• Preoperative non-invasive testing aims to provide information primarily about coronary artery disease (myocardial ischemia or reduced blood supply to the heart muscle), left ventricular (LV) dysfunction, and heart valve abnormalities in selected patients. (cadth.ca)
  • Angina pectoris is a clinical syndrome of precordial discomfort or pressure due to transient myocardial ischemia without infarction. (msdmanuals.com)
  • Stunned myocardium is myocardium that suffers transient reversible myocardial contractile dysfunction that is caused by acute ischemia during which the blood supply is almost completely restored by reperfusion, with no metabolic deterioration. (medscape.com)
  • The term hibernating myocardium is also used to indicate chronic myocardial contractile dysfunction due to ischemia, in which there is reduced coronary blood flow at rest and increased myocardial demand results in impaired contractility. (medscape.com)
  • Myocardial ischemia is a clinical syndrome manifesting a variety of tissue effects and global cardiac effects that impair cardiac function. (medscape.com)
  • The concomitant presence of myocardial necrosis with myocardial ischemia, stunning, or hibernation may complicate appraisal of left ventricular (LV) function and patient management. (medscape.com)
  • Clinically, discerning the etiology of depressed myocardial contractile function is difficult, whether due to stunned myocardium, silent ischemia, or hibernating myocardium. (medscape.com)
  • In patients with severe coronary artery disease with low ischemic threshold, as in the present case, acetazolamide might reduce peripheral vascular resistance, increase the cardiac output ratio, increase myocardial oxygen consumption by increasing cardiac output, and induce myocardial ischemia with elevation of double product. (journalmc.org)
  • Although the frequency of acute heart failure due to myocardial ischemia after an acetazolamide challenge may be low, its occurrence in patients with severe arteriosclerotic disease should be routinely considered. (journalmc.org)
  • It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. (lookformedical.com)
  • 10. Sasayama S, Nonogi H , Asanoi H, Yamanishi K, Kawai C: Effects of nifedipine on pacing-induced ischemia:modification of regional myocardial function and coronary hemodynamics. (fiercecert.com)
  • 15. Nakamura Y, Sasayama S, Nonogi H , Miyazaki S, Fujita M, Kihara Y, Konishi T, Kawai C: Effects of pacing-induced ischemia on early left ventricular filling and regional myocardial dynamics and their modification by nifedipine. (fiercecert.com)
  • Acute Myocardial Infarction (MI) Acute myocardial infarction is myocardial necrosis resulting from acute obstruction of a coronary artery. (msdmanuals.com)
  • Until now there have been a few reports of serious adverse reactions after acetazolamide challenge, and here we report our experience of a case of acute heart failure that occurred after cerebrovascular SPECT with intravenous administration of acetazolamide and required many life-saving treatments. (journalmc.org)
  • 13. Sakaguchi K, Hattori R, Yui Y, Takatsu Y, Susawa T, Yui N, Nonogi H , Tamaki S, Kawai C: Altered platelet alpha 2 adrenoreceptor in acute myocardial infarction and its relationship to plasma catecholamine concentrations. (fiercecert.com)
  • If a pharmacologic stress test with a vasodilator such as adenosine or dipyridamole is to be performed, the patient should abstain from medications containing methylxanthines and beverages, food (such as chocolate), and medications containing caffeine for 12 h ( 2 ) to 24 h ( 3 , 4 ). (snmjournals.org)
  • Transient ischemic dilation (TID) in the setting of abnormal stress-rest cardiac SPECT myocardial perfusion imaging (MPI) has been linked with increased cardiovascular risk. (snmjournals.org)
  • In this study, cardiac CT was used to evaluate the prevalence of atherosclerotic lesions and the severity of coronary artery stenosis in patients with TID of the left ventricle with or without associated myocardial perfusion defects on SPECT MPI. (snmjournals.org)
  • The study population consisted of 1,553 consecutive patients who had undergone both cardiac CT and SPECT MPI within 1 mo between January 1, 2006, and September 1, 2011. (snmjournals.org)
  • The presence of TID with an otherwise normal SPECT MPI study does not translate into a greater extent of coronary artery disease as assessed by cardiac CT or increased risk for future major adverse cardiac events. (snmjournals.org)
  • As a result, automated, objective approaches for measuring cardiac MPI SPECT are in great demand. (news-medical.net)
  • While Cardiac PET has been shown to be superior to SPECT, not all tracers are equal. (ionetix.com)
  • The enrolled population did not include individuals with myocardial infarction. (news-medical.net)
  • A man in his seventies presented with a history of cerebral infarction with occlusion of the left middle cerebral artery, diabetes mellitus, renal dysfunction, as well as prior myocardial infarction and arteriosclerosis obliterans. (journalmc.org)
  • He also had diabetes mellitus and renal dysfunction, as well as a prior history of myocardial infarction and arteriosclerosis obliterans. (journalmc.org)
  • MRI is considered the gold standard in the evaluation of myocardial function. (ecrjournal.com)
  • MRI is now considered the gold standard in the evaluation of myocardial function because of its high accuracy as well as inter- and intra-observer reproducibility. (ecrjournal.com)
  • Previous studies have suggested that TID in the context of reversible myocardial perfusion defects is associated with increased risk of severe, extensive multivessel coronary artery disease (CAD) ( 1 , 6 , 7 ). (snmjournals.org)
  • Transient ischemic dilation (TID) on stress SPECT myocardial perfusion imaging (MPI) is defined as the apparent presence of left ventricular (LV) dilation on poststress relative to rest images. (snmjournals.org)
  • In a recent study published in Scientific Reports , researchers investigated the performance of a machine learning (ML)-based model in evaluating radiomic features to diagnose coronary artery disease (CAD) and its susceptibility using myocardial perfusion imaging (MPI) single-photon emission computed tomography (SPECT) images. (news-medical.net)
  • MPI-SPECT imaging is a great asset for CAD diagnosis since it may offer a functional evaluation of the myocardium and heart arteries non-invasively. (news-medical.net)
  • Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with technetium-99m ( 99m Tc)-labelled radiotracers. (cadth.ca)
  • Diagnosis is by symptoms, electrocardiography, and myocardial imaging. (msdmanuals.com)
  • Several imaging modalities have been proposed for accurate assessment of myocardial necrosis, viability, stunning, and hibernation, with mixed results. (medscape.com)
  • Nuclear stress myocardial perfusion imaging (MPI) is a nuclear cardiology test that shows how well blood flows to the muscle of the heart (myocardium). (ottawaheart.ca)
  • Myocardial perfusion imaging (MPI) is the most widely used nuclear cardiology technique that deals with the assessment of blood flow to the heart (the myocardium). (azheartdoctor.com)
  • 1. Aggarwal NR, Drozdova A, Askew JW, Kemp BJ, Chareonthaitawee P. Feasibility and diagnostic accuracy of exercise treadmill nitrogen-N-13 Ammonia PET myocardial perfusion imaging of obese patients. (ionetix.com)
  • N-13 Ammonia Injection is a radioactive diagnostic agent for Positron Emission Tomography (PET) indicated for diagnostic PET imaging of the myocardium under rest or pharmacologic stress conditions to evaluate myocardial perfusion in patients with suspected or existing coronary artery disease. (ionetix.com)
  • Myocardial perfusion imaging (MPI) is an important imaging modality in the management of patients with cardiovascular disease. (snmjournals.org)
  • Myocardial perfusion imaging (MPI) is a valuable tool in the management of patients with cardiovascular disease. (snmjournals.org)
  • A heart perfusion imaging scan, or myocardial perfusion scan, is a test that tells doctors how well a person's heart pumps blood. (medicalnewstoday.com)
  • Imaging, Billig Online Adalat Miami a SPECT camera such as the Digirad and appropriate treatment of patients with hypertension, including lifestyle information regarding the type of closure device that was disorders, including atrial flutter. (rsmraiganj.in)
  • METHODS: Twenty-five patients with untreated mild essential hypertension and normal coronary vessels and 10 control subjects underwent dipyridamole-rest Tc-99m sestamibi imaging. (cnr.it)
  • CONCLUSION: Sestamibi imaging may detect impaired coronary vascular function in response to dipyridamole in patients with untreated mild essential hypertension and normal coronary arteries. (cnr.it)
  • Treadmill exercise produces larger perfusion defects than dipyridamole stress N-13 ammonia positron emission tomography. (ionetix.com)
  • Comparison of 99mTc-sestamibi-18F-fluorodeoxyglucose dual isotope simultaneous acquisition and rest-stress 99mTc-sestamibi single photon emission computed tomography for the assessment of myocardial viability. (nih.gov)
  • Diagnostic accuracy of dipyridamole technetium 99m-labeled sestamibi myocardial tomography for detection of coronary artery disease. (nih.gov)
  • Feasibility of simultaneous stress 99mTc-sestamibi/rest 201Tl dual-isotope myocardial perfusion SPECT in the detection of coronary artery disease. (nih.gov)
  • Specific techniques used are generally either of the following: Single-photon emission computed tomography (SPECT), which creates 3-dimensional images of the target organ or organ system. (wikipedia.org)
  • A single photon emission computed tomography (SPECT) camera detects the radiation released by the tracer to produce images of the heart. (ottawaheart.ca)
  • In this procedure, a radioactive tracer is injected into the bloodstream and heart function is analyzed by the doctor using a scanner called a SPECT (single photon emission computed tomography) camera. (azheartdoctor.com)
  • Regional cerebrovascular reactivity to acetazolamide (DIAMOX ® , LEDERLE PHARMACEUTICAL DIVISION, NY, USA, Sanwa Kagaku Kenkyusho CO., LTD., Nagoya, Japan) using single-photon emission computed tomography (SPECT) is commonly evaluated in patients with cerebrovascular disease and has proven to be an indispensable diagnostic technique [ 1 - 3 ]. (journalmc.org)
  • However, the optical assessment of MPI SPECT is observer-dependent, error-prone, and time-consuming. (news-medical.net)
  • The left ventricular (LV) myocardium, eliminating the heart cavities, was delineated manually on rest-stress MPI-SPECT scans to determine the desired volume for investigation. (news-medical.net)
  • Rahimtoola suggested that hibernating myocardium is characterized by a state of persistently impaired myocardial and LV function at rest due to reduced coronary blood flow that can be partially or completely restored to normal by improving blood flow or by reducing oxygen demand (see the image below). (medscape.com)
  • These disorders can also decrease relative myocardial perfusion because myocardial mass is increased (causing decreased diastolic flow). (msdmanuals.com)
  • Because myocardial oxygen demand is determined mainly by heart rate, systolic wall tension, and contractility, narrowing of a coronary artery typically results in angina that occurs during exertion and is relieved by rest. (msdmanuals.com)
  • 7 Viable myocardial cells take up the radionuclide tracer (either thallium isotope [ 201 TI] or isotope 99m Tc-labelled radiotracer) in proportion to blood flow. (cadth.ca)
  • The study included 395 individuals with suspected CAD who underwent a 48-hour rest-stress MPI SPECT. (news-medical.net)
  • This concept of an adaptive process that shuts down the contractile process and decreases myocardial oxygen demand in the presence of chronically or intermittently reduced blood flow has generated considerable interest in clinical and experimental settings. (medscape.com)
  • In the present radiomics study, researchers investigated MP-SPECT image-based CAD diagnosis by ML. In particular, the team evaluated the performance of different ML models applied to delta, stress, and rest MPI SPECT radiomics for CAD diagnosis and risk classification. (news-medical.net)
  • The physicians could access conventional SPECT scores, including the summed stress score (SSS), summed rest score (SRS), summed difference score (SDS), and wall thickening and motion data. (news-medical.net)
  • 1 The basic principle of radionuclide MPI is to administer a radiopharmaceutical intravenously and image blood flow to the heart muscle (myocardial perfusion), both at rest and under stress. (cadth.ca)
  • Two sets of images are taken, one after an injection at rest and another after an injection during a stress test - either exercise stress on a treadmill or drug-induced stress with persantine (dipyridamole) medication, which simulates exercise. (ottawaheart.ca)
  • An Incidentally Detected Case of Atypical Bronchial Carcinoid on Stress Myocardial Perfusion SPECT/CT. (nih.gov)
  • Myocardial blood flow (MBF) was estimated by measuring first transit counts in pulmonary artery and myocardial counts from tomograhic images. (cnr.it)
  • 6. Sasayama S, Nonogi H , Fujita M, Sakurai T, Wakabayashi A, Kawai C, Eiho S, Kuwahara M: Three-dimensional analysis of regional myocardial function in response to nitroglycerin in patients with coronary artery disease. (fiercecert.com)
  • Finding all 3 entities in the same patient with chronic myocardial dysfunction is not uncommon (see the image above). (medscape.com)
  • An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. (lookformedical.com)
  • Recovery of myocardial contractile function after spontaneous restoration of flow may be protracted similarly after angioplasty or revascularization surgery. (medscape.com)
  • Cardiologists cannot solely rely on the angiographic appearance of epicardial coronary artery stenosis when evaluating patients with myocardial ischaemia. (rcpe.ac.uk)
  • Regional myocardial function can be estimated visually in an SSFP sequence, but can be quantified more accurately using myocardial tagging techniques such as spatial modulation of magnetisation. (ecrjournal.com)
  • Regional myocardial function and electrophysiological alteration after coronary artery occlusion. (medscape.com)
  • Hence, dipyridamole is a pharmacological success diagnostically, but a artery supplying the heart with blood and oxygen becomes. (rsmraiganj.in)
  • Nuclear cardiology studies employ non-invasive techniques for assessing myocardial blood flow, the heart's pumping function, and also to identify the size and location of the damaged heart tissue. (azheartdoctor.com)
  • and high retention in the heart and kidney , and because of the high density of mitochondria , in the myocardial muscle the image contrast is very good. (turkupetcentre.net)
  • The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. (lookformedical.com)
  • The SPECT camera will take a series of pictures for about 15 minutes. (ottawaheart.ca)
  • A series of images are taken with the specially designed SPECT camera. (azheartdoctor.com)
  • However, the significance of TID in the setting of an otherwise normal SPECT MPI study has not been clearly established. (snmjournals.org)
  • TID in the setting of an abnormal SPECT MPI study has also been linked with increased cardiovascular risk and poor cardiovascular outcomes ( 8 - 11 ). (snmjournals.org)
  • SPECT examination using 123 I-IMP with acetazolamide challenge was performed 1 week later in accordance with the Japanese Extracranial-Intracranial Bypass Trial (JET study) [ 5 ] using autoradiography method [ 2 , 4 , 6 ]. (journalmc.org)
  • The overwhelming majority of MPI studies are now performed using SPECT and electrocardiographic (ECG) gating, which further add to the complexity of the study. (snmjournals.org)
  • Changes in myocardial blood flow in a canine model of left sided breast cancer radiotherapy. (ottawaheart.ca)
  • this later came to be called myocardial stunning (see the image below). (medscape.com)
  • The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image. (lookformedical.com)
  • In detection of CAD [ 18 F]flurpiridaz PET is superior to SPECT (Maddahi et al. (turkupetcentre.net)