early human brain cell types, including preplate cells. (uth.edu)
CDK46
  • NAP1L1 promotes proliferation and chemoresistance in glioma by inducing CCND1/CDK4/CDK6 expression through its interaction with HDGF and activation of c-Jun. (omicsdi.org)
  • Furthermore, HDGF could interact with c-Jun, an oncogenic transcription factor, which eventually induced the expressions of cell cycle promoters, CCND1/CDK4/CDK6. (omicsdi.org)
  • This finding suggested that NAP1L1 could interact with HDGF, and the latter recruited c-Jun, a key oncogenic transcription factor, that further induced CCND1/CDK4/CDK6 expression, thereby promoting proliferation and chemoresistance in glioma cells. (omicsdi.org)
  • Cell Cycle Protein Expression in Neuroendocrine Tumors: Association of CDK4/CDK6, CCND1, and Phosphorylated Retinoblastoma Protein With Proliferative Index. (omicsdi.org)
  • The phosphorylation of pRB is initiated by cyclin D/cdk4, cdk6 complex and continued by cyclin E/cdk2. (wikipedia.org)
  • 15. Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancer. (nih.gov)
Cyclin2
  • In this study, Genevestigator, Kaplan-Meier Plotter, and the Human Protein Atlas databases were used to analyze the expression of p27, cell division protein kinase 6 (CDK6), and cyclin D1 (CCND1), as well as its prognostic value in different tumor tissues and corresponding normal tissues. (omicsdi.org)
  • 16. miR-218 suppresses gastric cancer cell cycle progression through the CDK6/Cyclin D1/E2F1 axis in a feedback loop. (nih.gov)
Cell cycle arrest2
Complex1
  • p27 regulated the cell cycle and inhibited cell proliferation by affecting formation of the cell cycle-dependent complex CDK6/CCND1, but did not directly affect the expression of CDK6 and CCND1. (omicsdi.org)