• Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts. (osteoporosis-studies.com)
  • Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells. (escipub.com)
  • Here, we aimed to obtain in vivo evidence showing that diosgenin signaling is mediated by 1,25D 3 -MARRS in the mouse brain. (nature.com)
  • Effect of diosgenin on lipid metabolism in rats" (abstract page). (wikipedia.org)
  • The purpose of this study was to determine whether diosgenin suppresses cholesterol absorption in rats, and to examine relevant changes in cholesterol and bile acid metabolism. (nih.gov)
  • diosgenin had no effect on serum cholesterol in normocholesterolemic rats. (nih.gov)
  • This study was aimed to evaluate the preventive role of treadmill exercise and diosgenin on cardiac marker enzymes, thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), lipids, and electrocardiographic (ECG) patterns in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. (ac.ir)
  • One hundred Wistar rats were divided into ten groups: Control rats (C), saline (S), L-cremephor (LC), exercise (E), diosgenin dissolved in L-cremephor (15 mg/kg/day) (D), exercise+ diosgenin (E+D), ISO injected (150 mg/kg) (ISO), exercise + ISO (E+ISO), diosgenin + ISO (D+ISO) and exercise+ diosgenin+ ISO (E+D+ISO). (ac.ir)
  • Exercise and diosgenin pretreatment significantly decreased serum total cholesterol and increased high density lipoprotein (HDL-C). ISO-treated rats showed pathological Q waves along with elevated ST segments. (ac.ir)
  • The altered electrocardiograms (ECG) of ISO-treated rats were also restored to near normal by diosgenin and exercise, but exercise and diosgenin had synergistic effects. (ac.ir)
  • Methods: Sprague Dawley rats were subjected to intra-striatal injection of lipopolysaccharide (LPS) and treated with diosgenin. (iospress.com)
  • Enriched environment enhanced the effect of diosgenin to ameliorate the LPS-induced motor deficits in rats and decreased the protein levels of TLR2, TLR4, and nuclear NF-κ B in diosgenin treated PD rats. (iospress.com)
  • 10 Hypercholestoleremic rats treated with diosgenin have experienced decreased cholesterol absorption, increased hepatic cholesterol synthesis, and increased biliary cholesterol secretion with no alteration in serum cholesterol. (sigmaaldrich.com)
  • In rats, oral administration of diosgenin increases cholesterol and phospholipid content in hepatocyte cell membranes while maintaining cholesterol/phospholipid molar ratios. (sigmaaldrich.com)
  • Feeding rats a 0.5% diosgenin diet for seven days almost completely prevents indomethacin-induced ulcers and lowers serum indomethacin levels. (sigmaaldrich.com)
  • Diosgenin Protects Rats from Myocardial Inflammatory Injury Induced by Ischemia-Reperfusion. (bioportfolio.com)
  • In vitro, diosgenin had no effect on the activity of rat pancreatic esterase. (nih.gov)
  • in vitro, diosgenin had no effect on bile acid binding. (nih.gov)
  • However, 1,25D 3 -MARRS-mediated diosgenin signaling was only shown in vitro in the previous study. (nature.com)
  • In the present study, we investigated the effects of water-soluble arginyl-diosgenin analog (Arg-DG) on the adult hippocampal neurogenesis using a central LPS-induced inflammatory mice model, along with the fundamental mechanisms in vivo and in vitro using LPS-stimulated microglial BV2 cells. (springer.com)
  • Conditioned media prepared from cells treated with diosgenin induced strong angiogenic activity in either in vitro or ex vivo angiogenesis assay. (osteoporosis-studies.com)
  • In vitro release studies performed in aqueous medium indicated a drug release dependence on the diosgenin hemiester linkers, the steroid content and the acidity of the solution. (escipub.com)
  • The present study was conducted to evaluate the in vitro anticancer and apoptotic effects on cell proliferation of diosgenin isolated from C. speciosus (Koen. (biomedcentral.com)
  • Diosgenin aswell causes an inhibition of the advance of fibroblast-like synoviocytes from animal rheumatoid arthritis, with apoptosis consecration associated with cyclooxygenase-2 (COX-2) up-regulation. (wordpress.com)
  • Celecoxib, a careful COX-2 inhibitor, affronted a ample abatement in diosgenin-induced apoptosis even in the attendance of exogenous prostaglandin E2, admitting interleukin-1β, a COX-2 inducer, acerb added diosgenin-induced apoptosis of these synoviocytes. (wordpress.com)
  • Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. (springer.com)
  • Our study demonstrates that FE [fenugreek extract] is selectively cytotoxic to cancer and not normal cells, while diosgenin is not capable of making such a differentiation," Shabbeer explained. (empowher.com)
  • Thus, the present review aims to provide collective information on the most recent pharmacological data on diosgenin and on the most relevant analytical techniques used to isolate, detect, and quantify this compound as well. (hindawi.com)
  • The crystal structure of the title compound, C 31 H 45 BrO 5 ·CH 2 Cl 2 , prepared in six steps from diosgenin, confirmed that the configurations of the stereogenic centers, positions 20 S and 25 R , remain unchanged during the reaction. (iucr.org)
  • The compound diosgenin has been previously identified as a cytotoxic agent. (empowher.com)
  • In the 1950s, scientists discovered that the roots of wild yam -- not to be confused with the sweet potato yam -- contain diosgenin. (umm.edu)
  • Both contain diosgenin and have similar medicinal properties. (umm.edu)
  • Many of them are wild species that flourish in damp woodlands and thickets, and not all of them contain diosgenin. (umm.edu)
  • Although each locale grows a different species of wild yam, both species contain diosgenin, the active ingredient in the plant. (livestrong.com)
  • Diosgenin fed with the diet for 1 week inhibited cholesterol absorption as determined by the serum isotope ratio technique, as well as by measuring in the feces the amount of unabsorbed radioactivity from orally administered [3H]cholesterol. (nih.gov)
  • Diosgenin treatment increased hepatic and intestinal cholesterol synthesis as well as the activity of hepatic HMG CoA reductase. (nih.gov)
  • Diosgenin had no effect on cholesterol synthesis when added to normal rat liver homogenates. (nih.gov)
  • The maximum accumulation of diosgenin was noticed on the 14th day in control and cholesterol-treated cell suspension culture and immobilised cell cultures. (iisc.ernet.in)
  • The highest concentration of diosgenin, 2.94% and 2.14% dry weight, was obtained in immobilised cell culture and cell suspension culture treated with 100 mg L- 1 cholesterol, respectively. (iisc.ernet.in)
  • Diosgenin seems to block the body from absorbing cholesterol, at least in animal studies. (umm.edu)
  • 3 , 15 Diosgenin is considered the primary active ingredient in wild yam, and is structurally similar to cholesterol. (sigmaaldrich.com)
  • Diosgenin has been found in multiple animal studies to decrease intestinal cholesterol absorption and reduce total serum cholesterol levels. (sigmaaldrich.com)
  • In everted rat jejunum, diosgenin has been found to competitively inhibit cholesterol absorption. (sigmaaldrich.com)
  • 8 , 9 Diosgenin has been found to reduce the total body pool of cholesterol. (sigmaaldrich.com)
  • 11 , 12 , 16 Hypercholesterolemic mice fed a 1% diosgenin diet for 15 days have had decreased cholesterol absorption, increased fecal excretion of cholesterol, and decreased plasma cholesterol levels. (sigmaaldrich.com)
  • however, the combination partially reversed the elevation in HDL cholesterol seen in the diosgenin-only group. (sigmaaldrich.com)
  • Administering vitamin C enhanced the cholesterol-lowering effects of clofibrate and diosgenin. (sigmaaldrich.com)
  • 14 In hypercholesterolemic monkeys, a synthetic analog of diosgenin decreased absorption of dietary cholesterol, increased biliary secretion of endogenous cholesterol, and reduced hypercholesterolemia. (sigmaaldrich.com)
  • Topical D. villosa (with an upper limit of 3.5% diosgenin) was not found to be systemically toxic or genotoxic. (drugs.com)
  • EPS and SPS showed moderate and relatively weak enhancement effects on cell growth and diosgenin accumulation, respectively. (mdpi.com)
  • The dynamics of cell growth and diosgenin accumulation when WPS was added to the medium at 20 mg/L on the 25th day of culture were investigated, and results showed that dry weight of cells reached a maximum value on day 30 but the maximum diosgenin content was achieved on day 31. (mdpi.com)
  • The diosgenin content was determined from tuber (fresh and dried) and callus of D. alata by acidic hydrolysis of the glycosides and extraction with an organic solvent, followed by the HPTLC analysis. (omicsonline.org)
  • Compared with regular hydrochloric acid hydrolysis, the developed approach obtained 96% diosgenin and reduced 93% reaction time, indicating that the catalytic hydrolysis with an acid-functionalized ionic liquid under microwave irradiation had a broad application prospect in diosgenin production. (xianghukeji.com)
  • In the present work, we studied extraction and estimation of Diosgenin content of the lesser explored tuber Diosocrea alata Var purpurae (purple yam), from Western Ghats, India [ 3 ]. (omicsonline.org)
  • We tried extracting diosgenin from fresh and dried tuber and callus developed by inoculating tuber as explant and optimizing the HPTLC method to analyze it. (omicsonline.org)
  • Since this type of yam plant has more amount of diosgenin, some scholars suggest that eating this tuber may increase the level of estrogen. (botanical-online.com)
  • However, in addition to this high synthetic relevance, diosgenin itself has several important biological activities also with great interest for the pharmaceutical industry [ 5 , 7 , 11 ]. (hindawi.com)
  • Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells. (osteoporosis-studies.com)
  • Based on our findings, our study suggests that diosgenin can enhance bone formation by stimulating the synthesis and secretion of Type 1 collagen and ALP and bone marker proteins Runx2 and osteopontin expression . (osteoporosis-studies.com)
  • Our in vivo data indicate that diosgenin is a memory-enhancing drug and that enhancement by diosgenin is mediated by 1,25D 3 -MARRS-triggered axonal growth. (nature.com)
  • Further, our results show that diosgenin protects the myocardium against ischemic insult through increasing enzymatic and nonenzymatic antioxidant levels in vivo and by decreasing oxidative stress damage. (hindawi.com)
  • These interesting compounds are 25R, spirostan-5a-diol-6-one-3-one (ecdybolin) (which demonstrates a 33:1 anabolic to androgenic ratio), the 6-keto derivative of diosgenin (6-keto-diosgenin), and 20- hydroxyecdysone decanoate isolated from Rhaponticum carthamoides extract. (supplementcentral.com)
  • Diosgenin treatment in normal mice enhanced object recognition memory and spike firing and cross-correlation in the medial prefrontal cortex and hippocampal CA1. (nature.com)
  • Inhibition of HIF-1alpha activity by transfection with DN-HIF-1alpha significantly diminished diosgenin -mediated VEGF-A up-regulation. (osteoporosis-studies.com)
  • Bone-specific transcription factor runt-related transcription factor 2 (Runx2) and Runx2-regulated osteopontin protein expressions were induced at low concentration (0.1-1 μM) and again decreased with high diosgenin concentrations. (osteoporosis-studies.com)
  • For murine MC3T3-E1 preosteoblast-like cells, VEGF-A mRNA and protein expression seemed to be significantly elevated in response to diosgenin in a concentration-dependent fashion. (osteoporosis-studies.com)
  • The effects of diosgenin in the regulation of renal proximal tubular fibrosis. (springer.com)
  • If this result was found, normal cognitive function could also be enhanced by the axonal growth-promoting effects of diosgenin. (nature.com)
  • Conclusion: In conclusion, our study, even if supported by preliminary results, showed how Diallyl Thiosulfinate, Nuciferine and Diosgenin is able to improve the control of ejaculation in patients suffering from PE, primary or secondary to ED without any significant adverse effects. (pagepressjournals.org)
  • Anticancer and apoptotic effects on cell proliferation of diosgenin isolated from Costus speciosus (Koen. (biomedcentral.com)
  • The results presented here may suggest that diosgenin isolated from C. speciosus possess anticancer and apoptotic effects on cell proliferation, and therefore, can be used as pharmaceuticals drugs. (biomedcentral.com)
  • 4 , 5 Consumers can expect a considerable range of diosgenin-related effects based on the source species as well as technique of growing, harvesting, processing, and storage conditions. (sigmaaldrich.com)
  • In this study, we examine whether diosgenin is able to induce VEGF-A expression and to promote angiogenesis in osteoblasts. (osteoporosis-studies.com)
  • The present investigation demonstrates that combination of diosgenin and exercise exhibited significant protection against ISO induced electrocardiographical and biochemical changes. (ac.ir)