• An homologous series of 6-imino-2-thioxo-5-{[3,4,5-tris(methyloxy)phenyl]methyl}-2,5-dihydro-4(3 H )-pyrimidinones has been tested for inhibition of DPP IV activity. (springer.com)
  • We conclude that pyrimidinone-like compounds are a promising new scaffold for reversible inhibition of DPP IV. (springer.com)
  • Oral administration of Ile-thiazolidide resulted in rapid inhibition of circulating DP IV levels by 65% in obese and lean Zucker rats. (diabetesjournals.org)
  • Aertgeerts K, Ye S, Tennant MG, Kraus ML, Rogers J, Sang BC, Skene RJ, Webb DR, Prasad GS (2004) Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation. (springer.com)
  • According to the molecular docking analysis, the inhibitors are anchored into the DPP IV hydrolytic site by interactions of the pyrimidinone core with Glu206, Tyr662, and Tyr547, with the alkyl chain entering the S1 pocket. (springer.com)
  • Brandt W (2000) Development of a tertiary-structure model of the C-terminal domain of DPP IV. (springer.com)
  • These results showed that inhibiting DP IV activity with Ile-thiazolidide blocked the formation of NH 2 -terminally truncated GIP and GLP-1. (diabetesjournals.org)